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At least 127 records · Page 7

The Human Phenotype Ontology in 2024: phenotypes around the world

The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs.

59 BASIC BIOLOGICAL SCIENCES↗

The European ERL Roadmap

Following the European Strategy process in 2019, five Roadmap Panels were set up to prepare the technologies needed for future accelerators and colliders: high-field magnets, SRF, muon colliders, plasma wakefield accelera-tors and Energy Recovery Linacs (ERLs). The ERL Roadmap Panel, consisting of ERL experts from around the world, first developed an overview of current and future ERLs. From this it was possible to carry out a gap analysis to see what R&D would be needed, from which the roadmap could be developed. The European ERL Roadmap [1] focused on three main aspects: 1) the con-tinuation and development of facility programs for which no additional funds are needed, S-DALINAC in Darm-stadt and MESA in Mainz; 2) technology development for room-temperature HOM damping and twin-axis SRF cavities; 3) the timely upgrade of bERLinPro for 100 mA current and the construction of PERLE at Orsay as a dedi-cated 10 MW power multi-turn facility. The roadmap entails a vision of a future energy frontier electron-positron and electron-hadron collider and describes a high-quality ERL program for 4.4K SRF technology at high Q0.

Hutton, A.↗

Specimen Size Artifacts Associated with a Glovebox Deployable Laser Flash Diffusivity Measurement System

To accelerate nuclear fuel qualification and deployment efforts, Oak Ridge National Laboratory has led the world in developing vehicles for accelerating burnup accumulation in nuclear fuel by testing miniature samples in the High Flux Isotope Reactor. However, a challenge remains to establish parity between post irradiation characterization methods for miniature fuel specimens in comparison to conventional fuel elements. This work aims to identify artifacts associated with the thermal analysis of miniature disk specimens in comparison to samples of standardized dimensions through a combination of experimental and computational tools. Using a newly procured Netzsch 427 laser flash diffusivity system, preliminary data on mild steel specimens were collected, and finite element techniques were used to model heat transfer using 1D conditions to assess issues associated with pulse width and data collection frequency effects. These preliminary investigations found that significant variability in measured thermal diffusivity exist within datasets. These variations are not necessarily attributed to limitations with respect to data collection rate; nor are they associated with limitations on pulse width. Instead, these artifacts may be a result of limitations in detector intensity. Future work aims to design a focusing lens to better measure the smaller surface area of miniature specimens analyzed using the laser flash analysis system.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

The European ERL Roadmap

Following the European Strategy process in 2019, five Roadmap Panels were set up to prepare the technologies needed for future accelerators and colliders: high-field magnets, SRF, muon colliders, plasma wakefield accelerators and Energy Recovery Linacs (ERLs). The ERL Roadmap Panel, consisting of ERL experts from around the world, first developed a comprehensive overview of current and future ERLs. From this a gap analysis was carried out to evaluate the necessary R&D, which led to the development of the Roadmap. The European ERL Roadmap focused on three main aspects: 1) the continuation and development of facility programs for which no additional funds are needed (S-DALINAC in Darmstadt and MESA in Mainz); 2) technology development for room-temperature HOM damping and twin-axis SRF cavities; 3) the timely upgrade of bERLinPro for 100mA current, and 4) the construction of PERLE at Orsay as a dedicated 10MW beam-power multi-turn facility. The Roadmap also describes a vision for future energy-frontier electron-positron and electron-hadron colliders, and describes a high-quality ERL program for 4.4K SRF technology at high Q0. The presentation will address the ERL Roadmap process and results in detail.

Hutton, Andrew↗

Rediscovered photographs of J. Robert Oppenheimer’s 1964 visit to LANL

National Security Research Center staff recently rediscovered a trove of images of J. Robert Oppenheimer’s last known visit to the Laboratory, tucked away among the NSRC’s collections of millions of classified and unclassified photographs and not seen for over thirty years. Oppenheimer, who served as our first Director from 1943–1945, led the United States’ successful wartime effort to develop the world’s first atomic weapons in just 27 months. He left the Lab shortly after World War II ended, but came back in May of 1964 to deliver a lecture about Niels Bohr at the Civic Auditorium (now Duane Smith Auditorium) and visit the Los Alamos Scientific Laboratory Museum (which would become the Bradbury Science Museum), as is captured in these photos.

99 GENERAL AND MISCELLANEOUS↗

Problems and perspectives in paraplegia

Improved clinical treatment of the paraplegic, developed during World War II, has reduced the overall mortality rate from close to 100 percent to 30 percent. Despite major clinical improvements, mainly in treatment of the acute phase of paraplegia, and despite greater rehabilitation efforts, the spinal injured person is never rehabilitated in the sense that he reaches an optimum and stays there. He is always exposed to the constant threat of deterioration of his physiological, sociological, and psychological state.

Nashold, B.↗

Survival in space

The evolution of space suit design to meet the needs of past and future manned space missions is discussed. Following a brief consideration of the purposes of the space suit in providing an artificial atmosphere and protection from environmental hazards, attention is given to the first high-altitude suits developed in the 1930's for the protection of balloon pilots, and for high-altitude airplane flights. The Mercury project space suit is presented as essentially similar to those for high-altitude military aircraft developed since World War II, providing pressurization and oxygen as a backup to the capsule systems. Modifications to the suit allowing it to be worn without discomfort during work outside the spacecraft, which were stimulated by experience in Gemini missions, are considered, which culminated in the suits of the Apollo and Skylab programs which provided insulation, cooling and life support for periods of up to eight hours. Finally, changes to suit design made necessary by the increasing numbers of men and women to perform Space Shuttle flights and space construction operations are considered.

Webbon, B.↗

High definition systems in Japan

The successful implementation of a strategy to produce high-definition systems within the Japanese economy will favorably affect the fundamental competitiveness of Japan relative to the rest of the world. The development of an infrastructure necessary to support high-definition products and systems in that country involves major commitments of engineering resources, plants and equipment, educational programs and funding. The results of these efforts appear to affect virtually every aspect of the Japanese industrial complex. The results of assessments of the current progress of Japan toward the development of high-definition products and systems are presented. The assessments are based on the findings of a panel of U.S. experts made up of individuals from U.S. academia and industry, and derived from a study of the Japanese literature combined with visits to the primary relevant industrial laboratories and development agencies in Japan. Specific coverage includes an evaluation of progress in R&D for high-definition television (HDTV) displays that are evolving in Japan; high-definition standards and equipment development; Japanese intentions for the use of HDTV; economic evaluation of Japan's public policy initiatives in support of high-definition systems; management analysis of Japan's strategy of leverage with respect to high-definition products and systems.

Elkus, Richard J., Jr.↗

IRAF in the nineties

The Interactive Data Reduction and Analysis Facility (IRAF) data reduction and analysis system has been around since 1981. Today it is a mature system with hundreds of applications, and is supported on all the major platforms. Many institutions, projects, and individuals around the US and around the world have developed software for IRAF. Some of these packages are comparable in size to the IRAF core system itself. IRAF is both a data analysis system, and a programming environment. As a data analysis system it can be easily installed by a user at a remote site and immediately used to view and process data. As a programming environment IRAF contains a wealth of high and low level facilities for developing new applications for interactive and automated processing of astronomical or other data. As important as the applications programs and user interfaces are to the scientist using IRAF, the heart of the IRAF system is the programming environment. The programming environment determines to a large extent the types of applications which can be built within IRAF, what they will look like, and how they will interact with one another and with the user. While applications can be easily added to or removed from a software system, the programming environment must remain fairly stable, with carefully planned evolution and growth, over the lifetime of a system. The IRAF programming environment is the framework on which the rest of the IRAF system is built. The IRAF programming environment as it exists in 1992, and the work currently underway to enhance the environment are discussed. The structure of the programming environment as a class hierarchy is discussed, with emphasis on the work being done on the image data structures, graphics and image display interfaces, and user interfaces. The new technologies which we feel IRAF must deal with successfully over the coming years are discussed. Finally, a preview of what IRAF might look like to the user by the end of the decade is presented.

Tody, D.↗

Scholarly Electronic Full-Text Publications via the Internet: Issues and Impacts

On-line access to complete texts of scholarly journal articles, conference papers, and books is facilitated by rapidly developing World-wide Web Internet access and capabilities. Meanwhile, print publications continue to be produced and read in spite of the proliferation of many networked electronic publications. The purpose of this presentation is to highlight fundamental issues impacting stakeholder groups, as the trend continues towards migration from paper to affordable ubiquitous networked full-text publications. Librarians, publishers, authors and end-users have various viewpoints, interests, and concerns. There are many issues challenging all stakeholder groups. For instance, all share concerns about administering copyright compliance and enforcing fair use. Uncontrollable electronic downstreaming could result in infringed copyright, while limiting a publisher's entitled revenue stream. Moreover, metered fee-based access may hamper scholarly information research. And, self-authoring on the Internet without peer filtering could lead to information clutter. Many related issues challenge librarians in particular. Among these are rising journal subscription prices, regardless if offered in print or electronic. Some electronic offerings are independent of print, others supplement or duplicate print; several publishers presently require subscribing to print in order to access electronic. Furthermore, numbers of publications are n'ow being marketed via the Internet directly to end-users, which can be viewed as encouraging users to bypass the traditional library. A key issue challenging publishers today is the rapidly expanding electronic user base that is demanding delivery of added-value full-text to desktop computers. Also of growing concern appears to be the decline in print sales to libraries, thereby reducing traditional revenue stream potential. Nowadays, publishers are more hesitant about investing in the production of publications geared toward small niche subjects, since these tend to require higher pricing and carry limited sales potential. Both electronic and print publications necessitate similar editorial, production, operating, and marketing dollars. Tradeoffs owing to delivery format difference do not necessarily mean less dollars need to be spent. Authors wishing to publish books are facing a decline in the role of scholarly monographs in electronic media. However, they are witnessing increased roles of electronic preprints and electronic journal articles. Moreover, the Internet fosters self-publishing without peer monitoring or formal review. Issues challenging end-users include electronic barriers to peer-reviewed formal published works (i.e., fee-based subscriptions to journal literature vs. traditional free-library concept). This often means password only access or IP address controlled site-licensed access. Also, in an uncontrolled Internet environment, sometimes there is a blurring of publication authorship/ownership, as various pieces of publications are cut/pasted into/re-posted on various, disconnected Web searchable home pages.

Kosmin, Linda J.↗

Biomass Burning Emissions in the Cerrado of Brazil Computed with Remote Sensing Data and GIS

Biomass burnin is a common force in much of the developing tropical world where it has wide-ranging environmental impacts. Fire is a component of tropical deforestation and is 0 p often used to clear broad expanses of land for shifting agriculture and cattle ranching. Frequent burning in the tropical savannas is a distinct problem from that of primary forest. In Brazil, most of the burning occurs in the cerrado which occupies approximately 1,800,000 km2, primarily on the great plateau in central Brazil. Wildland and agricultural fires are dramatic sources of regional air pollution in central Brazil. Biomass burning is an important source of a large number of trace gases including greenhouse gases and other chemically active species. Knowledge of trace gas emissions from biomass burning in Brazil is limited by a number of factors, most notably relative emission factors for gases from specific fire types/fuels and accurate estimates of temporal and spatial distribution and extent of fire activity. Estimates of trace gas emissions during September 1992 will be presented that incorporates a digital map of vegetation classes, pyrogenic emission factors calculated from ground and aircraft missions, and Instituto Nacional de Pesquisas Espaciais (INPE) fire products derived from Advanced Very High Resolution Radiometer (AVHRR) data. The regional emissions calculated from National Oceanographic and Atmospheric Administration (NOAA) AVHRR estimates of fire activity will provide an independent estimate for comparison with results obtained by the National Aeronautics and Space Administration (NASA) Transport and Atmospheric Chemistry Near the Equator - Atlantic (TRACE-A) experiments.

Guild, Liane S.↗

Intelligent Fasteners

Under a Small Business Innovation Research contract from Marshall Space Flight Center, Ultrafast, Inc. developed the world's first, high-temperature resistant, "intelligent" fastener. NASA needed a critical-fastening appraisal and validation of spacecraft segments that are coupled together in space. The intelligent-bolt technology deletes the self-defeating procedure of having to untighten the fastener, and thus upset the joint, during inspection and maintenance. The Ultrafast solution yielded an innovation that is likely to revolutionize manufacturing assembly, particularly the automobile industry. Other areas of application range from aircraft, computers and fork-lifts to offshore platforms, buildings, and bridges.

Source record↗

Test and Analysis Capabilities of the Space Environment Effects Team at Marshall Space Flight Center

Marshall Space Flight Center has developed world-class space environmental effects testing facilities to simulate the space environment. The combined environmental effects test system exposes temperature-controlled samples to simultaneous protons, high- and low-energy electrons, vacuum ultraviolet (VUV) radiation, and near-ultraviolet (NUV) radiation. Separate chambers for studying the effects of NUV and VUV at elevated temperatures are also available. The Atomic Oxygen Beam Facility exposes samples to atomic oxygen of 5 eV energy to simulate low-Earth orbit (LEO). The LEO space plasma simulators are used to study current collection to biased spacecraft surfaces, arcing from insulators and electrical conductivity of materials. Plasma propulsion techniques are analyzed using the Marshall magnetic mirror system. The micro light gas gun simulates micrometeoroid and space debris impacts. Candidate materials and hardware for spacecraft can be evaluated for durability in the space environment with a variety of analytical techniques. Mass, solar absorptance, infrared emittance, transmission, reflectance, bidirectional reflectance distribution function, and surface morphology characterization can be performed. The data from the space environmental effects testing facilities, combined with analytical results from flight experiments, enable the Environmental Effects Group to determine optimum materials for use on spacecraft.

Finckenor, M. M.↗

Advanced mid-IR Solid-State Laser Developments

This paper reviews the state-of-the-art 2-micron solid-state laser developments. A world record one-Joule-per-pulse energy laser system and an advanced thermal management with fully conductive cooled laser technique are discussed

Yu, Jirong↗

Concepts for a NASA Applied Spaceflight Environments Office

The National Aeronautics and Space Administration (NASA) is launching a bold and ambitious new space initiative. A significant part of this new initiative includes exploration of new worlds, the development of more innovative technologies, and expansion our presence in the solar system. A common theme to this initiative is the exploration of space beyond Low Earth Orbit (LEO). As currently organized, NASA does not have an Agency-level office that provides coordination of space environment research and development. This has contributed to the formation of a gap between spaceflight environments knowledge and the application of this knowledge for multi-program use. This paper outlines a concept to establish a NASA-level Applied Spaceflight Environments (ASE) office that will provide coordination and funding for sustained multi-program support in three technical areas that have demonstrated these needs through customer requests. These technical areas are natural environments characterization and modeling, materials and systems analysis and test, and operational space environments modeling and prediction. This paper will establish the need for the ASE, discuss a concept for organizational structure and outline the scope in the three technical areas

Edwards, David L.↗

A NASA Applied Spaceflight Environments Office Concept

The National Aeronautics and Space Administration (NASA) is launching a bold and ambitious new space initiative. A significant part of this new initiative includes exploration of new worlds, the development of more innovative technologies, and expansion our presence in the solar system. A common theme to this initiative is the exploration of space beyond Low Earth Orbit (LEO). As currently organized, NASA does not have an Agency-level office that provides coordination of space environment research and development. This has contributed to the formation of a gap between spaceflight environments knowledge and the application of this knowledge for multi-program use and for use outside NASA. This paper outlines a concept to establish a NASA-level Applied Spaceflight Environments (ASE) office that will provide coordination and funding for sustained multi-program support in three technical areas that have demonstrated these needs through customer requests. These technical areas are natural environments characterization and modeling, materials and systems analysis and test, and operational space environments modeling. Additionally the ASE office will serve as an entry point of contact for external users who wish to take advantage of data and assets associated with space environments, including space weather. This paper will establish the need for the ASE, discuss a concept for organizational structure and outline the scope in the three technical areas.

Spann, James F.↗

Space-Based Detection of Missing Sulfur Dioxide Sources of Global Air Pollution

Sulfur dioxide is designated a criteria air contaminant (or equivalent) by virtually all developed nations. When released into the atmosphere, sulfur dioxide forms sulfuric acid and fine particulate matter, secondary pollutants that have significant adverse effects on human health, the environment and the economy. The conventional, bottom-up emissions inventories used to assess impacts, however, are often incomplete or outdated, particularly for developing nations that lack comprehensive emission reporting requirements and infrastructure. Here we present a satellite-based, global emission inventory for SO2 that is derived through a simultaneous detection, mapping and emission-quantifying procedure, and thereby independent of conventional information sources. We find that of the 500 or so large sources in our inventory, nearly 40 are not captured in leading conventional inventories. These missing sources are scattered throughout the developing world-over a third are clustered around the Persian Gulf-and add up to 7 to 14 Tg of SO2 yr(exp -1), or roughly 6-12% of the global anthropogenic source. Our estimates of national total emissions are generally in line with conventional numbers, but for some regions, and for SO2 emissions from volcanoes, discrepancies can be as large as a factor of three or more. We anticipate that our inventory will help eliminate gaps in bottom-up inventories, independent of geopolitical borders and source types.

OMI↗