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At least 127 records · Page 7

Interference effects on the hypersonic, rarefied flow about a flat plate

The Direct Simulation Monte Carlo method is used to study the hypersonic, rarified flow interference effects on a flat plate caused by nearby surfaces. Calculations focus on shock-boundary-layer and shock-lip interactions in hypersonic inlets. Results are presented for geometries consisting of a flat plate with different leading-edge shapes over a flat lower wall and a blunt-edge flat plate over a 5-degree wedge. The problems simulated correspond to a typical entry flight condition of 7.5 km/s at altitudes of 75 to 90 km. The results show increases in predicted local heating rates for shock-boundary-layer and shock-lip interactions that are quantitatively similar to those observed experimentally at much higher densities.

Wilmoth, Richard G.↗

Interference effects on the hypersonic, rarefied flow about a flat plate

The Direct Simulatiaon Monte Carlo method is used to study the hypersonic, rarefied flow interference effects on a flat plate caused by nearby surfaces. Calculations focus on shock-boundary-layer and shock-lip interactions in hypersonic inlets. Results are presented for geometries consisting of a flat plate with different leading-edge shapes over a flat lower wall and a blunt-edge flat plate over a 5-degree wedge. The problems simulated correspond to a typical entry flight condition of 7.5 km/s at altitudes of 75 to 90 km. The results show increases in predicted local heating rates for shock-boundary-layer and shock-lip interactions that are quantitatively similar to those observed experimentally at much higher densities.

Wilmoth, Richard G.↗

Painleve-gullstrand-type Coordinates for the Five-dimensional Myers-Perry Black Hole

The Painleve-Gullstrand coordinates provide a convenient framework for presenting the Schwarzschild geometry because of their flat constant-time hypersurfaces, and the fact that they are free of coordinate singularities outside r=0. Generalizations of Painlev´e-Gullstrand coordinates suitable for the Kerr geometry have been presented by Doran and Nat´ario. These coordinate systems feature a time coordinate identical to the proper time of zero-angular-momentum observers that are dropped from infinity. Here, the methods of Doran and Nat´ario are extended to the five-dimensional rotating black hole found by Myers and Perry. The result is a new formulation of the Myers-Perry metric. The properties and physical significance of these new coordinates are discussed.

Generalizations↗

Comparative Pore Structure and Dynamics for Bacterial Microcompartment Shell Protein Assemblies in Sheets or Shells

Bacterial microcompartments (BMCs) are protein-bound organelles found in some bacteria that encapsulate enzymes for enhanced catalytic activity. These compartments spatially sequester enzymes within semipermeable shell proteins, analogous to many membrane-bound organelles. The shell proteins assemble into multimeric tiles; hexamers, trimers, and pentamers, and these tiles self-assemble into larger assemblies with icosahedral symmetry. While icosahedral shells are the predominant form in vivo , the tiles can also form nanoscale cylinders or sheets. The individual multimeric tiles feature central pores that are key to regulating transport across the protein shell. Our primary interest is to quantify pore shape changes in response to alternative component morphologies at the nanoscale. We used molecular modeling tools to develop atomically detailed models for both planar sheets of tiles and curved structures representative of the complete shells found in vivo . Subsequently, these models were animated using classical molecular dynamics simulations. From the resulting trajectories, we analyzed the overall structural stability, water accessibility to individual residues, water residence time, and pore geometry for the hexameric and trimeric protein tiles from the Haliangium ochraceu m model BMC shell. These exhaustive analyses suggest no substantial variation in pore structure or solvent accessibility between the flat and curved shell geometries. We additionally compare our analysis to hydroxyl radical footprinting data to serve as a check against our simulation results, highlighting specific residues where water molecules are bound for a long time. Although with little variation in morphology or water interaction, we propose that the planar and capsular morphology can be used interchangeably when studying permeability through BMC pores.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Effect of geometry variations on lee-surface vortex-induced heating for flat-bottom three-dimensional bodies at Mach 6

Studies have shown that vortices can produce relatively severe heating on the leeward surfaces of conceptual hypersonic vehicles and that surface geometry can strongly influence this vortex-induced heating. Results which show the effects of systematic geometry variations on the vortex-induced lee-surface heating on simple flat-bottom three-dimensional bodies at angles of attack of 20 deg and 40 deg are presented. The tests were conducted at a free-stream Mach number of 6 and at a Reynolds number of 1.71 x 10 to the 7th power per meter.

Hefner, J. N.↗

Evaluation of leading- and trailing-edge flaps on flat and cambered delta wings at supersonic speeds

An experimental investigation has been conducted to evaluate the effectiveness of leading- and trailing-edge flaps on a flat and cambered wing at superconic speeds. Results from the experimental tests showed that highly complex and three-dimensional flow can occur over the wings with leading- and/or trailing-edge flaps deflected. An analysis of the data also showed that flap effectiveness varies significantly between a cambered and flat wing of identical planform and flap geometry. Mach number effects are similar for both flat and cambered wings for all aerodynamic parameters.

Hernandez, Gloria↗

Turbulent boundary layer on a convex, curved surface

The effects of strong convex curvature on boundary layer turbulence were investigated. The data gathered on the behavior of Reynolds stress suggested the formulation of a simple turbulence model. Three sets of data were taken on two separate facilities. Both rigs had flow from a flat surface, over a convex surface with 90 deg of turning, and then onto a flat recovery surface. The geometry was adjusted so that, for both rigs, the pressure gradient along the test surface was zero - thus avoiding any effects of streamwise acceleration on the wall layers. Results show that after a sudden introduction of curvature, the shear stress in the outer part of the boundary layer is sharply diminished and is even slightly negative near the edge. The wall shear also drops off quickly downstream. In contrast, when the surface suddenly becomes flat again, the wall shear and shear stress profiles recover very slowly towards flat wall conditions.

Gillis, J. C.↗

Experimental data and model for the turbulent boundary layer on a convex, curved surface

Experiments were performed to determine how boundary layer turbulence is affected by strong convex curvature. The data gathered on the behavior of the Reynolds stress suggested the formulation of a simple turbulence model. Data were taken on two separate facilities. Both rigs had flow from a flat surface, over a convex surface with 90 deg of turning and then onto a flat recovery surface. The geometry was adjusted so that, for both rigs, the pressure gradient along the test surface was zero. Two experiments were performed at delta/R approximately 0.10, and one at weaker curvature with delta/R approximately 0.05. Results show that after a sudden introduction of curvature the shear stress in the outer part of the boundary layer is sharply diminished and is even slightly negative near the edge. The wall shear also drops off quickly downstream. When the surface suddenly becomes flat again, the wall shear and shear stress profiles recover very slowly towards flat wall conditions. A simple turbulence model, which was based on the theory that the Prandtl mixing length in the outer layer should scale on the velocity gradient layer, was shown to account for the slow recovery.

Gillis, J. C.↗

Topological Exact Flat Bands in Two-Dimensional Materials under Periodic Strain

Here we study flat bands and their topology in 2D materials with quadratic band crossing points under periodic strain. In contrast to Dirac points in graphene, where strain acts as a vector potential, strain for quadratic band crossing points serves as a director potential with angular momentum . We prove that when the strengths of the strain fields hit certain “magic” values, exact flat bands with emerge at charge neutrality point in the chiral limit, in strong analogy to magic angle twisted-bilayer graphene. These flat bands have ideal quantum geometry for the realization of fractional Chern insulators, and they are always fragile topological. The number of flat bands can be doubled for certain point group, and the interacting Hamiltonian is exactly solvable at integer fillings. We further demonstrate the stability of these flat bands against deviations from the chiral limit, and discuss possible realization in 2D materials.

36 MATERIALS SCIENCE↗

Transfer Function Models and Sensitivity Analysis

In many situations, real or induced flaws such as tight cracks with known morphology cannot be manufactured in part configuration specimens or in real parts. Typically, fatigue cracks are manufactured in simple geometry specimens such as flat plates, dog-bone shaped flat or round specimens. If a nondestructive evaluation (NDE) technique is required to provide a reliably detectable target flaw size denoted as α_(90/95) for induced flaws in real part, then the direct method for qualifying the NDE procedure is to use the appropriate induced flaw specimens and perform probability of detection analysis using these flaws. This can be described as direct POD demonstration testing, which may follow guidelines of MIL-HDBK-1823. This paper considers a case, where induced flaws are not available in part configuration specimens. Therefore, a direct POD demonstration study cannot be undertaken. In such situation, general practice for NDE procedure qualification is to use artificial flaws in simple geometry and part configuration specimens, and induced flaws in the chosen simple geometry specimens. Signal response data is taken on all sets of artificial and induced flaws. NDE procedure testing on induced flaw in simple geometry specimen is called NDE demonstration testing here. A transfer function NDE procedure qualification method for forward case calculates predicted induced flaw size for demonstration using a chosen target flaw size. Another transfer function method for inverse case, calculates the target flaw size using a given demonstration flaw size. The transfer function analysis assumes relationship of artificial flaw signal responses in real parts and simple geometry specimens; and induced flaw responses in simple geometry specimens to induced flaws in real parts. The signal response transfer relationships model should be defined before transfer function models can be devised. Assuming that the signal response transfer relationships model is valid, forward and inverse case transfer function methods have been devised. Because of lack of signal response data from induced flaws in real part, 90/95% POD/confidence (P/C) cannot be demonstrated directly. However, the transfer function method may be assessed using simulation to evaluate whether the resulting target flaw size or demonstration flaw size provides adequate confidence to the assumed signal response transfer relationships model. Therefore, the transfer function approach is a risk assessment approach. Both the signal response transfer relationships model and the transfer function model are important in managing risk in results provided by the transfer function NDE technique qualification or assessment. The signal response transfer relationships model needs to be validated with empirical data and then transfer function model needs to be validated for desired P/C on case-by-case basis.

Nondestructive evaluation↗

Transfer function models for using empirical and physics-based simulation signal response data

In many situations, real or induced flaws such as tight cracks with known morphology cannot be manufactured in part geometry specimens or in real parts. Typically, surface fatigue cracks are manufactured in simple geometry specimens such as flat plates, dog-bone shaped flat or cylindrical specimens. If a nondestructive evaluation (NDE)technique is required to provide a reliably detectable flaw size, denoted asa90/95, for induced flaws in a part, then a direct method for qualifying the NDE procedure is to use appropriate induced flaw specimens and perform NDE procedure demonstration on the specimens. Probability of detection (POD)analysis of the empirical data may provide estimation of a90/95. This approach is described as direct POD demonstration testing, which may follow guidelines of MIL-HDBK-1823. This paper considers a case, where embedded tight cracklike induced flaws are to be detected reliably using a signal response based NDE procedure. Here, it is assumed that it is not practical to make surface or embedded induced flaw specimens in part geometry or configuration. Therefore, a direct POD demonstration testing cannot be undertaken. It is also assumed that simulation of signal response is possible for both surface and embedded induced flaws in part geometry specimens using a physics-based model. The proposed approach for NDE procedure qualification uses artificial flaws in simple geometry and part geometry specimens, and induced flaws in the same type of simple geometry specimens. Signal response data is taken on all sets of artificial and induced flaws in simple geometry and part geometry specimens. Moreover, simulated signal response data is generated for surface and embedded flaws. Thus, a case of five signal response versus flaw size datasets is considered. Three of the datasets are empirical and two datasets are physics model-based simulation datasets. A method of devising and using transfer function calculation dataset blocks to estimate the either the reliably detectable flaw size or the demonstration flaw size is provided.

Nondestructive evaluation↗

An Eddy Current Case Study using NASA’s Transfer Function and Limited-Sample Probability of Detection Guidebooks

Probability of detection (POD) requirements for NASA fracture-critical human-rated systems can be met by (1) claiming ‘similarity’ to NASA Standard Nondestructive Evaluation (NDE) flaw sizes or (2) by inspector-specific POD demonstration, known as NASA Special NDE. Standard NDE flaw sizes are intended to represent the detection capability of most qualified inspectors, and were primarily based on POD studies in the development of the Space Shuttle Program Orbiter fracture control plan. However, these Standard NDE flaw sizes were based on fatigue cracks in flat panels of one material alloy over a limited range of panel thicknesses. While the POD study was comprehensive, the inspection conditions are relatively narrow. An evaluation of similarity between the Standard NDE POD study and flight component conditions is required to apply Standard NDE to specific flight component inspections. A similarity evaluation may include differences in materials, surface finish, component geometry (e.g., curvature, corners, welds), and inspection access. Similarity is typically based on a qualitative engineering evaluation. Recently, NASA published a quantitative methodology to assess similarity. If similarity is not supported by test and analysis, then the methodology provides a transfer function of flaw size for Special NDE POD demonstration. NASA recommends that Special POD demonstrations use flaws that are flight-like or more difficult to detect than flight component flaws, which are commonly induced fatigue cracks. Often, it is not feasible to induce fatigue cracks in flight component geometry, and therefore, a simpler representative geometry is used, commonly a flat panel, for POD demonstration. Inducing cracks in simple geometry specimens can be time-consuming and expensive, and thus, minimizing the number of flawed specimens is desired. Traditionally, NASA Special NDE demonstration was limited to MIL-HDBK-1823A methods or the binomial point-estimate method (PEM), commonly known as 29/29. Recently, NASA published a limited-sample POD (LS-POD) methodology for signal-response NDE techniques (e.g., eddy current) that provides POD demonstration with fewer specimens than previous approaches. LS-POD suggests a minimum of 10 flawed specimens, compared to 29 in the PEM and the suggested minimum of 40 from MIL-HDBK-1823A. The methodology also includes new guidance on evaluating the probability of false calls. In this presentation, these new transfer function and LS-POD methodologies are described and illustrated through an eddy current detection capability of far-side flaws on thin welded panels. A geometry-based transfer function is developed using electro-discharge machined (EDM) notches in flight component and simple geometry to estimate the Special NDE flaw size that is representative of the critical initial flaw size required by the fracture analysis. Then, fatigue cracks are induced in simple flat panels of the transferred flaw size, and the LS-POD methodology is used for Special NDE demonstration.

P. A. Parker↗

Design Study of a 16-T Block Dipole for FCC

© 2016 IEEE. The Future Circular Collider (FCC) study at CERN is investigating the design of a proton-proton collider with a center of mass energy of 100 TeV and a tunnel circumference of 100 km (FCC-hh). Nb3Sn arc dipoles with 50-mm aperture and 16-T operating field are required for this application. Among the possible magnetic layouts, block coils offer attractive features, in terms of conductor packing, separation between high-field and high-stress locations, use of flat cables, and simpler geometries for windings and parts. In order to assess these potential advantages, the HD series of block-coil models was developed at LBNL. These models achieved fields of 15-16 T in technology tests, and 13-14 T in accelerator relevant configurations, with bore diameters of 36-43 mm. In this paper, we discuss the implications of increasing the bore diameter to 50 mm, which is consistent with the latest FCC-hh design targets. A detailed quench protection analysis is performed using the new coupling-loss-based CLIQ system, expanding the safe parameter space with respect to the traditional approach based on quench heaters. Finally, alternative magnet design options, and further studies required to select among them, are outlined.

Sabbi, Gianluca↗

TU-EF-207-00: Advances in Breast Imaging

Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

60 APPLIED LIFE SCIENCES↗

TU-EF-207-01: Introductory Remarks on Recent Advances in Breast Imaging

Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

60 APPLIED LIFE SCIENCES↗

TU-EF-207-02: Spectral Mammography Based on Photon Counting Detectors

Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

60 APPLIED LIFE SCIENCES↗

TU-EF-207-03: Advances in Stationary Breast Tomosynthesis Using Distributed X-Ray Sources

Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

60 APPLIED LIFE SCIENCES↗

TU-EF-207-04: Advances in Detector Technology for Breast Tomosynthesis

Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

60 APPLIED LIFE SCIENCES↗