Plasma tocopherol concentrations and vitamin E deficiency in dogs
Plasma tocopherol concentrations and vitamin E deficiency in dogs, noting pathologic changes in smooth muscle, central nervous system, skeletal muscle and retina
Hayes, K. C.↗
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Retinal dehydrogenases in rabbits exposed to 100 percent oxygen
Dehydrogenases activities in rabbit retina homogenates exposed to oxygen at high partial pressure for various time periods
Leon, H. A.↗
Frequency of light-flashes induced by Cerenkov radiation from heavy cosmic-ray nuclei
The expected frequency was calculated for light flashes induced in the dark-adapted eye by Cerenkov radiation from the flux of heavy nuclei that exists in space beyond the geomagnetic field. The expected frequency of light flashes depends on the threshold number of photons that must be absorbed in a rod cluster. The results of the calculation are presented as a curve of the mean frequency of light flashes versus the threshold number of absorbed photons. The results are not sensitive to variations in the path length from 5 to 15 grams per square centimeter of water-equivalent before the nucleus reaches the retina. Calculations were based on the fluxes and energy spectra of galactic cosmic ray nuclei of helium to iron, measured at a time of minimum solar modulation. The expected light flash frequencies induced by Cerenkov radiation are consistent with the frequencies reported by the astronauts on Apollo missions 11 through 14.
Madey, R.↗
Experimental study of visual accommodation
A summary report of a research effort related to the human visual accommodation system is presented. A theoretical study of the accommodation system was made. Subsequent effort was aimed at the development of specialized instrumentation for experiments designed to lead to understanding the nature of the control system in human accommodation. The necessary instrumentation consisted primarily of: (1) an automatic optometer to measure the state of eye focus, (2) a focus stimulator device to control the apparent optical distance to any target, and (3) a two-dimensional eye tracker. The concepts and designs of the first two instruments have been published in the open literature, but this report contains the first detailed treatment of the Purkinje eye tracker developed under this program. The report also discusses an accommodation lag model to explain the ability of the eye to apparently know the polarity of focus error even though the blur on the retina is to a first-approximation an even function. The interaction of the accommodation and eye movement systems is also discussed, as is the ability to train the visual accommodation system to a surprisingly responsive condition in only a few hours of training.
Cornsweet, T. N.↗
Star magnitude and manual navigation sighting accuracy using the Apollo T2 sextant.
This laboratory study investigated the effect of four star magnitudes (0, +1, +2, +3) upon the angular sighting accuracy attainable between a star and a lunar limb using a space-rated sextant with an 8-power telescope. Four males were tested. The results indicated that over a series of daily sightings sighting accuracy increases as star magnitude decreases; i.e., the angle between the actual lunar limb and the perceived lunar limb decreases as the intensity of the star increases. The significant subject and day main effects that were found indicate that each individual must be calibrated against himself and that extreme care must be taken to center the various images correctly within the sextant's field of view each time the instrument is set up. These findings are discussed in relation to further refinement of a graphic model of the distribution of energy on the retina. A discussion is also presented on the differences between sextant sighting research conducted in the laboratory and in the real, high-altitude or space environment.
Haines, R. F.↗
Effect of bedrest and positive radial acceleration upon peripheral visual response time.
Attempt to determine if peripheral visual response time (RT) could be used as a reliable advanced predictor of +G sub z-related blackout or grayout. The relatively high luminance of the peripheral stimuli used in the experiments may account for the finding that peripheral RT was not sensitive to impending blackout or grayout. The relatively consistent mean RTs within subjects across test days in bed is probably due to the relatively constant response characteristics of the retina and to the high repeatability of the stimuli.
Haines, R. F.↗
Theoretical aspects of color vision
The three color receptors of Young-Helmholtz and the opponent colors type of information processing postulated by Hering are both present in the human visual system. This mixture accounts for both the phenomena of color matching or hue discrimination and such perceptual qualities of color as the division of the spectrum into color bands. The functioning of the cells in the visual system, especially within the retina, and the relation of this function to color perception are discussed.
Wolbarsht, M. L.↗
Effect of elimination of nitrogen and/or hypoxia or restricted visual environment on color vision and range of accommodation
The effects upon range of accommodation and color vision of reduced atmospheric pressure, at partial and complete elimination of nitrogen, of hypoxia, and of exposure for varying periods of time to restricted visual environment, have been studied alone or in various combinations. Measurements were made on the electroretinogram, the electrooculogram, and the diameter of the retinal vessels as an indicator of blood flow to the retina at the time of total elimination of nitrogen. An objective method was used to test range of accommodation. In the color vision test the flicker colors of a Benham's top were matched with a colorimeter.
Wolbarsht, M. L.↗
Biocore experiment
The Apollo 17 biological cosmic ray experiment to determine the effect of heavy cosmic ray particles on the brain and eyes is reported. The pocket mouse was selected as the biological specimen for the experiment. The radiation monitors, animal autopsy and animal processing are described, and the radiation effects on the scalp, retina, and viscera are analyzed.
Bailey, O. T.↗
Visual light flash phenomenon
Light flash phenomenon observed by crewmen on Apollo 14, 15, 16, and 17 are analyzed. The passage of cosmic rays through the crewman's head and eyes was recorded by the Apollo light flash moving emulsion detector. Events of all the light flash observations are tabulated. It is suggested that the most probable explanation of the phenomenon is that it is caused by cosmic rays penetrating the eyes and retinas of the observers.
Pinsky, L. S.↗
An analysis of the circuitry of the visual pathway of the lateral eye of limullus
The methodology is discussed for three-dimensional analysis of the nervous system on the basis of electron micrographs of serial sections. An analysis is presented of a part of the circuitry of the rabbit retina. In addition, some exploratory work is reported with respect to the visual cortex of the cat brain. A proper technique for preservation of the visual cortex was worked out and a technique to localize microelectrode tips in the tissue in connection with electron microscopy was partially worked out.
Sjoestrand, F. S.↗
Peripheral visual response time to colored stimuli imaged on the horizontal meridian
Two male observers were administered a binocular visual response time task to small (45 min arc), flashed, photopic stimuli at four dominant wavelengths (632 nm red; 583 nm yellow; 526 nm green; 464 nm blue) imaged across the horizontal retinal meridian. The stimuli were imaged at 10 deg arc intervals from 80 deg left to 90 deg right of fixation. Testing followed either prior light adaptation or prior dark adaptation. Results indicated that mean response time (RT) varies with stimulus color. RT is faster to yellow than to blue and green and slowest to red. In general, mean RT was found to increase from fovea to periphery for all four colors, with the curve for red stimuli exhibiting the most rapid positive acceleration with increasing angular eccentricity from the fovea. The shape of the RT distribution across the retina was also found to depend upon the state of light or dark adaptation. The findings are related to previous RT research and are discussed in terms of optimizing the color and position of colored displays on instrument panels.
Haines, R. F.↗
Ontogenesis of receptive fields in the rabbit striate cortex
The development of receptive fields in rabbit pups was investigated by measuring their responses to various light stimuli and to electric shock delivered to the optic nerve head. The pups ranged in age from three to twenty-five days, allowing correlation of findings with maturation. The data, classified according to relation with symmetric or asymmetric field types, strongly suggest that retina maturation is the key factor in the rate of development in central visual pathways, and that central synaptic connections are made before the onset of retinal activity.
Mathers, L. H.↗
Response time to colored stimuli in the full visual field
Peripheral visual response time was measured in seven dark adapted subjects to the onset of small (45' arc diam), brief (50 msec), colored (blue, yellow, green, red) and white stimuli imaged at 72 locations within their binocular field of view. The blue, yellow, and green stimuli were matched for brightness at about 2.6 sub log 10 units above their absolute light threshold, and they appeared at an unexpected time and location. These data were obtained to provide response time and no-response data for use in various design disciplines involving instrument panel layout. The results indicated that the retina possesses relatively concentric regions within each of which mean response time can be expected to be of approximately the same duration. These regions are centered near the fovea and extend farther horizontally than vertically. Mean foveal response time was fastest for yellow and slowest for blue. Three and one-half percent of the total 56,410 trials presented resulted in no-responses. Regardless of stimulus color, the lowest percentage of no-responses occurred within 30 deg arc from the fovea and the highest within 40 deg to 80 deg arc below the fovea.
Haines, R. F.↗
Preflight studies on tolerance of pocket mice to oxygen and heat. III - Effects on eyes
A study was made of the eyes of eight pocket mice exposed to oxygen at partial pressures of 8, 10, or 12 psi over a period of 7 d. At the termination of the exposure, the animals were decompressed to sea-level O2, either immediately or over a period of 30, 60, or 90 min. No pathological changes were found in any of the eyes, except in the retina of one of the animals exposed to 12 psi O2. Here, only a single rod photoreceptor was found damaged, an observation not regarded as significant. Hence, an oxygen partial pressure as high as 12 psi in the canister in which pocket mice were expected to fly on Apollo XVII would probably have no deleterious effect on the eyes of the animals.
Philpott, D. E.↗
Results of eye examination
Five pocket mice (Perognathus longimembris) were flown on Apollo XVII, and four survived. All the eyes, except one eye from the dead flight mouse, were examined histologically. In the four surviving mice, a total of five cosmic-ray particles which had registered in the subscalp particle detectors had trajectories that intersected the eyes. Four of them (Z = 6.9 for three of the particles and Z greater than or equal to 10 for the fourth) most likely went through the head before reaching the particle detector, while the thindown direction of the fifth (Z greater than or equal to 10) was not determinable. The retinas of the flight animals were found free from histological alterations such as might have been expected from encounters with cosmic-ray particles.
Philpott, D. E.↗
Quantitative observation of light flash sensations experiment MA-106
Light flashes caused by the interaction of cosmic particles with the visual apparatus have been observed by astronauts on all space missions since Apollo 11. This Apollo Soyuz Test Project experiment compared measurements of the observer's visual sensitivity with measurements of the ambient radiation environment and with the frequency and character of the flashes observed. The data obtained reveal a latitude dependence of the frequency of observed flashes. This distribution of flashes is correlated with the distribution of cosmic particles with stopping power greater than 15 keV/ micrometers in the eye. The interaction of dark adaptation, specific ionization, and range of particles in the retina as factors in the visualization of particle passage is discussed.
Budinger, T. F.↗
Monte Carlo simulation of astronaut light flash observations on Apollo and Skylab missions
Monte Carlo calculations are performed to study the relation between cosmic ray nuclei and visual flashes observed by astronauts, in space. A satisfactory overall fit to all available data excluding the Skylab observations in the South Atlantic Anomaly (SAA) has been achieved by varying three visual system parameters: effective retinal thickness, minimum projected track length inside retina and minimum energy loss rate. All light flash data from space excluding the SAA observations can be understood fully upon the basis of the primary cosmic ray charge and energy spectra together with the fitted values of the three visual system parameters. Monte Carlo simulations of the SAA observations suggest the existence of a previously unobserved multiply-charged component of the inner radiation belt.
Osborne, W. Z.↗