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At least 127 records · Page 7

Complex patterns of abnormal heartbeats

Individuals having frequent abnormal heartbeats interspersed with normal heartbeats may be at an increased risk of sudden cardiac death. However, mechanistic understanding of such cardiac arrhythmias is limited. We present a visual and qualitative method to display statistical properties of abnormal heartbeats. We introduce dynamical "heartprints" which reveal characteristic patterns in long clinical records encompassing approximately 10(5) heartbeats and may provide information about underlying mechanisms. We test if these dynamics can be reproduced by model simulations in which abnormal heartbeats are generated (i) randomly, (ii) at a fixed time interval following a preceding normal heartbeat, or (iii) by an independent oscillator that may or may not interact with the normal heartbeat. We compare the results of these three models and test their limitations to comprehensively simulate the statistical features of selected clinical records. This work introduces methods that can be used to test mathematical models of arrhythmogenesis and to develop a new understanding of underlying electrophysiologic mechanisms of cardiac arrhythmia.

Non-NASA Center↗

Norton-Thevenin Receptance Coupling (NTRC) as a Payload Analysis Tool

The NASA Engineering and Safety Center (NESC) has funded a study of a new method formulated by NASA Engineers called Norton-Thevenin Receptance Coupling (NTRC) to perform coupled loads analysis (CLA). The problem that NTRC attempts to solve is the dependency of the payload organization to high CLA costs, long schedules, lack of standard capabilities to evaluate multiple configurations and unavailability of loads when needed. NTRC solves the problem by providing a tool that payload developers can use to obtain loads at a fraction of the cost of a CLA at any time that it is required. While NTRC is not intended to replace the formal load cycles performed by the launch vehicle (LV) provider, it will provide the ability to reduce the conservatism in defining preliminary design loads, assess the impact of design changes between formal load cycles, perform trade studies and perform parametric loads analysis where many different design configurations can be evaluated with a minimum amount of data required from the LV provider. NTRC condenses all the necessary information into the launch vehicle to payload/s connection points or boundary degrees of freedom (BD). The launch vehicle model is represented by its impedance at its BDs; its forcing functions are represented by the acceleration at those BDs when the payload is absent and the latter is represented by its impedance at the same BDs. Payload responses are represented by transfer functions of selected response to interface BDs. The methodology has contributed to the Loads and Dynamics discipline advancement and successfully passed Peer Reviews. NTRC is exact in the frequency domain. Time domain replication and accuracy is outstanding. A second phase is envisioned to benchmark the whole set of CLA events for the Agency's most utilized Launch Vehicles, and ready it for operational deployment at NASA.

Kaufman, Daniel↗

Time-dependent oral absorption models

The plasma concentration-time profiles following oral administration of drugs are often irregular and cannot be interpreted easily with conventional models based on first- or zero-order absorption kinetics and lag time. Six new models were developed using a time-dependent absorption rate coefficient, ka(t), wherein the time dependency was varied to account for the dynamic processes such as changes in fluid absorption or secretion, in absorption surface area, and in motility with time, in the gastrointestinal tract. In the present study, the plasma concentration profiles of propranolol obtained in human subjects following oral dosing were analyzed using the newly derived models based on mass balance and compared with the conventional models. Nonlinear regression analysis indicated that the conventional compartment model including lag time (CLAG model) could not predict the rapid initial increase in plasma concentration after dosing and the predicted Cmax values were much lower than that observed. On the other hand, all models with the time-dependent absorption rate coefficient, ka(t), were superior to the CLAG model in predicting plasma concentration profiles. Based on Akaike's Information Criterion (AIC), the fluid absorption model without lag time (FA model) exhibited the best overall fit to the data. The two-phase model including lag time, TPLAG model was also found to be a good model judging from the values of sum of squares. This model also described the irregular profiles of plasma concentration with time and frequently predicted Cmax values satisfactorily. A comparison of the absorption rate profiles also suggested that the TPLAG model is better at prediction of irregular absorption kinetics than the FA model. In conclusion, the incorporation of a time-dependent absorption rate coefficient ka(t) allows the prediction of nonlinear absorption characteristics in a more reliable manner.

Non-NASA Center↗

University Pipeline (with UNM) for Criticality Safety Professionals [Slides]

The scope of the University Pipeline is to provide students with knowledge of NCS and to inspire students to pursue a career in NCS after graduation. There are several benefits of the University Pipeline: reduced training time and costs; interested students that naturally self-sort and pursue the discipline at the university level; and a pipeline of criticality safety candidates readily available within the DOE Complex so that unexpected organizational or mission changes can be reacted to with increased agility.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Olrando Miera: the way of the iron fist

Orlandi Miera has donated his time to the kids of Española for 15 years, teaching them confidence and discipline through boxing.

99 GENERAL AND MISCELLANEOUS↗

PSEC5 Physical Verification

Ultra-Fast timing detectors, having a time resolution of 10pSec or less, are becoming increasingly important for many scientific disciplines, including High Energy Physics, Nuclear Physics, Medical Imaging and more. When developing ultra-fast detectors such as MCPs, LAPPDs, LGADs, SNSPDs, it is necessary to have access to a readout system that is low power, can support many channels and is cost effective. The PSEC5 chip was an application specific integrated circuit (ASIC) developed by the pioneering group of Prof. Henry Frisch at University of Chicago and micro electronic engineers at Fermi National Accelerator Laboratory. Three boards were designed, two to implement the readout system for an LAPPD and one to only characterize the PSEC1 chip. The main goal of the project shifted to setting up a testing environment to focus on the characterization of the chip. My student and I tested and characterized this ASIC using the third chip-on-board printed circuit board. Results show the successful fabrication and operation of some of the key building blocks and lead to the suggestions on modification for the second iteration of the chip.

Rico Aniles, H. D. [Unlisted]↗

Apollo experience report: Flight anomaly resolution

The identification of flight anomalies, the determination of their causes, and the approaches taken for corrective action are described. Interrelationships of the broad range of disciplines involved with the complex systems and the team concept employed to ensure timely and accurate resolution of anomalies are discussed. The documentation techniques and the techniques for management of anomaly resolution are included. Examples of specific anomalies are presented in the original form of their progressive documentation. Flight anomaly resolution functioned as a part of the real-time mission support and postflight testing, and results were included in the postflight documentation.

Lobb, J. D.↗

Gigaflop performance on a CRAY-2: Multitasking a computational fluid dynamics application

The methodology is described for converting a large, long-running applications code that executed on a single processor of a CRAY-2 supercomputer to a version that executed efficiently on multiple processors. Although the conversion of every application is different, a discussion of the types of modification used to achieve gigaflop performance is included to assist others in the parallelization of applications for CRAY computers, especially those that were developed for other computers. An existing application, from the discipline of computational fluid dynamics, that had utilized over 2000 hrs of CPU time on CRAY-2 during the previous year was chosen as a test case to study the effectiveness of multitasking on a CRAY-2. The nature of dominant calculations within the application indicated that a sustained computational rate of 1 billion floating-point operations per second, or 1 gigaflop, might be achieved. The code was first analyzed and modified for optimal performance on a single processor in a batch environment. After optimal performance on a single CPU was achieved, the code was modified to use multiple processors in a dedicated environment. The results of these two efforts were merged into a single code that had a sustained computational rate of over 1 gigaflop on a CRAY-2. Timings and analysis of performance are given for both single- and multiple-processor runs.

Tennille, Geoffrey M.↗

Conceptual Design Oriented Wing Structural Analysis and Optimization

Airplane optimization has always been the goal of airplane designers. In the conceptual design phase, a designer's goal could be tradeoffs between maximum structural integrity, minimum aerodynamic drag, or maximum stability and control, many times achieved separately. Bringing all of these factors into an iterative preliminary design procedure was time consuming, tedious, and not always accurate. For example, the final weight estimate would often be based upon statistical data from past airplanes. The new design would be classified based on gross characteristics, such as number of engines, wingspan, etc., to see which airplanes of the past most closely resembled the new design. This procedure works well for conventional airplane designs, but not very well for new innovative designs. With the computing power of today, new methods are emerging for the conceptual design phase of airplanes. Using finite element methods, computational fluid dynamics, and other computer techniques, designers can make very accurate disciplinary-analyses of an airplane design. These tools are computationally intensive, and when used repeatedly, they consume a great deal of computing time. In order to reduce the time required to analyze a design and still bring together all of the disciplines (such as structures, aerodynamics, and controls) into the analysis, simplified design computer analyses are linked together into one computer program. These design codes are very efficient for conceptual design. The work in this thesis is focused on a finite element based conceptual design oriented structural synthesis capability (CDOSS) tailored to be linked into ACSYNT.

Lau, May Yuen↗

Examining 18 Years of Journal Publications to Characterize Usage Modes of Giovanni, a Versatile Earth Science Data Web Service

Introduction to Giovanni (Geospatial Interactive Online Visualization ANd aNalysis Infrastructure) Giovanni … is a Web-based visualization and analysis system that provides 22 different visualization and analysis options, operating on thousands of Earth science data variables generated by satellite instrument observations and from related model datasets Giovanni … was originally conceived as a data exploration tool, but its ease-of-use, analytical capabilities (spatial and temporal subsetting, multi-period averaging, data mapping and time-series, and more) have led to its use as a multi-discipline research tool Giovanni … provided unprecedented access to NASA Earth science data for many different disciplines, AND is still providing a simple way to find, analyze, visualize, and utilize such data for a wide spectrum of research topics

James Acker↗

Extension of a Kolmogorov Atmospheric Turbulence Model for Time-Based Simulation Implementation

The development of any super/hypersonic aircraft requires the interaction of a wide variety of technical disciplines to maximize vehicle performance. For flight and engine control system design and development on this class of vehicle, realistic mathematical simulation models of atmospheric turbulence, including winds and the varying thermodynamic properties of the atmosphere, are needed. A model which has been tentatively selected by a government/industry group of flight and engine/inlet controls representatives working on the High Speed Civil Transport is one based on the Kolmogorov spectrum function. This report compares the Dryden and Kolmogorov turbulence forms, and describes enhancements that add functionality to the selected Kolmogorov model. These added features are: an altitude variation of the eddy dissipation rate based on Dryden data, the mapping of the eddy dissipation rate database onto a regular latitude and longitude grid, a method to account for flight at large vehicle attitude angles, and a procedure for transitioning smoothly across turbulence segments.

McMinn, John D.↗

Long-lived electronic spin qubits in single-walled carbon nanotubes

Abstract Electron spins in solid-state systems offer the promise of spin-based information processing devices. Single-walled carbon nanotubes (SWCNTs), an all-carbon one-dimensional material whose spin-free environment and weak spin-orbit coupling promise long spin coherence times, offer a diverse degree of freedom for extended range of functionality not available to bulk systems. A key requirement limiting spin qubit implementation in SWCNTs is disciplined confinement of isolated spins. Here, we report the creation of highly confined electron spins in SWCNTs via a bottom-up approach. The record long coherence time of 8.2 µs and spin-lattice relaxation time of 13 ms of these electronic spin qubits allow demonstration of quantum control operation manifested as Rabi oscillation. Investigation of the decoherence mechanism reveals an intrinsic coherence time of tens of milliseconds. These findings evident that combining molecular approaches with inorganic crystalline systems provides a powerful route for reproducible and scalable quantum materials suitable for qubit applications.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Stabilization of gaze during circular locomotion in darkness. II. Contribution of velocity storage to compensatory eye and head nystagmus in the running monkey

1. Yaw eye in head (Eh) and head on body velocities (Hb) were measured in two monkeys that ran around the perimeter of a circular platform in darkness. The platform was stationary or could be counterrotated to reduce body velocity in space (Bs) while increasing gait velocity on the platform (Bp). The animals were also rotated while seated in a primate chair at eccentric locations to provide linear and angular accelerations similar to those experienced while running. 2. Both animals had head and eye nystagmus while running in darkness during which slow phase gaze velocity on the body (Gb) partially compensated for body velocity in space (Bs). The eyes, driven by the vestibuloocular reflex (VOR), supplied high-frequency characteristics, bringing Gb up to compensatory levels at the beginning and end of the slow phases. The head provided substantial gaze compensation during the slow phases, probably through the vestibulocollic reflex (VCR). Synchronous eye and head quick phases moved gaze in the direction of running. Head movements occurred consistently only when animals were running. This indicates that active body and limb motion may be essential for inducing the head-eye gaze synergy. 3. Gaze compensation was good when running in both directions in one animal and in one direction in the other animal. The animals had long VOR time constants in these directions. The VOR time constant was short to one side in one animal, and it had poor gaze compensation in this direction. Postlocomotory nystagmus was weaker after running in directions with a long VOR time constant than when the animals were passively rotated in darkness. We infer that velocity storage in the vestibular system had been activated to produce continuous Eh and Hb during running and to counteract postrotatory afterresponses. 4. Continuous compensatory gaze nystagmus was not produced by passive eccentric rotation with the head stabilized or free. This indicates that an aspect of active locomotion, most likely somatosensory feedback, was responsible for activating velocity storage. 5. Nystagmus was compared when an animal ran in darkness and in light. the beat frequency of eye and head nystagmus was lower, and the quick phases were larger in darkness. The duration of head and eye quick phases covaried. Eye quick phases were larger when animals ran in darkness than when they were passively rotated. The maximum velocity and duration of eye quick phases were the same in both conditions. 6. The platform was counterrotated under one monkey in darkness while it ran in the direction of its long vestibular time constant.(ABSTRACT TRUNCATED AT 400 WORDS).

NASA Discipline Neuroscience↗

Earth rotation from lunar laser ranging

Since the time when the first laser retroreflector was placed on the lunar surface by the Apollo 11 astronauts, lunar laser ranging (LLR) has led to advances in a wide range of disciplines, including the study of variations in the rotation of the earth. The conventional techniques used to monitor earth rotation suffer from lack of precision on time scales of a few months and less. LLR, by contrast, makes it possible to monitor small changes in earth rotation with a temporal resolution of the order of 1 day. Studies of earth rotation by LLR are discussed, taking into account data sensitivity, aspects of data analysis, the variation of latitude, and UTO, the mean solar time at the site as affected by polar motion.

Langley, R. B.↗

Effects of restricted feeding schedules on circadian organization in squirrel monkeys

Free running circadian rhythms of motor activity, food-motivated lever-pressing, and either drinking (N = 7) or body temperature (N = 3) were recorded from 10 squirrel monkeys maintained in constant illumination with unlimited access to food. Food availability was then restricted to a single unsignaled 3-hour interval each day. The feeding schedule failed to entrain the activity rhythms of 8 monkeys, which continued to free-run. Drinking was almost completely synchronized by the schedule, while body temperature showed a feeding-induced rise superimposed on a free-running rhythm. Nonreinforced lever-pressing showed both a free-running component and a 24-hour component that anticipated the time of feeding. At the termination of the schedule, all recorded variables showed free-running rhythms, but in 3 animals the initial phase of the postschedule rhythms was advanced by several hours, suggesting relative coordination. Of the remaining 2 animals, one exhibited stable entrainment of all 3 recorded rhythms, while the other appeared to entrain temporarily to the feeding schedule. These results indicate that restricted feeding schedules are only a weak zeitgeber for the circadian pacemaker generating free-running rhythms in the squirrel monkey. Such schedules, however, may entrain a separate circadian system responsible for the timing of food-anticipatory changes in behavior and physiology.

Non-NASA Center↗

PyGDH: Python Grid Discretization Helper

Mathematical models expressed in the form of discretized equations play an important role inmany scientific disciplines. In our experience, few domain scientists have sufficient backgroundin numerical computing (or the time required to acquire such a background) to use manyflexible and powerful but complex open source packages, such as FEniCS (Alnæs et al., 2015)and OpenFOAM (The OpenFOAM Foundation Ltd, n.d.). Many user-friendly open sourcepackages, such as FiPy (J. E. Guyer & Warren, 2009), and many commercial packages, suchas COMSOL Multiphysics (COMSOL AB, n.d.) and Simcenter STAR-CCM+ (Siemens DigitalIndustries Software, n.d.), provide limited flexibility in the equations that users can express.Additionally, the use of commercial packages, which by nature do not perform calculationstransparently, can hinder reproducibility, which is vital to the scientific process. PyGDH(“pigged”) is a Python 2 / Python 3 (Python Software Foundation, 1991–2020) package thatis meant to be accessible to scientists who might not be specialists in scientific computing,while approaching the level of flexibility associated with writing dedicated programs tailoredto solving specific problems. The PyGDH User’s Guide provides detailed instructions forcreating numerical models, including a brief introduction to necessary command line andPython (Python Software Foundation, 1991–2020) skills, and discussions of discretization andvalidation. Note that PyGDH emphasizes flexibility and simplicity over performance, and wasnot designed for high-performance applications or models describing complex spatial domains.

97 MATHEMATICS AND COMPUTING↗

Position Papers for the ASCR Workshop on the Science of Scientific-Software Development and Use

Software is an increasingly important component in the pursuit of scientific discovery. Both its development and use are essential activities for many scientific teams. At the same time, very little scientific study has been conducted to understand, characterize, and improve the development and use of software for science. Computational science teams have diversified over time to include contributions from domain scientists who provide expertise in scientific and engineering disciplines, applied mathematicians and computer scientists who provide optimal algorithms and data structures, and software and data engineers who provide methodologies and tools adapted and adopted from other software domains. These diverse contributions have enabled tremendous advances in the pursuit of scientific discovery, even as models, computer architectures, and software environments have become more complicated. With this increasing diversity, we believe the next opportunity for qualitative improvement comes from applying the scientific method to understanding, characterizing, and improving how scientific software is developed and used. We believe that this pursuit requires expertise from computational scientists themselves, and from the cognitive and social sciences as well as the software engineering research community. As we look to increase the productivity and sustainability of the scientific-software-development-and-use cycle, a more systematic application of the scientific method to understand processes for software development and use will be a valuable tool to guide future work and result in more usable and sustainable software. This workshop will bring together computer scientists, software engineering researchers, computational scientists, applied mathematicians, social scientists, cognitive scientists, and others, to explore how we can conduct such systematic investigations, what can be learned, and how doing so will benefit the scientific enterprise. The workshop will be structured around a set of breakout sessions, with every attendee expected to participate actively in the discussions. Afterward, workshop attendees — from DOE, industry, and academia — will produce a report for ASCR that summarizes the findings of the workshop.

42 ENGINEERING↗