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Epidemiological research on radiation-induced cancer in atomic bomb survivors
The late effects of exposure to atomic bomb radiation on cancer occurrence have been evaluated by epidemiological studies on three cohorts: a cohort of atomic bomb survivors (Life Span Study; LSS), survivors exposed in utero, and children of atomic bomb survivors (F1). The risk of leukemia among the survivors increased remarkably in the early period after the bombings, especially among children. Increased risks of solid cancers have been evident since around 10 years after the bombings and are still present today. The LSS has clarified the dose– response relationships of radiation exposure and risk of various cancers, taking into account important risk modifiers such as sex, age at exposure, and attained age. Confounding by conventional risk factors including lifestyle differences is not considered substantial because people were non-selectively exposed to the atomic bomb radiation. Uncertainty in risk estimates at low-dose levels is thought to be derived from various sources, including different estimates of risk at background levels, uncertainty in dose estimates, residual confounding and interaction, strong risk factors, and exposure to residual radiation and/or medical radiation. The risk of cancer in subjects exposed in utero is similar to that in LSS subjects who were exposed in childhood. Regarding hereditary effects of radiation exposure, no increased risk of cancers associated with parental exposure to radiation have been observed in the F1 cohort to date. In addition to biological and pathogenetic interpretations of the present results, epidemiological investigations using advanced technology should be used to further analyze these cohorts.
Machine-Learning-Based High-Resolution Earthquake Catalog Reveals How Complex Fault Structures Were Activated during the 2016–2017 Central Italy Sequence
The 2016–2017 central Italy seismic sequence occurred on an 80 km long normal-fault system. The sequence initiated with the Mw 6.0 Amatrice event on 24 August 2016, followed by the Mw 5.9 Visso event on 26 October and the Mw 6.5 Norcia event on 30 October. We analyze continuous data from a dense network of 139 seismic stations to build a high-precision catalog of ~900,000 earthquakes spanning a 1 yr period, based on arrival times derived using a deep-neural-network-based picker. Our catalog contains an order of magnitude more events than the catalog routinely produced by the local earthquake monitoring agency. Aftershock activity reveals the geometry of complex fault structures activated during the earthquake sequence and provides additional insights into the potential factors controlling the development of the largest events. Activated fault structures in the northern and southern regions appear complementary to faults activated during the 1997 Colfiorito and 2009 L’Aquila sequences, suggesting that earthquake triggering primarily occurs on critically stressed faults. Delineated major fault zones are relatively thick compared to estimated earthquake location uncertainties, and a large number of kilometer-long faults and diffuse seismicity were activated during the sequence. These properties might be related to fault age, roughness, and the complexity of inherited structures. The rich details resolvable in this catalog will facilitate continued investigation of this energetic and well-recorded earthquake sequence.
Directly Determined Properties of HD 97658 from Interferometric Observations
We conducted interferometric observations with the CHARA Array of transiting super-Earth host HD 97658 and measured its limb-darkened angular diameter to be θ {sub LD} = 0.314 ± 0.004 mas. The combination of the angular diameter with the Gaia EDR3 parallax value with zero-point correction (π = 46.412 ± 0.022 mas, d =21.546 ± 0.011 pc) yields a physical radius of R {sub ·} = 0.728 ± 0.008 R {sub ⊙}. We also measured the bolometric flux of the star to be F {sub bol} = 2.42 ± 0.05 × 10{sup -8} erg s{sup -1} cm{sup -2}, which, together with angular size, allows a measurement of the effective temperature T {sub eƒƒ} = 5212 ± 43 K. Our directly determined physical stellar properties are in good agreement with previous estimates derived from spectroscopy. We used our measurements in combination with stellar evolutionary models and properties of the transit of HD 97658 b to determine the mass and age of HD 97658 as well as constrain the properties of the planet. Our results and our analysis of the TESS light curve on the planet (TOI-1821) corroborate previous studies of this system with tighter uncertainties.
Possible Counterpart Signal of the Fermi Bubbles at the Cosmic-Ray Positrons
The inner Galaxy has hosted cosmic-ray burst events, including those responsible for the gamma-ray Fermi bubbles and the eROSITA bubbles in X-rays. In this work, we study the Alpha Magnetic Spectrometer positron fraction and find three features around 12, 21, and 48 GeV, of which the lowest energy has a 1.4–4.9σ significance, depending on astrophysical background assumptions. Using background simulations that explain the cosmic-ray positron fraction, positron flux, and electron plus positron flux by primary and secondary cosmic rays and cosmic rays from local pulsars, we test these spectral features as originating from electron/positron burst events from the inner Galaxy. We find the 12 GeV feature to be explained by an event of age τ ≃ 3–10 Myr, in agreement with the proposed age of the Fermi bubbles. Furthermore, the energy in cosmic-ray electrons and positrons propagating along the Galactic disk and not within the Fermi bubbles volume is estimated to be 10 51.5 –10 57.5 erg, or O(10 –4 ) – O(1) the cosmic-ray energy causing the Fermi bubbles. We advocate that these positron fraction features are the counterpart signals of the Fermi bubbles, or of substructures within them, or of the eROSITA bubbles.
CCN activity and organic hygroscopicity of aerosols downwind of an urban region in central Amazonia: Seasonal and diel variations and impact of anthropogenic emissions
During the Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign, size-resolved cloud condensation nuclei (CCN) spectra were characterized at a research site (T3) 60km downwind of the city of Manaus, Brazil, in central Amazonia for one year (12 March 2014 to 3 March 2015). Particle hygroscopicity (κCCN) and mixing state were derived from the size-resolved CCN spectra, and the hygroscopicity of the organic component of the aerosol (κorg) was then calculated from κCCN and concurrent chemical composition measurements. The annual average κCCN increased from 0.13 at 75 nm to 0.17 at 171 nm, and the increase was largely due to an increase in sulfate volume fraction. Also, during both wet and dry seasons, κCCN, κorg, and particle composition under background conditions exhibited essentially no diel variations. The constant κorg of ~0.15 is consistent with the largely uniform and high O:C value (~0.8), indicating that the aerosols under background conditions are dominated by the aged regional aerosol particles consisting of highly oxygenated organic compounds. For air masses strongly influenced by urban pollution and/or local biomass burning, lower values of κorg and organic O:C atomic ratio were observed during night, due to accumulation of freshly emitted particles, dominated by primary organic aerosol (POA) with low hygroscopicity, within a shallow nocturnal boundary layer. The O:C, κorg, and κCCN increased from the early morning hours and peaked around noon, driven by the formation and aging of secondary organic aerosol (SOA) and dilution of POA emissions into a deeper boundary layer, while the development of the boundary layer, which leads to mixing with aged particles from the residual layer aloft, likely also contributed to the increases. The hygroscopicities associated with individual organic factors, derived from PMF analysis of AMS spectra, were estimated through multi-variable linear regression. For the SOA factors, the variation of the κ value with O:C agrees well with the linear relationship reported from earlier laboratory studies of SOA hygroscopicity. On the other hand, the variation in O:C of ambient aerosol organics is largely driven by the variation in the volume fractions of POA and SOA factors, which have very different O:C values. As POA factors have hygroscopicity values well below the linear relationship between SOA hygroscopicity and O:C, mixtures with different POA and SOA fractions exhibit a steeper slope for the increase of κorg with O:C, as observed during this and earlier field studies. Our finding helps better understand and reconcile the differences in the relationships between κorg and O:C observed in laboratory and field studies, therefore providing a basis for improved parameterization in global models, especially in a tropical context.
Near noise field characteristics of Nike rocket motors for application to space vehicle payload acoustic qualification
Results of a series of noise measurements that were made under controlled conditions during the static firing of two Nike solid propellant rocket motors are presented. The usefulness of these motors as sources for general spacecraft noise testing was assessed, and the noise expected in the cargo bay of the orbiter was reproduced. Brief descriptions of the Nike motor, the general procedures utilized for the noise tests, and representative noise data including overall sound pressure levels, one third octave band spectra, and octave band spectra were reviewed. Data are presented on two motors of different ages in order to show the similarity between noise measurements made on motors having different loading dates. The measured noise from these tests is then compared to that estimated for the space shuttle orbiter cargo bay.
The first 800 million years of earth's history
It is pointed out that there is no direct geological information on the first 750 Ma of earth history. Consequently the reported study is based on controversial inferences drawn from the moon, other planets and meteorites, coupled with backward extrapolation from surviving terrestrial rocks, especially those of Archaean age. Aspects of accretion are considered, taking into account cosmochemical and cosmophysical evidence, a new earth model, and convection systems. Attention is given to phase-equilibrium constraints, estimates of heat production, the bombardment history of the moon and implications for the earth, and the nature of the early crust. From a combination of physical, chemical, and petrological arguments, it is concluded that the earth's surface underwent intense volcanism in the pre-Archaean era, and that the rock types were chemically similar to those found in the early Archaean era.
Service-Life Extension of Explosive Escape Devices
Chemical and functional tests yield conservative service-life estimates. Approach to extension of service lives of explosive devices in aircraft escape system developed, supported by testing of representative candidate devices to evaluate quantitatively effects of service, age, and degradation, and to enable responsible, conservative service-life determinations. Five types of explosive components evaluated: rigid and flexible explosive transfer lines; one-way transfers; flexible, linear-shaped charges; and initiation-handles. Extension of service in realistic manner provides both cost savings and increased system reliability.
4 Draconis - A unique triple system containing an M3 giant and a cataclysmic binary
The M3 III giant 4 Dra has a UV bright companion discovered with IUE as a probable cataclysmic variable (CV). The orbit of the M giant around the center of gravity of the system that it forms with the cataclysmic binary is determined. 4 Dra B shows spectrum variations like a CV; the photometric period is 3 h 58.5 m + or - 1 m is determined. 4 Dra B is the first CV for which an independent distance estimate can be given from the spectroscopic parallax of the companion. Properties of the CV, which is probably of the magnetic type (AM Her), are briefly discussed. The age of the CV may be less than 100 million yr.
Global Distortion of GPS Networks Associated with Satellite Antenna Model Errors
Recent studies of the GPS satellite phase center offsets (PCOs) suggest that these have been in error by approx.1 m. Previous studies had shown that PCO errors are absorbed mainly by parameters representing satellite clock and the radial components of site position. On the basis of the assumption that the radial errors are equal, PCO errors will therefore introduce an error in network scale. However, PCO errors also introduce distortions, or apparent deformations, within the network, primarily in the radial (vertical) component of site position that cannot be corrected via a Helmert transformation. Using numerical simulations to quantify the effects of PC0 errors, we found that these PCO errors lead to a vertical network distortion of 6-12 mm per meter of PCO error. The network distortion depends on the minimum elevation angle used in the analysis of the GPS phase observables, becoming larger as the minimum elevation angle increases. The steady evolution of the GPS constellation as new satellites are launched, age, and are decommissioned, leads to the effects of PCO errors varying with time that introduce an apparent global-scale rate change. We demonstrate here that current estimates for PCO errors result in a geographically variable error in the vertical rate at the 1-2 mm/yr level, which will impact high-precision crustal deformation studies.
Impacts of Disturbance History on Forest Carbon Stocks and Fluxes: Merging Satellite Disturbance Mapping with Forest Inventory Data in a Carbon Cycle Model Framework
Forest carbon stocks and fluxes are highly dynamic following stand-clearing disturbances from severe fire and harvest and this presents a significant challenge for continental carbon budget assessments. In this work we use forest inventory data to parameterize a carbon cycle model to represent post-disturbance carbon trajectories of carbon pools and fluxes for specific forest types growing in high and low site productivity class settings. We then apply these trajectories to landscapes and regions based on forest age distributions derived from either the FIA data or from Landsat time series stacks (1985-2006) for 54 representative scenes throughout most of the conterminous United States. We estimate the net carbon uptake in forests caused by post-disturbance growth and decomposition ("regrowth sink") for forested regions across the country. At the landscape scale, the prevailing condition of positive net ecosystem productivity (NEP) is in stark contrast to local patches with large sources, particularly in the west where fires and clear cuts create contiguous disturbed patches. At the continental scale, regional differences in disturbance rates reflect management patterns of high disturbance rates in the Southeastern and South Central states, and lower disturbance rates in the Northeast and Northern Lakes States. Despite low contemporary disturbance rates in the Northeast and Northern Lakes States (0.61 and 0.74% y(exp −1)), the regrowth sink there remains of moderate to large strength (88 and 57 g C m(exp −2) y(exp −1)) owing to the continued legacy from historical clearing. Large regrowth sinks are also found in the Southeast, South Central, and Pacific Southwest regions (85, 86, and 95 g C m(exp −2) y(exp −1)) where disturbance rates also tend to be higher (1.59, 1.38, and 0.93% y(exp −1)). Overall, the Landsat-derived disturbance rates are elevated relative to FIA-derived rates (1.19 versus 0.93% y(exp −1)) particularly for western regions. The differences only modestly adjust regional- and continental-scale carbon budgets, reducing NEP from forest regrowth by about 8%.
Estimation of cerebral blood flow velocity during breath-hold challenge using artificial neural networks
The effect of untreated Obstructive Sleep Apnoea (OSA) on cerebral haemodynamics and CA impairment is an active field of research interest. A breath-hold challenge is usually used in clinical and research settings to simulate cardiovascular and cerebrovascular changes that mimic OSA events. This work utilises temporal arterial oxygen saturation (SpO 2 ) and photoplethysmography (PPG) signals to estimate the temporal cerebral blood flow velocity (CBFv) waveform. Measurements of CBFv, SpO 2 , and PPG, were acquired concurrently from volunteers performing two different protocols of breath-hold challenge in the supine position. Past values of the SpO 2 and PPG signals were used to estimate the current values of CBFv using different permutations and topologies of supervised learning with shallow artificial neural networks (ANNs). Measurements from one protocol were used to train the ANNs and find the optimum topologies, which in turn were tested using the other protocol. Data collected from 10 normotensive, healthy subjects (four females, age 28.5 ± 6.1 years, Body Mass Index (BMI) 24.0 ± 4.7 kg/m 2 ) were used in this study. The results show that different subjects have different optimum topologies for ANNs, thus indicating the effects of inter-subject variability on ANNs. Successfully reconstructed blind waveforms for the same subject group in the second protocol showed a reasonable accuracy of 60–80% estimation compared to the measured waveforms.
Effect Modification by Age on the Benefit or Harm of Antihypertensive Treatment for Elderly Hypertensives: A Systematic Review and Meta-analysis
Abstract BACKGROUND The influence of age on balance of benefit vs. potential harm of blood pressure (BP)-lowering therapy for elderly hypertensives is unclear. We evaluated the modifying effects of age on BP lowering for various adverse outcomes in hypertensive patients older than 60 years without specified comorbidities. METHODS All relevant randomized controlled trials (RCTs) were systematically identified. Coronary heart disease, stroke, heart failure (HF), cardiovascular death, major adverse cardiovascular events (MACE), renal failure (RF), and all-cause death were assessed. Meta-regression analysis was used to explore the relationship between achieved systolic BP (SBP) and the risk of adverse events. Random-effects meta-analysis was used to pool the estimates. RESULTS Our study included 18 RCTs (n = 53,993). Meta-regression analysis showed a lower achieved SBP related with a lower risk of stroke and cardiovascular death, but an increased risk of RF. The regression slopes were comparable between populations stratifying by age 75 years. In subgroup analysis, the relative risks of a more aggressive BP lowering strategy were similar between patients aged older or less than 75 years for all outcomes except for RF (P for interaction = 0.02). Compared to treatment with final achieved SBP 140–150 mm Hg, a lower achieved SBP (<140 mm Hg) was significantly associated with decreased risk of stroke (relative risk = 0.68; 95% confidence interval = 0.55–0.85), HF (0.77; 0.60–0.99), cardiovascular death (0.68; 0.52–0.89), and MACE (0.83; 0.69–0.99). CONCLUSIONS To treat hypertension in the elderly, age had trivial effect modification on most outcomes, except for renal failure. Close monitoring of renal function may be warranted in the management of elderly hypertension.
The SUrvey for Pulsars and Extragalactic Radio Bursts - IV. Discovery and polarimetry of a 12.1-s radio pulsar
We report the discovery of PSR J2251−3711, a radio pulsar with a spin period of 12.1 s, the second longest currently known. Its timing parameters imply a characteristic age of 15 Myr, a surface magnetic field of 1.3 × 10^(13) G, and a spin-down luminosity of 2.9 × 10^(29) erg/s. Its dispersion measure of 12.12(1) pc/cu. cm leads to distance estimates of 0.5 and 1.3 kpc according to the NE2001 and YMW16 Galactic free electron density models, respectively. Some of its single pulses show an uninterrupted 180-deg sweep of the phase-resolved polarization position angle, with an S-shape reminiscent of the rotating vector model prediction. However, the fact that this sweep occurs at different phases from one pulse to another is remarkable and without straightforward explanation. Although PSR J2251−3711 lies in the region of the P − P˙ parameter space occupied by the X-ray isolated neutron stars (XINS), there is no evidence for an X-ray counterpart in our Swift XRT observation; this places a 99 per cent-confidence upper bound on its unabsorbed bolometric thermal luminosity of 1.1 × 10^(31) (d/1 kpc)^2 erg/s for an assumed temperature of 85 eV, where d is the distance to the pulsar. Further observations are needed to determine whether it is a rotation-powered pulsar with a true age of at least several Myr, or a much younger object such as an XINS or a recently cooled magnetar. Extreme specimens like PSR J2251−3711 help bridge populations in the so-called neutron star zoo in an attempt to understand their origins and evolution.
Observations of 14 CO 2 in ecosystem respiration from a temperate deciduous forest in Northern Wisconsin
We show that the 14 CO 2 composition of plant and soil respiration can be used to determine the residence time of photosynthetically fixed carbon before it is released back to the atmosphere. To estimate the residence time of actively cycled carbon in a temperate forest, we employed two approaches for estimating the Δ 14 CO 2 of ecosystem respiration (Δ 14 C-R eco ) at the Willow Creek AmeriFlux site in Northern Wisconsin, USA. Our first approach was to construct nighttime Keeling plots from subcanopy profiles of Δ 14 CO 2 and CO 2 , providing estimates of Δ 14 C-R eco of 121.7‰ in June and 42.0‰ in August 2012. These measurements are likely dominated by soil fluxes due to proximity to the ground level. Our second approach utilized samples taken over 20 months within the forest canopy and from 396 m above ground level at the nearby LEF NOAA tall tower site (Park Falls, WI). In this canopy-minus-background approach we employed a mixing model described by Miller and Tans (2003) for estimating isotopic sources by subtracting time-varying background conditions. For the period from May 2011 to December 2012 the estimated Δ 14 C-R eco using the Miller-Tans model was 76.8‰. Together, these Δ 14 C-R eco values represent mean R eco carbon ages of approximately 1–19 years. We also found that heterotrophic soil-respired Δ 14 C at Willow Creek was 5–38‰ higher (i.e., 1–10 years older) than predicted by the Carnegie-Ames-Stanford Approach global biosphere carbon model for the 1 × 1 pixel nearest to the site. Finally, this study provides much needed observational constraints of ecosystem carbon residence times, which are a major source of uncertainty in terrestrial carbon cycle models.
2023 Status Report - Fiberboard Properties and Degradation Rates for Storage of 9975 Shipping Package in KAC
Thermal, mechanical, and physical properties have been measured on fiberboard samples aging for up to 18 years at accelerated conditions. The aging environments include elevated temperature up to 250 ºF (the maximum allowed service temperature for fiberboard in 9975 packages) and elevated humidity. Accelerated aging results have been analyzed and used to build aging models. Correlations relating several properties (thermal conductivity, energy absorption, weight, dimensions, and density) to their rate of change in potential storage environments have been developed. Combined with an estimate of the actual conditions the fiberboard experiences in K-Area Complex (KAC), these models allow development of service life predictions.
2024 Status Report - Fiberboard Properties and Degradation Rates for Storage of 9975 Shipping Package in KAC
Fiberboard assemblies in the 9975 package were identified as susceptible to aging and degradation under long-term storage conditions. Thermal, mechanical, and physical properties have been measured on fiberboard samples aging for up to 19 years at accelerated conditions. The aging environments include elevated temperature up to 250 ºF (the maximum allowed service temperature for fiberboard in 9975 packages) and elevated humidity. Accelerated aging results have been analyzed and used to build aging models. Correlations relating several properties (thermal conductivity, energy absorption, weight, dimensions, and density) to their rate of change in potential storage environments have been developed. Combined with an estimate of the actual conditions the fiberboard experiences in K-Area Complex (KAC), these models allow development of service life predictions.