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NASA NTRS2000

Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individuals

The purposes of the present studies were to test the hypotheses that lower dosages of oral pyruvate ingestion would increase blood pyruvate concentration and that the ingestion of a commonly recommended dosage of pyruvate (7 g) for 7 days would enhance performance during intense aerobic exercise in well-trained individuals. Nine recreationally active subjects (8 women, 1 man) consumed 7, 15, and 25 g of pyruvate and were monitored for a 4-h period to determine whether blood metabolites were altered. Pyruvate consumption failed to significantly elevate blood pyruvate, and it had no effect on indexes of carbohydrate (blood glucose, lactate) or lipid metabolism (blood glycerol, plasma free fatty acids). As a follow-up, we administered 7 g/day of either placebo or pyruvate, for a 1-wk period to seven, well-trained male cyclists (maximal oxygen consumption, 62.3 +/- 3.0 ml. kg(-1). min(-1)) in a randomized, double-blind, crossover trial. Subjects cycled at 74-80% of their maximal oxygen consumption until exhaustion. There was no difference in performance times between the two trials (placebo, 91 +/- 9 min; pyruvate, 88 +/- 8 min). Measured blood parameters (insulin, peptide C, glucose, lactate, glycerol, free fatty acids) were also unaffected. Our results indicate that oral pyruvate supplementation does not increase blood pyruvate content and does not enhance performance during intense exercise in well-trained cyclists.

Randomized Controlled Trial↗

DOE OSTI2020

High Resolution Data Analysis: Plans and Prospects [Book Chapter]

Herein, a report on the progress on the high resolution data analysis of the ADMX experimental results is presented. In this paper, tools are developed and tested on a blind injection mimicking a Maxwellian like signal in the frequency domain. This blind injection will be used as a test bed which can be later implemented on all the high resolution data. The high resolution data is stored in the Fermilab server. In this analysis a PostgreSQL query was made to ensure the blind injection is in the middle of the frequency spectrum and 19 such files were found. The time series data is read using a c++ program. An apodization function is applied on the time series data and zero filled to reduce the frequency spacing in order to achieve a better interpolation. A FFTW header is used to compute the Fourier transform of the time series data. A Savitzky–Golay filter is applied on the unnormalized power which then can be used to remove the spectral shape. Each frequency spectrum has a bandwidth of 50 kHz.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

NASA NTRS2019

Discovery of Activities via Statistical Clustering of Fixation Patterns

Human behavior often consists of a series of distinct activities, each characterized by a unique pattern of interaction with the visual environment. This is true even in a restricted domain, such as a pilot flying an airplane; in this case, activities with distinct visual signatures might be things like communicating, navigating, monitoring, etc. We propose a novel analysis method for gaze-tracking data, to perform blind discovery of these hypothetical activities. We compare, not individual fixations, but groups of fixations aggregated over a fixed time interval (Tau). We assume that the environment has been divided into a finite set of discrete areas-of-interest (AOIs). For a given time interval, we compute the proportion of time spent fixating each AOI, resulting in an N-dimensional vector, where N is the number of AOIs. These proportions can be converted to integer counts by multiplying by Tau divided by the average fixation duration, a parameter that we fix at 283 milliseconds. We compare different intervals by computing the chi-squared statistic. The p-value associated with the statistic is the likelihood of observing the data under the hypothesis that the data in the two intervals were generated by a single process with a single set of probabilities governing the fixation of each AOI. We cluster the intervals, first by merging adjacent intervals that are sufficiently similar, optionally shifting the boundary between non-merged intervals to maximize the difference. Then we compare and cluster non-adjacent intervals. The method is evaluated using synthetic data generated by a hand-crafted set of activities. While the method generally finds more activities than put into the simulation, we have obtained agreement as high as 80 percent between the inferred activity labels and ground truth.

Eye Movements↗

NASA NTRS2005

VEGF165 Stimulates Vessel Density and Vessel Diameter Differently in Angiogenesis and Lymphangiogenesis

Vascular endothelial growth factor-165 (VEGF(sub 165)) stimulated angiogenesis in the quail chorioallantoic membrane (CAM) by vessel expansion from the capillary network. However, lymphangiogenesis was stimulated by the filopodial guidance of tip cells located on blind-ended lymphatic sprouts. As quantified by fractal/generational branching analysis using the computer code VESGEN, vascular density increased maximally at low VEGF concentrations, and vascular diameter increased most at high VEGF concentrations. Increased vascular density and diameter were statistically independent events (r(sub s), -0.06). By fluorescence immunohistochemistry of VEGF receptors VEGFR-1 and VEGFR-2, alpha smooth muscle actin ((alpha) SMA) and a vascular/lymphatic marker, VEGF(sub 165) increased the density and diameter of sprouting lymphatic vessels guided by tip cells (accompanied by the dissociation of lymphatics from blood vessels). Isolated migratory cells expressing (alpha)SMA were recruited to blood vessels, whereas isolated cells expressing VEGFR-2 were recruited primarily to lymphatics. In conclusion, VEGF(sub 165) increased lymphatic vessel density by lymphatic sprouting, but increased blood vessel density by vascular expansion from the capillary network.

Parsons-Wingerter, Patricia↗

NASA NTRS1973

Ejection time by ear densitogram and its derivative - Clinical and physiologic applications.

Ear densitographic ejection times (EDET) and first derivative ear densitogram ejection times (dEDET) were studied to determine whether their reliability and validity justify their substitution for ejection times derived from the far less stable carotid pulse tracing. Inter- and intra-subject comparisons were made on thirty individuals under a wide variety of disease and challenge states. Statistical analysis of the data - which had been obtained through a blinded procedure - showed an overall correlation (r) of .98 for carotid vs EDET and .99 for carotid vs dEDET. The t-test demonstrated no significant differences among ejection times derived from the three methods. Moreover, the close tracking at rest and during challenges of ejection times derived from these curves with those from the carotid indicate that either method may be substituted for standard carotid curves without sacrificing reliability or validity of the measure.

Quarry-Pigott, V.↗

NASA NTRS1993

Broadband Venetian Blind polarizer with dual vanes

During development of a Venetian Blind polarizer, high reflections and substantial pattern deformation were noted. Analysis showed that when the polarizer was illuminated slightly off axis, a degenerate mode was excited. This mode is resonant at the design center frequency, and was the cause of the problems. A design developed using dual vanes has been shown to be free of the problem. It also has greater bandwidth.

Conroy, Bruce L.↗

DOE OSTI2025

Validation of the DESI DR2 measurements of baryon acoustic oscillations from galaxies and quasars

The Dark Energy Spectroscopic Instrument (DESI) Data Release 2 (DR2) galaxy and quasar clustering data represents a significant expansion of data from Data Release 1 (DR1), providing improved statistical precision in baryon acoustic oscillation (BAO) constraints across multiple tracers, including bright galaxies, luminous red galaxies, emission line galaxies, and quasars. In this paper, we validate the BAO analysis of DR2. We present the results of robustness tests on the blinded DR2 data and, after unblinding, consistency checks on the unblinded DR2 data. All results are compared with those obtained from a suite of mock catalogs that replicate the selection and clustering properties of the DR2 sample. We confirm the consistency of DR2 BAO measurements with DR1 while achieving a reduction in statistical uncertainties due to the increased survey volume and completeness. The combined BAO precision, including both statistical and systematic errors, improves from ∼0.52% in DR1 to 0.30% in DR2—a factor of 1.7 gain. We assess the impact of analysis choices, including different data vectors (correlation function vs power spectrum), modeling approaches and systematics treatments, and an assumption of the Gaussian likelihood, finding that our BAO constraints are stable across these variations and assumptions with a few minor refinements to the baseline setup of the DR1 BAO analysis. We summarize a series of pre-unblinding tests that confirmed the readiness of our analysis pipeline, the final systematic errors, and the DR2 BAO analysis baseline. The successful completion of these tests led to the unblinding of the DR2 BAO measurements, ultimately leading to the DESI DR2 cosmological analysis, with their implications for the expansion history of the Universe and the nature of dark energy presented in the DESI key paper (companion paper).

79 ASTRONOMY AND ASTROPHYSICS↗

DOE OSTI2022

Uniform Recalibration of Common Spectrophotometry Standard Stars onto the CALSPEC System Using the SuperNova Integral Field Spectrograph

Abstract We calibrate spectrophotometric optical spectra of 32 stars commonly used as standard stars, referenced to 14 stars already on the Hubble Space Telescope–based CALSPEC flux system. Observations of CALSPEC and non-CALSPEC stars were obtained with the SuperNova Integral Field Spectrograph over the wavelength range 3300–9400 Å as calibration for the Nearby Supernova Factory cosmology experiment. In total, this analysis used 4289 standard-star spectra taken on photometric nights. As a modern cosmology analysis, all presubmission methodological decisions were made with the flux scale and external comparison results blinded. The large number of spectra per star allows us to treat the wavelength-by-wavelength calibration for all nights simultaneously with a Bayesian hierarchical model, thereby enabling a consistent treatment of the Type Ia supernova cosmology analysis and the calibration on which it critically relies. We determine the typical per-observation repeatability (median 14 mmag for exposures ≳5 s), the Maunakea atmospheric transmission distribution (median dispersion of 7 mmag with uncertainty 1 mmag), and the scatter internal to our CALSPEC reference stars (median of 8 mmag). We also check our standards against literature filter photometry, finding generally good agreement over the full 12 mag range. Overall, the mean of our system is calibrated to the mean of CALSPEC at the level of ∼3 mmag. With our large number of observations, careful cross-checks, and 14 reference stars, our results are the best calibration yet achieved with an integral-field spectrograph, and among the best calibrated surveys.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS2007

Dramatic Expression in Opera, and Its Implications for Conversational Agents

This article has discussed principles, techniques, and methods of dramatic portrayal in opera, and their application to the development of embodied conversational agents. Investigations such as this complement studies of natural human behavior, and offer insights as to how to make such behavior understandable and interesting when adapted for use by embodied conversational agents. However, one should use caution in applying such lessons. The unique characteristics of computer-based media are still being identified and explored. In any case, one must always be careful about applying principles blindly to any artistic form. Such principles are post-hoc analysis of the intuitive skill of great artists; this was as true in Aristotle's day as it is today. We should not let structural principles stand in the way of injecting creativity into the design of ECAs. Opera at its best possesses an element of magic that is difficult to describe, much less analytically reconstruct. We can only hope to achieve a similar result with conversational agents.

Johnson, W. Lewis↗

NASA NTRS2013

Impact of Gender on Pharmocokinetics of Intranasal Scopolamine

Introduction: An intranasal gel dosage formulation of scopolamine (INSCOP) was developed for the treatment of Space Motion Sickness (SMS), which is commonly experienced by astronauts during space missions. The bioavailability and pharmacokinetics (PK) were evaluated under IND guidelines. Since information is lacking on the effect of gender on the PK of Scopolamine, we examined gender differences in PK parameters of INSCOP at three dose levels of 0.1, 0.2 and 0.4 mg. Methods: Plasma scopolamine concentrations as a function of time data were collected from twelve normal healthy human subjects (6 male/6 female) who participated in a fully randomized double blind crossover study. The PK parameters were derived using WinNonlin. Covariate analysis of PK profiles was performed using NONMEN and statistically compared using a likelihood ratio test on the difference of objective function value (OFV). Statistical significance for covariate analysis was set at P<0.05(ΔOFV=3.84). Results: No significant difference in PK parameters between male and female subjects was observed with 0.1 and 0.2 mg doses. However, CL and Vd were significantly different between male and female subjects at the 0.4 mg dose. Results from population covariate modeling analysis indicate that a onecompartment PK model with first-order elimination rate offers best fit for describing INSCOP concentration-time profiles. The inclusion of sex as a covariate enhanced the model fitting (ΔOFV=-4.1) owing to the genderdependent CL and Vd differences after the 0.4 mg dose. Conclusion: Statistical modeling of scopolamine concentration-time data suggests gender-dependent pharmacokinetics of scopolamine at the high dose level of 0.4 mg. Clearance of the parent compound was significantly faster and the volume of distribution was significantly higher in males than in females, As a result, including gender as a covariate to the pharmacokinetic model of scopolamine offers the best fit for PK modeling of the drug at dose of 0.4 mg or higher.

Putcha, L.↗

DOE OSTI2020

System and method for automated extraction of high resolution structural dynamics from video

A method for extracting vibrational modes of a structure includes: receiving a plurality of video frames, each of the video frames including a plurality of pixels; decomposing each of the video frames on a plurality of spatial scales in accordance with complex steerable pyramid filters to obtain a filter response for each of the spatial scales; computing a plurality of local phases of the pixels of each frame; removing a temporal mean from each frame to obtain a plurality of factored vibration motion functions; performing principal component analysis on the factored vibration motion functions to obtain principal components; blind source separating the principal components to compute a plurality of modal coordinates; computing frequency and damping ratios in accordance with the modal coordinates; and outputting the computed frequency and damping ratios.

42 ENGINEERING↗

NASA NTRS1994

A Perceptual Repetition Blindness Effect

Before concluding Repetition Blindness is a perceptual phenomenon, alternative explanations based on memory retrieval problems and report bias must be rejected. Memory problems were minimized by requiring a judgment about only a single briefly displayed field. Bias and sensitivity effects were empirically measured with an ROC-curve analysis method based on confidence ratings. Results from five experiments support the hypothesis that Repetition Blindness can be a perceptual phenomenon.

Hochhaus, Larry↗

DOE OSTI2020

TDCOSMO - IV. Hierarchical time-delay cosmography – joint inference of the Hubble constant and galaxy density profiles

The H0LiCOW collaboration inferred via strong gravitational lensing time delays a Hubble constant value of H0 = 73.3−1.8+1.7 km s−1 Mpc−1, describing deflector mass density profiles by either a power-law or stars (constant mass-to-light ratio) plus standard dark matter halos. The mass-sheet transform (MST) that leaves the lensing observables unchanged is considered the dominant source of residual uncertainty in H0. We quantify any potential effect of the MST with a flexible family of mass models, which directly encodes it, and they are hence maximally degenerate with H0. Our calculation is based on a new hierarchical Bayesian approach in which the MST is only constrained by stellar kinematics. The approach is validated on mock lenses, which are generated from hydrodynamic simulations. We first applied the inference to the TDCOSMO sample of seven lenses, six of which are from H0LiCOW, and measured H0 = 74.5−6.1+5.6 km s−1 Mpc−1. Secondly, in order to further constrain the deflector mass density profiles, we added imaging and spectroscopy for a set of 33 strong gravitational lenses from the Sloan Lens ACS (SLACS) sample. For nine of the 33 SLAC lenses, we used resolved kinematics to constrain the stellar anisotropy. From the joint hierarchical analysis of the TDCOSMO+SLACS sample, we measured H0 = 67.4−3.2+4.1 km s−1 Mpc−1. This measurement assumes that the TDCOSMO and SLACS galaxies are drawn from the same parent population. The blind H0LiCOW, TDCOSMO-only and TDCOSMO+SLACS analyses are in mutual statistical agreement. The TDCOSMO+SLACS analysis prefers marginally shallower mass profiles than H0LiCOW or TDCOSMO-only. Without relying on the form of the mass density profile used by H0LiCOW, we achieve a ∼5% measurement of H0. While our new hierarchical analysis does not statistically invalidate the mass profile assumptions by H0LiCOW – and thus the H0 measurement relying on them – it demonstrates the importance of understanding the mass density profile of elliptical galaxies. The uncertainties on H0 derived in this paper can be reduced by physical or observational priors on the form of the mass profile, or by additional data.Key words: gravitational lensing: strong / galaxies: general / galaxies: kinematics and dynamics / distance scale / cosmological parameters / cosmology: observations⋆ The full analysis is available at https://github.com/TDCOSMO/hierarchy_analysis_2020_public.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS2017

Mapping by VESGEN of Blood Vessels in the Retinas of Astronauts Pre- and Post-Flight to the ISS

Research by NASA [1] established that significant risks for visual and ocular impairments associated with increased intracranial pressure (VIIP) are incurred by microgravity spaceflight, especially long-duration missions. It is well established in physiology and pathology that a fundamental role of the microvasculature is to mediate fluid transfers and remodel actively in response to environmental, immune and other stresses. We therefore hypothesize that remodeling of retinal blood vessels necessarily occurs during accommodation of microgravity-induced fluid shifts prior to subsequent development of visual and ocular impairments. Potential contributions of retinal vascular remodeling to VIIP etiology are therefore being investigated by NASA's innovative VESsel GENeration Analysis (VESGEN) software for two studies: (1) U.S. crew members before and after ISS missions, and (2) head-down tilt in human subjects before and after 70 days of bed rest. We anticipate that results of the two studies will be complete by the Investigators Workshop (January 22, 2017). METHODS: For the 2013 NASA NRA award, we are concluding the analysis of 30 degree infrared (IR) Heidelberg Spectralis images of retinal blood vessels by VESGEN (patents pending), a mature, automated software developed as a translational and basic vascular research discovery tool, particularly for retinal vascular disease. Subjects of our retrospective study include eight ISS crew members monitored for routine occupational surveillance pre- and post-flight, who provided their study consents to NASAs Lifetime Surveillance of Astronaut Health (LSAH) in coordination with approval of the VESGEN retrospective study protocol by NASAs Institutional Review Board (IRB). The ophthalmic retinal images (average image resolution, approximately 5.6 microns per pixel) are blinded as to pre and post ISS status until the second portion of our study, when VESGEN results will be correlated with other ophthalmic and medical findings for the crew members. Due to image resolution challenges, a novel Matlab tool was developed for aligning pre and post images, and comparing (querying) the two images for differences in the morphology of small vessels. RESULTS: During the past year, LSAH approved the release of all astronaut retinal images to our study for VESGEN analysis. Substantial progress on the initial blinded portion of the study is in place. We anticipate that VESGEN analysis of the 32 Spectralis IR retinal images will be complete for presentation at the 2017 IWS meeting. CONCLUSIONS: Modified retinal vascular patterning may offer early-stage predictions of ocular changes resulting in decreased visual acuity for the VIIP syndrome. Novel insights provided by VESGEN into progressively pathological and blinding vascular remodeling in the human retina currently help to guide other NIH- and NASA-supported therapeutic studies of retinal disease and modeling of the VIIP risk. Results of our vascular investigation of the retinas of astronauts pre- and post-flight may help advance the understanding of both healthy and pathological adaptations to fluid shifts in microgravity associated with the VIIP syndrome. Preliminary results indicate that imaging of higher resolution, such as the new OCT angiography (OCT-A) technology, will be required to determine conclusively the role of the smaller retinal and choroidal vessels in VIIP etiology.

VESGEN↗

DOE OSTI2021

Spread Spectrum Symbol Detection With Blind Interference Suppression in FBMC-SS

Recent works have demonstrated Filter Bank Multicarrier Spread Spectrum (FBMC-SS) to be a robust communication scheme in the presence of high-power interferers. Existing FBMC-SS symbol detector designs based on analysis filter banks (AFB) suggest using an optimal combining scheme to suppress the interferers, necessitating some noise/interference power estimation method. In this paper, we introduce a symbol detector with blind interference suppression by extending a recently developed packet detection method. We then provide an analysis to show that the existing AFB-based symbol detector and the one proposed in this paper are equivalent in typical usage scenarios. A fully-fledged receiver design is proposed utilizing this symbol detector, with specifics presented for estimation of the channel impulse response and carrier frequency offset (CFO). We also outline a method of iterating upon the channel and CFO estimations to improve the quality of both parameters. Moreover, a modification to allow improved performance of the symbol detector at high SNR is provided. Finally, simulated performance results are presented to corroborate these findings and demonstrate the efficiency of this receiver design.

99 GENERAL AND MISCELLANEOUS↗

NASA NTRS2006

Impact of Three-Dimensional Radiative Effects on Satellite Retrievals of Cloud Droplet Sizes

There are several dozen papers that study the effects of cloud horizontal inhomogeneity on the retrievals of cloud optical thickness, but only a few of them deal with cloud droplet sizes. This paper is one of the first comprehensive attempts to fill this gap: It takes a close theoretical look at the radiative effects of cloud 3-D structure in retrievals of droplet effective radii. Under some general assumptions, it was found that ignoring subpixel (unresolved) variability produces a negative bias in the retrieved effective radius, while ignoring cloud inhomogeneity at scales larger than a pixel scale (resolved variability), on the contrary, leads to overestimation of the domain average droplet size. The theoretical results are illustrated with examples from Large Eddy Simulations (LES) of cumulus (Cu) and stratocumulus (Sc) cloud fields. The analysis of cloud drop size distributions retrieved from both LES fields confirms that ignoring shadowing in 1-D retrievals results in substantial overestimation of effective radii which is more pronounced for broken Cu than for Sc clouds. Collocated measurements of broken Cu clouds by Moderate Resolution Imaging Spectrometer (MODIS) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) are used to check simulations and theory with observations. The analysis of ASTER and MODIS data and associated derived products recommends against blindly using retrieved effective radii for broken cloud fields, especially if one wants to relate aerosol amounts to cloud droplet sizes.

Marshak, Alexander↗

DOE OSTI2025

Pivotal trial characteristics and types of endpoints used to support Food and Drug Administration rare disease drug approvals between 2013 and 2022

Background/aims Rare disease drug development faces unique challenges, such as genotypic and phenotypic heterogeneity within small patient populations and a lack of established outcome measures for conditions without previously successful drug development programs. These challenges complicate the process of selecting the appropriate trial endpoints and conducting clinical trials in rare diseases. In this descriptive study, we examined novel drug approvals for non-oncologic rare diseases by the U.S. Food and Drug Administration’s Center for Drug Evaluation and Research over the past decade and characterized key regulatory and trial design elements with a focus on the primary efficacy endpoint utilized as the basis of approval. Methods Using the Food and Drug Administration’s Data Analysis Search Host database, we identified novel new drug applications and biologics license applications with orphan drug designation that were approved between 2013 and 2022 for non-oncologic indications. From Food and Drug Administration review documents and other external databases, we examined characteristics of pivotal trials for the included drugs, such as therapeutic area, trial design, and type of primary efficacy endpoints. Differences in trial design elements associated with primary efficacy endpoint type were assessed such as randomization and blinding. Then, we summarized the primary efficacy endpoint types utilized in pivotal trials by therapeutic area, approval pathway, and whether the disease etiology is well defined. Results One hundred and seven drugs that met our inclusion criteria were approved between 2013 and 2022. Assessment of the 107 drug development programs identified 150 pivotal trials that were subsequently analyzed. The pivotal trials were mostly randomized (80%) and blinded (69.3%). Biomarkers (41.1%) and clinical outcomes (42.1%) were commonly utilized as primary efficacy endpoints. Analysis of the use of clinical trial design elements across trials that utilized biomarkers, clinical outcomes, or composite endpoints did not reveal statistically significant differences. The choice of primary efficacy endpoint varied by the drug’s therapeutic area, approval pathway, and whether the indicated disease etiology was well defined. For example, biomarkers were commonly selected as primary efficacy endpoints in hematology drug approvals (70.6%), whereas clinical outcomes were commonly selected in neurology drug approvals (69.6%). Further, if the disease etiology was well defined, biomarkers were more commonly used as primary efficacy endpoints in pivotal trials (44.7%) than if the disease etiology was not well defined (27.3%). Discussion In the past 10 years, numerous novel drugs have been approved to treat non-oncologic rare diseases in various therapeutic areas. To demonstrate their efficacy for regulatory approval, biomarkers and clinical outcomes were commonly utilized as primary efficacy endpoints. Biomarkers were not only frequently used as surrogate efficacy endpoints in accelerated approvals, but also in traditionally approved rare disease drugs. The choice of primary efficacy endpoints varied by therapeutic area, approval pathway, and understanding of disease etiology.

Hong, Kyungwan [Rare Diseases Team, Office of New ↗

DOE OSTI2026

SPT-3G D1: CMB temperature and polarization power spectra and cosmology from 2019 and 2020 observations of the SPT-3G main field

Here, we present measurements of the temperature and E-mode polarization angular power spectra of the cosmic microwave background (CMB) from observations of 4% of the sky with SPT-3G, the current camera on the South Pole Telescope (SPT). The maps used in this analysis are the deepest used in a CMB TT / TE / EE analysis to date. The maps and resulting power spectra have been validated through blind and unblind tests. The measurements of the lensed EE and TE spectra are the most precise to date at ℓ = 1800 – 4000 and ℓ = 2200 – 4000 , respectively. Combining our TT / TE / EE spectra with previously published SPT-3G CMB lensing results, we find parameters for the standard Λ cold dark matter ( Λ CDM ) model consistent with Planck and ACT DR6 with comparable constraining power. We report a Hubble constant of H 0 = 66.66 ± 0.60 km s - 1 Mpc - 1 from SPT-3G alone, 6.2 σ away from local measurements from SH0ES. For the first time, combined ground-based ( SPT + ACT ) CMB primary and lensing data have reached Planck’s constraining power on some parameters, a milestone for CMB cosmology. The combination of these three CMB experiments yields the tightest CMB constraints to date, with H 0 = 67.19 ± 0.38 km s - 1 Mpc - 1 , and the amplitude of clustering σ 8 = 0.8137 ± 0.0037 . CMB data alone show no evidence for physics beyond Λ CDM , however, we observe a 2.8 σ difference in Λ CDM between CMB and baryon acoustic oscillation (BAO) results from DESI-DR2, which is relaxed in extended models. The combination of CMB and BAO yields 2 − 3 σ shifts from Λ CDM in the curvature of the Universe, the amplitude of CMB lensing, or the dark energy equation of state. It also drives mild preferences for models that address the Hubble tension through modified recombination or variations in the electron mass in a nonflat Universe. This work highlights the growing power of ground-based CMB experiments and lays a foundation for further cosmological analyses with SPT-3G.

Camphuis, Etienne [Sorbonne Université; CNRS; Inst↗