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Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery

Electronic Health Record (EHR) systems typically define laboratory test results using the Laboratory Observation Identifier Names and Codes (LOINC) and can transmit them using Fast Healthcare Interoperability Resource (FHIR) standards. LOINC has not yet been semantically integrated with computational resources for phenotype analysis. Here, we provide a method for mapping LOINC-encoded laboratory test results transmitted in FHIR standards to Human Phenotype Ontology (HPO) terms. We annotated the medical implications of 2923 commonly used laboratory tests with HPO terms. Using these annotations, our software assesses laboratory test results and converts each result into an HPO term. We validated our approach with EHR data from 15,681 patients with respiratory complaints and identified known biomarkers for asthma. Finally, we provide a freely available SMART on FHIR application that can be used within EHR systems. Our approach allows readily available laboratory tests in EHR to be reused for deep phenotyping and exploits the hierarchical structure of HPO to integrate distinct tests that have comparable medical interpretations for association studies.

60 APPLIED LIFE SCIENCES↗

A multi-beamlet analysis of the MITICA accelerator

The thermo-mechanical analysis and the mechanical design of the accelerator of MITICA (i.e. the full size prototype of the ITER neutral beam injector under construction at RFX [1]) are based on the calculation of the power deposition induced by particle impacts. This calculation is performed by EAMCC [2], a relativistic particle tracking code based on the Monte-Carlo method for describing collisions inside the accelerator, under prescribed electric and magnetic fields. The magnetic field maps are produced by 3D codes, while the electric field maps come from the 2D axi-symmetric code SLACCAD [3]. In order to perform a multi-beamlet analysis, which allows to take into account the beamlet-beamlet repulsion, and to consider other effects neglected under the hypothesis of axi-symmetric beam, a fully 3D version of the code is required. In this paper, a modified version of EAMCC, fully 3D, capable of modifying the mesh of the 3D maps and of dealing with uneven meshes is presented. A finer mesh is used just in the regions where a more detailed description of the fields is required, for a more realistic simulation. A comparison between the original code and the modified version is presented at first, as a validation of the modifications introduced in the latter. Subsequently, the main results of a single-beamlet analysis performed with the two versions of the code are shown and the differences between the 2D and the 3D simulations discussed. The last part is dedicated to the multi-beamlet simulation of the accelerator.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Optimization of the design of thick, segmented scintillators for megavoltage cone-beam CT using a novel, hybrid modeling technique

Purpose: Active matrix flat-panel imagers (AMFPIs) incorporating thick, segmented scintillators have demonstrated order-of-magnitude improvements in detective quantum efficiency (DQE) at radiotherapy energies compared to systems based on conventional phosphor screens. Such improved DQE values facilitate megavoltage cone-beam CT (MV CBCT) imaging at clinically practical doses. However, the MV CBCT performance of such AMFPIs is highly dependent on the design parameters of the scintillators. In this paper, optimization of the design of segmented scintillators was explored using a hybrid modeling technique which encompasses both radiation and optical effects. Methods: Imaging performance in terms of the contrast-to-noise ratio (CNR) and spatial resolution of various hypothetical scintillator designs was examined through a hybrid technique involving Monte Carlo simulation of radiation transport in combination with simulation of optical gain distributions and optical point spread functions. The optical simulations employed optical parameters extracted from a best fit to measurement results reported in a previous investigation of a 1.13 cm thick, 1016μm pitch prototype BGO segmented scintillator. All hypothetical designs employed BGO material with a thickness and element-to-element pitch ranging from 0.5 to 6 cm and from 0.508 to 1.524 mm, respectively. In the CNR study, for each design, full tomographic scans of a contrast phantom incorporating various soft-tissue inserts were simulated at a total dose of 4 cGy. Results: Theoretical values for contrast, noise, and CNR were found to be in close agreement with empirical results from the BGO prototype, strongly supporting the validity of the modeling technique. CNR and spatial resolution for the various scintillator designs demonstrate complex behavior as scintillator thickness and element pitch are varied—with a clear trade-off between these two imaging metrics up to a thickness of ∼3 cm. Based on these results, an optimization map indicating the regions of design that provide a balance between these metrics was obtained. The map shows that, for a given set of optical parameters, scintillator thickness and pixel pitch can be judiciously chosen to maximize performance without resorting to thicker, more costly scintillators. Conclusions: Modeling radiation and optical effects in thick, segmented scintillators through use of a hybrid technique can provide a practical way to gain insight as to how to optimize the performance of such devices in radiotherapy imaging. Assisted by such modeling, the development of practical designs should greatly facilitate low-dose, soft tissue visualization employing MV CBCT imaging in external beam radiotherapy.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

SPSP Phase III Recruiting, Selecting, and Developing Secure Power Systems Professionals: Individual and Team Performance Guidelines

The pending retirement of significant numbers of power system experts and a continuing trend of increasing complexity in modern power systems prompted the U.S. Department of Energy (DOE) to establish the three-phase Secure Power Systems Professional (SPSP) project. The project developed resources for job definition and competency analysis along with tools to guide assessment and curriculum design and to help identify and develop required knowledge, skills, and abilities in technical and operational aspects of power systems cybersecurity. The Secure Power Systems Professional Phase III final report was released last year which an appendix of Individual and Team Performance Guidelines. This new report is that appendix broken out as a standalone document to assist utilities in recruiting and developing Secure Power Systems Professionals at their site. Individual/Team Performance Guidelines were developed for each of the four job roles: the secure power systems engineer, incident responder, intrusion analyst, and security operator. They enable an “at-a-glance” view of the multidisciplinary and collaborative nature of SPSP job roles, for which skill sets were studied and then mapped to stories of critical incidents or vignettes. This afforded an enumeration of tasks required of each job role to effectively perform responsibilities and to meet bestpractice goals for that operation. Assignment of these tasks among the job roles, either as an individual responsibility or a collaborative responsibility, was validated during a job performance model analysis. The analysis identified 13 master vignettes from the collection of critical incident stories, many of which shared a common set of job responsibilities and tasks that were grouped into four vignette categories according to the task requirement for effective response to each event.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Multiscale Auroral Emission Statistics as Evidence of Turbulent Reconnection in Earth's Midtail Plasma Sheet

We provide indirect evidence for turbulent reconnection in Earth's midtail plasma sheet by reexamining the statistical properties of bright, nightside auroral emission events as observed by the UVI experiment on the Polar spacecraft and discussed previously by Uritsky et al. The events are divided into two groups: (1) those that map to absolute value of (X(sub GSM)) < 12 R(sub E) in the magnetotail and do not show scale-free statistics and (2) those that map to absolute value of (X(sub GSM)) > 12 R(sub E) and do show scale-free statistics. The absolute value of (X(sub GSM)) dependence is shown to most effectively organize the events into these two groups. Power law exponents obtained for group 2 are shown to validate the conclusions of Uritsky et al. concerning the existence of critical dynamics in the auroral emissions. It is suggested that the auroral dynamics is a reflection of a critical state in the magnetotail that is based on the dynamics of turbulent reconnection in the midtail plasma sheet.

Klimas, Alex↗

Spatial and Temporal Dust Source Variability in Northern China Identified Using Advanced Remote Sensing Analysis

The aim of this research is to provide a detailed characterization of spatial patterns and temporal trends in the regional and local dust source areas within the desert of the Alashan Prefecture (Inner Mongolia, China). This problem was approached through multi-scale remote sensing analysis of vegetation changes. The primary requirements for this regional analysis are high spatial and spectral resolution data, accurate spectral calibration and good temporal resolution with a suitable temporal baseline. Landsat analysis and field validation along with the low spatial resolution classifications from MODIS and AVHRR are combined to provide a reliable characterization of the different potential dust-producing sources. The representation of intra-annual and inter-annual Normalized Difference Vegetation Index (NDVI) trend to assess land cover discrimination for mapping potential dust source using MODIS and AVHRR at larger scale is enhanced by Landsat Spectral Mixing Analysis (SMA). The combined methodology is to determine the extent to which Landsat can distinguish important soils types in order to better understand how soil reflectance behaves at seasonal and inter-annual timescales. As a final result mapping soil surface properties using SMA is representative of responses of different land and soil cover previously identified by NDVI trend. The results could be used in dust emission models even if they are not reflecting aggregate formation, soil stability or particle coatings showing to be critical for accurately represent dust source over different regional and local emitting areas.

spectral mixing analysis↗

An Overview of Production and Validation of the SMAP Passive Soil Moisture Product

The Soil Moisture Active Passive (SMAP) mission is an L-band mission scheduled for launch in Jan. 2015. The SMAP instruments consist of a radar and a radiometer to obtain complementary information from space for soil moisture and freeze/thaw state research and applications. By utilizing novel designs in antenna construction, retrieval algorithms, and acquisition hardware, SMAP provides a capability for global mapping of soil moisture and freeze/thaw state with unprecedented accuracy, resolution, and coverage. This improvement in hydrosphere state measurement is expected to advance our understanding of the processes that link the terrestrial water, energy and carbon cycles, improve our capability in flood prediction and drought monitoring, and enhance our skills in weather and climate forecast. For swath-based soil moisture measurement, SMAP generates three operational geophysical data products: (1) the radiometer-only soil moisture product (L2_SM_P) posted at 36-kilometer resolution, (2) the radar-only soil moisture product (L2_SM_A) posted at 3-kilometers resolution, and (3) the radar-radiometer combined soil moisture product (L2_SM_AP) posted at 9-kilometers resolution. Each product draws on the strengths of the underlying sensor(s) and plays a unique role in hydroclimatological and hydrometeorological applications. A full suite of SMAP data products is given in Table 1.

passive microwave↗

LOFTID Heat Flux Gauge Calibration: What is Truth?

The Low-Earth Orbit Flight Test of an Inflatable Decelerator (LOFTID) is a demonstration of Hypersonic Inflatable Aerodynamic Decelerator (HIAD) technology, which may enable the delivery of heavy payloads to Mars, Venus, and Titan, as well as return to Earth. Unlike rigid aeroshells that are constrained by the size of the rocket’s shroud, inflatable aeroshells can be deployed to a much larger scale, thus allowing a spacecraft to begin its deceleration earlier and experience less heating. On LOFTID, there will be 4 total heat flux gauges (HFG) with a range of 70 W/cm2 and 1 radiometer with a range of 3 W/cm2, arranged as shown in Fig. 1. Both the radiometer and total HFGs are Schmidt-Boelter gauges purchased from an external vendor. Radiative calibrations were performed in-house at NASA Ames’ Sensors and TPS Advanced Research Laboratories (STAR Labs) before and after environmental testing to investigate how the testing affected the sensors' response. Additional rounds of radiative calibration at STAR Labs were also performed in order to investigate the large uncertainties associated with these tests. For example, a survey of multiple calibration facilities concluded that the uncertainty within a given facility was +/-3% [1]. An additional NIST study that calibrated heat flux gauges at 7 different facilities also found the variation in calibration coefficients to be up to ~3% within a given facility, but up to 15% between facilities, suggesting systematic differences between test setups [2]. Finally, the response of heat flux gauges to radiative versus convective heat flux has shown to differ by up to 20% [3],[4]. Because the heat flux gauges on LOFTID will predominantly experience convective heat flux during flight, a convective calibration study was performed at Boeing's Large-Core Arc Tunnel (LCAT) facility. Radiative Calibration Procedure The calibrations performed at STAR Labs utilize a quartz lamp bank (QLB) that provides a maximum heat flux of 50 W/cm2, which bounds the expected LOFTID flight environment. The calibration involves exposing a water-cooled Gardon gauge (reference) and then the unit-under-test (UUT) to 5 different heat fluxes multiple times for 10 seconds each, and then calculating a linear fit. The test setup is shown in Fig. 2. The total HFGs were calibrated at STAR Labs 3 times, denoted as STAR 1 (before environmental testing), STAR 2 (after protoflight vibration and thermal-vacuum testing), and STAR 3 (no change from previous test). All 8 flight-lot total HFGs showed a decrease in full-scale output from STAR 1 to STAR 2 by between 0.5% and 10. The first portion of this investigation was to determine whether the change could be due to differences in temperature between the two calibration runs. A typical linear fit to the calibration data was performed using Eq. 1 where q’ is the heat flux in W/cm2, c is the calibration coefficient, and mV is the sensor output. To account for temperature, the data were fit to a nonlinear function that included both the sensor output (mV) and the temperature from the thermocouple embedded inside the HFG near the surface (T): q'=mV/(c1* T + c0}. The residuals between the fits and the actual data points were calculated for every point, and proven to be much smaller for the temperature-compensated fits than for the linear fits for all sensors. An example is shown in Fig. 3. When the temperature-compensated fits from STAR 1 were applied to the STAR 2 data, the residuals did not improve, suggesting that the change in sensitivity between these two calibration runs was not due to temperature. A third round of calibration (STAR 3) was conducted to further address the temperature dependence of the total HFGs, and the resulting sensitivities matched closely to STAR 2 (within 2%). Temperature-compensated calibration curves were once again fit to the data. In this case, when the temperature-compensated fits from STAR 3 were applied to STAR 2 data, the residuals between the fits and STAR 2 data were much lower than the residuals due to the linear fits. This suggests that the changes seen between STAR 1 and STAR 2 were likely due to actual changes in the sensors caused by the environmental testing between the two calibrations. A modification of the original calibration process, in which the UUT was exposed to each heat flux for just 3 seconds (instead of 10) to reduce the temperature increase during the test, was additionally performed on several of the HFGs. In general, the sensitivities were 1-1.5% lower than from the 10-second tests, but the temperatures were also significantly lower. When the temperature-compensated fits from the 10-second tests were applied to the 3-second test data, the residuals were greatly improved than when just using the linear fits, further suggesting that the temperature-compensated fits may lead to better accuracy than the linear fits in flight. Convective Calibration The second portion of this study was to create a mapping between the radiative and convective calibration coefficients. The majority of the heating during flight will be convective, so it is important to understand how the HFG response differs under these conditions. However, there are no standardized methods for convective calibration [5]. Because the TPS aerothermal response models were validated at LCAT, the same facility was chosen for convective calibration of two of the total HFGs (Fig. 4). Preliminary results showed that the full-scale output was 3% and 8% higher in convective heat flux as compared to radiative heat flux. However, tunnel variation may have contributed to noise and uncertainty in the measurements, and more testing and analysis remains to be done. Scope of Presentation The presentation will include an overview of the changes seen in HFG calibration before and after environmental testing, differences between radiative and convective calibrations, the modeling work done to aid in understanding the sensor response to varying environments, and recommended future work.

H S Alpert↗

A peak position comparison method for high-speed quantitative Laue microdiffraction data processing

Indexing Laue patterns of a synchrotron microdiffraction scan can take as much as ten times longer than collecting the data, impeding efficient structural analysis using this technique. Here in this paper, a novel strategy is developed. By comparing the peak positions of adjacent Laue patterns and checking the intensity sequence, grain and phase boundaries are identified, requiring only a limited number of indexing steps for each individual grain. Using this protocol, the Laue patterns can be indexed on the fly as they are taken. The validation of this method is demonstrated by analyzing the microstructure of a laser 3D printed multi-phase/multi-grain Ni-based superalloy.

36 MATERIALS SCIENCE↗

Capitalize on the benefits of OAB - looking beyond the standard setup

Going beyond the initial setup of OAB, how to customize and maintain OAB to fit your current business process. There are many challenges in mapping data from outside sources into OAB and interfacing it to Payroll. Also, life events and fast formulas play a critical role in the customization of OAB.

Oracle validation↗

Distribution Model Creation using Circuit Maps for Applied PV Impact Studies

Photovoltaic (PV) generation is becoming increasingly common on power distribution systems. The output fluctuations of this variable resource necessitate the creation of an accurate model to ensure that any adverse impacts to the distribution system are properly addressed. To reduce model creation time, a method of extracting data from AutoCAD drawings using scripted methods was developed. This paper will present a distribution model creation and validation process, document case studies of evaluating the impact of PV interconnections on utility distribution feeders, and discuss future applications. PV integration was found to be easier on 23 kV circuits compared to 4.16 kV circuits.

integrated circuit modeling↗

Mapping the downwelling atmospheric radiation at the Earth's surface: A research strategy

A strategy is presented along with background material for determining downward atmospheric radiation at the Earth's surface on a regional scale but over the entire globe, using available information on the temperature and humidity of the air near the ground and at cloud base altitudes. Most of these parameters can be inferred from satellite radiance measurements. Careful validation of the derived radiances will be required using ground-based direct measurements of radiances, to avoid systematic biases of these derived field quantities.

Raschke, E.↗

Meta-analysis of North American Arctic and boreal aboveground biomass datasets: assessing accuracy, dynamics, and similarities

The North American arctic and boreal regions (ABRs) are rapidly warming and experiencing intensifying disturbances. Accurately quantifying aboveground biomass (AGB) is critical for understanding the impacts of these changes on the carbon cycle and for designing climate change mitigation strategies. Several AGB maps have been developed for the North American ABRs, including recent contributions from National Aeronautics and Space Administration’s Arctic-Boreal Vulnerability Experiment (ABoVE) campaign. However, these maps differ widely in training data, methodology, and resulting AGB density estimates. Presently, a comprehensive comparative evaluation is lacking, making it difficult for users to select datasets suited to their research or management needs. Here, in this study, we conducted a comparative analysis of nine AGB density datasets across North American ABRs, specifically for Alaska and Canada. We (1) summarized AGB by ecoregion and Canadian provinces, (2) evaluated their accuracy against field-based measurements, (3) analyzed spatial and temporal similarities among datasets, and (4) assessed their ability to capture disturbance (fire and harvest) impacts on AGB. We found substantial variation in regional and local AGB estimates across datasets, with overall accuracy ranging from R 2 = 0.25–0.62 and Bias% from −47.8% to 69.9% when validated against field plots. Despite these differences, most datasets have comparatively consistent spatial patterns in AGB (r > 0.8 for most cases). In contrast, agreement on the temporal patterns of AGB change is generally low. We found datasets with spatial resolutions ⩽300 m are capable of capturing disturbance impacts on AGB dynamics, though sensitivity varies across products. Our findings and dataset summary provide guidance for selecting appropriate AGB datasets for different applications within our study area. Our analysis also highlights the need to decrease map bias and increase capability to detect temporal change to decrease uncertainty of AGB datasets potentially by using training data which is representative of major plant functional types within the mapped area.

ABoVE↗

Alterations in the nuclear proteome of HIV-1 infected T-cells

Virus infection of a cell involves the appropriation of host factors and the innate defensive response of the cell. The identification of proteins critical for virus replication may lead to the development of novel, cell-based inhibitors. In this study we mapped the changes in T-cell nuclei during human immunodeficiency virus type 1 (HIV-1) at 20 hpi. Using a stringent data threshold, a total of 13 and 38 unique proteins were identified in infected and uninfected cells, respectively, across all biological replicates. An additional 15 proteins were found to be differentially regulated between infected and control nuclei. STRING analysis identified four clusters of protein–protein interactions in the data set related to nuclear architecture, RNA regulation, cell division, and cell homeostasis. Immunoblot analysis confirmed the differential expression of several proteins in both C8166-45 and Jurkat E6-1 T-cells. These data provide a map of the response in host cell nuclei upon HIV-1 infection. - Highlights: • We identify changes in the expression of nuclear proteins during HIV-1 infection. • 163 nuclear proteins were found differentially regulated during HIV-1 infection. • Bioinformatic analysis identified several nuclear pathways altered by HIV infection. • Candidate factors were validated in two independent cell lines.

60 APPLIED LIFE SCIENCES↗

Gas-Phase Temperature Mapping of Evaporating Microdroplets

Evaporation is a ubiquitous and complex phenomenon of importance to many natural and industrial systems. Evaporation occurs when molecules near the free interface overcome intermolecular attractions with the bulk liquid. As molecules escape the liquid phase, heat is removed, causing evaporative cooling. The influence of evaporative cooling on inducing a temperature difference with the surrounding atmosphere as well as within the liquid is poorly understood. Here, we develop a technique to overcome past difficulties encountered during the study of heterogeneous droplet evaporation by coupling a piezo-driven droplet generation mechanism to a controlled micro-thermocouple to probe microdroplet evaporation. The technique allowed us to probe the gas-phase temperature distribution using a micro-thermocouple (50 μm) in the vicinity of the liquid–vapor interface with high spatial (±10 μm) and temporal (±100 ms) resolution. We experimentally map the temperature gradient formed surrounding sessile water droplets having varying curvature dictated by the apparent advancing contact angle (100° ≲ θ ≲ 165°). The experiments were carried out at temperatures below and above ambient for a range of fixed droplet radii (130 μm ≲ R ≲ 330 μm). Our results provide a primary validation of the centuries-old theoretical framework underpinning heterogeneous droplet evaporation mediated by the working fluid, substrate, and gas thermophysical properties, droplet apparent contact angle, and droplet size. We show that microscale droplets residing on low-thermal-conductivity substrates such as glass absorb up to 8× more heat from the surrounding gas compared to droplets residing on high-thermal-conductivity substrates such as copper. Finally, our work not only develops an experimental understanding of the heat transfer mechanisms governing droplet evaporation but also presents a powerful platform for the study and characterization of liquid–vapor transport at curved interfaces wetting and nonwetting advanced functional surfaces.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Downscaling SSP-consistent global spatial urban land projections from 1/8-degree to 1-km resolution 2000–2100

Abstract Long-term, spatial urban land projections that simultaneously offer global coverage and local-scale empirical accuracy are rare. Recently a set of such projections was produced using data-science-based simulations and the Shared Socioeconomic Pathways (SSPs). These projections update at decadal time intervals from 2000 to 2100 with a spatial resolution of 1/8 degree, while many socio-environmental studies customarily run their analysis and modelling at finer spatial resolutions, e.g. 1-km. Here we develop and validate an algorithm to downscale the 1/8-degree spatial urban land projections to the 1-km resolution. The algorithm uses an iterative process to allocate the decadal amount of urban land expansion originally projected for each 1/8-degree grid to its constituent 1-km grids. The results are a set of global maps showing urban land fractions at the 1-km resolution, updated at decadal intervals from 2000 to 2100, under five different urban land expansion scenarios consistent with the SSPs. The data can support studies of potential interactions between future urbanization and environmental changes across spatial and temporal scales.

97 MATHEMATICS AND COMPUTING↗

Eulerian frequency analysis of structural vibrations from high-speed video

An approach for the analysis of the frequency content of structural vibrations from high-speed video recordings is proposed. The techniques and tools proposed rely on an Eulerian approach, that is, using the time history of pixels independently to analyse structural motion, as opposed to Lagrangian approaches, where the motion of the structure is tracked in time. The starting point is an existing Eulerian motion magnification method, which consists in decomposing the video frames into a set of spatial scales through a so-called Laplacian pyramid [1]. Each scale — or level — can be amplified independently to reconstruct a magnified motion of the observed structure. The approach proposed here provides two analysis tools or pre-amplification steps. The first tool provides a representation of the global frequency content of a video per pyramid level. This may be further enhanced by applying an angular filter in the spatial frequency domain to each frame of the video before the Laplacian pyramid decomposition, which allows for the identification of the frequency content of the structural vibrations in a particular direction of space. This proposed tool complements the existing Eulerian magnification method by amplifying selectively the levels containing relevant motion information with respect to their frequency content. This magnifies the displacement while limiting the noise contribution. The second tool is a holographic representation of the frequency content of a vibrating structure, yielding a map of the predominant frequency components across the structure. In contrast to the global frequency content representation of the video, this tool provides a local analysis of the periodic gray scale intensity changes of the frame in order to identify the vibrating parts of the structure and their main frequencies. Validation cases are provided and the advantages and limits of the approaches are discussed. The first validation case consists of the frequency content retrieval of the tip of a shaker, excited at selected fixed frequencies. The goal of this setup is to retrieve the frequencies at which the tip is excited. The second validation case consists of two thin metal beams connected to a randomly excited bar. It is shown that the holographic representation visually highlights the predominant frequency content of each pixel and locates the global frequencies of the motion, thus retrieving the natural frequencies for each beam.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Mapping extragalactic dark matter annihilation with galaxy surveys: A systematic study of stacked group searches

Dark matter in the halos surrounding galaxy groups and clusters can annihilate to high-energy photons. Recent advancements in the construction of galaxy group catalogs provide many thousands of potential extragalactic targets for dark matter. In this paper, we outline a procedure to infer the dark matter signal associated with a given galaxy group. Applying this procedure to a catalog of sources, one can create a full-sky map of the brightest extragalactic dark matter targets in the nearby Universe (z≲0.03), supplementing sources of dark matter annihilation from within the local group. As with searches for dark matter in dwarf galaxies, these extragalactic targets can be stacked together to enhance the signals associated with dark matter. We validate this procedure on mock Fermi gamma-ray data sets using a galaxy catalog constructed from the DarkSky N-body cosmological simulation and demonstrate that the limits are robust, at O(1) levels, to systematic uncertainties on halo mass and concentration. We also quantify other sources of systematic uncertainty arising from the analysis and modeling assumptions. Lastly, our results suggest that a stacking analysis using galaxy group catalogs provides a powerful opportunity to discover extragalactic dark matter and complements existing studies of Milky Way dwarf galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗