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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Constraining off-shell Higgs boson production and the Higgs boson total width using WW → ℓνℓν final states with the ATLAS detector

A measurement of off-shell Higgs boson production is performed in the H* → WW channel. The measurement uses a proton–proton collision dataset with an integrated luminosity of 140 fb -1 collected at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. Final states in which both W bosons decay leptonically are targeted, and events are categorised based on the flavour of the final-state leptons, the jet multiplicity, and the output of neural network-based classifiers. The data are found to be compatible with the Standard Model expectation. An observed (expected) upper bound on the 95 % symmetric confidence level interval is set on the rate of off-shell Higgs boson production at a value of 3.4 (4.4) times the Standard Model prediction. These results are combined with the results from the measurement of on-shell Higgs boson production in the same final states to obtain an observed (expected) upper bound at 95 % confidence level on the Higgs boson total width of 13.1 (17.3) MeV.

Aad, G. [Aix-Marseille Univ., Marseille (France)] ↗
DOE OSTI2025

Measurement of substructure-dependent suppression of large-radius jets with charged particles in Pb+Pb collisions with ATLAS

Measurements of jet substructure in Pb+Pb collisions provide key insights into the mechanism of jet quenching in the hot and dense QCD medium created in these collisions. This Letter presents a measurement of the suppression of large-radius jets with a radius parameter of $R = 1.0$ and its dependence on the jet substructure. The measurement uses 1.72 nb$^{-1}$ of Pb+Pb data and 255 pb$^{-1}$ of $pp$ data, both at $\sqrt{s_{_\mathrm{NN}}} = 5.02$ TeV, recorded with the ATLAS detector at the Large Hadron Collider. Large-radius jets are reconstructed by reclustering $R = 0.2$ calorimetric jets and are measured for transverse momentum above $200$ GeV. Jet substructure is evaluated using charged-particle tracks, and the overall level of jet suppression is quantified using the jet nuclear modification factor ($R_\mathrm{AA}$). The jet $R_\mathrm{AA}$ is measured as a function of jet $p_{\mathrm{T}}$, the charged $k_t$ splitting scale ($\sqrt{d_{12}}$), and the angular separation ($dR_{12}$) of two leading sub-jets. The jet $R_\mathrm{AA}$ gradually decreases with increasing $\sqrt{d_{12}}$, implying significantly stronger suppression of large-radius jets with larger $k_t$ splitting scale. The jet $R_\mathrm{AA}$ gradually decreases for $dR_{12}$ in the range $0.01{-}0.2$ and then remains consistent with a constant for $ΔR_{12} \gtrsim 0.2$. The observed significant dependence of jet suppression on the jet substructure will provide new insights into its role in the quenching process.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2025

Observation of W + W – γ production in pp collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector and constraints on anomalous quartic gauge-boson couplings

This Letter reports the observation of W + W – γ triboson production in 140 fb –1 of data collected by the ATLAS detector from proton–proton collisions at a centre-of-mass energy of $\sqrt{s}$ = 13 TeV at the LHC. Events with an opposite-charge eμ pair, a high transverse-momentum photon, and significant missing transverse momentum are considered. The observed (expected) significance of the signal is 5.9 (6.0) standard deviations. The measured fiducial cross-section, defined for the W + W – γ → e ± μ ∓ $ν\bar{ν}$γ final state is 6.2 ± 0.8 (stat.) ± 0.6 (sys.) fb, in good agreement with the Standard Model prediction of 6.1$^{+1.0}_{–0.7}$ fb. Constraints on the Wilson coefficients of 13 dimension-8 operators describing physics beyond the Standard Model through anomalous quartic gauge-boson couplings are derived using the effective field theory framework.

Anomalous quartic gauge couplings↗
DOE OSTI2026

Observation of $t\bar{t}γγ$ production at $\sqrt{s} = 13$ TeV with the ATLAS detector

This paper presents the first observation of top-quark pair production in association with two photons ($t\bar{t}γγ$). The measurement is performed in the single-lepton decay channel using proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider. The data correspond to an integrated luminosity of 140 fb −1 recorded during Run 2 at a centre-of-mass energy of 13 TeV. The $t\bar{t}γγ$ production cross section, measured in a fiducial phase space based on particle-level kinematic criteria for the lepton, photons, and jets, is found to be 2.42$_{− 0.53}^{+ 0.58}$ fb , corresponding to an observed significance of 5.2 standard deviations. Additionally, the ratio of the production cross section of $t\bar{t}γγ$ to top-quark pair production in association with one photon is determined, yielding (3.30$_{− 0.65}^{+ 0.70}$) × 10 −3 .

Aad, G. (ORCID:0000000266654934)↗
DOE OSTI2026

Search for Higgs bosons produced in association with a high-energy photon via vector-boson fusion and decaying to a pair of b -quarks in the ATLAS detector

A search for Standard Model Higgs bosons produced in association with a high-energy photon and decaying to $b\bar{b}$ is performed using 133 fb −1 of $\sqrt{s}$ = 13 TeV pp collision data collected with the ATLAS detector at the Large Hadron Collider at CERN. The photon requirement reduces the multijet background, and the H → $b\bar{b}$ decay is the dominant decay mode. Event selection requirements target events produced by vector-boson fusion, the dominant production mode in this channel. Several improvements enhance the search sensitivity compared to previous measurements. These improvements include better background modelling and characterization, the use of a neural-network classifier, and an updated signal extraction strategy adopting a direct binned-likelihood fit to the classifier output. With these improvements, the Higgs boson signal strength is measured to be 0.2 ± 0.7 relative to the Standard Model prediction. This corresponds to an observed significance of 0.3 standard deviations, compared to an expectation of 1.5 standard deviations assuming the Standard Model.

ATLAS experiment↗
DOE OSTI2026

Study of Higgs boson pair production in the HH → b $\overline{b}$ γγ final state with 308 fb −1 of data collected at $\sqrt{s}$ = 13 TeV and 13.6 TeV by the ATLAS experiment

A search for Higgs boson pair production in the b $\overline{b}$ γγ −1, consisting of two samples, 140 fb −1 at a centre-of-mass energy of s = 13 TeV and 168 fb −1 at $\sqrt{s}$ = 13.6 TeV , recorded between 2015 and 2024 by the ATLAS detector at the CERN Large Hadron Collider. In addition to a larger dataset, this analysis improves upon the previous search in the same final state through several methodological and technical developments. The Higgs boson pair production cross section divided by the Standard Model prediction is found to be μ HH = 0.9$^{+1.4}_{−1.1}$ (μ HH = 1$^{+1.3}_{−1.0}$ expected), which translates into a 95% confidence-level upper limit of μ HH < 3.7. At the same confidence level the Higgs self-coupling modifier is constrained to be in the range −1.6 < κ λ < 6.6 (−1.8 < κ λ < 6.9 expected).

ATLAS↗
DOE OSTI2026

Search for the Higgs boson decay to a Z boson and a photon in pp collisions at $\sqrt{s}$ = 13 TeV and 13.6 TeV with the ATLAS detector

A search for the Higgs boson decay to a Z boson and a photon in the ℓℓγ (ℓ = 𝑒,𝜇) final state is performed using pp collisions at $\sqrt{s}$ = 13.6 TeV recorded with the ATLAS detector at the Large Hadron Collider during 2022–2024, corresponding to an integrated luminosity of 165 fb−1. The signal yield, normalised to the Standard Model prediction, is measured to be 𝜇 = 0.9$^{+0.7}_{−0.6}$, compatible with the expected value of 𝜇 = 1.0 ± 0.7. This corresponds to an observed (expected) signal significance of 1.4 (1.5) standard deviations under the background-only hypothesis. This result is combined with that of a similar search performed with 140 fb −1 of $\sqrt{s}$ = 13 TeV pp collisions to provide the best expected sensitivity to date to this rare decay, namely an observed (expected) signal strength of 𝜇 = 1.3$^{+0.6}_{−0.5}$ (𝜇 = 1.0$^{+0.6}_{−0.5}$), corresponding to an observed (expected) significance of 2.5 (1.9) standard deviations. The measurement is consistent with the Standard Model expectation.

Aad, G. (ORCID:0000000266654934)↗
DOE OSTI2026

Search for a resonance decaying into a scalar particle and a Higgs boson in the final state with two bottom quarks and two photons with 199 fb −1 of data collected at $\sqrt{s}$ = 13 and 13.6 TeV with the ATLAS detector

A search for the resonant production of a heavy scalar X decaying into a lighter scalar S and a Higgs boson, through the process X → S (→ $b\bar{b}$) H (→ γγ) , where the two photons are consistent with the Higgs boson decay, is performed. The search is conducted using integrated luminosities of 140 and 59 fb −1 of proton–proton collision data at centre-of-mass energies of 13 and 13.6 TeV, respectively, recorded with the ATLAS detector at the LHC. The search is performed over the mass ranges of 170 ≤ m X ≤ 1000 GeV and 15 ≤ m S ≤ 500 GeV. No significant excess over the Standard Model background predictions is observed and limits at 95% confidence level are set on the product of cross section and branching fraction for the process X → S (→ $b\bar{b}$) H (→ γγ) at 13 TeV, ranging from 9 fb to 0.06 fb.

Aad, G. (ORCID:0000000266654934)↗
DOE OSTI2026

Characterization of nuclear breakup as a function of hard-scattering kinematics using dijets measured by ATLAS in p+Pb collisions

This Letter analyzes the sensitivity of event geometry estimators to the initial-state kinematics of hard scattering in proton–lead collisions. This analysis uses dijets as a proxy for the parton–parton scattering configuration, correlating it with event geometry estimators, namely the energy deposited in the Zero-Degree Calorimeter and the transverse energy recorded in the Forward Calorimeter in the Pb-going direction. The analysis uses data recorded by the ATLAS detector at the Large Hadron Collider with a nucleon–nucleon center-of-mass energy of 8.16 TeV, corresponding to an integrated luminosity of 56 nb − 1 . The jets are measured within the pseudorapidity interval −2.8 < η < 4.5, where positive η values correspond to the direction of the proton beam. Results are presented as a function of the Bjorken-x of the parton originating from the proton, xp . Both event geometry estimators are found to be dependent on xp , with the energy deposited in the Zero-Degree Calorimeter about six times less sensitive to xp compared with the transverse energy deposited in the Forward Calorimeter.

Aad, G↗
DOE OSTI2024

Combination and summary of ATLAS dark matter searches interpreted in a 2HDM with a pseudo-scalar mediator using 139 fb -1 of $\sqrt{s} =$ 13 TeV $pp$ collision data

Results from a wide range of searches targeting different experimental signatures with and without missing transverse momentum ($E^{miss}_T$) ) are used to constrain a Two-Higgs-Doublet Model (2HDM) with an additional pseudo-scalar mediating the interaction between ordinary and dark matter (2HDM+a). The analyses use up to 139 fb -1 of proton–proton collision data at a centre-of-mass energy $\sqrt{s} =$ 13 TeV recorded with the ATLAS detector at the Large Hadron Collider during 2015–2018. The results from three of the most sensitive searches are combined statistically. These searches target signatures with large $E^{miss}_T$ and a leptonically decaying Z boson; large $E^{miss}_T$ and a Higgs boson decaying to bottom quarks; and production of charged Higgs bosons in final states with top and bottom quarks, respectively. Constraints are derived for several common and new benchmark scenarios in the 2HDM+a.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2023

Deep learning integrates histopathology and proteogenomics at a pan-cancer level

We introduce a pioneering approach that integrates pathology imaging with transcriptomics and proteomics to identify predictive histology features associated with critical clinical outcomes in cancer. We utilize 2,755 H&E-stained histopathological slides from 657 patients across 6 cancer types from CPTAC. Our models effectively recapitulate distinctions readily made by human pathologists: tumor vs. normal (AUROC = 0.995) and tissue-of-origin (AUROC = 0.979). We further investigate predictive power on tasks not normally performed from H&E alone, including TP53 prediction and pathologic stage. Importantly, we describe predictive morphologies not previously utilized in a clinical setting. The incorporation of transcriptomics and proteomics identifies pathway-level signatures and cellular processes driving predictive histology features. Model generalizability and interpretability is confirmed using TCGA. We propose a classification system for these tasks, and suggest potential clinical applications for this integrated human and machine learning approach. A publicly available web-based platform implements these models.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Dynamic enhancer landscapes in human craniofacial development

The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development. However, a lack of accurate maps of the genomic locations and cell type-resolved activities of craniofacial enhancers prevents their systematic exploration in human genetics studies. Here, we combine histone modification, chromatin accessibility, and gene expression profiling of human craniofacial development with single-cell analyses of the developing mouse face to define the regulatory landscape of facial development at tissue- and single cell-resolution. We provide temporal activity profiles for 14,000 human developmental craniofacial enhancers. We find that 56% of human craniofacial enhancers share chromatin accessibility in the mouse and we provide cell population- and embryonic stage-resolved predictions of their in vivo activity. Taken together, our data provide an expansive resource for genetic and developmental studies of human craniofacial development.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival

Approximately a quarter of the human genome consists of gene deserts, large regions devoid of genes often located adjacent to developmental genes and thought to contribute to their regulation. However, defining the regulatory functions embedded within these deserts is challenging due to their large size. Here, we explore the cis-regulatory architecture of a gene desert flanking the Shox2 gene, which encodes a transcription factor indispensable for proximal limb, craniofacial, and cardiac pacemaker development. We identify the gene desert as a regulatory hub containing more than 15 distinct enhancers recapitulating anatomical subdomains of Shox2 expression. Ablation of the gene desert leads to embryonic lethality due to Shox2 depletion in the cardiac sinus venosus, caused in part by the loss of a specific distal enhancer. The gene desert is also required for stylopod morphogenesis, mediated via distributed proximal limb enhancers. In summary, our study establishes a multi-layered role of the Shox2 gene desert in orchestrating pleiotropic developmental expression through modular arrangement and coordinated dynamics of tissue-specific enhancers.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity

High-throughput massively parallel reporter assays (MPRAs) and phenotype-rich in vivo transgenic mouse assays are two potentially complementary ways to study the impact of noncoding variants associated with psychiatric diseases. Here, we investigate the utility of combining these assays. Specifically, we carry out an MPRA in induced human neurons on over 50,000 sequences derived from fetal neuronal ATAC-seq datasets and enhancers validated in mouse assays. We also test the impact of over 20,000 variants, including synthetic mutations and 167 common variants associated with psychiatric disorders. We find a strong and specific correlation between MPRA and mouse neuronal enhancer activity. Four out of five tested variants with significant MPRA effects affected neuronal enhancer activity in mouse embryos. Mouse assays also reveal pleiotropic variant effects that could not be observed in MPRA. Our work provides a catalog of functional neuronal enhancers and variant effects and highlights the effectiveness of combining MPRAs and mouse transgenic assays.

Kosicki, Michael↗
DOE OSTI2025

Uncovering hidden enhancers through unbiased in vivo testing

Chromatin signatures are widely used to identify tissue-specific in vivo enhancers, but their sensitivity and specificity remains unclear. Here we show that many developmental enhancers remain undetectable using currently available chromatin data. In an initial comparison of over 1200 developmental enhancers with tissue-matched chromatin data, 14% (n = 285) lacked canonical enhancer-associated chromatin signatures. To further assess the prevalence of enhancers missed by chromatin profiling approaches, we used a high-throughput transgenic enhancer assay to screen the regulatory landscapes of two key developmental genes at 5 kb resolution, spanning 1.3 Mb of mouse sequence in total. We observed that 23 of 88 (26%) in vivo enhancers discovered by this approach lacked enhancer-associated chromatin signatures in the respective tissue. Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.

Epigenomics↗
DOE OSTI2026

Transforming jet flavour tagging at ATLAS

Jet flavour tagging enables the identification of jets originating from heavy-flavour quarks in proton–proton collisions at the Large Hadron Collider, playing a critical role in its physics programmes. This paper presents GN2, a transformer-based flavour tagging algorithm deployed by the ATLAS Collaboration that represents a different methodology compared to previous approaches. Designed to classify jets based on the flavour of their constituent particles, GN2 processes low-level tracking information in an end-to-end architecture and incorporates physics-informed auxiliary training objectives to enhance both interpretability and performance. Its performance is validated in both simulation and collision data. The measured c-jet (light-jet) rejection in data is improved by a factor of 3.5 (1.8) for a 70% b-jet tagging efficiency, compared to the previous algorithm. GN2 provides substantial benefits for physics analyses involving heavy-flavour jets, such as measurements of Higgs boson pair production and the couplings of bottom and charm quarks to the Higgs boson, and demonstrates the impact of advanced machine learning methods in experimental particle physics.

Characterization and analytical techniques↗
DOE OSTI2021

Event Horizon Telescope observations of the jet launching and collimation in Centaurus A

AbstractVery-long-baseline interferometry (VLBI) observations of active galactic nuclei at millimetre wavelengths have the power to reveal the launching and initial collimation region of extragalactic radio jets, down to 10–100 gravitational radii (rg ≡ GM/c2) scales in nearby sources1. Centaurus A is the closest radio-loud source to Earth2. It bridges the gap in mass and accretion rate between the supermassive black holes (SMBHs) in Messier 87 and our Galactic Centre. A large southern declination of −43° has, however, prevented VLBI imaging of Centaurus A below a wavelength of 1 cm thus far. Here we show the millimetre VLBI image of the source, which we obtained with the Event Horizon Telescope at 228 GHz. Compared with previous observations3, we image the jet of Centaurus A at a tenfold higher frequency and sixteen times sharper resolution and thereby probe sub-lightday structures. We reveal a highly collimated, asymmetrically edge-brightened jet as well as the fainter counterjet. We find that the source structure of Centaurus A resembles the jet in Messier 87 on ~500 rg scales remarkably well. Furthermore, we identify the location of Centaurus A’s SMBH with respect to its resolved jet core at a wavelength of 1.3 mm and conclude that the source’s event horizon shadow4 should be visible at terahertz frequencies. This location further supports the universal scale invariance of black holes over a wide range of masses5,6.

79 ASTRONOMY AND ASTROPHYSICS↗