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Microgravity science and applications bibliography, 1990 revision

This edition of the Microgravity Science and Applications (MSA) Bibliography is a compilation of government reports, contractor reports, conference proceedings, and journal articles dealing with flight experiments utilizing a low gravity environment to elucidate and control various processes, or with ground based activities that provide supporting research. It encompasses literature published but not cited in the 1989 Revision and that literature which has been published in the past year. Subdivisions of the bibliography include: electronic materials; metals, alloys, and composites; fluids, interfaces, and transport; glasses and ceramics; biotechnology; combustion science; and experimental technology, facilities, and instrumentation. Also included are publications from the European, Soviet, and Japanese programs.

Source record↗

Transcapillary fluid shifts in head and neck tissues during and after simulated microgravity

To understand the mechanism, magnitude, and time course of facial puffiness that occurs in microgravity, seven male subjects were tilted 6 degrees head down for 8 hr, and all four Starling transcapillary pressures were directly measured before, during, and after tilt. Head-down tilt (HDT) caused facial edema and a significant elevation of microvascular pressures measured in the lower lip: capillary pressures increased from 27.2 +/- 5 mm Hg pre-HDT to 33.9 +/- 1.7 mm Hg by the end of tilt. Subcutaneous and intramuscular interstitial fluid pressures in the neck also increased as a result of HDT, while interstitial fluid colloid osmotic pressures remained unchanged. Plasma colloid osmotic pressures dropped significantly after 4 hr of HDT, suggesting a transition from fluid filtration to absorption in capillary beds between the heart and feet during HDT. After 4 hr of seated recovery from HDT, microvascular pressures remained significantly elevated by 5 to 8 mm Hg above baseline values, despite a significant HDT diuresis and the orthostatic challenge of an upright, seated posture. During the control (baseline) period, urine output was 46.7 ml/hr; during HDT, it was 126.5 ml/hr. These results indicate that facial edema resulting from HDT is primarily caused by elevated capillary pressures and decreased plasma colloid osmotic pressures. Elevation of cephalic capillary pressures sustained for 4 hr after HDT suggests that there is a compensatory vasodilation to maintain microvascular perfusion. The negativity of interstitial fluid pressures above heart level also has implications for the maintenance of tissue fluid balance in upright posture.

Parazynski, S. E.↗

Microgravity research at LeRC

The NASA Lewis Research Center is conducting a wide variety of ground-based science and microgravity flight experiments in the disciplines of fluid physics and transport phenomena, combustion science, and materials science. Extensive use is made of low-gravity ground-based facilities such as drop towers and a Learjet aircraft, as well as extensive normal-gravity laboratories. The ground-based facilities are utilized to execute science programs, perform precursor tests to define space experiment science requirements and conceptual designs, and also to perform tests for space experiment technology development and verification. Finally, flight hardware is designed, developed and flown on the Space Shuttle.

Kohl, Fred J.↗

A study of murine bone marrow cells cultured in bioreactors which create an environment which simulated microgravity

Previous research indicated that mouse bone marrow cells could be grown in conditions of simulated microgravity. This environment was created in rotating bioreactor vessels. On three attempts mouse cells were grown successfully in the vessels. The cells reached a stage where the concentrations were doubling daily. Phenotypic analysis using a panel of monoclonal antibodies indicated that the cell were hematopoietic pluripotent stem cells. One unsuccessful attempt was made to reestablish the immune system in immunocompromised mice using these cells. Since last summer, several unsuccessful attempts were made to duplicate these results. It was determined by electron microscopy that the cells successfully grown in 1989 contained virus particles. It was suggested that these virally parasitized cells had been immortalized. The work of this summer is a continuation of efforts to grow mouse bone marrow in these vessels. A number of variations of the protocol were introduced. Certified pathogen free mice were used in the repeat experiments. In some attempts the medium of last summer was used; in others Dexture Culture Medium containing Iscove's Medium supplemented with 20 percent horse serum and 10-6 M hydrocortisone. Efforts this summer were directed solely to repeating the work of last summer. Plans were made for investigations if stem cells were isolated. Immortalization of the undifferentiated stem cell would be attempted by transfection with an oncogenic vector. Selective differentiation would be induced in the stem cell line by growing it with known growth factors and immune response modulators. Interest is in identifying any surface antigens unique to stem cells that would help in their characterization. Another goal was to search for markers on stem cells that would distinguish them from stem cells committed to a particular lineage. If the undifferentiated hematopoietic stem cell was obtained, the pathways that would terminally convert it to myeloid, lyphoid, erythroid, or other cell lines would be studied. Transfection with a known gene would be attempted and then conversion to a terminally identifiable cell.

Lawless, Brother Desales↗

Solution growth of Triglycine Sulfate (TGS) crystals on the International Microgravity Laboratory (IML-1)

An experiment was planned for the International Microgravity Laboratory (IML-1) to be launched around Feb. 1991. Crystals of triglycine sulfate (TGS) will be grown by low temperature solution crystal growth technique using a multiuser facility called Fluid Experiment System (FES). A special cooled sting technique of solution crystal growth will be used where heat is extracted from the seed crystal through a semi-insulating sting, thereby creating the desired supersaturation near the growing crystal. Also, a holocamera will be used to provide tomography of the three dimensional flow field and particle image displacement velocimetry to monitor the convective flows.

Lal, Ravi B.↗

Minor surgery in microgravity

The purpose is to investigate and demonstrate equipment and techniques proposed for minor surgery on Space Station Freedom (SSF). The objectives are: (1) to test and evaluate methods of surgical instrument packaging and deployment; (2) to test and evaluate methods of surgical site preparation and draping; (3) to evaluate techniques of sterile procedure and maintaining sterile field; (4) to evaluate methods of trash management during medical/surgical procedures; and (4) to gain experience in techniques for performing surgery in microgravity. A KC-135 parabolic flight test was performed on March 30, 1990 with the goal of investigating and demonstrating surgical equipment and techniques under consideration for use on SSF. The flight followed the standard 40 parabola profile with 20 to 25 seconds of near-zero gravity in each parabola.

Billica, Roger↗

Microgravity laboratory simulations of planetary and stellar circulations

This paper summarizes experiments on thermal convection in a rotating differentially heated spherical shell of liquid that were carried out in the microgravity laboratory of Spacelab III. In these experiments, dielectric polarization forces were used to generate a radially-directed buoyancy force. This enabled the simulation of a number of geophysically and astrophysically important situations in which sphericity and rotation both impose strong constraints on the global scale fluid dynamics. Recent theoretical and numerical interpretations of the original data are discussed. Further laboratory experiments in the areas of geophysical and g-jitter fluid dynamics are suggested.

Hart, John E.↗

Instability of multi-layer fluid configurations in the presence of time-dependent accelerations in a microgravity environment

The increasing number of research opportunities in a microgravity environment will benefit not only fundamental studies in fluid dynamics, but also technological applications such as those involving materials processing. In particular, fluid configurations which involve fluid-fluid interfaces would occur in a variety of experimental investigations. This work investigates the stability of a configuration involving fluid-fluid interfaces in the presence of a time-dependent forcing. Both periodic (g-jitter) and nonperiodic accelerations are considered. The fluid configuration is multilayered, and infinite in extent. The analysis is linear and inviscid, and the acceleration vector is oriented perpendicular to each interface. A Floquet analysis is employed in the case of the periodic forcing. In the problem of nonperiodic forcing, the resulting system of equations are integrated in time. Specific nondimensional parameters appear in each problem. The configuration behavior is investigated for a range of parameter values.

Lyell, M. J.↗

Programmable multi-zone furnace for microgravity research

In order to provide new furnace technology to accommodate microgravity research studies and commercial applications in material processes, research has been initiated on the development of the Programmable-Multi-zone Furnace (PMZF). The PMZF is described as a multi-user materials processing furnace facility that is composed of thirty or more heater elements in series on a muffle tube or in a stacked ring-type configuration and independently controlled by a computer. One of the aims of the PMZF project is to allow furnace thermal gradient profiles to be reconfigured without physical modification of the hardware by creating the capability of reconfiguring thermal profiles in response to investigators' requests. The future location of the PMZF facility is discussed; the preliminary science survey results and preliminary conceptual designs for the PMZF are presented; and a review of multi-zone furnace technology is given.

Rosenthal, Bruce N.↗

Ground based preparation for microgravity growth of alloy semiconductors

Ground-based research conducted in order to prepare a microgravity space flight experiment is presented. The thermophysical properties of a PbSnTe alloy used for semiconductors are investigated, and furnace calibration and fluid-flow measurements are performed. The alloy has a zero energy crossing at approximately 40 percent SnTe in its band-gap vs composition diagram, which facilitates the design of long-wavelength IR detectors and lasers. The uniformity of devices made from this material depends on the ratio of PbTe and SnTe and requires the composition of the crystal growth to be closely controlled. The main obstacle to such control is the fact that liquid of this material is always solutally or thermally unstable, and, in a high-temperature gradient, the double convective instability cannot be made stable by balancing thermal and solutal expansion. In order to extend the science of crystal growth, the limits of suppression of convection have to be tested in low earth orbit.

Fripp, Archibald L.↗

A preview of a microgravity laser light scattering instrument

The development of a versatile, miniature, modular light scattering instrument to be used in microgravity is described. The instrument will measure microscopic particles in the size range of thirty angstroms to above three microns. This modular instrument permits several configurations, each optimized for a particular experiment. In particular, a multiangle instrument will probably be mounted in a rack in the Space Shuttle and on the Space Station. It is possible that a Space Shuttle glove-box and a lap-top computer containing a correlator card can be used to perform a number of experiments and to demonstrate the technology needed for more elaborate investigations.

Meyer, W. V.↗

Thermocapillary flow and melt/solid interfaces in floating-zone crystal growth under microgravity

Computer simulation of steady-state axisymmetrical heat transfer and fluid flow was conducted to study thermocapillary flow and melt/solid interfaces in floating-zone crystal growth under microgravity. The effects of key variables on the extent of thermocapillary flow in the melt zone, the shapes of melt/solid interfaces and the length of the melt zone were discussed. These variables are: (1) the temperature coefficient of surface tension (or the Marangoni number), (2) the pulling speed (or the Peclet number), (3) the feed rod radius, (4) the ambient temperature distribution, (5) the heat transfer coefficient (or the Biot number), and (6) the thermal diffusivity of the material (or the Prandtl number).

Lan, C. W.↗

A half-zone study of Marangoni convection in floating-zone crystal growth under microgravity

Floating-zone crystal growth under microgravity, though free from natural convection, can still be susceptible to Marangoni convection. The use of a ring heater in contact with most of the surface of the melt zone, has recently been considered as one way of reducing Marangoni convection in the melt zone. In order to study Marangoni convection in the melt zone in this modified floating-zone crystal growth process, a half-zone system was adopted. Computer simulation and direct observation of Marangoni convection in the half-zone system were carried out for two different cases. In the first case, the surface of the melt zone was completely free, while in the second it was mostly in contact with a quartz ring. The results of computer simulation and direct observation both indicated that in the second case Marangoni convection was significantly reduced near the melt/solid interface as well as in the bulk melt.

Lan, C. W.↗

A new approach to controller design for microgravity isolation systems

A new method has been developed to design an active vibration isolation system for microgravity space experiments. This method yields the required controller transfer functions for a specified transmissibility. Hence, it is a straightforward task to guarantee that the desired vibration isolation performance is achieved at each frequency. The theory for such a controller design has been presented by considering a single degree of freedom system. The magnitude of the control force required by the new method has been found to be less than that used by a standard phase lead/lag compensator.

Sinha, A.↗

Limitations on vibration isolation for microgravity space experiments

The vibration-isolation limitations of spaceborne microgravity experiments are largely due to isolation-system volume restrictions. In the present one-degree-of-freedom representation of an experimental aircraft, assuming an ideal vibration actuator, wall motion is characterized as sinusoidal at a single frequency. The result is a kinematic representation which poses the problem of the minimum acceleration trajectory within a pair of moving walls; analysis then yields a simple condition under which a closed-form solution is available. The results obtained demonstrate that isolation from low-frequency vibration requires more interior space than is available for vibration isolation on manned orbiters.

Knospe, C.↗

Decreased susceptibility to motion sickness during exposure to visual inversion in microgravity

Head and body movements made in microgravity tend to bring on symptoms of motion sickness. Such head movements, relative to comparable ones made on earth, are accompanied by unusual combinations of semicircular canal and otolith activity owing to the unloading of the otoliths in 0G. Head movements also bring on symptoms of motion sickness during exposure to visual inversion (or reversal) on earth because the vestibulo-ocular reflex is rendered anti-compensatory. Here, evidence is presented that susceptibility to motion sickness during exposure to visual inversion is decreased in a 0G relative to 1G force background. This difference in susceptibility appears related to the alteration in otolith function in 0G. Some implications of this finding for the etiology of space motion sickness are described.

Lackner, James R.↗

An approach to counteracting long-term microgravity-induced muscle atrophy

To find means of alleviating muscle atrophy induced by long-term microgravity, the effects of a 19-week-long heavy-resistance training regime (using either concentric muscle actions only or concentric and eccentric muscle actions) on the strengths of the exercised knee extensor muscle group were investigated in two groups of male human subjects performing two types of training exercises: supine leg press or/and seated knee extension. Results show that a training program in which both the concentric and the eccentric muscle action was performed led to substantially greater increases in maximal muscle strength than when only concentric exercises were performed.

Tesch, P. A.↗

Maximum expiratory flow-volume curves during short periods of microgravity

Nine normal subjects were studied in a NASA microgravity research aircraft to elucidate the effect of normal gravitation on the shape of the maximum expiratory flow-volume (MEFV). They performed multiple MEFV maneuvers at 0, 1, and approximately 2 G. The MEFV curves for each subject were filtered, aligned at residual volume, and ensemble-averaged to produce an average MEFV curve for each state, allowing differences to be studied. Most subjects showed a decrease in the forced vital capacity at 0 G. The mean lung volume associated with a given flow was lower at 0 G over about the upper half of the vital capacity. There were consistent but highly individual changes in the position and magnitude of detailed features of the curve. This supports the concept that the location and motion of choke points that determine the detailed individual configuration of MEFG curves can be significantly influenced by gravitational forces, presumably via the effects of change in longitudinal tension on local airway pressure-diameter behavior and thus wave speed.

Guy, H. J. B.↗