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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,351 records · Page 75
All sourcesNASA NTRSDOE OSTI
NASA NTRS1990

Microgravity strategic plan, 1990

The mission of the NASA Microgravity program is to utilize the unique characteristics of the space environment, primarily the near absence of gravity, to understand the role of gravity in materials processing, and to demonstrate the feasibility of space production of improved materials that have high technological, and possible commercial, utility. The following five goals for the Microgravity Program are discussed: (1) Develop a comprehensive research program in fundamental sciences, materials science, and biotechnology for the purpose of attaining a structured understanding of gravity dependent physical phenomena in both Earth and non-Earth environments; (2) Foster the growth of interdisciplinary research community to conduct research in the space environment; (3) Encourage international cooperation for the purpose of conducting research in the space environment; (4) Utilize a permanently manned, multi-facility national microgravity laboratory in low-Earth orbit to provide a long-duration, stable microgravity environment; (5) Promote industrial applications of space research for the development of new, commercially viable products, services, and markets resulting from research in the space environment.

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NASA NTRS2003

Space Station Science Supported by Marshall Space Flight Center

The science program at Marshall Space Flight Center will be reviewed in the context of the overall NASA science program. An overview will be given on how Marshall science supports the International Space Station research program. The Microgravity research capabilities at Marshall's Biological and Physical Space Research Laboratory will be reviewed. The environment in orbit provides a unique opportunity to study Materials Science and Biotechnology in the absence of sedimentation and convection. There are a number of peer-selected investigations that have been selected to fly on the Space Station that have been conceived and are led by Marshall civil service and contractor scientists. In addition to Microgravity research the Station will enable research in New Initiative Research Areas that focus on enabling humans to live, work, and explore the solar system safely. The specific scientific instruments that have been developed for Materials Science and Biotechnology Research on the International Space Station will be discussed.

Whitaker, Ann F.↗
NASA NTRS1988

Wave drag and high-speed performance of supersonic STOVL fighter configurations

A supersonic STOVL fighter aircraft aerodynamic research program is being conducted at NASA Ames Research Center. The research focuses on technology development for this type of aircraft and includes generating an extensive aerodynamic database and resolving particular aerodynamic uncertainties for various twin- and single-engine aircraft concepts. Highlights of the results from this program are presented. The highlights include propulsion-induced effects on the aircraft drag, prediction capabilities, volume integration for minimizing drag, and wave drag and aerodynamic efficiency comparisons. Results indicate that estimated STOVL fighter performance is roughly comparable to the performance of modern conventional fighters in terms of wave drag and aerodynamic efficiency.

Durston, Donald A.↗
NASA NTRS1988

Wave Drag and High-speed Performance of Supersonic STOVL Fighter Configuration

A supersonic STOVL fighter aircraft aerodynamic research program is under way at NASA Ames Research Center. The research focuses on technology development for this type of aircraft and includes generating an extensive aerodynamic database and resolving particular aerodynamic uncertainties for various twin- and single-engine aircraft concepts. Highlights of the results from this program are presented. The highlights include propulsion-induced effects on the aircraft drag, prediction capabilities, volume integration for minimizing drag, and wave drag and aerodynamic efficiency comparisons. Results indicate that estimated STOVL fighter performance is roughly comparable to the performance of modern conventional fighters in terms of wave drag and aerodynamic efficiency.

Durston, Donald A.↗
NASA NTRS1982

Space Research and Technology Program: Program and specific objectives, document approval

A detailed view of the Space Research and Technology program work breakdown structure is provided down to the specific objective level. Goals or objectives at each of these levels are set forth. The specific objective narratives are structured into several parts. First, a short paragraph statement of the specific objective is given. This is followed by a list of subobjectives. A list of targets is then provided for those areas of the specific objective that are amenable to a quantitative description of technical accomplishment and schedule. Fluid and thermal physics, materials and structures, computer science and electronics, space energy conversion, multidisciplinary research, controls and human factors, chemical propulsion, spacecraft systems, transportation systems, platform systems, and spacecraft systems technology comprise the principal research programs.

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NASA NTRS1979

Spin flight research summary

An extensive general aviation stall/spin research program is underway at the NASA Langley Research Center. Flight tests have examined the effects of tail design, wing leading edge design, mass distribution, and minor airframe modifications on spin and recovery characteristics. Results and observations on test techniques are presented for the first airplane in the program. Configuration changes produced spins varying from easily recoverable slow, steep spins to unrecoverable, fast flat spins.

Patton, J. M., Jr.↗
NASA NTRS1983

A NASA high-power space-based laser research and applications program

Applications of high power lasers are discussed which might fulfill the needs of NASA missions, and the technology characteristics of laser research programs are outlined. The status of the NASA programs or lasers, laser receivers, and laser propulsion is discussed, and recommendations are presented for a proposed expanded NASA program in these areas. Program elements that are critical are discussed in detail.

Deyoung, R. J.↗
NASA NTRS1989

Mach 5 inlet CFD and experimental results

An experimental research program was conducted in the NASA Lewis Research Center 10 x 10 ft supersonic wind tunnel. The 2-D inlet model was designed to study the Mach 3.0 to 5.0 speed range for an over-under turbojet plus ramjet propulsion system. The model was extensively instrumented to provide both analytical code validation data as well as inlet performance information. Support studies for the program include flow field predictions with both 3-D parabolized Navier-Stokes (PNS) and 3-D full Navier-Stokes (FNS) analytical codes. Analytical predictions and experimental results are compared.

Weir, Lois J.↗
NASA NTRS1989

Mach 5 inlet CFD and experimental results

An experimental research program was conducted in the NASA Lewis Research Center 10 ft. by 10 ft. supersonic wind tunnel. The two-dimensional inlet model was designed to study the Mach 3.0 to 5.0 speed range for an 'over-under' turbojet plus ramjet propulsion system. The model was extensively instrumented to provide both analytical code validation data as well as inlet performance information. Support studies for the program include flow field predictions with both three-dimensional parabolized Navier-Stokes (PNS) and three-dimensional full Navier-Stokes (FNS) analytical codes. Analytical predictions and experimental results are compared.

Weir, Lois J.↗
NASA NTRS2006

Miniature Wireless Sensors Size Up to Big Applications

Like the environment of space, the undersea world is a hostile, alien place for humans to live. But far beneath the waves near Key Largo, Florida, an underwater laboratory called Aquarius provides a safe harbor for scientists to live and work for weeks at a time. Aquarius is the only undersea laboratory in the world. It is owned by the National Oceanic and Atmospheric Administration (NOAA), administered by NOAA s National Undersea Research Program, and operated by the National Undersea Research Center at the University of North Carolina at Wilmington. Aquarius was first deployed in underwater operations in 1988 and has since hosted more than 200 scientists representing more than 90 organizations from around the world. For NASA, Aquarius provides an environment that is analogous to the International Space Station (ISS) and the space shuttle. As part of its NASA Extreme Environment Mission Operations (NEEMO) program, the Agency sends personnel to live in the underwater laboratory for up to 2 weeks at a time, some of whom are crew members or "aquanauts" who are subjected to the same tasks and challenges underwater that they would face in space. In fact, many participants have found the deep-sea diving experience to be much akin to spacewalking. To maintain Aquarius, the ISS, and the space shuttle as safe, healthy living/research habitats for its personnel, while keeping costs in mind, NASA, in 1997, recruited the help of Conroe, Texas-based Invocon, Inc., to develop wireless sensor technology that monitors and measures various environmental and structural parameters inside these facilities.

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NASA NTRS1993

The atmospheric effects of stratospheric aircraft: A third program report

A third report from the Atmospheric Effects of Stratospheric Aircraft (AESA) component of NASA's High-Speed Research Program (HSRP) is presented. Market and technology considerations continue to provide an impetus for high-speed civil transport research. A recent United Nations Environment Program scientific assessment showed that considerable uncertainty still exists about the possible impact of aircraft on the atmosphere. The AESA was designed to develop the body of scientific knowledge necessary for the evaluation of the impact of stratospheric aircraft on the atmosphere. The first Program report presented the basic objectives and plans for AESA. This third report marks the midpoint of the program and presents the status of the ongoing research on the impact of stratospheric aircraft on the atmosphere as reported at the third annual AESA Program meeting in June 1993. The focus of the program is on predicted atmospheric changes resulting from projected HSCT emissions. Topics reported on cover how high-speed civil transports (HSCT) might affect stratospheric ozone, emissions scenarios and databases to assess potential atmospheric effects from HSCT's, calculated results from 2-D zonal mean models using emissions data, engine trace constituent measurements, and exhaust plume/aircraft wake vortex interactions.

Stolarski, Richard S.↗
NASA NTRS1992

Large space-based systems for dealing with global environment change

Increased concern over the effects of global climate change and depletion of the ozone layer has resulted in support for the Global Change Research Program and the Mission to Planet Earth. Research to understand Earth system processes is critical, but it falls short of providing ways of mitigating the effects of change. Geoengineering options and alternatives to interactively manage change need to be developed. Space-based concepts for dealing with changes to the environment should be considered in addition to Earth-based actions. 'Mission for Planet Earth' describes those space-based geoengineering solutions that may combine with an international global change program to stabilize the Global environment. Large space systems that may be needed for this response challenge guidance and control engineering and technology. Definition, analysis, demonstration, and preparation of geoengineering technology will provide a basis for policy response if global change consequences are severe.

Jenkins, Lyle M.↗
DOE OSTI2016

SU-F-SPS-08: Measuring the Interaction Of DDR Cell Receptors and Extracellular Matrix Collagen in Prostate Cells

Purpose: Discoidin domain receptors (DDR) have recently been recognized as important players in cancer progression. DDRs are cell receptors that interact with collagen, an extracellular matrix (ECM) protein. However the detailed mechanism of their interaction is unclear. Here we attempted to examine their interaction in terms of structural (surface topography), mechanical (rupture force), and kinetic (binding probability) information on the single molecular scale with the use of atomic force microscopy (AFM). Methods: The Quantitative Nano-mechanical property Mapping (QNM) mode of AFM allowed to assess the cells in liquid growth media at their optimal physiological while being viable. Human benign prostate hyperplasia (BPH-1) cell line was genetically regulated to suppress DDR expression (DDR- cells) and was compared with naturally DDR expressing cells (DDR+). Results: Binding force measurements (n = 1000) were obtained before and after the two groups were treated with fibronectin (FN), an integrin-inhibiting antibody to block the binding of integrin. The quantification indicates that cells containing DDR bind with collagen at a most probable force of 80.3–83.0 ±7.6 pN. The probability of them binding is 0.167 when other interactions (mainly due to integrin-collagen binding) are minimized. Conclusion: Together with further force measurements at different pulling speeds will determine dissociation rate, binding distance and activation barrier. These parameters in benign cells provides some groundwork in understanding DDR’s behavior in various cell microenvironments such as in malignant tumor cells. Funding supported by Richard Barber Interdisciplinary Research Program of Wayne State University.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1992

Toward a microgravity research strategy

Recommendations of the Committee on Microgravity Research (CMGR) of the Space Studies Board of the National Research Council are found in the Summary and Recommendations in the front of the report. The CMGR recommends a long-range research strategy. The main rationale for the microgravity research program should be to improve our fundamental scientific and technical knowledge base, particularly in the areas that are likely to lead to improvements in processing and manufacturing on earth. The CMGR recommends research be categorized as Biological science and technology, Combustion, Fluid science, Fundamental phenomena, Materials, and Processing science and technology. The committee also recommends that NASA apply a set of value criteria and measurement indicators to define the research and analysis program more clearly. The CMGR recommends that the funding level for research and analysis in microgravity science be established as a fixed percentage of the total program of NASA's Microgravity Science and Applications Division in order to build a strong scientific base for future experiments. The committee also recommends a cost-effective approach to experiments. Finally the CMGR recommends that a thorough technical review of the centers for commercial development of space be conducted to determine the quality of their activities and to ascertain to what degree their original mission has been accomplished.

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DOE OSTI2018

Radiation Therapy Research: A Global Analysis 2001-2015

Radiation therapy is a core modality of cancer treatment; however, concerns have been expressed regarding its underutilization and its lack of prioritization as a research domain relative to other cancer treatment modalities, despite its rapid technical evolution. It is therefore important to understand, from a public policy perspective, the evolution of global radiation therapy research, to identify strengths, weaknesses, and opportunities. This study used a bibliometric approach to undertake a quantitative analysis of global radiation therapy research published between 2001 and 2015 and available in the Web of Science (Wos) database, with particular focus on the 25 leading research-active countries. A total of 62,550 radiation therapy research articles from 127 countries, published in 2531 international journals, were analyzed. The United States was responsible for 32.3% of these outputs, followed by Japan (8.0%) and Germany (7.7%). Nearly half of all publications related to preparation and delivery of radiation therapy, combined-modality regimens, and dose fractionation studies. Health services research, palliative care, and quality of life studies represented only 2%, 5%, and 4% of all research outputs, respectively. Countries varied significantly in their commitment to different research domains, and trial-related publications represented only 5.1% of total output. Research impact was analyzed according to 3 different citation scores, with research outputs from Denmark, The Netherlands, and the United States consistently the highest ranked. Globally, radiation therapy publication outputs continue to increase but lag behind other spheres of cancer management. The types of radiation therapy research undertaken appear to be regionally patterned, and there is a clear disconcordance between the volume of research output from individual countries and its citation impact. Greater support for radiation therapy research in low- and middle-income countries is required, including international collaboration. The study findings are expected to provide the requisite knowledge to guide future radiation therapy research programs.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2015

TU-CD-303-05: Unveiling Tumor Heterogeneity by Molecular Imaging

Recent advances in cancer research have shed new light on the complex processes of how therapeutic radiation initiates changes at cellular, tissue, and system levels that may lead to clinical effects. These new advances may transform the way we use radiation to combat certain types of cancers. For the past two decades many technological advancements in radiation therapy have been largely based on the hypothesis that direct radiation-induced DNA double strand breaks cause cell death and thus tumor control and normal tissue damage. However, new insights have elucidated that in addition to causing cellular DNA damage, localized therapeutic radiation also initiates cascades of complex downstream biological responses in tissue that extend far beyond where therapeutic radiation dose is directly deposited. For instance, studies show that irradiated dying tumor cells release tumor antigens that can lead the immune system to a systemic anti-cancer attack throughout the body of cancer patient; targeted irradiation to solid tumor also increases the migration of tumor cells already in bloodstream, the seeds of potential metastasis. Some of the new insights may explain the long ago discovered but still unexplained non-localized radiation effects (bystander effect and abscopal effect) and the efficacy of spatially fractionated radiation therapy (microbeam radiation therapy and GRID therapy) where many “hot” and “cold” spots are intentionally created throughout the treatment volume. Better understanding of the mechanisms behind the non-localized radiation effects creates tremendous opportunities to develop new and integrated cancer treatment strategies that are based on radiotherapy, immunology, and chemotherapy. However, in the multidisciplinary effort to advance new radiobiology, there are also tremendous challenges including a lack of multidisciplinary researchers and imaging technologies for the microscopic radiation-induced responses. A better grasp of the essence of these advances in cancer biology research will give medical physicists a new perspective in daily clinical physics practice and in future radiation therapy technological development. Furthermore, academic medical physics should continue to be an integral part of the multidisciplinary cancer research community, harnessing our newly acquired understanding of radiation effects, and developing novel cost-effective treatment strategies to better combat cancer. Learning Objectives: Understand that localized radiation can lead to non-localized secondary effects such as radiation-induced immune response, bystander effect, and abscopal effect. Understand that the non-localized radiation effects may be harnessed to improve cancer treatment. Learn examples of physics participation in multidisciplinary research to advance cancer biology. Recognize the challenges and possibilities of physics applications in cancer research. Chang: NIH 5RC2CA148487-02 and 1U54CA151652-01 Graves: IDEA award (19IB-0106) from the California Breast Cancer Research Program (CBCRP), and by NIH P01 CA67166.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2010

Life Sciences Data Archives (LSDA) in the Post-Shuttle Era

Now, more than ever before, NASA is realizing the value and importance of their intellectual assets. Principles of knowledge management-the systematic use and reuse of information, experience, and expertise to achieve a specific goal-are being applied throughout the agency. LSDA is also applying these solutions, which rely on a combination of content and collaboration technologies, to enable research teams to create, capture, share, and harness knowledge to do the things they do well, even better. In the early days of spaceflight, space life sciences data were collected and stored in numerous databases, formats, media-types and geographical locations. These data were largely unknown/unavailable to the research community. The Biomedical Informatics and Health Care Systems Branch of the Space Life Sciences Directorate at JSC and the Data Archive Project at ARC, with funding from the Human Research Program through the Exploration Medical Capability Element, are fulfilling these requirements through the systematic population of the Life Sciences Data Archive. This project constitutes a formal system for the acquisition, archival and distribution of data for HRP-related experiments and investigations. The general goal of the archive is to acquire, preserve, and distribute these data and be responsive to inquiries for the science communities. Information about experiments and data, as well as non-attributable human data and data from other species' are available on our public Web site http://lsda.jsc.nasa.gov. The Web site also includes a repository for biospecimens, and a utilization process. NASA has undertaken an initiative to develop a Shuttle Data Archive repository. The Shuttle program is nearing its end in 2010 and it is critical that the medical and research data related to the Shuttle program be captured, retained, and usable for research, lessons learned, and future mission planning. Communities of practice are groups of people who share a concern or a passion for something they do, and learn how to do it better as they interact regularly. LSDA works with the HRP community of practice to ensure that we are preserving the relevant research and data they need in the LSDA repository. An evidence-based approach to risk management is required in space life sciences. Evidence changes over time. LSDA has a pilot project with Collexis, a new type of Web-based search engine. Collexis differentiates itself from full-text search engines by making use of thesauri for information retrieval. The high-quality search is based on semantics that have been defined in a life sciences ontology. Additionally, Collexis' matching technology is unique, allowing discovery of partially matching dicuments. Users do not have to construct a complicated (Boolean) search query, but can simply enter a free text search without the risk of getting "no results". Collexis may address these issues by virtue of its retrieval and discovery capabilities across multiple repositories.

Fitts, Mary A.↗
DOE OSTI2016

SU-F-P-33: Combining Research and Professional Practice in the Clinical Setting: A Medical Physicist Personal Experience

Purpose: To initiate a discussion on the current and evolving role of Medical Physicists based on author’s professional and research experience in patient safety and quality control. Methods: Several professionals of the departments of Medical Physics and Radiation Oncology, chiefly devoted to clinical tasks, began a research program on patient safety and quality control in a framework provided by the implementation of intraoperative radiotherapy (IORT). We performed studies on virtual simulation for IORT, in vivo dosimetry, failure mode and effect analysis (FMEA), statistical process control (SPC), and receiver operating characteristics of dosimetric equipment. This was done with the support of our research foundation and different grants while continuing with our departmental clinical routine involving about 1600 annual treatments with two linacs and different brachytherapy techniques. Results: We published 5 papers in international journals in the last two years. This author conducted a doctoral research which resulted in a dissertation in 2015. The extra time spent after treatments was essential to succeed. Funding and support achieved via our foundation played a crucial role; but this would have not been possible without punctual external mentoring and partnership. FMEA conclusions were able to be implemented only with staff commitment; however, conclusions concerning equipment cannot be easily communicated to manufacturers. These tasks required extra training in the appropriated methods. Conclusion: Research needed the support of a dedicated foundation, which would have been very difficult to obtain with the sole participation of our departments. FMEA and SPC results may need engagement of staff and manufacturers, respectively, hard to achieve without strong recommendations or even a regulatory framework. All these fields need evolution of Medical Physicists’ roles and additional training. Devotion to both clinical tasks and research could be unfeasible for Medical Physicists in the clinical setting without the appropriate rearrangement of their schedules and tasks. Supported by grants IPT-300000-2010-3 and PI11/01659. ERDF funds and Spanish Government.

60 APPLIED LIFE SCIENCES↗