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At least 127 records · Page 7

Analysis of Near Simultaneous Jimsphere and AMPS High Resolution Wind Profiles

The high-resolution wind profile of the Automated Meteorological Profiling System (HRAMPS) is the proposed replacement for the Jimsphere measurement system used to support NASA Shuttle launches from the Eastern Test Range (ETR). Samples of twenty-six ETR near simultaneous Jimsphere and HRAMPS wind profiles were obtained for Shuttle program HRAMPS certification studies. Shuttle systems engineering certification is to ensure that spacecraft and launch vehicle systems performance and safety evaluations for each launch (derived from flight simulations with Jimsphere wind profile data bases) retain their validity when HRAMPS profiles are used on day-of-launch (DOL) in trajectory and loads simulations to support the commit-to-launch decision. This paper describes a statistical analysis of the near simultaneous profiles. In principle the differences between a Jimsphere profile and an HRAMPS profile should be attributed to tracking technology (radar versus GPS tracking of a Jimsphere flight element) and the method for derivation of wind vectors from the raw tracking data. In reality, it is not technically feasible to track the same Jimsphere balloon with the two systems. The aluminized Mylar surface of the standard Jimsphere flight element facilitates radar tracking, but it interferes with HRAMPS during simultaneous tracking. Suspending a radar reflector from an HRAMPS flight element (Jimsphere without aluminized coating) does not produce satisfactory Jimsphere profiles because of intermittent radar returns. Thus, differences between the Jimsphere and HRAMPS profiles are also attributed to differences in the trajectories of separate flight elements. Because of small sample size and a test period limited to one winter season, test measurements during extreme high winds aloft could not have been expected and did not occur. It is during the highest winds that the largest differences between Jimsphere and HRAMPS would occur because the distance between flight elements would be larger. Jimsphere radar tracking noise increases as a function of balloon displacement downrange. The Jimsphere data processing compensates for tracking signal/noise degradation by increasing the smoothing interval. The Jimsphere wind profile effective resolution is a function of downrange distance and altitude, whereas the effective resolution of the HRAMPS should be independent of those variables. The procedure used for editing Jimsphere spikes in Shuttle DOL profiles was not implemented for the Jimsphere profile measurements during the AMPS field tests. For this analysis a code was developed that essentially mimics DOL Jimsphere spike editing. Jimsphere profiles have somewhat more noise in the wavelength range less than 200m defined as the noise floor. No differences between Jimsphere and HRAMPS wind profile pairs have been found that would support denial of HRAMPS certification for application in Shuttle DOL applications. The reliability of the HRAMPS system, which is an important certification issue, is not addressed in this study.

Adelfang, S. I.↗

A phase response curve to single bright light pulses in human subjects

The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported human phase response curves (PRCs) to single bright light exposures have employed small sample sizes, and were often based on relatively imprecise estimates of circadian phase and phase resetting. In the present study, 21 healthy, entrained subjects underwent pre- and post-stimulus constant routines (CRs) in dim light (approximately 2-7 lx) with maintained wakefulness in a semi-recumbent posture. The 6.7 h bright light exposure stimulus consisted of alternating 6 min fixed gaze (approximately 10 000 lx) and free gaze (approximately 5000-9000 lx) exposures. Light exposures were scheduled across the circadian cycle in different subjects so as to derive a PRC. Plasma melatonin was used to determine the phase of the onset, offset, and midpoint of the melatonin profiles during the CRs. Phase shifts were calculated as the difference in phase between the pre- and post-stimulus CRs. The resultant PRC of the midpoint of the melatonin rhythm revealed a characteristic type 1 PRC with a significant peak-to-trough amplitude of 5.02 h. Phase delays occurred when the light stimulus was centred prior to the critical phase at the core body temperature minimum, phase advances occurred when the light stimulus was centred after the critical phase, and no phase shift occurred at the critical phase. During the subjective day, no prolonged 'dead zone' of photic insensitivity was apparent. Phase shifts derived using the melatonin onsets showed larger magnitudes than those derived from the melatonin offsets. These data provide a comprehensive characterization of the human PRC under highly controlled laboratory conditions.

Randomized Controlled Trial↗

Monitoring occupational exposure to cancer chemotherapy drugs

Reports of the health effects of handling cytotoxic drugs and compliance with guidelines for handling these agents are briefly reviewed, and studies using analytical and biological methods of detecting exposure are evaluated. There is little conclusive evidence of detrimental health effects from occupational exposure to cytotoxic drugs. Work practices have improved since the issuance of guidelines for handling these drugs, but compliance with the recommended practices is still inadequate. Of 64 reports published since 1979 on studies of workers' exposure to these drugs, 53 involved studies of changes in cellular or molecular endpoints (biological markers) and 12 described chemical analyses of drugs or their metabolites in urine (2 involved both, and 2 reported the same study). The primary biological markers used were urine mutagenicity, sister chromatid exchange, and chromosomal aberrations; other studies involved formation of micronuclei and measurements of urinary thioethers. The studies had small sample sizes, and the methods were qualitative, nonspecific, subject to many confounders, and possibly not sensitive enough to detect most occupational exposures. Since none of the currently available biological and analytical methods is sufficiently reliable or reproducible for routine monitoring of exposure in the workplace, further studies using these methods are not recommended; efforts should focus instead on wide-spread implementation of improved practices for handling cytotoxic drugs.

Review, Academic↗

Evaluation of Neutral Body Posture on Shuttle Mission STS-57 (SPACEHAB-1)

Research has shown that the space environment induces physiological changes in the human body, such as fluid shifts in the upper body and chest cavity, spinal lengthening, muscular atrophy, space motion sickness, cardiopulmonary deconditioning, and bone mass loss, as well as some changes in visual perception. These require a period of adaptation and can substantially affect both crew member performance and posture. These physiological effects, when work activities are conducted, have been known to impact the body's center of gravity, reach, flexibility, and dexterity. All these aspects of posture must be considered to safely and efficiently design space systems and hardware. NASA has documented its microgravity body posture in the Man-Systems Integration Standards (MSIS); the space community uses the MSIS posture to design workstations and tools for space application. However, the microgravity body posture should be further investigated for several reasons, including small sample size in previous studies, possible imprecision, and lack of detail. JSC undertook this study to investigate human body posture exhibited under microgravity conditions. STS-57 crew members were instructed to assume a relaxed posture that was not oriented to any work area or task. Crew members were asked to don shorts and tank tops and to be blindfolded while data were recorded. Video data were acquired once during the mission from each of the six crew members. No one crew member exhibited the typical NBP called out in the MSIS; one composite posture is not adequate. A range of postures may be more constructive for design purposes. Future evaluations should define precise posture requirements for workstation, glove box, maintenance, foot-restraint, and handhold activities.

Mount, Frances E.↗

Nutrititional Status Assessment of International Space Station Crew Members

Defining optimal nutrient requirements is imperative to ensure crew health on long-duration space exploration missions. To date, nutrient requirement data have been extremely limited because of small sample sizes and difficulties associated with collecting biological samples. In this study, we examined changes in body composition, bone metabolism, hematology, general blood chemistry, and blood levels of selected vitamins and minerals after long-duration (128-195 d) space flight aboard the International Space Station. Crew members consumed an average of 80% of the recommended energy intakes, and on landing day their body weight had decreased (P=0.051). After flight, hematocrit was less, and serum femtin was greater than before flight (P<0.01). Serum iron, ferritin saturation, and transferrin had decreased after flight. The finding that other acute-phase proteins, including ceruloplasmin, retinol binding protein, transthyretin, and albumin were not changed after flight suggests that the changes in iron metabolism may not be strictly due to an inflammatory response. Urinary 8- hydroxy-2'-deoxyguanosine concentration was greater and superoxide dismutase was less after flight, indicating that oxidative damage had increased (P<0.05). Despite the reported use of vitamin D supplements during flight, serum 25-hydroxyvitamin D was significantly decreased after flight (P<0.01). Bone resorption was increased after flight, as indicated by several urinary markers of bone resorption. Bone formation, assessed by serum concentration of bone-specific alkaline phosphatase, was elevated only in crew members who landed in Russia, probably because of the longer time lapse between landing and sample collection. These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage remain critical concerns for long-duration space flight.

Smith, S. M.↗

An Update on Mortality in the U.S. Astronaut Corps: 1959-2009

Although it has now been over 50 years since mankind first ventured into space, the long-term health impacts of human space flight remain largely unknown. Identifying factors that affect survival and prognosis among those who participate in space flight is vitally important, as the era of commercial space flight approaches and NASA prepares for missions to Mars. The Longitudinal Study of Astronaut Health is a prospective study designed to examine trends in astronaut morbidity and mortality. The purpose of this analysis was to describe and explore predictors of overall and cause-specific mortality among individuals selected for the U.S. astronaut corps. All U.S. astronauts (n=321), regardless of flight status, were included in this analysis. Death certificate searches were conducted to ascertain vital status and cause of death through April 2009. Data were collected from medical records and lifestyle questionnaires. Multivariable Cox regression modeling was used to calculate the mortality hazard associated with embarking on space flight, adjusted for sex, race, and age at selection. Between 1959 and 2009, there were 39 (12.1%) deaths. Of these deaths, 18 (42.2%) were due to occupational accidents; 7 (17.9%) were due to other accidents; 6 (15.4%) were attributable to cancer; 6 (15.4%) resulted from cardiovascular/circulatory diseases; and 2 (5.1%) were from other causes. Participation in space flight did not significantly increase mortality hazard over time (adjusted hazard ratio=0.57; 95% confidence interval=0.26-1.26. Because our results are based on a small sample size, future research that includes payload specialists, other space flight participants, and international crew members is warranted to maximize statistical power.

Amirian, E.↗

Use of Smoothed Measured Winds to Predict and Assess Launch Environments

Since many of the larger launch vehicles are operated near their design limits during the ascent phase of flight to optimize payload to orbit, it often becomes necessary to verify that the vehicle will remain within certification limits during the ascent phase as part of the go/no-go review made prior to launch. This paper describes the approach used to predict Ares I-X launch vehicle structural air loads and controllability prior to launch which represents a distinct departure from the methodology of the Space Shuttle and Evolved Expendable Launch Vehicle (EELV) programs. Protection for uncertainty of key environment and trajectory parameters is added to the nominal assessment of launch capability to ensure that critical launch trajectory variables would be within the integrated vehicle certification envelopes. This process was applied by the launch team as a key element of the launch day go/no-go recommendation. Pre-launch assessments of vehicle launch capability for NASA's Space Shuttle and the EELV heavy lift versions require the use of a high-resolution wind profile measurements, which have relatively small sample size compared with low-resolution profile databases (which include low-resolution balloons and radar wind profilers). The approach described in this paper has the potential to allow the pre-launch assessment team to use larger samples of wind measurements from low-resolution wind profile databases that will improve the accuracy of pre-launch assessments of launch availability with no degradation of mission assurance or launch safety.

Cordova, Henry S.↗

Functional Task Test: 3. Skeletal Muscle Performance Adaptations to Space Flight

The functional task test is a multi-disciplinary study investigating how space-flight induced changes to physiological systems impacts functional task performance. Impairment of neuromuscular function would be expected to negatively affect functional performance of crewmembers following exposure to microgravity. This presentation reports the results for muscle performance testing in crewmembers. Functional task performance will be presented in the abstract "Functional Task Test 1: sensory motor adaptations associated with postflight alternations in astronaut functional task performance." METHODS: Muscle performance measures were obtained in crewmembers before and after short-duration space flight aboard the Space Shuttle and long-duration International Space Station (ISS) missions. The battery of muscle performance tests included leg press and bench press measures of isometric force, isotonic power and total work. Knee extension was used for the measurement of central activation and maximal isometric force. Upper and lower body force steadiness control were measured on the bench press and knee extension machine, respectively. Tests were implemented 60 and 30 days before launch, on landing day (Shuttle crew only), and 6, 10 and 30 days after landing. Seven Space Shuttle crew and four ISS crew have completed the muscle performance testing to date. RESULTS: Preliminary results for Space Shuttle crew reveal significant reductions in the leg press performance metrics of maximal isometric force, power and total work on R+0 (p<0.05). Bench press total work was also significantly impaired, although maximal isometric force and power were not significantly affected. No changes were noted for measurements of central activation or force steadiness. Results for ISS crew were not analyzed due to the current small sample size. DISCUSSION: Significant reductions in lower body muscle performance metrics were observed in returning Shuttle crew and these adaptations are likely contributors to impaired functional tasks that are ambulatory in nature (See abstract Functional Task Test: 1). Interestingly, no significant changes in central activation capacity were detected. Therefore, impairments in muscle function in response to short-duration space flight are likely myocellular rather than neuromotor in nature.

Ryder, Jeffrey W.↗

Accelerated Aging in Electrolytic Capacitors for Prognostics

The focus of this work is the analysis of different degradation phenomena based on thermal overstress and electrical overstress accelerated aging systems and the use of accelerated aging techniques for prognostics algorithm development. Results on thermal overstress and electrical overstress experiments are presented. In addition, preliminary results toward the development of physics-based degradation models are presented focusing on the electrolyte evaporation failure mechanism. An empirical degradation model based on percentage capacitance loss under electrical overstress is presented and used in: (i) a Bayesian-based implementation of model-based prognostics using a discrete Kalman filter for health state estimation, and (ii) a dynamic system representation of the degradation model for forecasting and remaining useful life (RUL) estimation. A leave-one-out validation methodology is used to assess the validity of the methodology under the small sample size constrain. The results observed on the RUL estimation are consistent through the validation tests comparing relative accuracy and prediction error. It has been observed that the inaccuracy of the model to represent the change in degradation behavior observed at the end of the test data is consistent throughout the validation tests, indicating the need of a more detailed degradation model or the use of an algorithm that could estimate model parameters on-line. Based on the observed degradation process under different stress intensity with rest periods, the need for more sophisticated degradation models is further supported. The current degradation model does not represent the capacitance recovery over rest periods following an accelerated aging stress period.

Celaya, Jose R.↗

Bayes Error Rate Estimation Using Classifier Ensembles

The Bayes error rate gives a statistical lower bound on the error achievable for a given classification problem and the associated choice of features. By reliably estimating th is rate, one can assess the usefulness of the feature set that is being used for classification. Moreover, by comparing the accuracy achieved by a given classifier with the Bayes rate, one can quantify how effective that classifier is. Classical approaches for estimating or finding bounds for the Bayes error, in general, yield rather weak results for small sample sizes; unless the problem has some simple characteristics, such as Gaussian class-conditional likelihoods. This article shows how the outputs of a classifier ensemble can be used to provide reliable and easily obtainable estimates of the Bayes error with negligible extra computation. Three methods of varying sophistication are described. First, we present a framework that estimates the Bayes error when multiple classifiers, each providing an estimate of the a posteriori class probabilities, a recombined through averaging. Second, we bolster this approach by adding an information theoretic measure of output correlation to the estimate. Finally, we discuss a more general method that just looks at the class labels indicated by ensem ble members and provides error estimates based on the disagreements among classifiers. The methods are illustrated for artificial data, a difficult four-class problem involving underwater acoustic data, and two problems from the Problem benchmarks. For data sets with known Bayes error, the combiner-based methods introduced in this article outperform existing methods. The estimates obtained by the proposed methods also seem quite reliable for the real-life data sets for which the true Bayes rates are unknown.

Tumer, Kagan↗

Remote Observations of Reentering Spacecraft Including the Space Shuttle Orbiter

Flight measurement is a critical phase in development, validation and certification processes of technologies destined for future civilian and military operational capabilities. This paper focuses on several recent NASA-sponsored remote observations that have provided unique engineering and scientific insights of reentry vehicle flight phenomenology and performance that could not necessarily be obtained with more traditional instrumentation methods such as onboard discrete surface sensors. The missions highlighted include multiple spatially-resolved infrared observations of the NASA Space Shuttle Orbiter during hypersonic reentry from 2009 to 2011, and emission spectroscopy of comparatively small-sized sample return capsules returning from exploration missions. Emphasis has been placed upon identifying the challenges associated with these remote sensing missions with focus on end-to-end aspects that include the initial science objective, selection of the appropriate imaging platform and instrumentation suite, target flight path analysis and acquisition strategy, pre-mission simulations to optimize sensor configuration, logistics and communications during the actual observation. Explored are collaborative opportunities and technology investments required to develop a next-generation quantitative imaging system (i.e., an intelligent sensor and platform) with greater capability, which could more affordably support cross cutting civilian and military flight test needs.

Horvath, Thomas J.↗

Preliminary Measurement of Lunar Particle Shapes.

Particle shape is a basic parameter and essential for many engineering applications. Very little data is published on the shape of lunar particles. An unpublished review found that even where the same samples were studied the results were contradictory, probably because of extremely small sample sizes. Other workers have made fundamental errors in algorithms. There are many ways to measure particle shape. One common approach is to examine the particles as intersected by a plain, such as a thin section. If discrete particles can be segmented from the image, programs such as ImageJ can readily obtain shape measurements for each particle.

Rickman, Doug↗

Temporal Wind Pairs for Space Launch Vehicle Capability Assessment and Risk Mitigation

Space launch vehicles incorporate upper-level wind assessments to determine wind effects on the vehicle and for a commit to launch decision. These assessments make use of wind profiles measured hours prior to launch and may not represent the actual wind the vehicle will fly through. Uncertainty in the winds over the time period between the assessment and launch introduces uncertainty in assessment of vehicle controllability and structural integrity that must be accounted for to ensure launch safety. Temporal wind pairs are used in engineering development of allowances to mitigate uncertainty. Five sets of temporal wind pairs at various times (0.75, 1.5, 2, 3 and 4-hrs) at the United States Air Force Eastern Range and Western Range, as well as the National Aeronautics and Space Administration's Wallops Flight Facility are developed for use in upper-level wind assessments on vehicle performance. Historical databases are compiled from balloon-based and vertically pointing Doppler radar wind profiler systems. Various automated and manual quality control procedures are used to remove unacceptable profiles. Statistical analyses on the resultant wind pairs from each site are performed to determine if the observed extreme wind changes in the sample pairs are representative of extreme temporal wind change. Wind change samples in the Eastern Range and Western Range databases characterize extreme wind change. However, the small sample sizes in the Wallops Flight Facility databases yield low confidence that the sample population characterizes extreme wind change that could occur.

Decker, Ryan K.↗

Revisiting Scaling Relations for Giant Radio Halos in Galaxy Clusters

Many galaxy clusters host megaparsec-scale radio halos, generated by ultrarelativistic electrons in the magnetized intracluster medium. Correlations between the synchrotron power of radio halos and the thermal properties of the hosting clusters were established in the last decade, including the connection between the presence of a halo and cluster mergers. The X-ray luminosity and redshift-limited Extended GMRT Radio Halo Survey provides a rich and unique dataset for statistical studies of the halos. We uniformly analyze the radio and X-ray data for the GMRT cluster sample, and use the new Planck Sunyaev-Zel'dovich (SZ) catalog to revisit the correlations between the power of radio halos and the thermal properties of galaxy clusters. We find that the radio power at 1.4 GHz scales with the cluster X-ray (0.1-2.4 keV) luminosity computed within R(sub 500) as P(sub 1.4) approx. L(2.1+/-0.2) - 500). Our bigger and more homogenous sample confirms that the X-ray luminous (L(sub 500) > 5 × 10(exp 44) erg/s)) clusters branch into two populations-radio halos lie on the correlation, while clusters without radio halos have their radio upper limits well below that correlation. This bimodality remains if we excise cool cores from the X-ray luminosities. We also find that P(sub 1.4) scales with the cluster integrated SZ signal within R(sub 500), measured by Planck, as P(sub 1.4) approx. Y(2.05+/-0.28) - 500), in line with previous findings. However, contrary to previous studies that were limited by incompleteness and small sample size, we find that "SZ-luminous" Y(sub 500) > 6×10(exp −5) Mpc(exp 2) clusters show a bimodal behavior for the presence of radio halos, similar to that in the radio-X-ray diagram. Bimodality of both correlations can be traced to clusters dynamics, with radio halos found exclusively in merging clusters. These results confirm the key role of mergers for the origin of giant radio halos, suggesting that they trigger the relativistic particle acceleration.

radiation mechanisms↗

Presolar Materials in a Giant Cluster IDP of Probable Cometary Origin

Chondritic porous interplanetary dust particles (CP-IDPs) have been linked to comets by their fragile structure, primitive mineralogy, dynamics, and abundant interstellar materials. But differences have emerged between 'cometary' CP-IDPs and comet 81P/Wild 2 Stardust Mission samples. Particles resembling Ca-Al-rich inclusions (CAIs), chondrules, and amoeboid olivine aggregates (AOAs) in Wild 2 samples are rare in CP-IDPs. Unlike IDPs, presolar materials are scarce in Wild 2 samples. These differences may be due to selection effects, such as destruction of fine grained (presolar) components during the 6 km/s aerogel impact collection of Wild 2 samples. Large refractory grains observed in Wild 2 samples are also unlikely to be found in most (less than 30 micrometers) IDPs. Presolar materials provide a measure of primitive-ness of meteorites and IDPs. Organic matter in IDPs and chondrites shows H and N isotopic anomalies attributed to low-T interstellar or protosolar disk chemistry, where the largest anomalies occur in the most primitive samples. Presolar silicates are abundant in meteorites with low levels of aqueous alteration (Acfer 094 approximately 200 ppm) and scarce in altered chondrites (e.g. Semarkona approximately 20 ppm). Presolar silicates in minimally altered CP-IDPs range from approximately 400 ppm to 15,000 ppm, possibly reflecting variable levels of destruction in the solar nebula or statistical variations due to small sample sizes. Here we present preliminary isotopic and mineralogical studies of a very large CP-IDP. The goals of this study are to more accurately determine the abundances of presolar components of CP-IDP material for comparison with comet Wild 2 samples and meteorites. The large mass of this IDP presents a unique opportunity to accurately determine the abundance of pre-solar grains in a likely cometary sample.

Messenger, S.↗

Temporal Wind Pairs for Space Launch Vehicle Capability Assessment and Risk Mitigation

Space launch vehicles incorporate upper-level wind assessments to determine wind effects on the vehicle and for a commit to launch decision. These assessments make use of wind profiles measured hours prior to launch and may not represent the actual wind the vehicle will fly through. Uncertainty in the winds over the time period between the assessment and launch introduces uncertainty in assessment of vehicle controllability and structural integrity that must be accounted for to ensure launch safety. Temporal wind pairs are used in engineering development of allowances to mitigate uncertainty. Five sets of temporal wind pairs at various times (0.75, 1.5, 2, 3 and 4-hrs) at the United States Air Force Eastern Range and Western Range, as well as the National Aeronautics and Space Administration's Wallops Flight Facility are developed for use in upper-level wind assessments on vehicle performance. Historical databases are compiled from balloon-based and vertically pointing Doppler radar wind profiler systems. Various automated and manual quality control procedures are used to remove unacceptable profiles. Statistical analyses on the resultant wind pairs from each site are performed to determine if the observed extreme wind changes in the sample pairs are representative of extreme temporal wind change. Wind change samples in the Eastern Range and Western Range databases characterize extreme wind change. However, the small sample sizes in the Wallops Flight Facility databases yield low confidence that the sample population characterizes extreme wind change that could occur.

Decker, Ryan K.↗

Determination of the Risk of Radiation-Associated Circulatory and Cancer Disease Mortality in a NASA Early Astronaut Cohort

Of the many possible health challenges posed during extended exploratory missions to space, the effects of space radiation on cardiovascular disease and cancer are of particular concern. There are unique challenges to estimating those radiation risks; care and appropriate and rigorous methodology should be applied when considering small cohorts such as the NASA astronaut population. The objective of this work was to determine if there was sufficient evidence for excess risk of cardiovascular disease and cancer in early NASA astronaut cohorts. NASA astronauts in selection groups 1-7 were chosen; this relatively homogeneous cohort consists of 73 white males, who unlike today's astronauts, maintained similar smoking and drinking habits to the general US population, and have published radiation doses. The participants flew in space on missions Mercury through Shuttle and received space radiation doses between 0-74.1 milligrays. Cause of death information was obtained from the Lifetime Surveillance of Astronaut Health (LSAH) program at NASA Johnson Space Center. Mortality was compared with the US male population. Trends of mortality with dose were assessed using a logistic model, fitted by maximum likelihood. Only 32 (43.84 percent) of the 73 early astronauts have died. Standard mortality ratios (SMRs) for cancer (n=7, SMR=43.4, 95 percent CI 17.8, 84.9), all circulatory disease (n=7, SMR=33.2, 95 percent CI 13.7, 65.0), and ischemic heart disease (IHD) (n=5, SMR=40.1, 95 percent CI 13.2, 89.4) were significantly lower than for the US white male population. For cerebrovascular disease, the upper confidence interval for SMR included 100, indicating it was not significantly different from the US population (n=2, SMR = 77.0, 95 percent CI 9.4, 268.2). The power of the study is low and remains below 10 percent even when risks 10 times those reported in the literature are assumed. Due to small sample size, there is currently insufficient statistical power to evaluate space radiation exposure effects on mortality in NASA astronauts. In addition to a comprehensive longitudinal study of NASA astronauts, a research strategy of low dose epidemiology data integration with cell and animal studies should be utilized for space radiation risk assessment in the astronauts.

Elgart, S. R.↗

Efficacy of FTIR Analysis in Determining CO2 Loading on Diglycolamine

In support of advanced air revitalization technologies to enable human spaceflight beyond low earth orbit, performance studies have been conducted using a liquid amine, Diglycolamine (DGA) between teams at NASA's Johnson Spaceflight Center (JSC) and Ames Research Center (ARC). Liquid amines have been used in regenerable earth-based systems to remove CO2 from industrial systems as well as for closed-environment air revitalization because they can be regenerated at lower temperatures than solid sorbent systems. As an additional advantage to solid sorbent-based systems, liquid sorbents can be cycled between an adsorbing contactor and degassing chamber, thereby reducing system complexity by operation in a continuous loop. In an effort to inform a regeneration system design for micro-gravity applications, ARC has performed a number of tests to characterize the degas mechanics of DGA. In order to accurately measure the amount of CO2 captured or released by the amine, methods such as gravimetric weighing and chemical desorption are reasonable, however the first iteration test setup for a scaled down degas system required analysis on small sample sizes. Fourier-transform infrared spectroscopy (FTIR) analysis was experimentally evaluated to analyze CO2 concentration because it can produce measurements with sample sizes on the order of 100's of μL. Calibration against chemical desorption showed relatively good correlation and test data showed reasonable adherence to expected trends, however more extensive testing should be conducted to fully validate the usage of FTIR to determine CO2 loading on DGA.

Diglycolamine↗