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At least 1,351 records · Page 75

Usefulness of a Pretreatment CT-Based Modified RENAL Nephrometry Score in Predicting Renal Function After Cryotherapy for T1a Renal Mass

Purpose: We investigated the usefulness of the modified RENAL nephrometry (mRN) scoring system for predicting post-cryotherapy renal function in patients with T1a renal mass. Patients and Methods: A total of 75 patients with a T1a renal mass were enrolled. The mRN score was determined based on the tumor size, the tumor’s exophytic/endophytic properties, the tumor’s nearness to the collecting system, and the anterior/posterior location of the kidney. The change in the estimated glomerular filtration rate (ΔeGFR) was calculated as follows: ΔeGFR = 100 × ([pretreatment eGFR − eGFR at 6 months after cryotherapy]/pretreatment eGFR). Based on the ΔeGFR results, we classified the patients into two groups: a preserved renal function group (ΔeGFR < 10%) and an impaired renal function group (ΔeGFR ≥ 10%). We then analyzed the relationships between the mRN score and ΔeGFR and between the mRN score and the chronic kidney disease (CKD) stage. Results: The mean ΔeGFR for all patients was 5.5%. The mRN scores of the preserved renal function group (5.8 ± 0.3) were significantly lower than those of the impaired group (7.4 ± 0.3) (p < 0.001). When the mRN score cutoff value was set at 7 points, the mRN had 67.7% sensitivity, 72.7% specificity, 61.8% positive predictive value (PPV), 76.1% negative predictive value (NPV), and 70.7% accuracy for predicting impaired renal function. For predicting a deterioration of CKD stage, the mRN had 92.9% sensitivity, 67.2% specificity, 39.4% PPV, 97.6% NPV, and 72% accuracy. Conclusion: Our newly proposed modified RENAL nephrometry score was suggested to be useful for predicting renal function after renal cryotherapy.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Penetrative convection - Parametrized expression for the growth rates

The equations determining the linear growth rate omega characterizing a convectively unstable fluid with Rayleigh number R(u) bounded below by an impenetrable free boundary and above by a convectively stable fluid with Rayleigh number R(s), are solved numerically. Using the analytical Rayleigh-Benard growth rate omega (RB) as a convenient functional form, it is possible to fit the numerical values for omega if the vertical wave number k(z) = n(pi) and the Rayleigh number R(RB) are taken to be functions of R(s), R(u), and the horizontal wave number k-perpendicular rather than n = integer as in the Rayleigh-Benard case. In addition, contrary to Rayleigh-Benard convection, in which the critical Rayleigh number is fixed, it is found that R super (cr) sub u is variable in the presence of a stable layer, (i.e., it depends on R(s)).

Savolainen, V.↗

Design of Multi-Parameter Steerable Functions Using Cascade Basis Reduction

A new cascade basis reduction method of computing the optimal least-squares set of basis functions steering a given function is presented. The method combines the Lie group-theoretic and the singular value decomposition approaches in such a way that their respective strengths complement each other. Since the Lie group-theoretic approach is used, the set of basis and steering functions computed can be expressed analytically. Because the singular value decomposition method is used, this set of basis and steering functions is optimal in the least-squares sense. Furthermore, the computational complexity in designing basis functions for transformation groups with large numbers of parameters is significantly reduced. The efficiency of the cascade basis reduction method is demonstrated by designing a set of basis functions that steers a Gabor function under the four-parameter linear transformation group.

Teo, P.↗

Horizon constraints on holographic Green’s functions

We explore a new class of general properties of thermal holographic Green’s functions that can be deduced from the near-horizon behaviour of classical perturbations in asymptotically anti-de Sitter spacetimes. We show that at negative imaginary Matsubara frequencies and appropriate complex values of the wavenumber the retarded Green’s functions of generic operators are not uniquely defined, due to the lack of a unique ingoing solution for the bulk perturbations. From a boundary perspective these ‘pole-skipping’ points correspond to locations in the complex frequency and momentum planes at which a line of poles of the retarded Green’s function intersects with a line of zeroes. As a consequence the dispersion relations of collective modes in the boundary theory at energy scales ω ~ T are directly constrained by the bulk dynamics near the black-brane horizon. For the case of conserved U(1) current and energy-momentum tensor operators we give examples where the dispersion relations of hydrodynamic modes pass through a succession of poleskipping points as real wavenumber is increased. We discuss implications of our results for transport, hydrodynamics and quantum chaos in holographic systems.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Design of fuzzy system by NNs and realization of adaptability

The issue of designing and tuning fuzzy membership functions by neural networks (NN's) was started by NN-driven Fuzzy Reasoning in 1988. NN-driven fuzzy reasoning involves a NN embedded in the fuzzy system which generates membership values. In conventional fuzzy system design, the membership functions are hand-crafted by trial and error for each input variable. In contrast, NN-driven fuzzy reasoning considers several variables simultaneously and can design a multidimensional, nonlinear membership function for the entire subspace.

Takagi, Hideyuki↗

Electrochemical CO2 Reduction over Metal-/Nitrogen-Doped Graphene Single-Atom Catalysts Modeled Using the Grand-Canonical Density Functional Theory

Renewably driven, electrochemical conversion of carbon dioxide into value-added products is expected to be a critical tool in global decarbonization. However, theoretical studies based on the computational hydrogen electrode largely ignore the nonlinear effects of the applied potential on the calculated results, leading to inaccurate predictions of catalytic behavior or mechanistic pathways. Here, we use grand canonical density functional theory (GC-DFT) to model electrochemical CO2 reduction (CO2R) over metal- and nitrogen-doped graphene catalysts (MNCs) and explicitly include the effects of the applied potential. We used GC-DFT to compute the CO2 to CO reaction intermediate energies at -0.3, -0.7, and -1.2 VSHE catalyzed by MNCs each doped with 1 of the 10 3d block metals coordinated by four pyridinic nitrogen atoms. Our results predict that Sc-, Ti-, Co-, Cu-, and Zn-N4Cs effectively catalyze CO2R at moderate to large reducing potentials (-0.7 to -1.2 VSHE). ZnN4C is a particularly promising electrocatalyst for CO2R to CO both at low and moderate applied potentials based on our thermodynamic analysis. Our findings also explain the observed pH independence of CO production over FeN4C and predict that the rate-determining step of CO2R over FeN4C is not *CO2- formation but rather *CO desorption. Additionally, the GC-DFT-computed density of states analysis illustrates how the electronic states of MNCs and adsorbates change non-uniformly with applied potential, resulting in a significantly increased *CO2- stability relative to other intermediates and demonstrating that the formation of the adsorbed *CO2- anion is critical to CO2R activation. This work demonstrates how GC-DFT paves the way for physically realistic and accurate theoretical simulations of reacting electrochemical systems.

CO2 reduction↗

Different bonding type along each crystallographic axis: Computational study of poly($\textit{p}$-phenylene terephthalamide)

Poly($\textit{p}$-phenylene terephthalamide) (PPTA) exhibits van der Waals (vdW) bonding along its $\textit{a}$ axis, hydrogen bonding along its $\textit{b}$ axis, and covalent bonding along its $\textit{c}$ axis. In this work, we explore the structural and mechanical properties of PPTA using density functional theory with various functionals including LDA, PBE, PBE+rVV10L, SCAN, and SCAN+rVV10, compared with available experiments. The hierarchy of nonempirical semilocal functionals LDA, PBE, and SCAN (not fitted to any multicenter bonded system) includes differing amounts of intermediate-range vdW interaction. rVV10 is the long-range vdW correction. (rVV10L differs from rVV10 only in the value of a range parameter.) Among the tested functionals, SCAN shows the best performance for the lattice parameters of PPTA along the two crystal directions involving vdW or hydrogen-bond interaction. The equilibrium lattice constants obtained by SCAN and PBE+rVV10L are closest to experimental data, while SCAN+rVV10 slightly overbinds the system. We study the mechanical response of PPTA by applying strain along three lattice directions. Due to the inclusion of vdW interaction, SCAN, PBE+rVV10L, and SCAN+rVV10 all exhibit correct bonding strain-energy curves. On the contrary, PBE strongly underestimates the vdW interaction needed to resist uniaxial stretching along the $\textit{a}$ axis. The Young's modulus and yield strength of PPTA are computed and compared with previous results. The experimental values are much smaller than the computed ones, mainly due to the fact that the PPTA fiber samples used for measurements are mechanically weaker than the perfect molecular crystals considered in the simulations. Interestingly, when a compressive uniaxial stress of 25 Kbar is applied along the $\textit{b}$ axis, a structural phase transition, in which the hydrogen bonds reform along one diagonal of the $\textit{ab}$ rectangle, is predicted by SCAN.

36 MATERIALS SCIENCE↗

Review of Power System Support Functions for Inverter-Based Distributed Energy Resources - Standards, Control Algorithms, and Trends

Penetration of renewable energy in power systems has been increasing in the past decades in response to increased global electricity demand and concerns for the environment. Distributed energy resources (DERs) based on renewables have experienced rapid growth thanks to the incentive programs and broad-based participation. With the growing prevalence of DERs, the risk of grid instability and vulnerability increases due to the intermittent nature of renewable energy. At the same time, the voltage and frequency deviation problems emerge more often when the reverse power flow occurs under supply-demand imbalance in distributed power systems. Standards and grid codes have been issued for DER inverters to interconnect with the distribution grid. The updated standard and grid codes expect DERs to provide a variety of power system support functions in order to incorporate higher DER penetration and to maximize DER value to the grid. This paper provides an overview of the power system support functions from renewable DER inverters, which are categorized as: voltage regulation by active/reactive power control, frequency regulation by active power control, voltage ride-through, and frequency ride-through. The benefits and drawbacks of each algorithm are presented and compared with its predecessor, manifesting the logic in the evolution of the algorithms.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Repeatable masking of sensitive data

The various technologies presented herein relate to enabling a value generated based upon a physical unclonable function (PUF) response to be available as needed, while also preventing exposure of the PUF to a malicious entity. A masked PUF response can be generated based upon applying a function to a combination of the PUF response and a data file (e.g., a bitstream), and the masked PUF response is forwarded to a requesting entity, rather than the PUF response. Hence, the PUF is masked from any entity requiring access to the PUF. The PUF can be located in a FPGA, wherein the data file is a bitstream pertinent to one or more configurable logic blocks included in the FPGA. A first masked PUF response generated with a first data file can have a different value to a second masked PUF response generated with a second data file.

Hamlet, Jason↗

Shorter function summaries for finite state machine-based high consequence systems using logic synthesis and tautologies (Final Report LDRD 24-1302)

Computer programs are often viewed as collections of functions – each function has parameters (inputs) and computes a return value, and each has potential side effects that modify program state (outputs). In this research, a Sandia symbolic execution tool designed to support “human-in-the-loop” analysis was modified to automatically create “function summaries,” and a new tool, “diaboolical,” was created to support enhancing readability of the summary using a novel approach to bit-vector simplification that leverages logic synthesis and tautologies. For this effort, students at Auburn University created several finite state machines (FSMs) to serve as exemplars for high-consequence systems. Function summaries for each of the machines were obtained, and then portions of the summaries were simplified using both diaboolical and the simplification procedure of a popular SMT solver. A comparison of the results shows that diaboolical can often produce smaller function summaries, with expression length improvements over the unsimplified function summaries ranging from 0% to 90% for diaboolical and 0% to 65% for the SMT solver, though diaboolical had a significantly greater cost in time. Diaboolical was evaluated against a collection of “arbitrary” C-code as well as FSM exemplars, and for both datasets it achieved an approximately 10% improvement in expression length compared to simplifications that could be obtained using existing techniques. Function summaries can assist assurance efforts that evaluate existing systems and their executable code. A smaller function summary is likely easier for humans to understand and could thus increase the ability and efficacy of assurance practices centered around the analysis of executable artifacts.

97 MATHEMATICS AND COMPUTING↗

Temporal RNA Integrity Analysis of Archived Spaceflight Biological Samples from ALSDA from 1991 to 2016

The purpose of this study is to assess the quality of spaceflight tissues stored in Ames Life Science Data Archive (ALSDA) freezers. Garnering information for downstream functional analysis such as generation of omics datasets from tissues is, in part, dependent on the state of sample preservation. To assess the viability of a select group of tissues, RNA integrity number (RIN) values were calculated for RNA extracted from rodent livers. Rat livers from Spacelab Life Sciences 1 (SLS-1) and mouse livers from Commercial Biomedical Test Module 3 (CBTM-3), Rodent Research 1 (RR1), and Rodent Research 3 (RR3) were tested. It was found that mean RIN values from CBTM3, RR1, and RR3 were suitable for downstream functional analysis (RIN greater than 5) while the mean RIN value for SLS-1 was not (RIN equal to 2.5 plus or minus 0.1). Information from this study could lay the foundation for future efforts in determining the types of assays that are most appropriate for different tissues in ALSDA freezers, which would maximize the scientific return on rare spaceflight samples.

ALSDA↗

Demand Curve Estimation of Locally Produced Woody Biomass Products

Abstract. The goal of the Waste-to-Wisdom project is to produce and sell value-added products derived from post-harvest forest residues including wood briquettes, torrefied briquettes, and biochar. The consumer demand for these products (i.e., market size) determines the success of manufacturers especially when the location of production is far away from a population center and the producer is a price taker. Consumers are often scattered and transportation costs from the factory to retail stores lower the net sales revenue at the plant. The objective of this study was to estimate the demand curves and the associated revenue functions of the bioenergy products in five case locations applying a market-based analysis. We first estimated the size of the potential market for the products in each location and then assumed a market penetration rate to estimate consumer demand. This information was used to develop a set of mathematical functions based on deductive logic. Plugging presumable values based on scenario assumptions into the models contributes to the economic feasibility studies. Keywords: Biochar, Forest products marketing, Market penetration rate, Price skimming strategy, Wood briquette.

Agriculture↗

Cosmological parameters and evolution of the galaxy luminosity function

The relationship between the observed distribution of discrete sources of a flux limited sample, the luminosity function of these sources, and the cosmological model is discussed. It is stressed that some assumptions about the form and evolution of the luminosity function must be made in order to determine the cosmological parameters from the observed distribution of sources. Presented is a method to test the validity of these assumptions using the observations. It is shown how, using higher moments of the observed distribution, one can determine, independently of the cosmological model, all parameters of the luminosity function except those describing evolution of the density and the luminosity of the luminosity function. These methods are applied to the sample of approximately 1000 galaxies recently used by Loh and Spillar to determine a value of the cosmological density parameter Omega approx = 1. It is shown that the assumptions made by Loh and Spillar about the luminosity function are inconsistent with the data, and that a self-consistent treatment of the data indicates a lower value of Omega approx = 0.2 and a flatter luminosity function. It should be noted, however, that incompleteness in the sample could cause a flattening of the luminosity function and lower the calculated value of Omega and that uncertainty in the values of these parameters due to random fluctuations is large.

Caditz, David↗

Cosmological parameters and evolution of the galaxy luminosity function

The relationship between the observed distribution of discrete sources of a flux limited sample, the luminosity function of these sources, and the cosmological model is discussed. It is stressed that some assumptions about the form and evolution of the luminosity function must be made in order to determine the cosmological parameters from the observed distribution of sources. Presented is a method to test the validity of these assumptions using the observations. It is shown how, using higher moments of the observed distribution, one can determine, independently of the cosmological model, all parameters of the luminosity function except those describing evolution of the density and the luminosity of the luminosity function. These methods are applied to the sample of approximately 1000 galaxies recently used by Loh and Spillar to determine a value of the cosmological density parameter Omega approx = 1. It is shown that the assumptions made by Loh and Spillar about the luminosity function are inconsistent with the data, and that a self-consistent treatment of the data indicates a lower value of Omega approx = 0.2 and a flatter luminosity function. It should be noted, however, that incompleteness in the sample could cause a flattening of the luminosity function and lower the calculated value of Omega and that uncertainty in the values of these parameters due to random fluctuations is large.

Caditz, David↗

Synthesis of feedback systems with large plant ignorance for prescribed time domain tolerances

There is given a minimum-phase plant transfer function, with prescribed bounds on its parameter values. The plant is imbedded in a two-degree-of freedom feedback system, which is to be designed such that the system time response to a deterministic input lies within specified boundaries. Subject to the above, the design should be such as to minimize the effect of sensor noise at the input to the plant. This report presents a design procedure for this purpose, based on frequency response concepts. The time-domain tolerances are translated into equivalent frequency response tolerances. The latter lead to bounds on the loop transmission function in the form of continuous curves on the Nichols chart. The properties of the loop transmission function which satisfy these bounds with minimum effect of sensor noise, are derived.

Horowitz, I. M.↗

Assessment at full scale of nozzle/wing geometry effects on OTW aero-acoustic characteristics

The effects on acoustic characteristics of nozzle type and location on a wing for STOL engine over-the-wing configurations are assessed at full scale on the basis of model-scale data. Three types of nozzle configurations are evaluated: a circular nozzle with external deflector mounted above the wing, a slot nozzle with external deflector mounted on the wing and a slot nozzle mounted on the wing. Nozzle exhaust plane locations with respect to the wing leading edge are varied from 10 to 46 percent chord (flaps retracted) with flap angles of 20 (takeoff altitude) and 60 (approach attitude). Perceived noise levels (PNL) are calculated as a function of flyover distance at 152 m altitude. From these plots, static EPNL values, defined as flyover relative noise levels, are calculated and plotted as a function of lift and thrust ratios. From such plots the acoustic benefits attributable to variations in nozzle/deflector/wing geometry at full scale are assessed for equal aerodynamic performance.

Groesbeck, D.↗

Assessment at full scale of nozzle/wing geometry effects on OTW aeroacoustic characteristics

The effects on acoustic characteristics of nozzle type and location on a wing for STOL engine over-the-wing configurations are assessed at full scale on the basis of model-scale data. Three types of nozzle configurations are evaluated: a circular nozzle with external deflector mounted above the wing, a slot nozzle with external deflector mounted on the wing and a slot nozzle mounted on the wing. Nozzle exhaust plane locations with respect to the wing leading edge are varied from 10 to 46 percent chord (flaps retracted) with flap angles of 20 deg (take-off attitude) and 60 deg (approach attitude). Perceived noise levels (PNL) are calculated as a function of flyover distance at 152 m altitude. From these plots, static EPNL values, defined as flyover relative noise levels, are calculated and plotted as a function of lift and thrust ratios. From such plots the acoustic benefits attributable to variations in nozzle/deflector/wing geometry at full scale are assessed for equal aerodynamic performance.

Groesbeck, D.↗