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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Magnonic analog of the Edelstein effect in antiferromagnetic insulators

Here we investigate the nonequilibrium spin polarization due to a temperature gradient in antiferromagnetic insulators, which is the magnonic analog of the inverse spin-galvanic effect of electrons. We derive a linear-response theory of a temperature-gradient-induced spin polarization for collinear and noncollinear antiferromagnets, which comprises both extrinsic and intrinsic contributions. We apply our theory to several noncentrosymmetric antiferromagnetic insulators, i.e., to a one-dimensional antiferromagnetic spin chain, a single layer of kagome noncollinear antiferromagnet, e.g., KFe 3 ( OH ) 6 ( SO 4 ) 2 , and a noncollinear breathing pyrochlore antiferromagnet, e.g., LiGaCr 4 O 8 . The shapes of our numerically evaluated response tensors agree with those implied by the magnetic symmetry. Furthermore, assuming a realistic temperature gradient of 10 K/mm , we find two-dimensional spin densities of up to ~ 10 6 ℏ / cm 2 and three-dimensional bulk spin densities of up to ~ 10 14 ℏ / cm 3 , encouraging an experimental detection

36 MATERIALS SCIENCE↗
DOE OSTI2020

Observation of T = 3/2 isobaric analog states in 9 Be using p + 8 Li resonance scattering

Background: Resonance scattering has been extensively used to study the structure of exotic, neutron-deficient nuclei. Extension of the resonance scattering technique to neutron-rich nuclei was suggested more than 20 years ago. This development is based on the isospin conservation law. In spite of broad field of the application, it has never gained a wide-spread acceptance. Purpose: To benchmark the experimental approach to study the structure of exotic neutron-rich nuclei through resonance scattering on a proton target. Method: In this work, the excitation function for p + 8 Li resonance scattering is measured using a thick target by recording coincidence between light and heavy recoils, populating T = 3/2 isobaric analog states (IAS) in 9 Be. Results: A good fit of the 8 Li(p, p) 8 Li resonance elastic scattering excitation function was obtained using previously tentatively known 5/2 – T = 3/2 state at 18.65 MeV in 9 Be and a new broad T = 3/2 s-wave state—the 5/2 + at 18.5 MeV. These results fit the expected isomirror properties for the T = 3/2 A = 9 isoquartet. Conclusions: Our analysis confirmed isospin as a good quantum number for the investigated highly excited T = 3/2 states and demonstrated that studying the structure of neutron-rich exotic nuclei through IAS is a promising approach.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2024

A Cryogenic readout integrated circuit with analog pile-up and in-Pixel ADC for high frame rate Skipper CCD-in-CMOS Sensors

The Skipper CCD-in-CMOS Parallel Read-Out Circuit V2 (SPROCKET2) is designed to enable high frame rate readout of Skipper CCD-in-CMOS image sensors. The SPROCKET2 pixel is fabricated in a 65 nm CMOS process and occupies a 60$\mu$m $\times$ 60$\mu$m footprint. SPROCKET2 is intended to be heterogeneously integrated with a pixelated Skipper CCD-in-CMOS sensor, such that one readout pixel is connected to a multiplexed array of 16 active image sensor pixels, to match their spatial geometry. Our design benefits from the Skipper CCD-in-CMOS sensor's non-destructive readout capability to achieve exceptionally low noise through multi-sampling and averaging while optimizing for total power consumption. The pixel readout utilizes correlated double sampling to minimize 1/f noise and includes "pile-up" of ten successive samples in the analog domain before digitizing at a rate of 66.7 ksps. Measurement results of in-pixel serial SAR ADC show DNL and INL of ~0. 44 LSB and 0.58 LBS respectively. A large area array of 20,000 SPROCKET2 ADC pixels (multiplexed 1:16 to 320,000 sensor pixels) is currently under test. By reading out data over a 10 Gbps optical link, this pixel design enables a frame rate of $\sim$ 4 kfps for large sensing areas with minimal sensing deadtime. In the highest gain mode, the pixelated ADC has an input-referred resolution of 10$\mu$V with a simulated power consumption of 50$\mu$W. The pixel operates with constant current draw to minimize power-rail crosstalk.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2023

Optical polarization analogs in inelastic free-electron scattering

Advances in the ability to manipulate free-electron phase profiles within the electron microscope have spurred development of quantum-mechanical descriptions of electron energy loss (EEL) processes involving transitions between phase-shaped transverse states. Here, we elucidate an underlying connection between two ostensibly distinct optical polarization analogs identified in EEL experiments as manifestations of the same conserved scattering flux. Our work introduces a procedure for probing general tensorial target characteristics including global mode symmetries and local polarization.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2020

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

Biased agonists of G protein–coupled receptors (GPCRs) preferentially activate a subset of downstream signaling pathways. In this work, we present crystal structures of angiotensin II type 1 receptor (AT1R) (2.7 to 2.9 angstroms) bound to three ligands with divergent bias profiles: the balanced endogenous agonist angiotensin II (AngII) and two strongly β-arrestin–biased analogs. Compared with other ligands, AngII promotes more-substantial rearrangements not only at the bottom of the ligand-binding pocket but also in a key polar network in the receptor core, which forms a sodium-binding site in most GPCRs. Divergences from the family consensus in this region, which appears to act as a biased signaling switch, may predispose the AT1R and certain other GPCRs (such as chemokine receptors) to adopt conformations that are capable of activating β-arrestin but not heterotrimeric G q protein signaling.

Wingler, Laura M. (ORCID:0000000236885088)↗
DOE OSTI2020

Real-time jitter correction in a photonic analog-to-digital converter

A real-time jitter meter is used to measure and digitally sample the pulse-to-pulse timing error in a laser pulse train. The jitter meter is self-referenced using a single-pulse delay line interferometer and measures timing jitter using optical heterodyne detection between two frequency channels of the pulse train. Jitter sensitivity down to 3×10 -10 fs 2 /Hz at 500 MHz has been demonstrated with a pulse-to-pulse noise floor of 1.6 fs. Furthermore, as a proof of principle, the digital correction of the output of a high-frequency photonic analog-to-digital converter (PADC) is demonstrated with an emulated jitter signal. Up to 23 dB of jitter correction, down to the noise floor of the PADC, is accomplished with radio-frequency modulation up to 40 GHz.

47 OTHER INSTRUMENTATION↗
DOE OSTI2021

Derivation of the Future Time Equation for Analog, Non-Multiplying Monte Carlo Simulation

The expected computational time required to simulate a particle from a point in phase space through a Monte Carlo history, termed the expected future time, is found by solving the Future Time Equation (FTE). The expected future time may be useful when generating variance reduction parameters for a Monte Carlo simulation with a method such as Consistent Adjoint Driven Importance Sampling (CADIS). This report presents a detailed derivation of the Future Time Probability Density Function (FTPDF) and FTE for neutral particle Monte Carlo transport to aid future researchers. For simplicity, this derivation only considers analog transport in non-multiplying media.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2022

Review of Analogous Basins

Sedimentary basins comprise extensive porous sandstone and carbonate reservoirs capable of hosting economically significant greenfield and brownfield residual oil zones (ROZs). Several basins in the United States, including the intracratonic Illinois Basin (ILB), have stacked, predominantly siliciclastic ROZs that are potential targets for tertiary recovery of petroleum and for storing large volumes of anthropogenic carbon in the subsurface. The rocks in these basins share facies and depositional settings with many reservoirs that have already been major producers in primary production and, in some cases, as carbon dioxide enhanced oil recovery (CO 2 -EOR)targets. The lessons learned from field data collection and testing of these intervals in a basin like the ILB have broad applications to analogous basins with potential ROZs.

02 PETROLEUM↗
DOE OSTI2024

Zero-Power Analog Optical Processing

The motivation behind this research is the growing challenge of handling the massive amounts of data generated by modern imaging systems. Conventional digital image processing techniques are struggling to keep pace with the demands of high-resolution and high-speed imaging systems for remote sensing due to their high-power consumption and data storage requirements. We present a novel approach based on analog photonics to address this challenge. The proposed system utilizes a silicon-photonics-based image encoder positioned after image formation and initial optical-to-electrical conversion. The photonic encoder compresses image data using a passive disordered photonic structure to perform kernel-type random projections of the raw data. The compressed data is then processed by a back-end neural network, which reconstructs the original image with high fidelity (structural similarity exceeding 90%). Our proposed approach has the potential to compress images with ~ 1000X lower power consumption compared to digital approaches with data rates exceeding 1 terapixel/second.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2024

Analog Computing for Science

Conventional digital computing faces fundamental physical limits: large scale computing systems already con sume tens of Megawatts of power, Dennard scaling has ended, and data movement costs dominate application performance. Next generation experimental facilities generate data at rates that overwhelm conventional pro cessing and demand real-time analysis at the source. Analog computing, which exploits the continuous dynamics of physical systems to perform computation, promises a transformative path toward orders-of-magnitude gains in energy efficiency and time-to-solution for scientific workloads.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2025

SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors

Ebola virus (EBOV) causes severe hemorrhagic fever with a high mortality rate in humans. In acute infection, an abnormal immune response results in excessive inflammatory cytokines and uncontrolled systemic inflammation that can result in organ damage and multi-organ failure. While vaccines and monoclonal antibody therapies are available, there is an urgent need for effective small-molecule antivirals against EBOV. Here, we report on the optimization of tamoxifen, an EBOV-glycoprotein (GP) binder that inhibits viral entry, using our Sulfur-Fluoride Exchange (SuFEx) click chemistry-based high-throughput medicinal chemistry (HTMC) strategy. Using a “Direct-to-Biology” approach, we generated a focused library of 2,496 tamoxifen analogs overnight and screened them in a cell-based pseudo-EBOV infection assay. The HTMC workflow enabled the development of a potent EBOV entry inhibitor with submicromolar EC 50 cellular antiviral activity and more than 50-fold improvement in binding affinity against EBOV-GP compared to the parent compound. Our findings underscore the use of SuFEx-enabled HTMC for rapidly generating and assessing potential therapeutic candidates against viral and immune-mediated diseases in a cell-based assay.

Immunology↗
DOE OSTI2022

Structural Characterization of Alzheimer DNA Promoter Sequences from the Amyloid Precursor Gene in the Presence of Thioflavin T and Analogs

Understanding DNA-ligand binding interactions requires ligand screening, crystallization, and structure determination. In order to obtain insights into the amyloid peptide precursor (APP) gene-Thioflavin T (ThT) interaction, single crystals of two DNA sequences 5'-GCCCACCACGGC-3' (PDB 8ASK) and d(CCGGGGTACCCCGG) 2 (PDB 8ASH) were grown in the presence of ThT or its analogue 2-((4-(dimethylamino)benzylidene)amino)-3,6-dimethylbenzo[d]thiazol-3-ium iodide (XRB). Both structures were solved by molecular replacement. In the case of 8ASK, the space group was H3 with unit cell dimensions of a = b = 64.49 Å, c = 46.19 Å. Phases were obtained using a model generated by X3DNA. The novel 12-base-pair B-DNA structure did not have extra density for the ThT ligand. The 14-base-pair A-DNA structure with bound ThT analog XRB was isomorphous with previously the obtained apo-DNA structure 5WV7 (space group was P 4 1 2 1 2 with unit cell dimensions a = b = 41.76 Å, c = 88.96 Å). Binding of XRB to DNA slightly changes the DNA's buckle parameters at the CpG regions. Comparison of the two conformations of the XRB molecule: alone and bound to DNA indicates that the binding results from the freedom of rotation of the two aromatic rings.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

CLASSY IV. Exploring UV Diagnostics of the Interstellar Medium in Local High- z Analogs at the Dawn of the JWST Era

The Cosmic Origins Spectrograph (COS) Legacy Archive Spectroscopic SurveY (CLASSY) provides the first high resolution spectral catalog of 45 local high-z analogs in the ultraviolet (UV; 1200–2000 Å) to investigate their stellar and gas properties. Here we present a toolkit of UV interstellar medium (ISM) diagnostics, analyzing the main emission lines of CLASSY spectra (N IV] λλ1483,87, C IV λλ1548,51, He IIλ1640, O III]λλ1661,6, Si III] λλ1883,92, C III] λ1907,9). Specifically, our aim is to provide accurate diagnostics for the reddening E(B - V), electron density n e , electron temperature T e , metallicity 12+log(O/H), and ionization parameter log(U), taking the different ISM ionization zones into account. We calibrate our UV toolkit using well-known optical diagnostics, analyzing archival optical spectra for all CLASSY targets. We find that UV density diagnostics estimate n e values that are ~1–2 dex higher (e.g., n e (C III] λλ1907,9) ~ 10 4 cm -3 ) than those inferred from their optical counterparts (e.g., n e ([S II]λλ6717,31) ~ 10 2 cm -3 ; n e ([Ar IV]λλ4714,41) ~ 10 3 cm -3 ). T e derived from the hybrid ratio [O III] λ1666/λ5007 proves to be reliable, implying differences in determining 12+log(O/H) compared to the optical counterpart O III] λ4363/[O III] λ5007 within ~ ±0.3 dex. We also investigate the relation between the stellar and gas E(B - V), finding consistent values at high specific star formation rates (sSFRs; log sSFR ≳ -8 yr -1 ), while at low sSFRs we confirmed an excess of dust attenuation in the gas. Finally, we investigate UV line ratios and equivalent widths to provide correlations with 12+log (O/H) and log(U), but note that there are degeneracies between the two. With this suite of UV-based diagnostics, we illustrate the pivotal role CLASSY plays in understanding the chemical and physical properties of high-z systems that JWST can observe in the rest-frame UV.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2025

Cosmological Simulations of Stellar Halos with Gaia Sausage–Enceladus Analogs: Two Sausages, One Bun?

Observations of the Milky Way’s stellar halo find that it is predominantly comprised of a radially biased population of stars, dubbed the Gaia Sausage–Enceladus, or GSE. These stars are thought to be debris from dwarf galaxy accretion early in the Milky Way’s history. Though typically considered to be from a single merger, it is possible that the GSE debris has multiple sources. To investigate this possibility, we use the IllustrisTNG50 simulation to identify stellar accretion histories in 98 Milky Way analogs—the largest sample for which such an identification has been performed—and find GSE-like debris in 32, with two-merger GSEs accounting for a third of these cases. Distinguishing single-merger GSEs from two-merger GSEs is difficult in common kinematic spaces, but differences are more evident through chemical abundances and star formation histories. This is because single-merger GSEs are typically accreted more recently than the galaxies in two-merger GSEs: the median infall times (with 16th and 84th percentiles) are $5.{9}_{-2.0}^{+3.3}$ and $10.{7}_{-3.7}^{+1.2}$ Gyr ago for single- and two-merger scenarios, respectively. The systematic shifts in abundances and ages that occur as a result suggest that efforts in modeling these aspects of the stellar halo prove ever-important in understanding its assembly.

galactic archaeology↗
DOE OSTI2026

Dwarf Galaxy Number Counts within 25 Mpc: Predictions from Local Group Analogs in TNG50

The modern generation of wide-field galaxy surveys, such as LSST, Euclid, and Roman, will enable studies of dwarf galaxies (10 6 ≤ M * /M ⊙ ≤ 10 9 ) beyond the Local Group (LG) in unprecedented detail. Improved theoretical understanding of this population is necessary to guide these observations, since predictions in this regime are generally limited to specific environments like the LG. We present predictions for the population of dwarf galaxies from the TNG50 run of the IllustrisTNG suite of cosmological hydrodynamical simulations, focusing on the environments within 1 < D/Mpc < 25 of LG analogs at z = 0. In the simulated sample, there are ∼1000 and ∼12,000 dwarf galaxies within 10 and 25 Mpc, respectively. We compare our results with the 50 Mpc Galaxy Catalog and estimate that current observations are highly incomplete at low masses: for 10 6 ≤ M * /M ⊙ ≤ 10 7 (−13 ≲ M r ≲ −10), we find completeness fractions of ∼23% within 10 Mpc and ∼4% within 25 Mpc. The simulated galaxies below the completeness limits of the observations exist in a range of environments, with notable populations of field dwarfs at all distances and satellites around centrals with masses 10 8 ≲ M * /M ⊙ ≲ 10 11 within 10–25 Mpc. We find that there are ∼8 times more quiescent dwarf galaxies in the TNG50 sample than are currently cataloged. Our results suggest that upcoming observations should uncover a substantial population of dwarf galaxies, and that ≳15% of these will be red, currently quenched galaxies in the field.

Shread, Evangela E. [California Institute of Techn↗