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At least 1,297 records · Page 72

Brachypodium sylvaticum , a Model for Perennial Grasses: Transformation and Inbred Line Development

Perennial species offer significant advantages as crops including reduced soil erosion, lower energy inputs after the first year, deeper root systems that access more soil moisture, and decreased fertilizer inputs due to the remobilization of nutrients at the end of the growing season. These advantages are particularly relevant for emerging biomass crops and it is projected that perennial grasses will be among the most important dedicated biomass crops. The advantages offered by perennial crops could also prove favorable for incorporation into annual grain crops like wheat, rice, sorghum and barley, especially under the dryer and more variable climate conditions projected for many grain-producing regions. Thus, it would be useful to have a perennial model system to test biotechnological approaches to crop improvement and for fundamental research. The perennial grass Brachypodium sylvaticum is a candidate for such a model because it is diploid, has a small genome, is self-fertile, has a modest stature, and short generation time. Its close relationship to the annual model Brachypodium distachyon will facilitate comparative studies and allow researchers to leverage the resources developed for B. distachyon. Here we report on the development of two keystone resources that are essential for a model plant: high-efficiency transformation and inbred lines. Using Agrobacterium tumefaciens-mediated transformation we achieved an average transformation efficiency of 67%. We also surveyed the genetic diversity of 19 accessions from the National Plant Germplasm System using SSR markers and created 15 inbred lines.

54 ENVIRONMENTAL SCIENCES↗

CurvilinearGrids.jl: A Julia package for curvilinear coordinate transformations

Finite-difference discretizations of partial differential equations are widespread throughout the scientific community. Oftentimes finite-differences are used to compute spatial gradients of fields on a discrete grid, which is typically a uniform or rectilinear Cartesian mesh. Arbitrary multidimensional geometry is difficult to discretize directly with finite differences, however, due to non-uniform grid spacing and non-orthogonality. Curvilinear coordinate transformations can be used as a strategy to enable arbitrary geometry. While these curvilinear transformations are straightforward, the governing PDEs require additional terms (metrics) and must adhere to strict conservation laws; these criteria complicate the application of the transformation and require careful implementation.

97 MATHEMATICS AND COMPUTING↗

High-Gradient, High-Transformer-Ratio, Dielectric Wake Field Accelerator

The Phase I work reported here responds to DoE'ss stated need "...to develop improved accelerator designs that can provide very high gradient (>200 MV/m for electrons...) acceleration of intense bunches of particles." Omega-P's approach to this goal is through use of a ramped train of annular electron bunches to drive a coaxial dielectric wakefield accelerator (CDWA) structure. This approach is a direct extension of the CDWA concept from acceleration in wake fields caused by a single drive bunch, to the more efficient acceleration that we predict can be realized from a tailored (or ramped) train of several drive bunches. This is possible because of a much higher transformer ratio for the latter. The CDWA structure itself has a number of unique features, including: a high accelerating gradient G, potentially with G > 1 GeV/m; continuous energy coupling from drive to test bunches without transfer structures; inherent transverse focusing forces for particles in the accelerated bunch; highly stable motion of high charge annular drive bunches; acceptable alignment tolerances for a multi-section system. What is new in the present approach is that the coaxial dielectric structure is now to be energized by-not one-but by a short train of ramped annular-shaped drive bunches moving in the outer coaxial channel of the structure. We have shown that this allows acceleration of an electron bunch traveling along the axis in the inner channel with a markedly higher transformer ratio T than for a single drive bunch. As described in this report, the structure will be a GHz-scale prototype with cm-scale transverse dimensions that is expected to confirm principles that can be applied to the design of a future THz-scale high gradient (> 500 MV/m) accelerator with mm-scale transverse dimensions. We show here a new means to significantly increase the transformer ratio T of the device, and thereby to significantly improve its suitability as a flexible and effective component in a future high energy, high gradient accelerator facility. We predict that the T of a high gradient CDWA can be increased by a substantial factor; this enhancement is dramatically greater than what has been demonstrated heretofore. This large enhancement in T that we predict arises from using a train of three or four drive bunches in which the spacing of the bunches and their respective charges are selected according to a simple principle that requires each bunch lose energy to the wakefields at the same rate, so as not to sacrifice drive beam efficiency as would be the case if one bunch exhausted its available energy while others had not. It is anticipated that results from the study proposed here can have a direct impact on design of the dielectric accelerator in a TeV-scale collider concept, and in the accelerator for an x-ray FEL.

43 PARTICLE ACCELERATORS↗

Parallelization and checkpointing of GPU applications through program transformation

GPUs have emerged as a powerful tool for accelerating general-purpose applications. The availability of programming languages that makes writing general-purpose applications for running on GPUs tractable have consolidated GPUs as an alternative for accelerating general purpose applications. Among the areas that have benefited from GPU acceleration are: signal and image processing, computational fluid dynamics, quantum chemistry, and, in general, the High Performance Computing (HPC) Industry. In order to continue to exploit higher levels of parallelism with GPUs, multi-GPU systems are gaining popularity. In this context, single-GPU applications are parallelized for running in multi-GPU systems. Furthermore, multi-GPU systems help to solve the GPU memory limitation for applications with large application memory footprint. Parallelizing single-GPU applications has been approached by libraries that distribute the workload at runtime, however, they impose execution overhead and are not portable. On the other hand, on traditional CPU systems, parallelization has been approached through application transformation at pre-compile time, which enhances the application to distribute the workload at application level and does not have the issues of library-based approaches. Hence, a parallelization scheme for GPU systems based on application transformation is needed. Like any computing engine of today, reliability is also a concern in GPUs. GPUs are vulnerable to transient and permanent failures. Current checkpoint/restart techniques are not suitable for systems with GPUs. Checkpointing for GPU systems present new and interesting challenges, primarily due to the natural differences imposed by the hardware design, the memory subsystem architecture, the massive number of threads, and the limited amount of synchronization among threads. Therefore, a checkpoint/restart technique suitable for GPU systems is needed. The goal of this work is to exploit higher levels of parallelism and to develop support for application-level fault tolerance in applications using multiple GPUs. Our techniques reduce the burden of enhancing single-GPU applications to support these features. To achieve our goal, this work designs and implements a framework for enhancing a single-GPU OpenCL application through application transformation.

97 MATHEMATICS AND COMPUTING↗

Laboratory report on iodine ( 129 I and 127 I) speciation, transformation and mobility in Handford groundwater, suspended particles and sediments

The Hanford Site in eastern Washington produced plutonium for several decades and in the process generated billions of gallons of radioactive waste. Included in this complex mixture of waste was 50 Ci of iodine-129 ( 129 I). Iodine-129’s high abundance, due to its high fission yield, and extreme toxicity result in iodine-129 becoming a key risk driver at many Department of Energy (DOE) sites. The mobility of radioiodine in arid environments, such as the Hanford Site, depends largely on its chemical speciation and is also greatly affected by many other environmental factors, especially natural sediment organic matter (SOM). Groundwater radioiodine speciation has not been measured in arid regions with major plumes or large disposed 129 I inventories, including the Hanford Site, Idaho National Laboratory, and Nevada Test Site. In this study, stable iodine-127 and radioiodine-129 speciation, pH, and dissolved organic carbon (DOC) of groundwater samples collected from seven wells located in the 200-West Area of the Hanford site were investigated. The most striking finding was that iodate (IO 3 - ) was the most abundant species. Unexpectedly, iodide (I - ), which was likely the form of iodine in the source materials and the expected dominant groundwater species based on thermodynamic considerations, only accounted for 1-2% of the total iodine concentration. It is likely that the relatively high pH and the low abundance of sedimentary organic matter (SOM) that is present at the site slowed down or even inhibited the reduction of iodate, as SOM abiotically reduce iodate into iodide. Moreover, a study on the kinetics of iodide and iodate uptake and aqueous speciation transformation by three representative subsurface Hanford sediments was performed over a period of about one month. This study was carried out by using iodide-125 or iodate-125 at the ambient iodine-127concentration found at the site. Iodate K d values were on average 89% greater than iodide K d values, and the K d values for both species tended to increase with the amount of organic carbon (OC) present in the sediment. It is especially noteworthy that this trend existed at the very low OC concentrations that naturally exist in the Hanford sediments. Iodine and OC can form essentially irreversible covalent bonds, thereby providing a yet unstudied 129 I retardation reaction at the Hanford Site. In addition to the transformation of iodine species, the sediment collected from the vadose zone also released stable iodide into the aqueous phase. It was found that the three sediments all took up the ambient iodate from the groundwater and slowly transformed it into iodide under the laboratory conditions, likely dependent on the abundance of reducing agents such as organic matter and Fe 2+ . Therefore two competitive iodine processes were identified, the tendency for the sediment to reduce iodate to iodide, and the groundwater chemistry to maintain the iodine as iodate, presumably it is largely the result of natural pH and dissolved O 2 /Eh levels. Suspended carbonate (and silica) particles collected from Hanford groundwater contained elevated amounts of iodine (142 ± 8 μg/g iodine), consisting mainly of iodate (>99%). Iodate was likely incorporated into the carbonate structure during calcite precipitation upon degasing of CO 2 as the groundwater samples were removed from the subsurface. This concentration of groundwater iodate in precipitated carbonate has implication to long-term fate and transport of 129 I and on active in-situ 129 I groundwater remediation. This study provides some of the first groundwater radioiodine speciation studies conducted in arid environments and provides much needed mechanistic descriptions to permit making informed decisions about low-cost/high intellectual input remediation options, such as monitored natural attenuation, or long-term stewardship of nuclear waste disposal sites.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Efficient transformer study: Analysis of manufacture and utility data

Distribution transformers convert power from the distribution system voltage to the end-customer voltage, which consists of residences, businesses, distributed generation, campus systems, and manufacturing facilities. Amorphous metal distribution transformers (AMDT) are also more expensive and heavier than conventional silicon steel distribution transformers. This and the difficulty to measure the benefit from energy efficiency and low awareness of the technology have hindered the adoption of AMDT. This report presents the cost savings for installing AMDT and the amount of energy saved based on the improved efficiency.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Polynomial Similarity Transformation Theory: A smooth interpolation between coupled cluster doubles and projected BCS applied to the reduced BCS Hamiltonian

We present a similarity transformation theory based on a polynomial form of a particle-hole pair excitation operator. In the weakly correlated limit, this polynomial becomes an exponential, leading to coupled cluster doubles. In the opposite strongly correlated limit, the polynomial becomes an extended Bessel expansion and yields the projected BCS wavefunction. In between, we interpolate using a single parameter. The e ective Hamiltonian is non-hermitian and this Polynomial Similarity Transformation Theory follows the philosophy of traditional coupled cluster, left projecting the transformed Hamiltonian onto subspaces of the Hilbert space in which the wave function variance is forced to be zero. Similarly, the interpolation parameter is obtained through minimizing the next residual in the projective hierarchy. We rationalize and demonstrate how and why coupled cluster doubles is ill suited to the strongly correlated limit whereas the Bessel expansion remains well behaved. The model provides accurate wave functions with energy errors that in its best variant are smaller than 1% across all interaction stengths. The numerical cost is polynomial in system size and the theory can be straightforwardly applied to any realistic Hamiltonian.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Power Hardware-in-the-Loop Testing of Distribution Solid State Transformers

Savannah River National Laboratory and Resilient Power Systems have developed a utility grade solid state transformer and are planning on deploying it for testing in January 2018. The solid state transformer is the next generation solution to implementation of distributed energy resources such as solar and batteries. They can directly connect the solar and battery systems to DC ports and rout power between these DC ports and load ports. The solid state transformer can revolutionize current grid modernization initiatives by supplying grid support and building support services at the edge of the grid. These services consist of volt-VAR optimization, power factor correction, voltage regulation, frequency regulation, fault current support, demand side management, DC bus for AC/DC capable houses, and power routing between multiple ports for transactive control. For this fiscal year a test plan for testing the SST capabilities was develop. Along with the FPGA controls for the SST output ports. These controls will allow for any waveform to be produced by each port of the SST. Finally, a hybrid distribution SST was tested at the eGRID resulting in medium voltage testing experience for SRNL engineering team. DOE is currently engaged, through the Building Technology Office and Infrastructure Security and Energy Restoration in future work building from this project.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Identification of Potential Locations for Placement of Strategic Transformers Reserve in Puerto Rico

Extreme weather events such as tropical storms cause extensive damage to energy infrastructures including generator stations, substations, poles, transformers, power transmission lines, etc. due to their presence in hazardous locations. Often these damages lead to long term power outage as was seen in Puerto Rico (PR) following the landfall of Hurricane Maria (2017). A potential solution to long-term power outage is strategic placement of reserve generators and transformers that would ensure continued power supply to enable restoration and recovery activities. The strategic placement of energy storage devices requires identification of potential sites such that (i) the damage from extreme events to energy infrastructures is minimized, (ii) power supply is optimized, and (iii) installation of these infrastructures is cost effective. To meet this goal, in this research, a Multi-Criteria Evaluation (MCE) technique-based site suitability analysis was implemented to identify potential sites for reserve generators and transformers in PR. To determine suitable sites and existing government facilities, the following steps were implemented: (i) identify physical, environmental, technical and socio-economic factors contributing to site suitability; (ii) determine siting constraints based on guidelines and standards used for energy sector (i.e., siting of nuclear plants, solar or wind farms), (iii) implement a raster data model using 30m x 30m spatial resolution to create suitability layers for each factor, (iv) combine suitability and exclusionary layers to create the final suitability layer. Results show that six hospitals, four colleges and universities, and five correctional facilities are in very high suitability areas and could be used for to store reserve generators. These facilities are in the eastern, south-eastern, south-western, and southern part of the island except for one correctional facility that is in the northern part of PR. Not surprisingly, coastal areas were found to be unsuitable for siting any energy facility. More than half (55.9%) of the island was also found to be unsuitable while only 14% of the island was found to be very highly suitable. Further assessment of current power plants and sub-stations indicated that only 16% and 42% of existing power plants and sub-stations respectively are in suitable areas. Given that northern part of the island lacks any facility that could be used for placement of reserve generators, suitable sites identified in this region could be used for placement of storage devices.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Eutectoid Transformation in U10Mo Alloy: Effect of Deformation History and Homogenization Heat Treatment

In the United States, uranium 10 wt.% molybdenum (U10Mo) alloy has been selected as the nuclear fuel that will be used when transitioning research reactors and radioisotope production facilities from highly enriched uranium (>85% 235 U) fuel to low-enriched uranium (<20% 235 U) fuel. The fabrication steps for producing U10Mo fuel foil involve multiple hot-rolling/cold-rolling/intermediate annealing steps. The U10Mo alloy, which can retain the desirable high-temperature body-centered cubic γ-U (A2) structure at room temperature as a metastable phase for optimum in-reactor performance, goes through a eutectoid reaction below ~560°C and forms a-U as a reaction product, which is highly undesirable. Because the fabrication steps are carried out in the temperature range of 500 to 700°C, it is critical to understand the eutectoid reaction kinetics as a function of rolling/annealing steps. In this study, we determined the eutectoid transformation behavior of various rolled/annealed U10Mo coupons at 450, 500, and 525°C. The results show that the highest degree of phase transformation occurs when the U10Mo billet is rolled down from the as-cast condition without any prior homogenization treatment. Further, we observed that mechanical deformation (in the form of hot-rolling/cold-rolling) leads to increased eutectoid transformation compared to the billets that were not deformed.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Application of symmetries to differential equations: symmetry reduction and solution transformation examples

In the following lecture notes, we provide an outline of what we mean by symmetries of differential equations and illustrate their utility in simplification of differential equations which may lead to solutions. Loosely, a symmetry of a differential equation is a local group of transformations acting on the space of independent and dependent variables that transform solutions of a differential equation to new solutions, i.e., if Δ(x,u,p)=0 denotes a differential equation with a solution prescribed by [x,u,p], then knowlege of a symmetry facilitates the attainment of a new solution, [$\tilde{x}$, $\tilde{u}$, $\tilde{p}$], such that Δ(x,u,p)=Δ($\tilde{x}$, $\tilde{u}$, $\tilde{p}$)=0. In Equations (1) and (2), x, u and p denote the independent variables, dependent variables and partial derivatives, respectively and the tildes denote the transformations. Equation (2) will subsequently be referred to as the symmetry criterion. We can apply the knowlede of the existence of a symmetry in two ways: 1) If not solution is known apriori, the symmetry can be applied to simplify the differential equation through the method of symmetry reduction. Often, the resultant simplification may enable a solution to be determined; 2) If we already possess a solution to a different equation, knowledge of an admissible symmetry enables us to generate new solutions.

97 MATHEMATICS AND COMPUTING↗

EVPSC modeling of 316 stainless steel with and without observed phase transformation

The following is a description of modeling the constitutive behavior of the transforming and non-transforming 316 stainless steel measured in-situ at APS. Details of the elasto-viscoplastic self-consistent (EVPSC) polycrystal deformation model are described in the literature and only the salient information is given here. The EVPSC model is a general rate-sensitive self-consistent polycrystal plasticity model valid at arbitrary large deformations. The homogenizing method used is the self-consistent approach, originally proposed by Kröner, assuming that each grain is an ellipsoidal inclusion embedded in an infinite homogeneous equivalent medium (HEM), where the interaction is determined using Eshelby's solution. The hardening behavior is described by a Voce type strain hardening law, and the phase transformation uses a strain energy criterion for choosing a single daughter grain for each parent grain that reaches a critical value of the Von Mises equivalent strain. The orientation relationship between parent and daughter grains is determined based upon a rotation matrix that preserves an invariant line between the parent and daughter. The evolution law for the growth of the martensite phase is based on an empirical accumulated shear strain law proposed by Olson and Cohen. The single crystal elastic constants for the austenite phase are as reported for 316 stainless steel and the single crystal elastic constants of the martensite are taken from hardened SAE 1050 plain-carbon steel.

36 MATERIALS SCIENCE↗

Quantification of MagLIF Morphology using the Mallat Scattering Transformation

The morphology of the stagnated plasma resulting from Magnetized Liner Inertial Fusion (MagLIF) is measured by imaging the self-emission x-rays coming from the multi-keV plasma, and the evolution of the imploding liner is measured by radiographs. Equivalent diagnostic response can be derived from integrated rad-MHD simulations from programs such as Hydra and Gorgon. There have been only limited quantitative ways to compare the image morphology, that is the texture, of simulations and experiments. We have developed a metric of image morphology based on the Mallat Scattering Transformation (MST), a transformation that has proved to be effective at distinguishing textures, sounds, and written characters. This metric has demonstrated excellent performance in classifying ensembles of synthetic stagnation images. We use this metric to quantitatively compare simulations to experimental images, cross experimental images, and to estimate the parameters of the images with uncertainty via a linear regression of the synthetic images to the parameter used to generate them. This coordinate space has proved very adept at doing a sophisticated relative back-ground subtraction in the MST space. This was needed to compare the experimental self emission images to the rad-MHD simulation images. We have also developed theory that connects the transformation to the causal dynamics of physical systems. This has been done from the classical kinetic perspective and from the field theory perspective, where the MST is the generalized Green's function, or S-matrix of the field theory in the scale basis. From both perspectives the first order MST is the current state of the system, and the second order MST are the transition rates from one state to another. An efficient, GPU accelerated, Python implementation of the MST was developed. Future applications are discussed.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Basic Research Needs for Transformative Manufacturing

This report is based on a Basic Research Needs workshop for Transformative Manufacturing, which was held March 9 - 11, 2020. The focus of the workshop was to identify the basic science research priorities that could accelerate innovation to transform manufacturing in the future. This was the first workshop of its kind to examine how basic energy science can drive manufacturing forward and innovate new ways to manufacture goods. Five Priority Research Directions were identified that address these science challenges: (1) innovative synthetic approaches to enable scalable assembly of matter, (2) computational methods and theoretical models to transform how manufacturing processes are controlled, (3) new characterization tools that can handle the necessary complexity, scales, and processing speeds to meet manufacturing needs, (4) new science to address opportunities relevant to sustainable and energy efficient manufacturing, and (5) foundational approaches to co-design of materials, process, and products.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Analytically Derived Piezoelectric Ejecta Data Transformations, with Implications for Claims of Experimentally Observed Self-Similarity

Building upon a previously documented analytic formalism, we derive a set of data transformations that relate piezoelectrically inferred time-dependent ejecta masses, dynamical ejecta cloud densities, and "radiographic" ejecta cloud density distributions. These transformation rules are derived rigorously, with careful attention to the assumption of instant ejecta production which is inherent in the piezoelectric mass inference procedure. Some of these relationships have not appeared previously in the literature, including solutions for the unique ejecta velocity distribution and radiographic ejecta cloud density distribution consistent with the instant-production assumption for a given piezoelectrically inferred mass dataset. In deriving the latter, we prove that—again subject to the ubiquitous instant-creation assumption—measurements at a single sensor are sufficient to determine properties of the ejecta cloud everywhere at all times. Other data transformation relationships have appeared in the literature without a rigorous derivation, or have been stated in forms that obscure the key mathematical relationships. We apply these results to arguments for self-similar ejecta cloud evolution, thereby deriving mathematical expressions by which claims of self-similarity may be examined. We prove that one analysis used in the literature to claim experimental evidence of a short ejecta production timescale—and consequently of self-similar cloud evolution—in fact places no constraint the ejecta production interval and therefore does not support the associated conclusion. We also provide a potentially useful uniqueness proof.

30 DIRECT ENERGY CONVERSION↗

Coupling of CTF and TRANSFORM using the Functional Mockup Interface

An in-memory coupling between the sub-channel thermal hydraulics code COBRA-TF (CTF), which is included in the Virtual Environment for Reactor Applications (VERA), and the systems code Transient Simulation Framework of Reconfigurable Models (TRANSFORM) was developed in this work. Data exchange is accomplished by using the Functional Mock-Up Interface (FMI), an open standard for coupling dynamic systems models together. The FMI-based coupling necessitated the development of a novel FORTRAN wrapper for communicating with Functional Mock-Up Units. This wrapper will facilitate future FMI-based code couplings with other FORTRAN-based programs. CTF-TRANSFORM is exercised on a simplified Molten Salt Reactor Experiment (MSRE) model in steady-state and transient configurations. The coupled CTF-TRANSFORM model is shown to predict core temperature deltas similar to those available in historical MSRE operational data and is shown to be robust to fast power transients.The coupling paves the way to performing sensitivity and design studies impossible with VERA/CTF alone, in which secondary and tertiary loop operating conditions and design parameters may be perturbed and their impact on the core operating conditions studied.

97 MATHEMATICS AND COMPUTING↗

Tapless Voltage Regulating Transformer. Final Report

Voltage regulation is a common practice in power grid operation. The conventional voltage regulation methods have been facing ever increasing challenges as the penetration of renewable generations deepens in the grid. The intermittent nature of the renewable sources may result in sudden rise or drop of power generation, possibly breaking the generation-load balance. A lack of adequate voltage control not only affects the power quality but is detrimental to the system operation with the potential for large economic losses. Most conventional voltage regulation devices rely on mechanical tap changers to impose the regulation in a step-wise manner. Although sufficient for normal operations, the mechanical tap changers can be easily worn out in the challenging situations created by renewables. In this project, a novel technology called tapless voltage regulating transformer (TAREX) was proposed and investigated. It has the potential to excel at addressing the new voltage regulation challenges and replace the conventional regulating transformers. TAREX is based on the concept of the saturable-core reactor (SCR). The voltage of a TAREX can be smoothly and continuously regulated in a reasonable range by using a low rating power electronics based controller. It uses control of the transformer core magnetization to regulate the voltage on the windings, and thus eliminates the mechanical tap changer. This project is to prove the principle of TAREX, understand the voltage regulation mechanism, and preliminarily understand its impacts on the power systems through modeling, prototyping, and testing.

24 POWER TRANSMISSION AND DISTRIBUTION↗

How Artificial Intelligence and Machine Learning Transform the Human Condition

Our July 2021 symposium, “How Artificial Intelligence and Machine Learning Transform the Human Condition,” was hosted through a partnership between Los Alamos National Laboratory and the National Academies of Sciences, Engineering, and Medicine’s Committee on Science, Technology, and Law. The symposium is part of a broader initiative focusing on harnessing transformative technologies, and builds on our September 2020 symposium titled, “COVID-19: Harnessing a Transformational Pandemic.” Topics such as systems biology and artificial intelligence not only represent compelling research frontiers but also highlight national security challenges with social, ethical, and legal implications.

60 APPLIED LIFE SCIENCES↗