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NASA NTRS2019

Prenatal 2g Exposure Alters Placental Expression of Stress-Related Genes

Extra-terrestrial colonization is of growing interest to space agencies and private entities, emphasizing the importance of research on reproduction and development in the absence of Earth's 1G. Maternal stressors can modify offspring development, exerting significant lifespan and crossgenerational changes through prenatal programming. The space environment is stressful, therefore exposure to altered gravity during pregnancy may impact later life outcomes in offspring. In ground-based studies, we exposed pregnant rats to continuous +G (above Earth gravity), and observed overweight and elevated anxiety in adult male (but not female) offspring, common phenotypes associated with prenatal maternal stress. Here we hypothesize that exposure to increased gravity during pregnancy elicits changes in the expression of stress-related genes in placenta that may mediate emergence of later life outcomes. While the placenta transports maternal factors to the fetus and produces endogenous fetal hormones, stress-induced changes at the placental-uterine interface may also alter communication between mother and fetus, facilitating prenatal transmission of unfavorable later life outcomes and cross-generational epigenetic alterations. Maternal stress elevates maternal glucocorticoids however placental 11b-hydroxysteroid dehydrogenase type 2 (HSD11B2) buffers fetal exposure by converting cortisol/corticosterone into inactive metabolites. Maternal stress during pregnancy down-regulates this enzyme and can induce epigenetic changes in placental and fetal tissues accounting for heightened adult HPA reactivity. Past studies have shown a placenta-specific increase in DNA methyltransferase (DNMT3a) mRNA in stressed mothers, an effect with implications for genome-wide epigenetic changes that may account for diverse phenotypic outcomes following maternal stress. Here we exposed groups of pregnant rats to one of five gravity loads (1, 1.5, 1.75 and 2G) and analyzed placental samples during late gestation. We predicted a systematic dose-response relationship between gravity load and the expression of the HSD11B2 and DNMT3 genes, thereby linking maternal exposure to altered gravity during pregancy with maternal stress.

Kalotia, Simranjit K.↗

NASA NTRS1992

Detection of the Earth with the SETI microwave observing system assumed to be operating out in the galaxy

This paper estimates the maximum range at which radar signals from the Earth could be detected by a search system similar to the NASA Search for Extraterrestrial Intelligence Microwave Observing Project (SETI MOP) assumed to be operating out in the galaxy. Figures are calculated for the Targeted Search, and for the Sky Survey parts of the MOP, both operating, as currently planned, in the second half of the decade of the 1990s. Only the most powerful terrestrial transmitters are considered, namely, the planetary radar at Arecibo in Puerto Rico, and the ballistic missile early warning systems (BMEWS). In each case the probabilities of detection over the life of the MOP are also calculated. The calculation assumes that we are only in the eavesdropping mode. Transmissions intended to be detected by SETI systems are likely to be much stronger and would of course be found with higher probability to a greater range. Also, it is assumed that the transmitting civilization is at the same level of technological evolution as ours on Earth. This is very improbable. If we were to detect another technological civilization, it would, on statistical grounds, be much older than we are and might well have much more powerful transmitters. Both factors would make detection by the NASA MOP a much more likely outcome.

NASA Center ARC↗

NASA NTRS2011

Examination of Communication Delays on Team Performance: Utilizing the International Space Station (ISS) as a Test Bed for Analog Research

Operational conjectures about space exploration missions of the future indicate that space crews will need to be more autonomous from mission control and operate independently. This is in part due to the expectation that communication quality between the ground and exploration crews will be more limited and delayed. Because of potential adverse effects on communication quality, both researchers and operational training and engineering experts have suggested that communication delays and the impact these delays have on the quality of communications to the crew will create performance decrements if crews are not given adequate training and tools to support more autonomous operations. This presentation will provide an overview of a research study led by the Behavioral Health and Performance Element (BHP) of the NASA Human Research Program that examines the impact of implementing a communication delay on ISS on individual and team factors and outcomes, including performance and related perceptions of autonomy. The methodological design, data collection efforts, and initial results of this study to date will be discussed . The results will focus on completed missions, DRATS and NEEMO15. Lessons learned from implementing this study within analog environments will also be discussed. One lesson learned is that the complexities of garnishing a successful data collection campaign from these high fidelity analogs requires perseverance and a strong relationship with operational experts. Results of this study will provide a preliminary understanding of the impact of communication delays on individual and team performance as well as an insight into how teams perform and interact in a space-like environment . This will help prepare for implementation of communication delay tests on the ISS, targeted for Increment 35/36.

Keeton, K. E.↗

NASA NTRSDate not supplied

Human Capabilities Assessments for Autonomous Missions: A Multi-Team Research Effort to Reduce Risk in the Human-System Integration Architecture for Future Deep-Space Missions

In future exploration missions beyond low earth-orbit, crew will have to execute complex operations and respond to off-nominal events, without real-time support from Mission Control. It is anticipated that increased reliance on automated systems, including human-centric vehicle and information architecture, will need to be designed to support the crew; increased risk to performance, health, and safety may occur if these are not implemented appropriately. The Human Factors and Behavioral Performance Element (HFBP) in the NASA Human Research Program supports research to characterize and mitigate such human health and performance risks, including the Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture (HSIA). The HSIA risk addresses the integration of onboard capability and the crew roles and responsibilities necessary to enable the crew to respond effectively and efficiently in the increasingly autonomous mission operations environment. In 2017, HFBP released the “Human Capabilities Assessments for Autonomous Missions” (HCAAM) research topic to address HSIA related questions. HCAAM is a major NASA research effort that has assembled a multidisciplinary team from seven institutions to work closely with design and engineering efforts on research towards developing and refining human performance standards, guidelines and automation tools. The scientific focus is on quantitative assessment of human capabilities relevant to future deep-space missions during which earth/spacecraft communication is so delayed and intermittent that the crew must be able to function autonomously. The integrated strategy of the HCAAM project characterizes human capabilities and limitations related to potential performance decrements during long duration exploration mission spaceflight as relevant to both routine and complex task performance; defines system characteristics that reduce the likelihood or impact of potential decrements in human performance capabilities; performs integrated assessment of intelligent system responses within the context of an operational environment with relevant NASA tools, systems, and data structures in order to determine positive or negative interactions and validate recommended approaches; and proposes specific updates to existing standards and guidelines for inclusion in NASA handbooks for the design of future spacecraft intelligent systems that provide crew performance assessment/feedback, and to also serve as decision-support aids for the onboard crew (i.e., NASA-STD-3001, and NASA/SP-Human Integration Design Handbook (HIDH)). The scientific research vectors being addressed by the seven HCAAM teams include: - crew task performance (accuracy, efficiency) (crew + automation) - crew performance (accuracy, efficiency) - crew Situation Awareness - procedure design and multi-modal enhancement - concurrent tasking (mixed manual + some level of autonomy) - task handover - crew self-planning and time-lining - task design - trust in automation, real-time calibration - human multi-sensory feedback and guidance - human trust in on-board software-based intelligent assistants - virtual assistants The presentation will highlight plans and progress made in each of these research areas as well as the methods by which surrogate astronaut crews in the NASA JSC HERA spaceflight analog facility will function as human test subjects for all of the HCAAM research projects.

HCAAM VNSCOR↗

NASA NTRS2003

Overview of atmospheric ionizing radiation (AIR) research: SST-present

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent lowering of ICRP-recommended exposure limits (1990) with the classification of aircrew as "radiation workers" renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented. Published by Elsevier Ltd on behalf of COSPAR.

Review↗

NASA NTRS2002

Overview of Atmospheric Ionizing Radiation (AIR) Research: SST - Present

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray (GCR) exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent (1990) lowering of recommended exposure limits by the International Commission on Radiological Protection with the classification of aircrew as "radiation workers" renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented.

Wilson, J. W.↗

NASA NTRS2003

Summary of Atmospheric Ionizing AIR Research: SST-Present

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray (GCR) exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent lowering of the radiation exposure limits by the International Commission on Radiological Protection with the classification of aircrew as radiation workers renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented.

Wilson, J. W.↗

NASA NTRS1996

Spinoff 1996

By their challenging nature, NASA programs are particularly demanding of technological input. Meeting the aeronautical and space goals of the past four decades has necessitated leading edge advancements across a diverse spectrum that embraces virtually every scientific and technological discipline. Technology is simply knowledge and, like other forms of knowledge, it is often broadly applied and transferable. For that reason, the vast storehouse of technology NASA has built is a national resource, a bank of knowledge available for commercial applications and enhancements to the quality of life-"spinoff"-to new products and processes of benefit to the national economy, industrial efficiency and human welfare. Multiple use of technology has never been more important. Budgetary stringency is reducing the amount of government funding available for new research and development, but at the same time intensifying international competition demands increasing technological innovation to strengthen the U.S. posture in the global marketplace. Reuse of technology offers a relatively inexpensive supplementary means of partnering with industry focused on bringing new products and processes to the market. More than a thousand of spinoff products and processes have emerged from reapplication of technology developed for NASA mission programs. Each has Contributed some measure of benefit to the national economy, productivity or lifestyle; some bring only moderate increments of gain, but many generate benefits of significant order with economic values in the millions of dollars. Other technologies with moderate economic return have added measurably to the quality of life of U.S. citizens. Collectively, they represent a substantial dividend on the national investment in aerospace research. By Congressional mandate, it is NASA's responsibility to promote expansion of spinoff in the public interest. Through its Technology Transfer Program, NASA seeks to encourage greater use of its technological resources by providing a link between the technology and those who might be able to put it to advantageous use. The program's aim is to broaden and accelerate the transfer accomplishments and thereby to gain national benefit in terms of new products, services, and new jobs. This publication is an instrument of-and documents the outcome of-that purpose. It is intended to heighten awareness of the technology available for transfer and its potential for public benefit. Spinoff 1996 is organized in three sections: Section 1, summarizes NASA's current mainline programs, whose objectives require development of new technology and therefore replenish and expand the bank of knowledge available for reapplication. Section 2, the focal point of this volume, contains a representative sampling of spinoff products and processes that resulted from secondary application of NASA technology. Section 3, describes the various mechanisms NASA employs to stimulate technology transfer and lists, in an appendix, contact sources for Further information about the Technology Transfer Program.

Haggerty, James J.↗

NASA NTRS2008

Outcome of Recent Satellite Impact Experiments

This paper summarizes three satellite impact tests completed in early 2007 through collaboration between Kyushu University and the NASA Orbital Debris Program Office. The previous experiments completed in late 2005 aimed to compare low- and hyper-velocity impacts on identical target satellites, whereas the new tests used larger satellites as targets and aimed to investigate the effects of impact directions. Three identical micro satellites equipped with fully-functional electronic devices were prepared as targets. Their dimensions were 20 cm by 20 cm by 20 cm, and the mass of each was approximately 1.3 kilograms. Aluminum alloy solid spheres, with diameters of 3 cm and masses of 39 grams were prepared as projectiles. The impact velocity was approximately 1.7 km/s. The impact tests were carried out at the two-stage light gas gun facility at the Kyushu Institute of Technology. All three target satellites were completely fragmented, but there were noticeable differences among the three sets of fragments due to the different impact directions. More than 1000 fragments from each test were collected, measured, photographed, and documented with material descriptions. The analysis of the fragments is currently in progress. Preliminary results of the new data and comparisons with previous data will be included in the paper.

Hanada, Toshiya↗

NASA NTRS1993

Direct broadcast satellite-radio, space-segment/receiver tradeoffs

The balance between receiver complexity and the required satellite equivalent isotropically radiated power (EIRP) for Direct Broadcast Satellite-Radio (DBS-R) service is addressed. In general the required receiver complexity and cost can be reduced at the expense of higher space-segment cost by allowing a higher satellite EIRP. The tradeoff outcome is sensitive to the total number of anticipated receivers in a given service area, the number of audio programs, and the required audio quality. An understanding of optimum choice of satellite EIRP for DBS-R under various service requirements is a critical issue at this time when International Radio Consultative Committee (CCIR) is soliciting input in preparation for the International Telecommunications Union (ITU) planning conference for the service.

Golshan, Nasser↗

NASA NTRS2013

Composite Crew Module (CCM) Permeability Characterization

In January 2007, the NASA Administrator chartered the NASA Engineering and Safety Center (NESC) to form an Agency team to design and build a composite crew module in 18 months in order to gain hands-on experience in anticipation that future exploration systems may be made of composite materials. One of the conclusions from this Composite Crew Module Primary Structure assessment was that there was a lack of understanding regarding the ability for composite pressure shells to contain consumable gases, which posed a technical risk relative to the use of a metallic design. After the completion of the Composite Crew Module test program, the test article was used in a new program to assess the overall leakage/permeability and identify specific features associated with high leak rates. This document contains the outcome of the leakage assessment.

Kirsch, Michael T.↗

NASA NTRSDate not supplied

Dissertation Defense: Three Papers on Organizational Decision-Making and Change at NASA Goddard Space Flight Center

This is a three-paper dissertation that responds to a call for empirical research on stakeholder influence in the implementation of evaluation recommendations. The literature is consistent but mostly theoretical: stakeholder participation should positively influence and increase the probability of implementation (see e.g., Christie, 2011; Cousins & Earl, 1992; Fetterman, 2004). In response, I use two Goddard Space Flight Center engineering technical training and development programs to build a causal argument supporting my proposition that stakeholder influence in the logic modeling process impacts organizational decision-making and change. I first introduce the logic modeling process as a tool to involve stakeholders in program and evaluation design (paper 1); then use the data collection process to implement the collaboratively constructed logic model outcomes (paper 2); and, finally, I triangulate the data using the Toal (2009) Evaluation Involvement Scale (paper 3). I do this to “increase the validity of the findings” (Noble & Heale, 2019, p. 67) and to garner potential mechanisms. I found that stakeholder participation in the logic modeling process positively influenced the use of data to inform recommendations which in turn positively influenced implementation of evaluation recommendations. I identified the process itself as the mechanism and the key decision points as links or influencers. Potential factors included power and interest (measured by role) and time-on-job.

organizational decision-making↗

NASA NTRS2023

The Impact (Influence) of Stakeholder Participation in the Logic Modeling Process: A Case Study from NASA Goddard Space Flight Center

This is a three-paper dissertation that responds to a call for empirical research on stakeholder influence in the implementation of evaluation recommendations. The literature is consistent but mostly theoretical: stakeholder participation should positively influence and increase the probability of implementation (see e.g., Christie, 2011; Cousins and Earl, 1992); Fetterman, 2004). In response, I use two Goddard Space Flight Center engineering technical training and development programs to build a causal pathway argument supporting my proposition that stakeholder influence in the logic modeling process impacts organizational decision-making and change. I first introduce the logic modeling process as a tool to involve stakeholders in program and evaluation design (paper 1), then use the data collection process to implement the collaboratively constructed logic model outcomes (paper 2), and finally, I triangulate the data using the Toal (2009) Evaluation Involvement Scale (paper 3). I do this to “increase the validity of the findings” (Noble & Heale, 2019, p. 67) and to garner potential mechanisms. I found that stakeholder participation in the logic modeling process positively influenced the use of data to inform recommendations which in turn positively influenced implementation of evaluation recommendations. I identified the process itself as the mechanism and the key decision points as links or influencers. Potential factors included power and interest (measured by role) and time-on-job.

Organizational Decision-Making↗

NASA NTRS2024

NASA Space Radiation Element Initiatives

The Space Radiation Element (SRE) with the Human Research Program (HRP) and NASA is tasked with the mission of characterizing and facilitating the management of the human health outcomes associated with space radiation exposure to ultimately protect astronaut health as well as enable human space exploration. To facilitate our mission, we provide funding for space radiation research but also provide several unique opportunities discussed below to educate and disseminate space radiation knowledge.

Space radiation↗

NASA NTRSDate not supplied

NASA HRP Space Radiation Element Initiatives

Space radiation↗

NASA NTRS2014

Optimizing Medical Kits for Spaceflight

The Integrated Medical Model (IMM) is a probabilistic model that estimates medical event occurrences and mission outcomes for different mission profiles. IMM simulation outcomes describing the impact of medical events on the mission may be used to optimize the allocation of resources in medical kits. Efficient allocation of medical resources, subject to certain mass and volume constraints, is crucial to ensuring the best outcomes of in-flight medical events. We implement a new approach to this medical kit optimization problem. METHODS We frame medical kit optimization as a modified knapsack problem and implement an algorithm utilizing a dynamic programming technique. Using this algorithm, optimized medical kits were generated for 3 different mission scenarios with the goal of minimizing the probability of evacuation and maximizing the Crew Health Index (CHI) for each mission subject to mass and volume constraints. Simulation outcomes using these kits were also compared to outcomes using kits optimized..RESULTS The optimized medical kits generated by the algorithm described here resulted in predicted mission outcomes more closely approached the unlimited-resource scenario for Crew Health Index (CHI) than the implementation in under all optimization priorities. Furthermore, the approach described here improves upon in reducing evacuation when the optimization priority is minimizing the probability of evacuation. CONCLUSIONS This algorithm provides an efficient, effective means to objectively allocate medical resources for spaceflight missions using the Integrated Medical Model.

Optimization↗

NASA NTRSDate not supplied

An Evaluation of Extended Reality Technologies for Use in Verification Testing at NASA 2024 HRP IWS Abstract

BACKGROUND At NASA, verification testing is the formal process of ensuring that a product conforms to requirements set by a project or program. Some verification methods, such as Demonstrations and Test, require either the end product or a mockup of the product with sufficient fidelity to stand-in for the product during the test. Traditionally, these mockups have been physical (e.g., foam-core and wood) but there is growing interest in exploring new methods for testing with these mockups. These methods include virtual reality (VR), mixed reality, and augmented reality which are collectively referred to as eXtended Reality (XR) technologies. VR has already been adopted and used by many in the aerospace industry as a tool for use in early design phases (e.g., developmental testing) and may have the most potential for use in verification tests. Benefits of using VR mockups offer cost effectiveness, ease of iteration, simulation of hazardous conditions (e.g., an egress through a hatch with smoke obscuring vision), and the ability to simulate microgravity conditions, which are challenging to do with physical mockups. However, the validity of test results obtained from VR mockup demonstrations or testing, compared to the current gold standard of physical mockups, remains uncertain. It is unlikely that there is one clean answer as there are many different types of verification outcomes and each XR technology must be evaluated on its own merits. This is not an issue during developmental testing as the design is still in flux and the total success of the design is not dependent upon the results of a developmental test. Verification tests, however, only happen once, assuming no change to the design, and the results are used to certify the product. Therefore, establishing the validity of XR mockup-based verification outcomes is essential before considering them for any use in verification tests. OBJECTIVE AND METHOD To address this concern, the Human Research Program has funded a project to explore and qualify how XR technologies might be used in verification demonstration and testing at NASA. Currently, we are conducting a review of the literature on the utilization of XR mockups for design activities, prototyping, and user testing. We are employing the Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis method to identify the pros, cons, and barriers to adoption of XR technologies for verification testing at NASA. Additionally, we are developing a framework to guide the deployment of XR mockups for verification tests. Building upon available evidence from the literature and subject-matter expert feedback, our goal for the framework is to provide guidelines for which forms of XR mockups are suitable for a given verification test, when only physical mockups should be employed and to highlight areas for which more evidence is needed. To further refine our framework and to contribute to the body of evidence, we are planning a lab-based experiment comparing a VR mockup to a physical twin for a set of select verification outcomes. ANTICIPATED RESULTS In this presentation, we will present the work we conducted to evaluate XR technologies for use in verification tests at NASA. We will summarize and report our findings from the SWOT analysis and our lab-based study, and we will present the current state of the XR Technologies for Verification Testing framework. We will conclude by summarizing remaining work and future directions for the project. Technologies for Verification Testing framework. We will conclude by summarizing remaining work and future directions for the project.

Extended Reality↗

NASA NTRS2022

Building a Transdisciplinary, Exascale-Capable Workforce for Geospace Science

Key Points: ●First-principles, self-consistent geospace modeling will require at least exascale-level computing capabilities; however, the technical skills necessary to develop such simulation codes are not taught as part of Heliophysics training/PhD programs. ●Developing exascale Heliophysics codes will require transdisciplinary collaborations between physicists, computer scientists, software engineers, data scientists, and applied mathematics. Such teams must be persistent and formed around specific skills, not specific problems. ●We must have stable, positive long-term career outcomes for Heliophysics scientific developers in order to retain knowledge of and promote future innovation in scientific algorithm development and advanced computing techniques. One such way to do this is by funding long-term scientific programming groups, akin to Heliophysics DRIVE Centers. ●We must have a balance between promoting innovation via funding short-term closed-source development and allowing the open-source community to benefit from and build on the newest scientific modeling techniques.

C Bard↗