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NASA NTRS2011

The Analysis of the Patterns of Radiation-Induced DNA Damage Foci by a Stochastic Monte Carlo Model of DNA Double Strand Breaks Induction by Heavy Ions and Image Segmentation Software

To create a generalized mechanistic model of DNA damage in human cells that will generate analytical and image data corresponding to experimentally observed DNA damage foci and will help to improve the experimental foci yields by simulating spatial foci patterns and resolving problems with quantitative image analysis. Material and Methods: The analysis of patterns of RIFs (radiation-induced foci) produced by low- and high-LET (linear energy transfer) radiation was conducted by using a Monte Carlo model that combines the heavy ion track structure with characteristics of the human genome on the level of chromosomes. The foci patterns were also simulated in the maximum projection plane for flat nuclei. Some data analysis was done with the help of image segmentation software that identifies individual classes of RIFs and colocolized RIFs, which is of importance to some experimental assays that assign DNA damage a dual phosphorescent signal. Results: The model predicts the spatial and genomic distributions of DNA DSBs (double strand breaks) and associated RIFs in a human cell nucleus for a particular dose of either low- or high-LET radiation. We used the model to do analyses for different irradiation scenarios. In the beam-parallel-to-the-disk-of-a-flattened-nucleus scenario we found that the foci appeared to be merged due to their high density, while, in the perpendicular-beam scenario, the foci appeared as one bright spot per hit. The statistics and spatial distribution of regions of densely arranged foci, termed DNA foci chains, were predicted numerically using this model. Another analysis was done to evaluate the number of ion hits per nucleus, which were visible from streaks of closely located foci. In another analysis, our image segmentaiton software determined foci yields directly from images with single-class or colocolized foci. Conclusions: We showed that DSB clustering needs to be taken into account to determine the true DNA damage foci yield, which helps to determine the DSB yield. Using the model analysis, a researcher can refine the DSB yield per nucleus per particle. We showed that purely geometric artifacts, present in the experimental images, can be analytically resolved with the model, and that the quantization of track hits and DSB yields can be provided to the experimentalists who use enumeration of radiation-induced foci in immunofluorescence experiments using proteins that detect DNA damage. An automated image segmentaiton software can prove useful in a faster and more precise object counting for colocolized foci images.

Ponomarev, Artem↗

NASA NTRS2012

Validation Tests of Fiber Optic Strain-Based Operational Shape and Load Measurements

Aircraft design has been progressing toward reduced structural weight to improve fuel efficiency, increase performance, and reduce cost. Lightweight aircraft structures are more flexible than conventional designs and require new design considerations. Intelligent sensing allows for enhanced control and monitoring of aircraft, which enables increased structurally efficiency. The NASA Dryden Flight Research Center (DFRC) has developed an instrumentation system and analysis techniques that combine to make distributed structural measurements practical for lightweight vehicles. Dryden's Fiber Optic Strain Sensing (FOSS) technology enables a multitude of lightweight, distributed surface strain measurements. The analysis techniques, referred to as the Displacement Transfer Functions (DTF) and Load Transfer Functions (LTF), use surface strain values to calculate structural deflections and operational loads. The combined system is useful for real-time monitoring of aeroelastic structures, along with many other applications. This paper describes how the capabilities of the measurement system were demonstrated using subscale test articles that represent simple aircraft structures. Empirical FOSS strain data were used within the DTF to calculate the displacement of the article and within the LTF to calculate bending moments due to loads acting on the article. The results of the tests, accuracy of the measurements, and a sensitivity analysis are presented.

FOSS↗

NASA NTRS1974

The structure of radio sources 3C 273B and 3C 84 deduced from the 'closure' phases and visibility amplitudes observed with three-element interferometers

The derived 'closure' phase relation for a three-element interferometer is used in a presented analysis of data obtained from observations at 7.8 GHz of the radio sources 3C 273B and 3C 84 by antennas in Massachusetts, California, Alaska, and Sweden (the first two antennas were used in combination with each of the last two separately to form two three-element interferometers). The brightness distribution is found for each source by expansion of both the fringe amplitude and the fringe phase in separate Fourier series.

Rogers, A. E. E.↗

NASA NTRS1980

Space construction and utility distribution

Technology advancement to effect an orderly development program leading to construction of space platforms was defined, in a program that utilized a viable platform and service module concept with concise OSS/OAST mission and payload models. Consideration was given to concepts for alternate platform servicing of the payloads described in the model. Using the baseline configuration, issues pertinent to platform development as well as orbit emplacement and operation and on orbit construction methodology were analyzed. These analyses provided the following data: (1) payload definitions and installation options; (2) identified structural and subsystems options; (3) developed integrated platform system concepts; and (4) identified technology deficiencies and recommended technology development timelines.

Bloom, K. A.↗

NASA NTRS1994

Contour advection with surgery: A technique for investigating finescale structure in tracer transport

We present a trajectory technique, contour advection with surgery (CAS), for tracing the evolution of material contours in a specified (including observed) evolving flow. CAS uses the algorithms developed by Dritschel for contour dynamics/surgery to trace the evolution of specified contours. The contours are represented by a series of particles, which are advected by a specified, gridded, wind distribution. The resolution of the contours is preserved by continually adjusting the number of particles, and finescale features are produced that are not present in the input data (and cannot easily be generated using standard trajectory techniques). The reliability, and dependence on the spatial and temporal resolution of the wind field, of the CAS procedure is examined by comparisons with high-resolution numerical data (from contour dynamics calculations and from a general circulation model), and with routine stratospheric analyses. These comparisons show that the large-scale motions dominate the deformation field and that CAS can accurately reproduce small scales from low-resolution wind fields. The CAS technique therefore enables examination of atmospheric tracer transport at previously unattainable resolution.

Waugh, Darryn W.↗

NASA NTRS1988

A survey of IRAS data on 41 classical novae

The IRAS database has been searched for detections of 41 classical novae using coadditions of survey scans; 15 were detected. IRAS temporal observations of novae in outburst are discussed. The observed long-wavelength infrared distributions of DQ Her, and possibly HR Del, can be explained by emission from small (a of about 0.1 microns) dust grains heated by the central object. An alternative explanation for the energy distributions of DQ Her and HR Del is emission from fine-structure lines. FH Ser and LW Ser display energy distributions that have color temperatures much too hot to be due to heating of dust by the central source in any plausible scenario. Line emission is probably the best explanation of their observed energy distributions. The novae NQ Vul and LV Vul have energy distributions that may be contaminated by emission from galactic cirrus. The unusual object PL 1547.3-5612 exhibits an energy distribution that does not resemble those of planetary nebulae or other novae detected in this sample. An IRAS low-resolution spectrum of RR Tel shows the 10-micron silicate emission feature.

Harrison, T. E.↗

NASA NTRS1974

Study of design and control of remote manipulators. Modeling manipulator arms with distributed flexibility for design and control

The interactions of control system and distributed flexible structural dynamics is explored for mechanical arms. A modeling process using 4 x 4 transfer matrices is described which permits the closed loop response of many current arm configurations to be evaluated. Root locus, frequency response, modal shapes, and time impulse response have all been obtained from the digital computer implementation of this model, which is oriented to arm design and allows for easy variation of the arm configuration through data cards. The model corresponds with experimentally observed natural frequencies with an average error of less than 5% in the first three flexible modes in the seven cases considered. The model was used to explore the limits imposed by structural flexibility on a nondimensionalized two link arm with one and two joints for planar motion.

Book, W. J.↗

NASA NTRS1975

Reliability-based optimum inspection and maintenance procedures

The development of reliability-based optimum inspection and maintenance schedules for engines needs an understanding of the fatigue behavior of the engines. Critical areas of the engine structure prone to fatigue damage are usually identified beforehand or after the fleet has been put into operation. In these areas, fatigue cracks initiate after several flight hours, and these cracks grow in length until failure takes place when these cracks attain the critical lengths. Crack initiation time and its growth rate are considered to be random variables. Usually, the inspection (fatigue) or test data from similar engines are used as prior distributions. The existing state-of-the-art is to ignore the different lengths of cracks obserbed at various inspections and to consider only the fact that a crack existed (or did not exist) at the time of inspection. In this paper, a procedure has been developed to obtain the probability of finding a crack of a given size at a certain time if the probability distributions for crack initiation and rates of growth are known. Application of the developed stochastic models to devise optimum procedures for inspection and maintenance are also discussed.

Nanagud, S.↗

NASA NTRS1984

Case studies of NOAA 6/TIROS N data impact on numerical weather forecasts

The impact of satellite temperatures from systems which predate the launching of the third generation of vertical sounding instruments aboard TIROS N (13 Oct 1978) and NOAA 6 (27 June 1979) is reported. The first evaluation of soundings from TIROS N found that oceanic, cloudy retrievals over NH mid latitudes show a cold bias in winter. It is confirmed for both satellite systems using a larger data base. It is shown that RMS differences between retrievals and colocated radiosonde observations within the swath 30-60N during the 1979-80 winter were generally 2-3K in clear air and higher for cloudy columns. A positive impact of TIROS N temperatures on the analysis of synoptic weather systems is shown. Analyses prepared from only satellite temperatures seemed to give a better definition to weather systems' thermal structure than that provided by corresponding NMC analyses without satellite data. The results of a set of 14 numerical forecast experiments performed with the PE model of the Israel Meteorological Service (IMS) are summarized; these were designed to test the impact of TIROS N and NOAA 6 temperatures within the IMS analysis and forecast cycle. The satellite data coverage over the NH, the mean area/period S1 and RMS verification scores and the spatial distribution of SAT versus NO SAT forecast differences are discussed and it is concluded that positive forecast impact occurs over ocean areas where the extra data improve the specification which is otherwise available from conventional observations. The forecast impact for three cases from the same set of experiments was examined and it is found that satellite temperatures, observed over the Atlantic Ocean contribute to better forecasts over Iceland and central Europe although a worse result was verified over Spain. It is also shown that the better scores of a forecast based also on satellite data and verified over North America actually represent a mixed impact on the forecast synoptic patterns. A superior 48 hr 500 mb forecast over the western US due to the better initial specification afforded by satellite observed temperatures over the North Pacific Ocean is shown.

Druyan, L. M.↗

NASA NTRS1988

Mentat: An object-oriented macro data flow system

Mentat, an object-oriented macro data flow system designed to facilitate parallelism in distributed systems, is presented. The macro data flow model is a model of computation similar to the data flow model with two principal differences: the computational complexity of the actors is much greater than in traditional data flow systems, and there are persistent actors that maintain state information between executions. Mentat is a system that combines the object-oriented programming paradigm and the macro data flow model of computation. Mentat programs use a dynamic structure called a future list to represent the future of computations.

Grimshaw, Andrew S.↗

NASA NTRS1993

The galaxy velocity field and CDM models

It is generally accepted that some kind of non-baryonic dark matter accounts for most of the mass density of the universe. Considering such a component has become, in the last decade, a key ingredient in current theories of structure formation. In particular, the Cold Dark Matter (CDM) scenario has proven to be quite successful in explaining most of the observed properties of galaxies and of their large-scale distribution. The standard CDM model is characterized by a primordial Zel'dovich spectrum, of random-phase adiabatic perturbations in a universe with density parameter omega sub 0 = 1 and vanishing cosmological constant. This poster paper presents an analysis of observational data on peculiar motion of optical galaxies in comparison to the predictions of CDM models where the assumptions of the standard scenario: omega sub 0 = 1, n = 1, and bias parameter b = 1 are relaxed. In particular, CDM models with 0 less than n less than 1 and 0.4 less than omega sub 0 less than 1 are considered.

Tormen, Giuseppe↗

NASA NTRS2001

Use of Pressure Sensitive Paint for Diagnostics in Turbomachinery Flows With Shocks

The technology of pressure sensitive paint (PSP) is well established in external aerodynamics. In internal flows in narrow channels and in turbomachinery cascades, however, there are still unresolved problems. In particular, the internal flows with complex shock structures inside highly curved channels present a challenge. It is not always easy and straightforward to distinguish between true signals and "ghost" images due to multiple internal reflections in narrow channels. To address some of the problems, investigations were first carried out in a narrow supersonic channel of Mach number 2.5. A single wedge or a combination of two wedges were used to generate a complex shock wave structure in the flow. The experience gained in a small supersonic channel was used for surface pressure measurements on the stator vane of a supersonic throughflow fan. The experimental results for several fan operating conditions are shown in a concise form, including performance map points, midspan static tap pressure distributions, and vane suction side pressure fields. Finally, the PSP technique was used in the NASA transonic flutter cascade to compliment flow visualization data and to acquire backwall pressure fields to assess the cascade flow periodicity. A summary of shortcomings of the pressure sensitive paint technology for internal flow application and lessons learned are presented in the conclusion of the paper.

Lepicovsky, Jan↗

NASA NTRS2003

Development of a Flexible Framework of Common Hypersonic Navier-Strokes Meshes for the Space Shuttle Orbiter

A flexible framework for the development of block structured volume grids for hypersonic Navier-Stokes flow simulations was developed for analysis of the Shuttle Orbiter Columbia. The development of the flexible framework, resulted in an ability to quickly generate meshes to directly correlate solutions contributed by participating groups on a common surface mesh, providing confidence for the extension of the envelope of solutions and damage scenarios. The framework draws on the experience of NASA Langely and NASA Ames Research Centers in structured grid generation, and consists of a grid generation process that is implemented through a division of responsibilities. The nominal division of labor consisted of NASA Johnson Space Center coordinating the damage scenarios to be analyzed by the Aerothermodynamics Columbia Accident Investigation (CAI) team, Ames developing the surface grids that described the computational volume about the orbiter, and Langely improving grid quality of Ames generated data and constructing the final volume grids. Distributing the work among the participants in the Aerothermodynamic CIA team resulted in significantly less time required to construct complete meshes than possible by any individual participant. The approach demonstrated that the One-NASA grid generation team could sustain the demand for new meshes to explore new damage scenarios within a aggressive timeline.

Alter, Stephen J.↗

NASA NTRS2010

Improved Phased Array Imaging of a Model Jet

An advanced phased array system, OptiNav Array 48, and a new deconvolution algorithm, TIDY, have been used to make octave band images of supersonic and subsonic jet noise produced by the NASA Glenn Small Hot Jet Acoustic Rig (SHJAR). The results are much more detailed than previous jet noise images. Shock cell structures and the production of screech in an underexpanded supersonic jet are observed directly. Some trends are similar to observations using spherical and elliptic mirrors that partially informed the two-source model of jet noise, but the radial distribution of high frequency noise near the nozzle appears to differ from expectations of this model. The beamforming approach has been validated by agreement between the integrated image results and the conventional microphone data.

Dougherty, Robert P.↗

NASA NTRSDate not supplied

Show Me the Money! Evaluating A Graduated Incentive Structure to Keep Respondents Engaged Through 101 Surveys in 28 Days

We report the results of a survey test conducted in advance of a series of community response tests (CRTs) to evaluate response to noise from NASA’s X-59 aircraft. The CRTs will require a substantial number of observations to generate a dose response curve for noise exposure and related annoyance levels and the timeframe is limited due to resource and scheduling constraints with an experimental aircraft. Within each CRT area, we will recruit a sample of residents in advance and ask them to fill out a brief survey each time the aircraft passes over. Respondents will be asked to fill out the survey either on the web or as part of an application they are able to download onto their mobile phones. Respondents will be notified each time the plane flies over, asking for their reactions. On many days, respondents will be asked to fill out the survey for multiple flights. Typical incentives are used during the recruitment phase (pre-incentive for a household screener and post-paid for a background survey completed by the selected respondent) and post-paid for an end of study survey. To improve response rates over such a demanding survey schedule (101 surveys in 28 days) we will implement a weekly incentive based upon participation rates, with higher incentives for greater participation and increasing rates each week. The survey test will follow the proposed methodology of the CRTs. We will report on the participation rates by incentive amount and the effectiveness of the incentive structure in obtaining and maintaining response rates over the 4 weeks. We will examine how quickly participation fades over the 4-week period and consider whether the incentive schedule could be improved by altering the distribution of payments. Finally, we will compare how these rates varied across web and app respondents. We will use the results of this work to confirm or improve the design of the CRTs, ensuring the collection of data needed by NASA to evaluate the impact of this innovative technology.

incentives↗

NASA NTRS1975

Analysis of spectrophotometric observations of Venus in the 3-4 micron region

Spectrophotometric data of Venus in the 3-4 micron region are analyzed in the context of current ideas concerning cloud properties. The results show that a homogeneous cloud model, using a unimodal particle size distribution compatible with the results of previous polarization studies, cannot satisfactorily explain the infrared observations. Assuming a composition of 75% H2SO4, agreement is possible if an upper layer of smaller particles is added to the homogeneous cloud. This inhomogeneous cloud structure, however, is not in agreement with the polarization results. Other models, involving bimodal particle size distributions, were also unsuccessful in explaining both sets of observations in a consistent manner.

Martonchik, J. V.↗

NASA NTRS1976

The structure and content of the galaxy and galactic gamma rays

Papers are presented dealing with galactic structure drawing on all branches of galactic astronomy with emphasis on the implications of the new gamma ray observations. Topics discussed include: (1) results from the COS-B gamma ray satellite; (2) results from SAS-2 on gamma ray pulsar, Cygnus X-3, and maps of the galactic diffuse flux; (3) recent data from CO surveys of the galaxy; (4) high resolution radio surveys of external galaxies; (5) results on the galactic distribution of pulsars; and (6) theoretical work on galactic gamma ray emission.

Fichtel, C. E.↗

NASA NTRS1985

An Idealized Short Period Comet Model: Surface Insolation, H2O Flux, Dust Flux and Mantle Evolution

The present cometary activity model integrates feedback processes that involve the transport of heat, gas, and dust, as well as dust mantle development, and includes the effects of latitude, rotation, and spin orientation. Attention is given to the development, structural change, and distribution of dust mantles and their mutual interaction with ice surface temperature and gas and dust production. The results obtained suggest that an initially homogeneous, short period comet with a cosmic dust to water ice ratio, as well as typical orbit, rotation rate, and grain size distribution, would develop only a thin, less than 1 mm cyclic mantle at all points on the nucleus. Most H2O dust histories deduced from brightness data are noted to be in reasonable agreement with the model, allowing for uncertainty in radius and albedo. The exceptional case of Comet Encke is discussed.

Fanale, F. P.↗