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NASA NTRS2018

Using NASA's Molecular Adsorber Coating Technology During Thermal Vacuum Testing to Protect Critical Laser Flight Optics on the ATLAS Instrument

The Molecular Adsorber Coating (MAC) is a sprayable coatings technology that was developed at NASA Goddard Space Flight Center (GSFC). The coating was designed to address molecular contamination concerns on or near sensitive surfaces and instruments within the spacecraft for flight or ground-based applications in vacuum conditions. This paper will discuss the use of NASA's MAC technology to isolate and protect the critical laser flight optics of the Advanced Topographic Laser Altimeter System (ATLAS) instrument on the Ice, Cloud, and land Elevation Satellite-2 (ICESat-2). MAC was strategically used during thermal vacuum (TVAC) testing efforts to reduce the risk of contaminating the laser optical components from non-baked items and other unknown outgassing sources from the chamber environment. This paper summarizes the design and implementation efforts, and the chemical analysis of the MAC samples that were used during two recent TVAC tests for the ICESat-2/ATLAS mission.

thermal vacuum↗

NASA NTRS2018

Using NASA's Molecular Adsorber Coating Technology During Thermal Vacuum Testing to Protect Critical Laser Flight Optics on the ATLAS Instrument

molecular adsorber coating↗

NASA NTRS2019

Deep Mapping of Small Solar System Bodies with Galactic Cosmic Ray Secondary Particle Showers

We will investigate the use of galactic cosmic ray (GCR) secondary particles to probe the deep interiors of small solar system bodies (SSBs), including comets, asteroids, and geologic structures on the surfaces of airless bodies. Applications include solar system science, planetary defense, and resource utilization. Our Phase I study demonstrated that muons, the long-range charged component of GCR showers, can penetrate SSBs up to a km in diameter, providing information on their interior structure. Muons produced in Earth’s atmosphere have been applied to image the interior of large objects for science and engineering. In Phase I, we found that the production of muons in the solid surfaces of airless bodies is much smaller than in Earth’s atmosphere. Nevertheless, the flux of transmitted muons is sufficient to detect inclusions within an asteroid or comet in a reasonable amount of time, ranging from hours to weeks, depending on the size of the SSB and the density contrast, position and size of the inclusion. For asteroids and comets, large density variations (e.g., porous soil or ice versus solid rock) are relatively easy to detect. The intrinsic spatial resolution of muon radiography (“muography”) is on the scale of a few meters. The spatial resolution that can be achieved in practice depends on signal intensity and integration time (counting statistics), the angular resolution of the muon tracker (hodoscope) and details of data reduction and analysis methodology. Our Phase II project will assess remaining unknowns for the application of muography to determining the interior structure of SSBs, assess risks for implementation, and provide a roadmap for development of SSB muography beyond the NIAC program. To achieve our objectives, we will focus on four interrelated tasks: Task1) Signal and background characterization: Characterize the production and transmission of muons and secondary particle backgrounds made by cosmic ray showers in SSBs; and near-surface features from radiographic and tomographic data; Task2) Imaging studies: Develop methods to determine the density structure of SSB interiors and near-surface features from radiographic and tomographic data; Task3) Instrument design: Using simulations and bench-top laboratory experiments, investigate specific concepts for the design of compact hodoscopes and components; Task4) Synthesis: Combine the results of the first three tasks to determine the range of applicability of the method, identify the steps needed for maturation of the concept, and explore concepts for a pilot muography mission.

Prettyman, Thomas H.↗

NASA NTRSDate not supplied

Retinal Image Quality Assessment for Spaceflight-Induced Visual Impairment Study

Medical reports have identified visual impairments as a risk associated with extended exposure to microgravity. Etiology of these ocular changes is currently unknown. Current hypotheses propose cephalad fluid shifts resulting from microgravity as the primary cause of ocular damage. One approach to studying ocular response to microgravity is by examining possible changes in retinal blood vessels using a NASA model of microgravity, the head-down tilt (HDT) of human subjects undergoing prolonged bed rest (BR). Retinal vessels in astronauts and BR subjects are monitored by Heidelberg Spectralis infrared (IR) imaging, in which retinal image quality is limited by insufficient resolution of small vessels. Yet small vessels respond and remodel most actively to physiological stress.For our NASA study of BR subjects, we identify retinal image quality as thecapability to capture vascular detail to acceptable resolution of small vessels. We therefore are analyzing Spectralis images acquired with fluorescein angiography(FA), where increased contrast significantly improves image resolution. The FA images are of normal subjects participating in a clinical study on diabeticretinopathy (US National Institutes of Health). We hypothesize that FA Spectralis images are of superior quality compared to non-FA Spectralis IR images.

Rodrigo Rene Rai Munoz Abujder↗

NASA NTRSDate not supplied

Bio-stasis: A Strategy for Survivability and Payload Cost Reduction in Long-duration Space Missions

As humans proceed with long-term space voyages, involving flights with lasting duration of months or years, “adaptation to space” will eventually lead to hard realities resultant physiological and psychological conditions must be realistically estimated and considered before it occurs. It is obvious that humans in their lifespan cannot adopt to spaceflight environment by reversible modification of their complex biochemical reactions and physiological functions without jeopardizing sustainable homeostasis shaped by multiple generations during evolution. In this case Nature offers an evolutionary proven alternative strategy- a coordinative adjustment of metabolism in order to survive. Incorporation of this metabolic adjustment strategy along with the relevant life support system into space flight architecture would protect humans during long term space flight from many irreversible physiological alterations and may dramatically reduce overall cost of space missions. In addition to the harmful space radiation and prolonged weightlessness, incorporation of this strategy may also benefit by solving other major medical unknowns in interplanetary flight such as isolation and psychological stress which still remains a risk. It is one of the priorities of NASA and other space agencies to figure out not only how to keep long-distance travelers alive and in good cognitive health but also how to return them to normal life on Earth with a minimum rehabilitation period after prolonged exposure to space. Presently re-adaptation of astronauts to Earth conditions and recovery from spaceflight exposure may take many months and years and, in some cases, require medical intervention. Therefore, recognizing physiological adjustment of the energy-regulating system as a viable life support strategy for human space exploration beyond LEO is essential.

Bio-stasis;↗

NASA NTRS2018

GeneLab: "Omics" Data System for Space Biology Research

Determining the biological impact of spaceflight through novel approaches is essential to reduce the health risks to astronauts for long-term space missions. The current established health risks due to spaceflight are only reflecting known symptomatic and physiologic responses and do not reflect early onset of other potential diseases. There are many unknown variables which still need to be identified to fully understand the health impacts due to the environmental factors in space. One method to uncover potential novel biological mechanisms responsible for health risks in astronauts is by utilizing NASA's GeneLab Data Systems (genelab.nasa.gov). GeneLab is public repository that hosts multiple omics datasets generated from space biology experiments that include experiments flown in space, simulated cosmic radiation experiments, and simulated microgravity experiments. This presentation will provide an overview of GeneLab and examples of analysis that are being done with GeneLab datasets. These example will include novel data and work being generated with various scientists around the world involved with GeneLab's Analysis Working Groups (AWG) that are assisting with the development of pipelines and advancing GeneLab to the next phase, a publication from GeneLab discovering novel Carbon Dioxide impact due to rodent habitats, another publication from GeneLab discovering a potential master regulator responsible for health risk associated due to spaceflight, and potential cardiovascular risk from space radiation.

microgravity↗

NASA NTRS2018

GeneLab: "Omics" Data Systems for Spaceflight and Simulated Spaceflight Environment

spaceflight↗

NASA NTRS2019

Science Driven By Space Biology Omics Data Utilizing NASA's GeneLab Platform

Beheshti, Afshin↗

NASA NTRS2003

Multiparametric Determination of Radiation Risk

Predicting risk of human cancer following exposure to ionizing space radiation is challenging in part because of uncertainties of low-dose distribution amongst cells, of unknown potentially synergistic effects of microgravity upon cellular protein-expression, and of processing dose-related damage within cells to produce rare and late-appearing malignant transformation, degrade the confidence of cancer risk-estimates. The NASA- specific responsibility to estimate the risks of radiogenic cancer in a limited number of astronauts is not amenable to epidemiologic study, thereby increasing this challenge. Developing adequately sensitive cellular biodosimeters that simultaneously report 1) the quantity of absorbed close after exposure to ionizing radiation, 2) the quality of radiation delivering that dose, and 3) the risk of developing malignant transformation by the cells absorbing that dose could be useful for resolving these challenges. Use of a multiparametric cellular biodosimeter is suggested using analyses of gene-expression and protein-expression whereby large datasets of cellular response to radiation-induced damage are obtained and analyzed for expression-profiles correlated with established end points and molecular markers predictive for cancer-risk. Analytical techniques of genomics and proteomics may be used to establish dose-dependency of multiple gene- and protein- expressions resulting from radiation-induced cellular damage. Furthermore, gene- and protein-expression from cells in microgravity are known to be altered relative to cells grown on the ground at 1g. Therefore, hypotheses are proposed that 1) macromolecular expression caused by radiation-induced damage in cells in microgravity may be different than on the ground, and 2) different patterns of macromolecular expression in microgravity may alter human radiogenic cancer risk relative to radiation exposure on Earth. A new paradigm is accordingly suggested as a national database wherein genomic and proteomic datasets are registered and interrogated in order to provide statistically significant dose-dependent risk estimation of radiogenic cancer in astronauts.

Richmond, Robert C.↗

NASA NTRSDate not supplied

Mitochondria Dysfunction Central in Driving Health Risks Associated with Spaceflight

Background: Determining the biological impact of spaceflight through novel approaches is essential to reduce the health risks to astronauts for long-term space missions. The current established health risks due to spaceflight are only reflecting known symptomatic and physiologic responses and do not reflect early onset of other potential diseases. There are many unknown variables which still need to be identified to fully understand the health impacts due to the environmental factors in space. Materials and Methods: One method to uncover potential novel biological mechanisms responsible for health risks in astronauts is by utilizing NASA’s GeneLab platform (genelab.nasa.gov). GeneLab is public repository that hosts multiple omics datasets generated from space biology experiments that include experiments flown in space, simulated cosmic radiation experiments, and simulated microgravity experiments. This presentation will provide an example of analysis and novel hypothesis generation that is being produced with GeneLab datasets. A comprehensive multi-omics approach was implemented correlating transcriptomics, proteomics, metabolomics, and methylation analysis. Results: We found that cells have stronger overall biological response than the tissues to spaceflight, with mitochondrial activity and innate immunity pathways being heavily impacted. NASA Twin Study results are consistent with a specific alteration in mitochondrial ATP production. Our results indicate that the space environment can directly induce mitochondrial damage, with mitochondrial dysfunctions being a cause for chronic inflammation and both being involved in the development of metabolic disorders that cause changes in lipid metabolism. We also found biological changes occurring during spaceflight with cell cycle, circadian rhythm and olfactory activity pathways can also influence and be influenced by alterations on mitochondrial activity

Afshin Beheshti↗

NASA NTRS2009

Approach for Mitigating Pressure Garment Design Risks in a Mobile Lunar Surface Systems Architecture

The stated goals of the 2004 Vision for Space Exploration focus on establishing a human presence throughout the solar system beginning with the establishment of a permanent human presence on the Moon. However, the precise objectives to be accomplished on the lunar surface and the optimal system architecture to achieve those objectives have been a topic of much debate since the inception of the Constellation Program. There are two basic styles of system architectures being traded at the Programmatic level: a traditional large outpost that would focus on techniques for survival off our home planet and a greater depth of exploration within one area, or a mobile approach- akin to a series of nomadic camps- that would allow greater breadth of exploration opportunities. The traditional outpost philosophy is well within the understood pressure garment design space with respect to developing interfaces and operational life cycle models. The mobile outpost, however, combines many unknowns with respect to pressure garment performance and reliability that could dramatically affect the cost and schedule risks associated with the Constellation space suit system. This paper provides an overview of the concepts being traded for a mobile architecture from the operations and hardware implementation perspective, describes the primary risks to the Constellation pressure garment associated with each of the concepts, and summarizes the approach necessary to quantify the pressure garment design risks to enable the Constellation Program to make informed decisions when deciding on an overall lunar surface systems architecture.

Aitchison, Lindsay↗

NASA NTRS2012

Rotary Percussive Sample Acquisition Tool

As part of a potential Mars Sample Return campaign NASA is studying a sample caching mission to Mars, with a possible 2018 launch opportunity. As such, a Sample Acquisition Tool (SAT) has been developed in support of the Integrated Mars Sample Acquisition and Handling (IMSAH) architecture as it relates to the proposed Mars Sample Return (MSR) campaign. The tool allows for core generation and capture directly into a sample tube. In doing so, the sample tube becomes the fundamental handling element within the IMSAH sample chain reducing the risk associated with sample contamination as well as the need to handle a sample of unknown geometry. The tool's functionality was verified utilizing a proposed rock test suite that encompasses a series of rock types that have been utilized in the past to qualify Martian surface sampling hardware. The corresponding results have shown the tool can effectively generate, fracture, and capture rock cores while maintaining torque margins of no less than 50% with an average power consumption of no greater than 90W and a tool mass of less than 6kg.

Sample Acquisition and Caching (SAC)↗

NASA NTRS2011

Risk Management of Jettisoned Objects in LEO

The construction and maintenance of the International Space Station (ISS) has led to the release of many objects into its orbital plane, usually during the course of an extra-vehicular activity (EVA). Such releases are often unintentional, but in a growing number of cases, the jettison has been intentional, conducted after a careful assessment of the net risk to the partnership and to other objects in space. Since its launch in 1998 the ISS has contributed on average at least one additional debris object that is simultaneously in orbit with the station, although the number varies widely from zero to eight at any one moment. All of these objects present potential risks to other objects in orbit. Whether it comes from known and tracked orbiting objects or from unknown or untrackable objects, collision with orbital debris can have disastrous consequences. Objects greater than 10cm are generally well documented and tracked, allowing orbiting spacecraft or satellites opportunities to perform evasive maneuvers (commonly known as Debris Avoidance Maneuvers, or DAMs) in the event that imminent collision is predicted. The issue with smaller debris; however, is that it is too numerous to be tracked effectively and yet still poses disastrous consequences if it intercepts a larger object. Due to the immense kinetic energy of any item in orbit, collision with debris as small as 1cm can have catastrophic consequences for many orbiting satellites or spacecraft. Faced with the growing orbital debris threat and the potentially catastrophic consequences of a collision-generated debris shower originating in an orbit crossing the ISS altitude band, in 2007 the ISS program manger asked program specialists to coordinate a multilateral jettison policy amongst the ISS partners. This policy would define the acceptable risk trade rationale for intentional release of a debris object, and other mandatory constraints on such jettisons to minimize the residual risks whenever a jettison was accepted. Although ISS-related debris often presents untenable risks to the EVA crew, IVA crew, or to a departing cargo vehicle for a controlled disposal, such released objects also present a ballistic nuisance to the visiting vehicle traffic, and a potential fragmentation threat to the hundreds of other functional and debris objects whose perigees lie below the ISS orbital altitude. Thus, every such jettison decision is a conscious risk trade.

Bacon, John B.↗

NASA NTRS2004

Radiation Risk Assessment of the Individual Astronaut: A Complement to Radiation Interests at the NIH

Predicting human risks following exposure to space radiation is uncertain in part because of unpredictable distribution of high-LET and low-dose-derived damage amongst cells in tissues, unknown synergistic effects of microgravity upon gene- and protein-expression, and inadequately modeled processing of radiation-induced damage within cells to produce rare and late-appearing malignant cancers. Furthermore, estimation of risks of radiogenic outcome within small numbers of astronauts is not possible using classic epidemiologic study. It therefore seems useful to develop strategies of risk-assessment based upon large datasets acquired from correlated biological models useful for resolving radiogenic risk-assessment for irradiated individuals. In this regard, it is suggested that sensitive cellular biodosimeters that simultaneously report 1) the quantity of absorbed dose after exposure to ionizing radiation, 2) the quality of radiation delivering that dose, and 3) the biomolecular risk of malignant transformation be developed in order to resolve these NASA-specific challenges. Multiparametric cellular biodosimeters could be developed using analyses of gene-expression and protein-expression whereby large datasets of cellular response to radiation-induced damage are analyzed for markers predictive for acute response as well as cancer-risk. A new paradigm is accordingly addressed wherein genomic and proteomic datasets are registered and interrogated in order to provide statistically significant dose-dependent risk estimation in individual astronauts. This evaluation of the individual for assessment of radiogenic outcomes connects to NIH program in that such a paradigm also supports assignment of a given patient to a specific therapy, the diagnosis of response of that patient to therapy, and the prediction of risks accumulated by that patient during therapy - such as risks incurred by scatter and neutrons produced during high-energy Intensity-Modulated Radiation Therapy. Value of assessment of radiogenic outcome for individuals exposed to radiation is suggested to be common to both NASA and NIH.

Richmond, Robert C.↗

NASA NTRS2020

An Experimental Approach to a Rapid Propulsion and Aeronautics Concepts Testbed

Modern aircraft design tools have limitations for predicting complex propulsion-airframe interactions. The demand for new tools and methods addressing these limitations is high based on the many recent Distributed Electric Propulsion (DEP) Vertical Take-Off and Landing (VTOL) concepts being developed for Urban Air Mobility (UAM) markets. We propose that low cost electronics and additive manufacturing can support the conceptual design of advanced autonomy-enabled concepts, by facilitating rapid prototyping for experimentally driven design cycles. This approach has the potential to reduce complex aircraft concept development costs, minimize unique risks associated with the conceptual design, and shorten development schedule by enabling the determination of many "unknown unknowns" earlier in the design process and providing verification of the results from aircraft design tools. A modular testbed was designed and built to evaluate this rapid design-build-test approach and to support aeronautics and autonomy research targeting UAM applications utilizing a complex, transitioning-VTOL aircraft configuration. The testbed is a modular wind tunnel and flight model. The testbed airframe is approximately 80% printed, with labor required for assembly. This paper describes the design process, fabrication process, ground testing, and initial wind tunnel structural and thermal loading of a proof-of-concept aircraft, the Langley Aerodrome 8 (LA-8).

McSwain, Robert G.↗

NASA NTRSDate not supplied

Individual Variability and Predictive Biomarkers of Human Sensitivity to Ionizing Radiation

High-linear energy transfer (LET) ionizing radiation is a major health hazard for astronauts who will be exposed to galactic cosmic rays during upcoming lunar and Mars missions. Predicting and mitigating personalized health risks from space radiation exposure requires understanding the factors underlying individual radiation sensitivity, which currently remain unknown. We started to address this challenge by identifying the genomic and demographic associations with sensitivity to low and high-LET ionizing radiation in the largest human sample cohort to date and by evaluating baseline DNA damage as a potential predictor of radiation responses. We have collected and irradiated peripheral blood mononuclear cells (PBMCs) from 768 healthy donors of matched ethnicity, 50/50 male/female, 18-70 years old. We have analyzed the responses of 576 donor PBMCs to irradiation with simulated galactic cosmic ray components: 350MeV/n 28Si, 350MeV/n 40Ar and 600MeV/n 56Fe, at 1.1 and 3 particles/100μm2 fluences, as well as 0.1Gy and 1Gy doses of gamma rays, at 4 and 24 hours post irradiation. We quantified post-irradiation DNA repair based on radiation-induced 53BP1+ foci formation, together with oxidative stress and cell death using a flow cytometry-based assay. We also assessed baseline levels of DNA repair in PBMCs at the time of sample collection prior to irradiation experiments. We observed a wide variability of subject- and LET-dependent radiation responses, with radiation-induced DNA repair foci increasing with LET, though oxidative stress being notably reduced by high-LET irradiation, potentially due to a switch between hydrogen peroxide and oxygen radical-based mechanisms. We also identified a relationship between few DNA repair foci at baseline and increased DNA repair after irradiation, accompanied by an alteration in immunoregulatory cytokine secretion, which might be adapted as biomarkers to predict ionizing radiation sensitivity. Among demographic variables, baseline foci levels were positively associated with age and latent cytomegalovirus infection. Finally, we have performed low-throughput whole genome sequencing of all samples and are currently in process of identifying the genes and pathways associated with low and high-LET ionizing radiation sensitivity in humans.

Space radiation, human spaceflight, DNA damage↗

NASA NTRSDate not supplied

Characterization of Jugular Venous Blood Flow During Acute Fluid Shifts

INTRODUCTION Exposure to weightlessness induces a headward fluid shift and redistribution of fluids, resulting in increased internal jugular vein (IJV) cross-sectional area and altered IJV blood flow dynamics including stasis and retrograde flow. These findings may contribute to various risks of spaceflight, including thrombosis or other risks affected by cerebral venous blood flow. To date, our understanding of the cerebral venous outflow dynamics is limited to the left IJV assessed ~45and ~150days into spaceflight. Therefore, it is unknown how quickly the alterations in venous blood flow dynamics change as a result of weightlessness. The purpose of this study is to determine 1) if venous stasis is an immediate effect of weightlessness, and therefore a risk for short-duration missions, and 2) the effect of weightlessness on brachiocephalic venous flow. METHODS In this study, we will determine the effects of acute weightlessness during parabolic flight on right and left IJV cross-sectional area, as well as blood flow dynamics through the IJV and brachiocephalic veins in 12 healthy subjects. Baseline ultrasound images will be obtained on the ground prior to the parabolic flight in the seated and supine postures to determine normal changes in blood flow with posture-induced fluid shifts in a 1genvironment. Subjects will then undergo parabolic flight withrepeated,~20 second exposure to 0g. Each data collection session will include 2D ultrasonography to quantify IJV cross-sectional area and Doppler ultrasonography to characterize venous blood flow patterns in the IJV and brachiocephalic veins. RESULTS Data collection for this study is planned to take place in October, 2021.CONCLUSIONS This study will characterize the immediate venous response in the left and right IJV and brachiocephalic veins upon entry into weightlessness. The results from this parabolic flight study will be compared with previous data from International Space Station crewmembers collectedafter~45 and ~150 days into spaceflight to provide a more complete understanding of the temporal profile of changes in venous blood flow dynamics during weightlessness and whether these findings develop in veins other than the left IJV. Supported by the NASA Human Research Program.

K Marshall-Bowman↗

NASA NTRS2008

Reliability of PWB Microvias for High Density Package Assembly

High density PWB (printed wiring board) with microvia technology is required for implementation of high density and high I/O area array packages (AAP). COTS (commercial off-the-shelf) AAP packaging technologies in high reliability versions with 1.27 mm pitch are now being considered for use in a number of NASA systems including Space Shuttle and Mars Rovers. NASA functional system designs are requiring more and more dense AAP packages and board space, which makes board microvia technology very attractive for effectively routing a large number of package inputs/outputs. However, the reliability of the fine feature microvias including via in pads is unknown for space applications. Understanding process and QA (quality assurance) indicators for reliability are important for low risk insertion of these newly available packages and PWBs. This paper presents literature search as well as test results for a high density board subjected to various thermal cycle and reflow profiles representative of tin-lead and lead-free solder reflow. Microvias sizes ranged from two to six mil with and without filling. Daisy chain microvias monitored during the test and PWBs were cross-sectioned to determine failure and locations. Optical and SEM photographs as well as resistance changes during cycling and Tg/Td (glass transition/decomposition temperature) characterisations are presented.

fill via↗