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At least 127 records · Page 7

Long-term effects of low-dose proton radiation on immunity in mice: shielded vs. unshielded

BACKGROUND: Outside the protection of the terrestrial environment, astronauts on any long-term missions will unavoidably be exposed to fields of charged particle radiation dominated by protons. These fields and their biological risks are modified in complex ways by the presence of protective shielding. METHODS: To examine the long-term effects of space-like proton exposures on immune status, we treated female C57BL/6 mice with 3 or 4 Gy of 250 MeV monoenergetic protons or the complex space-like radiation field produced after 250 MeV protons are transported through 15 g x cm(-2) aluminum shielding. The animals were euthanized 122 d post-irradiation and lymphocyte phenotypes, hematological parameters, and lymphocyte blastogenesis were characterized. RESULTS: There were significant dose-dependent decreases in macrophage, CD3+/CD8+ T, NK, platelet, and red blood cell populations, as well as low hematocrit and hemoglobin levels. In contrast, dose-dependent increases in spontaneous, but not mitogen-induced, blastogenesis were noted. The differences in dose composition between pristine and shielded proton fields did not lead to significant effects in most measures, but did result in significant changes in monocyte and macrophage populations and spontaneous blastogenesis in the spleen. CONCLUSIONS: The data indicate that whole body exposure to proton radiation at doses of the order of large solar particle events or clinical treatment fractions may have long-term effects on immune system status.

NASA Discipline Radiation Health↗

The effects of proton exposure on neurochemistry and behavior

Future space missions will involve long-term travel beyond the magnetic field of the Earth, where astronauts will be exposed to radiation hazards such as those that arise from galactic cosmic rays. Galactic cosmic rays are composed of protons, alpha particles, and particles of high energy and charge (HZE particles). Research by our group has shown that exposure to HZE particles, primarily 600 MeV/n and 1 GeV/n 56Fe, can produce significant alterations in brain neurochemistry and behavior. However, given that protons can make up a significant portion of the radiation spectrum, it is important to study their effects on neural functioning and on related performance. Therefore, these studies examined the effects of exposure to proton irradiation on neurochemical and behavioral endpoints, including dopaminergic functioning, amphetamine-induced conditioned taste aversion learning, and spatial learning and memory as measured by the Morris water maze. Male Sprague-Dawley rats received a dose of 0, 1.5, 3.0 or 4.0 Gy of 250 MeV protons at Loma Linda University and were tested in the different behavioral tests at various times following exposure. Results showed that there was no effect of proton irradiation at any dose on any of the endpoints measured. Therefore, there is a contrast between the insignificant effects of high dose proton exposure and the dramatic effectiveness of low dose (<0.1 Gy) exposures to 56Fe particles on both neurochemical and behavioral endpoints. Published by Elsevier Ltd on behalf of COSPAR.

Non-NASA Center↗

Observations of proton spectra /Ep ranging from 1.0 to 300 keV/ and fluxes at the plasmapause.

Discussion of proton flux data recorded for 32 samples per spin period by two solid state proton detectors and a three-axis fluxgate magnetometer aboard Explorer 45 which was launched from Kenia into a 220-km-to-5.24 earth radius orbit. The occurrence of an amplifier saturation effect in the presence of high energy protons is noted. Diagrams are included for proton intensities, proton differential flux vs altitude in six energy bands, evolution of proton differential energy spectra through a steep gradient region, omnidirectional fluxes vs altitude, and plasma densities.

Williams, D. J.↗

High-energy proton radiation belt.

The experiments and theories to explain the high-energy protons trapped in the earth's radiation belt are reviewed. The theory of cosmic ray albedo neutron decay injection of protons into the radiation belt is discussed. Radial diffusion and change in the earth's dipole moment are considered along with losses of protons by ionization and nuclear collision. It is found that the measured albedo neutron escape current is sufficient to supply trapped protons above 30 MeV. The theoretical calculations of the trapped protons are in agreement with the measurements for L less than or equal to 1.7 both on and off the equator. For L greater than or equal to 1.7, additional trapped proton differential energy measurements should be made before the theory can be adequately tested. It appears that an additional loss mechanism such as pitch angle scattering may be required.

White, R. S.↗

On the anisotropies of interplanetary low-energy proton intensities

Explorer 35 proton anisotropic flux data (proton energies between 0.3 and 6.3 MeV) and simultaneous magnetic field measurements were used to supply more information on the propagation characteristics of low-energy protons in the interplanetary medium. During the rising portions of the proton events, large field-aligned anisotropies were observed. During the decaying part of the proton events, either radial anisotropy or near-isotropy was noticed. In addition, certain observations made during the decaying part of the proton events revealed anisotropies deviating significantly from the radial direction.

Pesses, M. E.↗

Ring current proton decay by charge exchange

Explorer 45 (S3-A) measurements were made during the recovery phase of the moderate magnetic storm of February 24, 1972, in which a symmetric ring current had developed and effects due to asymmetric ring current losses could be eliminated. It was found that after the initial rapid decay of the proton flux, which is a consequence of the dissipation of the asymmetric ring current, the equatorially mirroring protons in the energy range 5-30 keV decayed throughout the L value range of 3.5-5.0 at the charge exchange decay rate calculated by Liemohn (1961). After several days of decay, the proton fluxes reached a lower limit where an apparent equilibrium was maintained, between weak particle source mechanisms and the loss mechanisms, until fresh protons were injected into the ring current region during substorms. While other proton loss mechanisms may also be operating, the results indicate that charge exchange is more than sufficient as a particle loss mechanism for the storm time proton ring current decay.

Smith, P. H.↗

Pitch angle dispersion of drifting energetic protons at synchronous orbit

The time of arrival at ATS 6 of substorm-associated energetic proton flux enhancements has been examined as a function of both energy and pitch angle by using electron-proton spectrometer data. The protons exhibit energy dispersion with the particles with the highest energy arriving first. This has generally been interpreted as evidence that these particles have gradient- and curvature-drifted to the spacecraft from an acceleration region on the nightside. In the evening quadrant, proton enhancements at 90 deg pitch angle arrived at the spacecraft prior to those at small pitch angles. However, on the dayside the increase occurs first at the smallest pitch angle (about 30 degrees). The difference between the arrival times of the 30 deg and 90 deg protons increases for more westward local times. For the highest energy range observed, drifting protons are rarely seen at large pitch angles. These observations place severe restrictions on the simple drift models. Since the pitch angle dependence of the particle drift velocity is a field geometric quantity, the observations require the modification of present magnetospheric magnetic field models. In particular, the models need to reproduce better the enhanced field observed on the dayside near synchronous orbit.

Walker, R. J.↗

Electron and proton absorption calculations for a graphite/epoxy composite model

The Bethe-Bloch stopping power relations for inelastic collisions were used to determine the absorption of electron and proton energy in cured neat epoxy resin and the absorption of electron energy in a graphite/epoxy composite. Absorption of electron energy due to bremsstrahlung was determined. Electron energies from 0.2 to 4.0 MeV and proton energies from 0.3 to 1.75 MeV were used. Monoenergetic electron energy absorption profiles for models of pure graphite, cured neat epoxy resin, and graphite/epoxy composites are reported. A relation is determined for depth of uniform energy absorption in a composite as a function of fiber volume fraction and initial electron energy. Monoenergetic proton energy absorption profiles are reported for the neat resin model. A relation for total proton penetration in the epoxy resin as a function of initial proton energy is determined. Electron energy absorption in the composite due to bremsstrahlung is reported. Electron and proton energy absorption profiles in cured neat epoxy resin are reported for environments approximating geosynchronous earth orbit.

Long, E. R., Jr.↗

Electronic properties of deep-level defects in proton irradiated AlGaAs-GaAs solar cells

Deep level transient spectroscopy and capacitance voltage techniques as well as analysis of the forward current voltage (I-V) characteristics and SEM-EIC data were carried out for proton irradiated GaAs solar cells over a wide range of proton energies and proton fluences. Defect and recombination parameters such as defect energy levels and density, carrier capture cross sections and lifetimes as well as diffusion lengths in the undoped n-GaAs LPE layers were determined. Good correlation between these defect parameters and solar cell performance parameters was obtained for GaAs solar cells irradiated by 200 and 290 KeV protons. It was found that 200 to 290 KeV protons will produce the most defects and damages to the GaAs solar cell structure used. The influence of the low temperature (200 to 400 C) periodic thermal annealing on the deep level defects and the performance of the 200 KeV proton irradiated cells is discussed.

Li, S. S.↗

Proton-induced noise in digicons

The Space Telescope, which carries four Digicons, will pass several times per day through a low-altitude portion of the radiation belt called the South Atlantic Anomaly. This is expected to create interference in what is otherwise anticipated to be a noise-free device. Two essential components of the Digicon, the semiconductor diode array and the UV transmitting window, generate noise when subjected to medium-energy proton radiation, a primary component of the belt. These trapped protons, having energies ranging from 2 to 400 Mev and fluences at the Digicon up to 4,000 P+/sec-sq cm, pass through both the window and the diode array, depositing energy in each. In order to evaluate the effect of these protons, engineering test models of Digicon tubes to be flown on the High Resolution Spectrograph were irradiated with low-flux monoenergetic proton beams at the University of Maryland cyclotron. Electron-hole pairs produced by the protons passing through the diodes or the surrounding bulk caused a background count rate. This is the result of holes diffusing over a distance of many diode spacings, causing counts to be triggered simultaneously in the output circuits of several adjacent diodes. Pulse-height spectra of these proton-induced counts indicate that most of the bulk-related counts overlap the single photoelectron peak. A geometrical model will be presented of the charge collection characteristics of the diode array that accounts for most of the observed effects.

Smith, L. C.↗

The Single Event Upset (SEU) response to 590 MeV protons

The presence of high-energy protons in cosmic rays, solar flares, and trapped radiation belts around Jupiter poses a threat to the Galileo project. Results of a test of 10 device types (including 1K RAM, 4-bit microP sequencer, 4-bit slice, 9-bit data register, 4-bit shift register, octal flip-flop, and 4-bit counter) exposed to 590 MeV protons at the Swiss Institute of Nuclear Research are presented to clarify the picture of SEU response to the high-energy proton environment of Jupiter. It is concluded that the data obtained should remove the concern that nuclear reaction products generated by protons external to the device can cause significant alteration in the device SEU response. The data also show only modest increases in SEU cross section as proton energies are increased up to the upper limits of energy for both the terrestrial and Jovian trapped proton belts.

Nichols, D. K.↗

Simulations of heavy ion heating by electromagnetic ion cyclotron waves driven by proton temperature anisotropies

Heating of heavy ions by the electromagnetic ion cyclotron (EMIC) waves, which are driven by proton temperature anisotropies, is studied by means of hybrid particle simulations. Initially, relaxation of the temperature anisotropies in the proton distribution and isotropic heating of the heavy ions are observed (phase I), followed by substantial perpendicular heating of the heavy ions (phase II). The heavy ions are distinctly gyrophase modulated by the EMIC waves. The isotropic heating in phase I is due to magnetic trapping by the excited proton cyclotron waves. The perpendicular heating in phase II is attributed to cyclotron resonance with the EMIC waves, which becomes possible by means of the preceding heating in phase I. Saturation of the EMIC instability is instead attributed to magnetic trapping of the majority ions: protons. When the proton anisotropy is very large, frequency shift (decrease) of the proton cyclotron waves to less than 1/2 Ohm(p) is observed. The present mechanism is not only relevant to He(+) heating in the dayside equator of the magnetosphere, but it also predicts hot He2(+) ions behind the earth's bow shock.

Tanaka, M.↗

Electron injection by relativistic protons in active galactic nuclei

It is shown that protons with Lorentz factors larger than about 1,000,000 are cooled very rapidly by collisions with soft photons in the environment of an AGN. If the energy distribution of accelerated protons is sufficiently flat, then most of the energy contained in relativistic protons will be transformed to pairs, and then to radiation. Under these conditions, proton cooling due to p-gamma interactions is much more important than energy losses due to inelastic proton-proton collisions.

Sikora, Marek↗

Simulation of proton-induced energy deposition in integrated circuits

A time-efficient simulation technique was developed for modeling the energy deposition by incident protons in modern integrated circuits. To avoid the excessive computer time required by many proton-effects simulators, a stochastic method was chosen to model the various physical effects responsible for energy deposition by incident protons. Using probability density functions to describe the nuclear reactions responsible for most proton-induced memory upsets, the simulator determines the probability of a proton hit depositing the energy necessary for circuit destabilization. This factor is combined with various circuit parameters to determine the expected error-rate in a given proton environment. An analysis of transient or dose-rate effects is also performed. A comparison to experimental energy-disposition data proves the simulator to be quite accurate for predicting the expected number of events in certain integrated circuits.

Fernald, Kenneth W.↗

Biological effectiveness of high-energy protons - Target fragmentation

High-energy protons traversing tissue produce local sources of high-linear-energy-transfer ions through nuclear fragmentation. The contribution of these target fragments to the biological effectiveness of high-energy protons using the cellular track model is examined. The effects of secondary ions are treated in terms of the production collision density using energy-dependent parameters from a high-energy fragmentation model. Calculations for mammalian cell cultures show that at high dose, at which intertrack effects become important, protons deliver damage similar to that produced by gamma rays, and with fragmentation the relative biological effectiveness (RBE) of protons increases moderately from unity. At low dose, where sublethal damage is unimportant, the contribution from target fragments dominates, causing the proton effectiveness to be very different from that of gamma rays with a strongly fluence-dependent RBE. At high energies, the nuclear fragmentation cross sections become independent of energy. This leads to a plateau in the proton single-particle-action cross section, below 1 keV/micron, since the target fragments dominate.

Cucinotta, Francis A.↗

Star tracker operation in a high density proton field

Algorithms that reject transient signals due to proton effects on charge coupled device (CCD) sensors have been implemented in the HDOS ASTRA-l Star Trackers to be flown on the TOPEX mission scheduled for launch in July 1992. A unique technique for simulating a proton-rich environment to test trackers is described, as well as the test results obtained. Solar flares or an orbit that passes through the South Atlantic Anomaly can subject the vehicle to very high proton flux levels. There are three ways in which spurious proton generated signals can impact tracker performance: the many false signals can prevent or extend the time to acquire a star; a proton-generated signal can compromise the accuracy of the star's reported magnitude and position; and the tracked star can be lost, requiring reacquisition. Tests simulating a proton-rich environment were performed on two ASTRA-1 Star Trackers utilizing these new algorithms. There were no false acquisitions, no lost stars, and a significant reduction in reported position errors due to these improvements.

Miklus, Kenneth J.↗

Lower hybrid turbulence at cometary bow wave and acceleration of cometary protons

The wave measurements at the spacecraft encounters with Comet Halley have shown intense wave activity at the lower hybrid frequency. The excitation of the lower hybrid instability by the pickup cometary ions (protons and water group) in the bow wave region and the quasi-linear diffusion of the ions in these fluctuations are discussed. The quasi-linear diffusion of the pickup protons takes place over a scale length shorter than that of the heavier water group ions. This enhances damping of the waves by protons, and when the pickup proton density is large enough, it can result in the saturation of the instability as this damping balances the heavy ion driven growth. The observed electric field amplitude and the scale length of proton relaxation are in agreement with the theory. For small pickup proton density the instability can saturate due to the wave energy cascade arising from the modulation instability of the large-amplitude lower hybrid waves. This saturation mechanism leads to electron acceleration and suprathermal tail formation.

Shapiro, V. D.↗

Contribution of proton-induced short range secondaries to the LET spectra on LDEF

The contribution to the LET (linear energy transfer) spectrum from proton-induced short range secondaries was investigated by making measurements of total track density and LET spectra in CR-39 Plastic Nuclear Track Detectors (PNTD's) at varying shielding depths in the A0015 West-side stack. Proton-induced short range secondaries were found to make a significant contribution to the LET spectra, especially in the region above 100 keV/micron. At present, calculational models do not include this component. Total track density was measured at five shielding depths and was seen to increase as a function of shielding. LET spectra were measured under two shielding depths (2.6 and 9.2 g/cm(exp 2)) and stayed fairly constant as a function of shielding. Prerecovery estimates of LET spectra dropped off rapidly in the 100-300 keV/micron region, while the measured LET spectra extended to higher LET's. Track density and LET spectra measurements of secondaries were made in a CR-39 PNTD stack exposed to 154 MeV accelerator protons. Similarities in LET spectra measured in the A0015 experiment and in the 154 MeV accelerator proton stack demonstrate that a useful first step in modeling the contribution to the LET spectra of secondaries induced by the spectrum of trapped protons would be to model a mono-energetic proton beam being transported through a one-dimensional geometry.

Benton, E. R.↗