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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,387 records · Page 77

Model Exploration of an Information-Based Healthcare Intervention Using Parallelization and Active Learning

This paper describes the application of a large-scale active learning method to characterize the parameter space of a computational agent-based model developed to investigate the impact of CommunityRx, a clinical information-based health intervention that provides patients with personalized information about local community resources to meet basic and self-care needs. Additionally, the diffusion of information about community resources and their use is modeled via networked interactions and their subsequent effect on agents' use of community resources across an urban population. A random forest model is iteratively fitted to model evaluations to characterize the model parameter space with respect to observed empirical data. We demonstrate the feasibility of using high-performance computing and active learning model exploration techniques to characterize large parameter spaces; by partitioning the parameter space into potentially viable and non-viable regions, we rule out regions of space where simulation output is implausible to observed empirical data. We argue that such methods are necessary to enable model exploration in complex computational models that incorporate increasingly available micro-level behavior data. We provide public access to the model and high-performance computing experimentation code.

97 MATHEMATICS AND COMPUTING↗

2020 State of the Science Report, Chapter 2: Marine Renewable Energy: Environmental Effects and Monitoring Strategies

As we learn more about interactions between marine renewable energy (MRE) devices, the animals and habitats near them, and the oceanographic processes with which they interact, we need to clarify the language used to discuss those interactions. For example, if an MRE device or system negatively affected a number of animals, we could say that the device or the system of foundations, anchors, and mooring lines had an impact on the population, and take steps to avoid the impact or, in some cases, mitigate the impact. However, at this stage in MRE development, there are few, if any, cases in which a negative impact has been observed or measured. Instead, we are developing the building blocks that support investigations of interactions and potential impacts. https://tethys.pnnl.gov/publications/state-of-the-science-2020-chapter-2-environmental-effects

54 ENVIRONMENTAL SCIENCES↗

Phosphorus Cycling in the Red Tide Incubator Region of Monterey Bay in Response to Upwelling

This study explores the cycling of phosphorus (P) in the euphotic zone following upwelling in northeastern Monterey Bay (the Red Tide Incubator region) of coastal California, with particular emphasis on how bacteria and phytoplankton that form harmful algal blooms mediate and respond to changes in P availability. In situ measurements of nutrient concentrations, phytoplankton community composition, and cell-specific alkaline phosphatase (AP) activity (determined via enzyme-labeled fluorescence assay) were measured during three cruises. Upwelling led to a 10-fold increase in dissolved inorganic (DIP) in surface waters, reaching ~0.5μmol L -1 . This DIP was drawn down rapidly as upwelling relaxed over a period of 1 week. Ratios of nitrate to DIP drawdown (~5:1, calculated as the change in nitrate divided by the change in DIP) were lower than the Redfield ratio of 16:1, suggesting that luxury P uptake was occurring as phytoplankton bloomed. Dissolved organic (DOP) remained relatively constant (~0.3μmol L -1 ) before and immediately following upwelling, but doubled as upwelling relaxed, likely due to phytoplankton excretion and release during grazing. This transition from a relatively high DIP:DOP ratio to lower DIP:DOP ratio was accompanied by a decline in the abundance of diatoms, which had low AP activity, toward localized, spatially heterogeneous blooms of dinoflagellates in the genera Prorocentrum, Ceratium, Dinophysis, Alexandrium, and Scrippsiella that showed high AP activity regardless of ambient DIP levels. A nutrient addition incubation experiment showed that phytoplankton growth was primarily limited by nitrate, followed by DIP and DOP, suggesting that P regulates phytoplankton physiology and competition, but is not a limiting nutrient in this region. AP activity was observed in bacteria associated with lysed cell debris and aggregates of particulate organic material, where it may serve to facilitate P regeneration, as well as affixed to the surfaces of intact phytoplankton cells, possibly indicative of close, beneficial phytoplankton–bacteria interactions.

59 BASIC BIOLOGICAL SCIENCES↗

Chronological Switch from Translesion Synthesis to Homology-Dependent Gap Repair In Vivo

Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere with the normal functions of DNA such as transcription and replication, and need to be either repaired or tolerated. DNA lesions are accurately removed via various repair pathways. In contrast, tolerance mechanisms do not remove lesions but only allow replication to proceed despite the presence of unrepaired lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS), which is an error-prone strategy and an accurate strategy based on homologous recombination (homology-dependent gap repair [HDGR]). Thus, the mutation frequency reflects the relative extent to which the two tolerance pathways operate in vivo. In the present paper, we review the present understanding of the mechanisms of TLS and HDGR and propose a novel and comprehensive view of the way both strategies interact and are regulated in vivo.

59 BASIC BIOLOGICAL SCIENCES↗

Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

The biosynthetic capabilities of microbes underlie their growth and interactions, playing a prominent role in microbial community structure. For large, diverse microbial communities, prediction of these capabilities is limited by uncertainty about metabolic functions and environmental conditions. To address this challenge, we propose a probabilistic method, inspired by percolation theory, to computationally quantify how robustly a genome-derived metabolic network produces a given set of metabolites under an ensemble of variable environments. We used this method to compile an atlas of predicted biosynthetic capabilities for 97 metabolites across 456 human oral microbes. This atlas captures taxonomically-related trends in biomass composition, and makes it possible to estimate inter-microbial metabolic distances that correlate with microbial co-occurrences. We also found a distinct cluster of fastidious/uncultivated taxa, including several Saccharibacteria (TM7) species, characterized by their abundant metabolic deficiencies. By embracing uncertainty, our approach can be broadly applied to understanding metabolic interactions in complex microbial ecosystems.

59 BASIC BIOLOGICAL SCIENCES↗

Metabolic model-based ecological modeling for probiotic design

The microbial community composition in the human gut has a profound effect on human health. This observation has lead to extensive use of microbiome therapies, including over-the-counter ‘probiotic’ treatments intended to alter the composition of the microbiome. Despite so much promise and commercial interest, the factors that contribute to the success or failure of microbiome-targeted treatments remain unclear. We investigate the biotic interactions that lead to successful engraftment of a novel bacterial strain introduced to the microbiome as in probiotic treatments. We use pairwise genome-scale metabolic modeling with a generalized resource allocation constraint to build a network of interactions between taxa that appear in an experimental engraftment study. We create induced sub-graphs using the taxa present in individual samples and assess the likelihood of invader engraftment based on network structure. To do so, we use a generalized Lotka-Volterra model, which we show has strong ability to predict if a particular invader or probiotic will successfully engraft into an individual’s microbiome. Furthermore, we show that the mechanistic nature of the model is useful for revealing which microbe-microbe interactions potentially drive engraftment.

59 BASIC BIOLOGICAL SCIENCES↗

Program for computer aided reliability estimation

A computer program for estimating the reliability of self-repair and fault-tolerant systems with respect to selected system and mission parameters is presented. The computer program is capable of operation in an interactive conversational mode as well as in a batch mode and is characterized by maintenance of several general equations representative of basic redundancy schemes in an equation repository. Selected reliability functions applicable to any mathematical model formulated with the general equations, used singly or in combination with each other, are separately stored. One or more system and/or mission parameters may be designated as a variable. Data in the form of values for selected reliability functions is generated in a tabular or graphic format for each formulated model.

Mathur, F. P.↗

Interactive aircraft flight control and aeroelastic stabilization

Several examples are presented in which flutter involving interaction between flight mechanics modes and elastic wind bending occurs for a forward swept wing flight vehicle. These results show the basic mechanism by which the instability occurs and form the basis for attempts to actively control such a vehicle.

Weisshaar, T. A.↗

Magnetospheres of Jupiter and Saturn

During the time from 1973 to 1981, the giant planets, Jupiter and Saturn, have been studied with the aid of the spacecraft Pioneers 10, 11, and Voyagers 1 and 2. The present investigation is concerned with the study of the magnetospheres of these planets, taking into account the immediate region of their environment in which the planetary magnetic field is the dominant physical force, and the boundary of the magnetospheres which is formed by the interaction with the solar wind. Attention is given to the recent results obtained by the Voyagers. It is found that the basic features of the magnetospheres of Jupiter and Saturn are similar to those of the earth. There are, however, also differences with the earth which relate to the large amount of entrapped low energy plasmas that form a magnetodisk and an Io associated torus at Jupiter, while at Saturn there is a Titan torus and a substantial ring current.

Ness, N. F.↗

IDIMS/GEOPAK: Users manual for a geophysical data display and analysis system

The application of an existing image analysis system to the display and analysis of geophysical data is described, the potential for expanding the capabilities of such a system toward more advanced computer analytic and modeling functions is investigated. The major features of the IDIMS (Interactive Display and Image Manipulation System) and its applicability for image type analysis of geophysical data are described. Development of a basic geophysical data processing system to permit the image representation, coloring, interdisplay and comparison of geophysical data sets using existing IDIMS functions and to provide for the production of hard copies of processed images was described. An instruction manual and documentation for the GEOPAK subsystem was produced. A training course for personnel in the use of the IDIMS/GEOPAK was conducted. The effectiveness of the current IDIMS/GEOPAK system for geophysical data analysis was evaluated.

Libert, J. M.↗

Technology research for strapdown inertial experiment and digital flight control and guidance

A helicopter flight-test program to evaluate the performance of Honeywell's Tetrad - a strapdown, laser gyro, inertial navitation system is discussed. The results of 34 flights showed a mean final navigational velocity error of 5.06 knots, with a standard deviation of 3.84 knots; a corresponding mean final position error of 2.66 n.mi., with a standard deviation of 1.48 n.m.; and a modeled mean-position-error growth rate for the 34 tests of 1.96 knots, with a standard deviation of 1.09 knots. Tetrad's four-ring laser gyros provided reliable and accurate angular rate sensing during the test program and on sensor failures were detected during the evaluation. Criteria suitable for investigating cockpit systems in rotorcraft were developed. This criteria led to the development of two basic simulators. The first was a standard simulator which could be used to obtain baseline information for studying pilot workload and interactions. The second was an advanced simulator which integrated the RODAAS developed by Honeywell into this simulator. The second area also included surveying the aerospace industry to determine the level of use and impact of microcomputers and related components on avionics systems.

Carestia, R. A.↗

Design for validation: An approach to systems validation

Every complex system built is validated in some manner. Computer validation begins with review of the system design. As systems became too complicated for one person to review, validation began to rely on the application of adhoc methods by many individuals. As the cost of the changes mounted and the expense of failure increased, more organized procedures became essential. Attempts at devising and carrying out those procedures showed that validation is indeed a difficult technical problem. The successful transformation of the validation process into a systematic series of formally sound, integrated steps is necessary if the liability inherent in the future digita-system-based avionic and space systems is to be minimized. A suggested framework and timetable for the transformtion are presented. Basic working definitions of two pivotal ideas (validation and system life-cyle) are provided and show how the two concepts interact. Many examples are given of past and present validation activities by NASA and others. A conceptual framework is presented for the validation process. Finally, important areas are listed for ongoing development of the validation process at NASA Langley Research Center.

Carter, William C.↗

Development of a Multi-Disciplinary Computing Environment (MDICE)

The growing need for and importance of multi-component and multi-disciplinary engineering analysis has been understood for many years. For many applications, loose (or semi-implicit) coupling is optimal, and allows the use of various legacy codes without requiring major modifications. For this purpose, CFDRC and NASA LeRC have developed a computational environment to enable coupling between various flow analysis codes at several levels of fidelity. This has been referred to as the Visual Computing Environment (VCE), and is being successfully applied to the analysis of several aircraft engine components. Recently, CFDRC and AFRL/VAAC (WL) have extended the framework and scope of VCE to enable complex multi-disciplinary simulations. The chosen initial focus is on aeroelastic aircraft applications. The developed software is referred to as MDICE-AE, an extensible system suitable for integration of several engineering analysis disciplines. This paper describes the methodology, basic architecture, chosen software technologies, salient library modules, and the current status of and plans for MDICE. A fluid-structure interaction application is described in a separate companion paper.

Kingsley, Gerry↗

Autonomous Science Analyses of Digital Images for Mars Sample Return and Beyond

To adequately explore high priority landing sites, scientists require rovers with greater mobility. Therefore, future Mars missions will involve rovers capable of traversing tens of kilometers (vs. tens of meters traversed by Mars Pathfinder's Sojourner). However, the current process by which scientists interact with a rover does not scale to such distances. A single science objective is achieved through many iterations of a basic command cycle: (1) all data must be transmitted to Earth and analyzed; (2) from this data, new targets are selected and the necessary information from the appropriate instruments are requested; (3) new commands are then uplinked and executed by the spacecraft and (4) the resulting data are returned to Earth, starting the process again. Experience with rover tests on Earth shows that this time intensive process cannot be substantially shortened given the limited data downlink bandwidth and command cycle opportunities of real missions. Sending complete multicolor panoramas at several waypoints, for example, is out of the question for a single downlink opportunity. As a result, long traverses requiring many science command cycles would likely require many weeks, months or even years, perhaps exceeding rover design life or other constraints. Autonomous onboard science analyses can address these problems in two ways. First, it will allow the rover to transmit only "interesting" images, defined as those likely to have higher science content. Second, the rover will be able to anticipate future commands, for example acquiring and returning spectra of "interesting" rocks along with the images in which they were detected. Such approaches, coupled with appropriate navigational software, address both the data volume and command cycle bottlenecks that limit both rover mobility and science yield. We are developing algorithms to enable such intelligent decision making by autonomous spacecraft. Reflecting the ultimate level of ability we aim for, this program has been dubbed the "Grad Student on Mars Project". We envision, for example, an appropriately intelligent Athena-like rover at the Pathfinder landing site might be able to traverse over the ridge towards "Twin Peaks" to obtain better information on the stratigraphy of these "streamlined islands" or of the size, composition and morphology of boulders located on them. Along the traverse, the intelligent rover would collect and analyze images and obtain spectra of geologically interesting features or regions. The intelligent rover might also traverse further up Arcs Vallis, and find additional paleoflood stage indicators such as slackwater deposits. Recognizing additional regions where boulders are imbricated, noting changes in their size, distribution, morphology, composition and the associated changes in channel geometry would yield important information on the outflow channel's paleoflood history, Representative images and associated supporting data from these locations could be downlinked to Earth along with the data requested by scientists from the previous uplink opportunity. Our initial work has focused on recognizing geologically interesting portions of images. Here we summarize some of the algorithms to date.

Gulick, V. C.↗

Total Ionizing Dose Effects in MOS Oxides and Devices

The development of military and space electronics technology has traditionally been heavily influenced by the commercial semiconductor industry. The development of MOS technology, and particularly CMOS technology, as dominant commercial technologies has occurred entirely within the lifetime of the NSREC. For this reason, it is not surprising that the study of radiation interactions with MOS materials, devices and circuits has been a major theme of this conference for most of its history. The basic radiation problem in a MOS transistor is illustrated. The application of an appropriate gate voltage causes a conducting channel to form between the source and drain, so that current flows when the device is turned on. In Fig. lb, the effect of ionizing radiation is illustrated. Radiation-induced trapped charge has built up in the gate oxide, which causes a shift in the threshold voltage (that is, a change in the voltage which must be applied to turn the device on). If this shift is large enough, the device cannot be turned off, even at zero volts applied, and the device is said to have failed by going depletion mode.

Oldham, Timothy R.↗

Computational Aero-acoustics As a Tool For Turbo-machinery Noise Reduction

This talk will provide an overview of the field of computational aero-acoustics and its use in fan noise prediction. After a brief history of computational fluid dynamics, some of the recent developments in computational aero-acoustics will be explored. Computational issues concerning sound wave production, propagation, and reflection in practical turbo-machinery applications will be discussed including: (a) High order/High Resolution Numerical Techniques. (b) High Resolution Boundary Conditions. [c] MIMD Parallel Computing. [d] Form of Governing Equations Useful for Simulations. In addition, the basic design of our Broadband Analysis Stator Simulator (BASS) code and its application to a 2 D rotor wake-stator interaction will be shown. An example of the noise produced by the wakes from a rotor impinging upon a stator cascade will be shown.

Dyson, Rodger W.↗

Numerical Simulation of Protoplanetary Vortices

The fluid dynamics within a protoplanetary disk has been attracting the attention of many researchers for a few decades. Previous works include, to list only a few among many others, the well-known prescription of Shakura & Sunyaev, the convective and instability study of Stone & Balbus and Hawley et al., the Rossby wave approach of Lovelace et al., as well as a recent work by Klahr & Bodenheimer, which attempted to identify turbulent flow within the disk. The disk is commonly understood to be a thin gas disk rotating around a central star with differential rotation (the Keplerian velocity), and the central quest remains as how the flow behavior deviates (albeit by a small amount) from a strong balance established between gravitational and centrifugal forces, transfers mass and momentum inward, and eventually forms planetesimals and planets. In earlier works we have briefly described the possible physical processes involved in the disk; we have proposed the existence of long-lasting, coherent vortices as an efficient agent for mass and momentum transport. In particular, Barranco et al. provided a general mathematical framework that is suitable for the asymptotic regime of the disk; Barranco & Marcus (2000) addressed a proposed vortex-dust interaction mechanism which might lead to planetesimal formation; and Lin et al. (2002), as inspired by general geophysical vortex dynamics, proposed basic mechanisms by which vortices can transport mass and angular momentum. The current work follows up on our previous effort. We shall focus on the detailed numerical implementation of our problem. We have developed a parallel, pseudo-spectral code to simulate the full three-dimensional vortex dynamics in a stably-stratified, differentially rotating frame, which represents the environment of the disk. Our simulation is validated with full diagnostics and comparisons, and we present our results on a family of three-dimensional, coherent equilibrium vortices.

Lin, H.↗

Designing Flight Deck Procedures

Three reports address the design of flight-deck procedures and various aspects of human interaction with cockpit systems that have direct impact on flight safety. One report, On the Typography of Flight- Deck Documentation, discusses basic research about typography and the kind of information needed by designers of flight deck documentation. Flight crews reading poorly designed documentation may easily overlook a crucial item on the checklist. The report surveys and summarizes the available literature regarding the design and typographical aspects of printed material. It focuses on typographical factors such as proper typefaces, character height, use of lower- and upper-case characters, line length, and spacing. Graphical aspects such as layout, color coding, fonts, and character contrast are discussed; and several cockpit conditions such as lighting levels and glare are addressed, as well as usage factors such as angular alignment, paper quality, and colors. Most of the insights and recommendations discussed in this report are transferable to paperless cockpit systems of the future and computer-based procedure displays (e.g., "electronic flight bag") in aerospace systems and similar systems that are used in other industries such as medical, nuclear systems, maritime operations, and military systems.

Degani, Asaf↗