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At least 127 records · Page 7

US Perspectives on the Conventional/Nuclear Interactions and the Impacts on Nuclear Escalation Risks and Future Arms Control Prospects

This short paper is organized around a few discrete questions. How have U.S. perspectives on conventional and nuclear interactions evolved in recent years? How have these changing perspectives shaped U.S. thinking on perceived nuclear escalation risks with Russia, both long standing and newly emerged? And finally, what do these U.S. perceptions of interactions and risks mean for future potential arms control either in the conventional or nuclear arena? The answers to these questions appear to show some promise for future work in this area. Conventional and nuclear interactions are increasing, and thus the two domains cannot be kept as deliberately or artificially separated as in the past. There is a growing mutual recognition regarding the interplay between conventional and nuclear capabilities in the strategic stability equation. There is also an increasingly shared recognition in the United States and Russia that nuclear escalation risks are likely to originate in conventional crises or conflict, placing an imperative on some form of conflict prevention procedures at the lower end of the spectrum. This requirement suggests some potential areas for risk reduction measures outside of those traditionally considered in conventional and nuclear arms control over the past several decades.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗

Advancing representations of equity and justice in climate mitigation futures

THIS PAPER WAS PRIMARILY COMPLETED PRIOR TO THE AUTHOR JOINING PNNL AND NO DOE FUNDING WAS USED FOR THIS PAPER. In this work, we review how equity and justice issues in global climate mitigation scenarios are addressed within Integrated Assessment Models (IAMs) and propose a new research agenda to strengthen their integration in model development and application. We begin by examining prominent concerns at the science-policy interface. We introduce a typology of equity and justice limitations in climate mitigation scenarios, distinguishing among structural, methodological, and epistemological biases that shape what integrated assessment models can reveal at policy-relevant scales. Reflecting on these concerns, we propose a research agenda that describes new avenues of work and draws together distinct emerging initiatives. This agenda is based on the feasibility and depth of required interventions, from incremental improvements to structural reforms and alternative participatory approaches. Drawing on reflexive insights from integrated assessment practitioners, it addresses the operational challenges of translating justice concepts into metrics, including risks of reductionism, tokenism, and narrow definitions. Underlying this research agenda is a recognition that modeling communities must engage more critically with implicit assumptions in model design and use that have equity and justice implications. Achieving equitable climate futures will require transformative actions that integrate diverse justice concerns, advance sustainable development goals, and confront systemic inequities across both human and ecological dimensions. Although models will never capture all these aspects, they can be significantly enhanced to support more informed discussion and practical application. Our contribution proposes a way forward to achieving this goal.

Pachauri, Shonali↗

A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity

Allergies have become a rising health problem, where plentiful substances can trigger IgE-mediated allergies in humans. While profilins are considered minor allergens, these ubiquitous proteins are primary molecules involved in cross-reactivity and pollen-food allergy syndrome. Here we report the first crystal structures of murine Fab/IgE, with its chains naturally paired, in complex with the allergen profilin from Hevea brasiliensis (Hev b 8). The crystallographic models revealed that the IgE’s six complementarity-determining regions (CDRs) interact with the allergen, comprising a rigid paratope-epitope surface of 926 Å 2 , which includes an extensive network of interactions. Interestingly, we also observed previously unreported flexibility at Fab/IgE’s elbow angle, which did not influence the shape of the paratope. The Fab/IgE exhibits a high affinity for Hev b 8, even when using 1 M NaCl in BLI experiments. Finally, based on the encouraging cross-reactivity assays using two mutants of the maize profilin (Zea m 12), this antibody could be a promising tool in IgE engineering for diagnosis and research applications.

59 BASIC BIOLOGICAL SCIENCES↗

Classification of Martian deltas

Water-borne sediments in streams are deposited, upon eventual cessation of flow, either as deltas or as alluvial fans or plains. Deltas and alluvial fans share a common characteristic; both may be described as deposition Al plains at the mouth of a river or stream. A delta is formed where a stream or river deposits its sedimentary load into a standing body of water such as an ocean or lake. An alluvial fan is produced where a stream loses capacity by a greatly decreased gradient. A delta has subaerial and subaqueous components, but an alluvial fan is entirely subaerial. In terrestrial conditions, deltas and alluvial fans are reasonably distinct landforms. The juxtaposition of concomitant features composition and internal structure are sufficiently explicit as to avoid any confusion regarding their proper identification on Mars, the recognition of deltas and their distinction from alluvial fans is made difficult by low resolution imaging. Further, although it may be demonstrated that standing bodies of water existed on the surface of Mars, many of these bodies may have existed for extremely short periods of time (a few days to months); hence, distinctive shoreline features were not developed. Thus, in an attempt to derive a Martian classification of deltas, the inclusion of wholly subaerial deposits may be unavoidable. A simple, broad, morphological classification of Martian deltas, primarily on planimetric shape, includes digitate deltas, fan-shaped deltas, and re-entrant deltas. A fourth, somewhat problematical class includes featureless plains at the end of many valley systems.

Dehon, R. A.↗

Architecture of Pseudomonas aeruginosa glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases

The aminoacyl-tRNA synthetases (AaRSs) are an ancient family of structurally diverse enzymes that are divided into two major classes. The functionalities of most AaRSs are inextricably linked to their oligomeric states. While GluRSs were previously classified as monomers, the current investigation reveals that the form expressed in Pseudomonas aeruginosa is a rotationally pseudosymmetrical homodimer featuring intersubunit tRNA binding sites. Both subunits display a highly bent, "pipe strap" conformation, with the anticodon binding domain directed toward the active site. The tRNA binding sites are similar in shape to those of the monomeric GluRSs, but are formed through an approximately 180-degree rotation of the anticodon binding domains and dimerization via the anticodon and D-arm binding domains. As a result, each anticodon binding domain is poised to recognize the anticodon loop of a tRNA bound to the adjacent protomer. Additionally, the anticodon binding domain has an α-helical C-terminal extension containing a conserved lysine-rich consensus motif positioned near the predicted location of the acceptor arm, suggesting dual functions in tRNA recognition. The unique architecture of PaGluRS broadens the structural diversity of the GluRS family, and member synthetases of all bacterial AaRS subclasses have now been identified that exhibit oligomerization.

Fenwick, Michael K↗

The role of UV-optical obscuration in starburst galaxies

The starburst phenomenon was viewed as increasingly important since the recognition that some galaxies have regions in which stars are forming so rapidly that a transient event must be seen. Such starbursts populate samples of galaxies selected either for UV or IR excess, and some were found from IRAS source identifications that must be quite heavily obscured at optical wavelengths. Many interpretations of the physical conditions in these objects and their stellar populations have relied on scaling from models of individual H II regions, and this certainly seems justified from the gross appearance of the optical spectra and IR spectral shapes. Collection of complementary UV, optical, and near-IR data is presented on a set of starbursts, with a preliminary analysis of models for more realistic internal structure.

Keel, William C.↗

Circumnuclear starbursts in Seyfert galaxies

Observational diagnostics for the recognition of circumnuclear star formation in Seyfert galaxies are described and illustrated. These methods include: (1) spatially resolved optical spectroscopy, which allows the emission lines for HII regions to be separated from those originating in gas ionized by the Seyfert nucleus; (2) radio continuum mapping, where the linear radio sources characteristic of the nuclear activity may be distinguished from the diffuse morphology of multiple supernova remnants generated in a starburst; (3) infrared spectroscopic searches for emission features of dust, which are seen in starbursts but not in Seyfert nuclei; (4) the shape of the IRAS spectrum. These various diagnostics agree well as to the presence or absence of ongoing star formation. The IRAS spectra of a significant fraction of Seyferts are dominated by emission from dust heated by stars, not the Seyfert nucleus itself. In these cases, the spectrum is curved, being steep between 25 and 60 microns and flatter between 60 and 100 microns. When the Seyfert nucleus dominates, the 25 to 100 micron spectrum is much flatter. It is suggested that the location of a Seyfert galaxy in the IRAS color-color diagram reflects primarily the relative contributions of the active nucleus and dust heated by stars to the infrared fluxes.

Wilson, Andrew S.↗

Neural networks for data compression and invariant image recognition

An approach to invariant image recognition (I2R), based upon a model of biological vision in the mammalian visual system (MVS), is described. The complete I2R model incorporates several biologically inspired features: exponential mapping of retinal images, Gabor spatial filtering, and a neural network associative memory. In the I2R model, exponentially mapped retinal images are filtered by a hierarchical set of Gabor spatial filters (GSF) which provide compression of the information contained within a pixel-based image. A neural network associative memory (AM) is used to process the GSF coded images. We describe a 1-D shape function method for coding of scale and rotationally invariant shape information. This method reduces image shape information to a periodic waveform suitable for coding as an input vector to a neural network AM. The shape function method is suitable for near term applications on conventional computing architectures equipped with VLSI FFT chips to provide a rapid image search capability.

Gardner, Sheldon↗

Unconventional Materials Processing Using Spark Plasma Sintering

Spark plasma sintering (SPS) has gained recognition in the last 20 years for its rapid densification of hard-to-sinter conventional and advanced materials, including metals, ceramics, polymers, and composites. Herein, we describe the unconventional usages of the SPS technique developed in the field. The potential of various new modifications in the SPS technique, from pressureless to the integration of a novel gas quenching system to extrusion, has led to SPS’ evolution into a completely new manufacturing tool. The SPS technique’s modifications have broadened its usability from merely a densification tool to the fabrication of complex-shaped components, advanced functional materials, functionally gradient materials, interconnected materials, and porous filter materials for real-life applications. The broader application achieved by modification of the SPS technique can provide an alternative to conventional powder metallurgy methods as a scalable manufacturing process. The future challenges and opportunities in this emerging research field have also been identified and presented.

36 MATERIALS SCIENCE↗

Connectivity strategies for higher-order neural networks applied to pattern recognition

Different strategies for non-fully connected HONNs (higher-order neural networks) are discussed, showing that by using such strategies an input field of 128 x 128 pixels can be attained while still achieving in-plane rotation and translation-invariant recognition. These techniques allow HONNs to be used with the larger input scenes required for practical pattern-recognition applications. The number of interconnections that must be stored has been reduced by a factor of approximately 200,000 in a T/C case and about 2000 in a Space Shuttle/F-18 case by using regional connectivity. Third-order networks have been simulated using several connection strategies. The method found to work best is regional connectivity. The main advantages of this strategy are the following: (1) it considers features of various scales within the image and thus gets a better sample of what the image looks like; (2) it is invariant to shape-preserving geometric transformations, such as translation and rotation; (3) the connections are predetermined so that no extra computations are necessary during run time; and (4) it does not require any extra storage for recording which connections were formed.

Spirkovska, Lilly↗

A new method for recognizing quadric surfaces from range data and its application to telerobotics and automation

Pose and orientation of an object is one of the central issues in 3-D recognition problems. Most of today's available techniques require considerable pre-processing such as detecting edges or joints, fitting curves or surfaces to segment images, and trying to extract higher order features from the input images. We present a method based on analytical geometry, whereby all the rotation parameters of any quadric surface are determined and subsequently eliminated. This procedure is iterative in nature and was found to converge to the desired results in as few as three iterations. The approach enables us to position the quadric surface in a desired coordinate system, and then to utilize the presented shape information to explicitly represent and recognize the 3-D surface. Experiments were conducted with simulated data for objects such as hyperboloid of one and two sheets, elliptic and hyperbolic paraboloid, elliptic and hyperbolic cylinders, ellipsoids, and quadric cones. Real data of quadric cones and cylinders were also utilized. Both of these sets yielded excellent results.

Alvertos, Nicolas↗

NASA Tech Briefs, August 2006

Topics covered include: Measurement and Controls Data Acquisition System IMU/GPS System Provides Position and Attitude Data Using Artificial Intelligence to Inform Pilots of Weather Fast Lossless Compression of Multispectral-Image Data Developing Signal-Pattern-Recognition Programs Implementing Access to Data Distributed on Many Processors Compact, Efficient Drive Circuit for a Piezoelectric Pump; Dual Common Planes for Time Multiplexing of Dual-Color QWIPs; MMIC Power Amplifier Puts Out 40 mW From 75 to 110 GHz; 2D/3D Visual Tracker for Rover Mast; Adding Hierarchical Objects to Relational Database General-Purpose XML-Based Information Managements; Vaporizable Scaffolds for Fabricating Thermoelectric Modules; Producing Quantum Dots by Spray Pyrolysis; Mobile Robot for Exploring Cold Liquid/Solid Environments; System Would Acquire Core and Powder Samples of Rocks; Improved Fabrication of Lithium Films Having Micron Features; Manufacture of Regularly Shaped Sol-Gel Pellets; Regulating Glucose and pH, and Monitoring Oxygen in a Bioreactor; Satellite Multiangle Spectropolarimetric Imaging of Aerosols; Interferometric System for Measuring Thickness of Sea Ice; Microscale Regenerative Heat Exchanger Protocols for Handling Messages Between Simulation Computers Statistical Detection of Atypical Aircraft Flights NASA's Aviation Safety and Modeling Project Multimode-Guided-Wave Ultrasonic Scanning of Materials Algorithms for Maneuvering Spacecraft Around Small Bodies Improved Solar-Radiation-Pressure Models for GPS Satellites Measuring Attitude of a Large, Flexible, Orbiting Structure

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Technical Issues in the Comprehensive Nuclear Test Ban Treaty (CTBT) Ratification Debate: A 20 Year Retrospective

Two decades after the U.S. Senate declined in 1999 to give its consent to ratification of the Comprehensive Nuclear Test Ban Treaty (CTBT), the treaty remains in legal and political limbo. Legally, the treaty cannot enter into force without U.S. ratification. However, the Senate’s rejection does not strip the treaty of its force as an element of customary international law or alter the will of other signatories to see it enter into force. Politically, the debate over the virtues and flaws of the treaty remains as strong as ever, with some CTBT advocates pushing energetically for U.S. re-review while some opponents seek ways to “un-sign” the treaty. Meanwhile, despite the Senate’s rejection of the treaty, the United States acts in a manner consistent with its main obligations by maintaining a moratorium on explosive nuclear testing and providing financial support (as well as technical expertise) to the CTBT Organization (CTBTO)—in particular the CTBTO’s International Monitoring System (IMS). The CTBT may well remain in such limbo for a long time to come, unless some catalytic event comes along to re-shape national perceptions and priorities, one way or the other. The treaty’s future, whatever it might be, will be determined in part by how much perspectives might have changed in light of interim developments. Our purpose is to shed light on some of those developments and to assess their relevance. The 1999 ratification debate addressed a large number of issues. Rejection was driven by various policy and technical judgments. The purpose of this paper is to re-examine those technical judgments in light of what has been learned over the following two decades. On some technical matters, there was explicit recognition of extant uncertainties, as well as a conviction and hope that time would dispel them. To be doubly clear, our purpose is not to recommend a way forward on CTBT ratification. The policy judgments of 1999 and 2020 are beyond the scope of this paper. This technical re-examination proceeds as follows. It begins with a short background section to introduce the key technical matters in discussion in the U.S. ratification process. Then it moves systematically through each of those topics with a review of relevant background information, a discussion of key points in debate, an analysis of subsequent experience, and a current assessment. The historical analysis draws on many sources including the primary documents of the Congressional debate, the official article-by-article interpretation by the Department of State, and the statements of key players in the process. We also relied on key technical reports and publications by subject matter experts that have addressed in more detail many of the issues in our focus. These sources include the 2002 and 2012 reports of the National Academy of Sciences as well as publications by senior technical staff of Lawrence Livermore National Laboratory (LLNL) who were actively involved in the ratification debate, including then-Laboratory Director Bruce Tarter. We also conducted several interviews with government officials from the 1990s, past laboratory directors, and other members of the scientific community. But, except where individuals are specifically cited by name, the judgments offered here are our own and should not be attributed to any other individual or to LLNL as such.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗

Path perception during rotation: influence of instructions, depth range, and dot density

How do observers perceive their direction of self-motion when traveling on a straight path while their eyes are rotating? Our previous findings suggest that information from retinal flow and extra-retinal information about eye movements are each sufficient to solve this problem for both perception and active control of self-motion [Vision Res. 40 (2000) 3873; Psych. Sci. 13 (2002) 485]. In this paper, using displays depicting translation with simulated eye rotation, we investigated how task variables such as instructions, depth range, and dot density influenced the visual system's reliance on retinal vs. extra-retinal information for path perception during rotation. We found that path errors were small when observers expected to travel on a straight path or with neutral instructions, but errors increased markedly when observers expected to travel on a curved path. Increasing depth range or dot density did not improve path judgments. We conclude that the expectation of the shape of an upcoming path can influence the interpretation of the ambiguous retinal flow. A large depth range and dense motion parallax are not essential for accurate path perception during rotation, but reference objects and a large field of view appear to improve path judgments.

Space Perception/physiology↗

Designing Facilities for Collaborative Operations

A methodology for designing operational facilities for collaboration by multiple experts has begun to take shape as an outgrowth of a project to design such facilities for scientific operations of the planned 2003 Mars Exploration Rover (MER) mission. The methodology could also be applicable to the design of military "situation rooms" and other facilities for terrestrial missions. It was recognized in this project that modern mission operations depend heavily upon the collaborative use of computers. It was further recognized that tests have shown that layout of a facility exerts a dramatic effect on the efficiency and endurance of the operations staff. The facility designs (for example, see figure) and the methodology developed during the project reflect this recognition. One element of the methodology is a metric, called effective capacity, that was created for use in evaluating proposed MER operational facilities and may also be useful for evaluating other collaboration spaces, including meeting rooms and military situation rooms. The effective capacity of a facility is defined as the number of people in the facility who can be meaningfully engaged in its operations. A person is considered to be meaningfully engaged if the person can (1) see, hear, and communicate with everyone else present; (2) see the material under discussion (typically data on a piece of paper, computer monitor, or projection screen); and (3) provide input to the product under development by the group. The effective capacity of a facility is less than the number of people that can physically fit in the facility. For example, a typical office that contains a desktop computer has an effective capacity of .4, while a small conference room that contains a projection screen has an effective capacity of around 10. Little or no benefit would be derived from allowing the number of persons in an operational facility to exceed its effective capacity: At best, the operations staff would be underutilized; at worst, operational performance would deteriorate. Elements of this methodology were applied to the design of three operations facilities for a series of rover field tests. These tests were observed by human-factors researchers and their conclusions are being used to refine and extend the methodology to be used in the final design of the MER operations facility. Further work is underway to evaluate the use of personal digital assistant (PDA) units as portable input interfaces and communication devices in future mission operations facilities. A PDA equipped for wireless communication and Ethernet, Bluetooth, or another networking technology would cost less than a complete computer system, and would enable a collaborator to communicate electronically with computers and with other collaborators while moving freely within the virtual environment created by a shared immersive graphical display.

Norris, Jeffrey↗

Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase

Recognition of promoters in bacterial RNA polymerases (RNAPs) is controlled by sigma subunits. The key sequence motif recognized by the sigma, the -10 promoter element, is located in the non-template strand of the double-stranded DNA molecule ~10 nucleotides upstream of the transcription start site. Here, we explain the mechanism by which the phage AR9 non-virion RNAP (nvRNAP), a bacterial RNAP homolog, recognizes the -10 element of its deoxyuridine-containing promoter in the template strand. The AR9 sigma-like subunit, the nvRNAP enzyme core, and the template strand together form two nucleotide base-accepting pockets whose shapes dictate the requirement for the conserved deoxyuridines. A single amino acid substitution in the AR9 sigma-like subunit allows one of these pockets to accept a thymine thus expanding the promoter consensus. Our work demonstrates the extent to which viruses can evolve host-derived multisubunit enzymes to make transcription of their own genes independent of the host.

59 BASIC BIOLOGICAL SCIENCES↗

Risk to civilization: A planetary science perspective

One of the most profound changes in our perspective of the solar system resulting from the first quarter century of planetary exploration by spacecraft is the recognition that planets, including Earth, were bombarded by cosmic projectiles for 4.5 aeons and continue to be bombarded today. Although the planetary cratering rate is much lower now than it was during the first 0.5 aeons, sizeable Earth-approaching asteroids and comets continue to hit the Earth at a rate that poses a finite risk to civilization. The evolution of this planetary perspective on impact cratering is gradual over the last two decades. It took explorations of Mars and Mercury by early Mariner spacecraft and of the outer solar system by the Voyagers to reveal the significance of asteroidal and cometary impacts in shaping the morphologies and even chemical compositions of the planets. An unsettling implication of the new perspective is addressed: the risk to human civilization. Serious scientific attention was given to this issue in July 1981 at a NASA-sponsored Spacewatch Workshop in Snowmass, Colorado. The basic conclusion of the 1981 NASA sponsored workshop still stands: the risk that civilization might be destroyed by impact with an as-yet-undiscovered asteroid or comet exceeds risk levels that are sometimes deemed unacceptable by modern societies in other contexts. Yet these impact risks have gone almost undiscussed and undebated. The tentative quantitative assessment by some members of the 1981 workshop was that each year, civilization is threatened with destruction with a probability of about 1 in 100,000. The enormous spread in risk levels deemed by the public to be at the threshold of acceptability derives from a host of psychological factors that were widely discussed in the risk assessment literature. Slovic shows that public fears of hazards are greatest for hazards that are uncontrollable, involuntary, fatal, dreadful, globally catastrophic, and which have consequences that seem inequitable, especially if they affect future generations.

Chapman, Clark R.↗

NASA Tech Briefs, December 2010

Topics include: Coherent Frequency Reference System for the NASA Deep Space Network; Diamond Heat-Spreader for Submillimeter-Wave Frequency Multipliers; 180-GHz I-Q Second Harmonic Resistive Mixer MMIC; Ultra-Low-Noise W-Band MMIC Detector Modules; 338-GHz Semiconductor Amplifier Module; Power Amplifier Module with 734-mW Continuous Wave Output Power; Multiple Differential-Amplifier MMICs Embedded in Waveguides; Rapid Corner Detection Using FPGAs; Special Component Designs for Differential-Amplifier MMICs; Multi-Stage System for Automatic Target Recognition; Single-Receiver GPS Phase Bias Resolution; Ultra-Wideband Angle-of-Arrival Tracking Systems; Update on Waveguide-Embedded Differential MMIC Amplifiers; Automation Framework for Flight Dynamics Products Generation; Product Operations Status Summary Metrics; Mars Terrain Generation; Application-Controlled Parallel Asynchronous Input/Output Utility; Planetary Image Geometry Library; Propulsion Design With Freeform Fabrication (PDFF); Economical Fabrication of Thick-Section Ceramic Matrix Composites; Process for Making a Noble Metal on Tin Oxide Catalyst; Stacked Corrugated Horn Rings; Refinements in an Mg/MgH2/H2O-Based Hydrogen Generator; Continuous/Batch Mg/MgH2/H2O-Based Hydrogen Generator; Strain System for the Motion Base Shuttle Mission Simulator; Ko Displacement Theory for Structural Shape Predictions; Pyrotechnic Actuator for Retracting Tubes Between MSL Subsystems; Surface-Enhanced X-Ray Fluorescence; Infrared Sensor on Unmanned Aircraft Transmits Time-Critical Wildfire Data; and Slopes To Prevent Trapping of Bubbles in Microfluidic Channels.

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