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Vestibulospinal reflexes as a function of microgravity

Data from previous manned space flights suggest that an exposure to microgravity produces significant alterations in vestibular, neuromuscular, and related sensory system functions. It is possible that the observed changes are a function of adaptation induced by altered otolith input. An experiment in Spacelab 1 was conducted with the aim to study this adaptation as it occurred in flight and after flight, and to relate the observed changes to mechanisms underlying space motion sickness. The concept was explored by making use of the anatomic pathway which links the otolith organs and spinal motoneurons. The overall sensitivity of the spinal motoneurons was tested by two related methods. One method involves the electrical excitation of neural tissue and the recording of vestibulospinal reflexes in conjunction with a brief linear acceleration. The second method is concerned with measurements of dynamic postural ataxia. Results suggest that more than a single time constant may be involved in man's ability to return to baseline values.

Reschke, M. F.↗

Supernova pointing capabilities of DUNE

The determination of the direction of a stellar core collapse via its neutrino emission is crucial for the identification of the progenitor for a multimessenger follow-up. A highly effective method of reconstructing supernova directions within the Deep Underground Neutrino Experiment (DUNE) is introduced. The supernova neutrino pointing resolution is studied by simulating and reconstructing electron-neutrino charged-current absorption on 40 Ar and elastic scattering of neutrinos on electrons. Procedures to reconstruct individual interactions, including a newly developed technique called “brems flipping,” as well as the burst direction from an ensemble of interactions are described. Performance of the burst direction reconstruction is evaluated for supernovae happening at a distance of 10 kpc for a specific supernova burst flux model. The pointing resolution is found to be 3.4 degrees at 68% coverage for a perfect interaction-channel classification and a fiducial mass of 40 kton, and 6.6 degrees for a 10 kton fiducial mass respectively. Assuming a 4% rate of charged-current interactions being misidentified as elastic scattering, DUNE’s burst pointing resolution is found to be 4.3 degrees (8.7 degrees) at 68% coverage.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Post-Test Analysis of the Deep Space One Spare Flight Thruster Ion Optics

The Deep Space 1 (DSl) spare flight thruster (FT2) was operated for 30,352 hours during the extended life test (ELT). The test was performed to validate the service life of the thruster, study known and identify unknown life limiting modes. Several of the known life limiting modes involve the ion optics system. These include loss of structural integrity for either the screen grid or accelerator grid due to sputter erosion from energetic ions striking the grid, sputter erosion enlargement of the accelerator grid apertures to the point where the accelerator grid power supply can no longer prevent electron backstreaming, unclearable shorting between the grids causes by flakes of sputtered material, and rouge hole formation due to flakes of material defocusing the ion beam. Grid gap decrease, which increases the probability of electron backstreaming and of arcing between the grids, was identified as an additional life limiting mechanism after the test. A combination of accelerator grid aperture enlargement and grid gap decrease resulted in the inability to prevent electron backstreaming at full power at 26,000 hours of the ELT. Through pits had eroded through the accelerator grid webbing and grooves had penetrated through 45% of the grid thickness in the center of the grid. The upstream surface of the screen grid eroded in a chamfered pattern around the holes in the central portion of the grid. Sputter deposited material, from the accelerator grid, adhered to the downstream surface of the screen grid and did not spall to form flakes. Although a small amount of sputter deposited material protruded into the screen grid apertures, no rouge holes were found after the ELT.

NASA Solar electric propulsion Technology Applicat↗

The Annual Glaciohydrology Cycle in the Ablation Zone of the Greenland Ice Sheet: Part 2. Observed and Modeled Ice Flow

Ice velocities observed in 2005/06 at three GPS stations along the Sermeq Avannarleq flowline, West Greenland, are used to characterize an observed annual velocity cycle. We attempt to reproduce this annual ice velocity cycle using a 1-D ice-flow model with longitudinal stresses coupled to a 1-D hydrology model that governs an empirical basal sliding rule. Seasonal basal sliding velocity is parameterized as a perturbation of prescribed winter sliding velocity that is proportional to the rate of change of glacier water storage. The coupled model reproduces the broad features of the annual basal sliding cycle observed along this flowline, namely a summer speed-up event followed by a fall slowdown event. We also evaluate the hypothesis that the observed annual velocity cycle is due to the annual calving cycle at the terminus. We demonstrate that the ice acceleration due to a catastrophic calving event takes an order of magnitude longer to reach CU/ETH ('Swiss') Camp (46km upstream of the terminus) than is observed. The seasonal acceleration observed at Swiss Camp is therefore unlikely to be the result of velocity perturbations propagated upstream via longitudinal coupling. Instead we interpret this velocity cycle to reflect the local history of glacier water balance.

ice flow↗

Measurement of charged hadron multiplicity in Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV with the sPHENIX detector

The pseudorapidity distribution of charged hadrons produced in Au + Au collisions at a center-of-mass energy of $\sqrt{s_{NN}}$ = 200 GeV is measured using data collected by the sPHENIX detector. Charged hadron yields are extracted by counting cluster pairs in the inner and outer layers of the Intermediate Silicon Tracker, with corrections applied for detector acceptance, reconstruction efficiency, combinatorial pairs, and contributions from secondary decays. The measured distributions cover |η| < 1.1 across various centralities, and the average pseudorapidity density of charged hadrons at mid-rapidity is compared to predictions from Monte Carlo heavy-ion event generators. This result, featuring full azimuthal coverage at mid-rapidity, is consistent with previous experimental measurements at the Relativistic Heavy Ion Collider, thereby supporting the broader sPHENIX physics program.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Voyager 2 test of the radar time-delay effect

By analyzing radio range measurements generated during the solar conjunction of the Voyager 2 spacecraft in 1985, the relativistic time-delay effect has been tested accurately with a spacecraft at a distance of 3 x 10 to the 9th km from the earth. Because the range measurements were generated simultaneously at two frequencies on the downlink, it was possible to derive calibrations for the delay resulting from intervening solar plasma. In addition, a record of attitude thruster firings was used to model small accelerations of the spacecraft that could have produced a range error. It was thereby possible to determine the parameterized post-Newtonian parameter gamma to an accuracy of 3 percent with only a sparse amount of range data.

Krisher, Timothy P.↗

Search for a light charged Higgs boson in $t \rightarrow H^{\pm } b$ decays, with $H^{\pm } \rightarrow cs$, in $pp$ collisions at $\sqrt{s}={13}\hbox { TeV}$ with the ATLAS detector

A search for a light charged Higgs boson produced in decays of the top quark, $t \rightarrow H^{\pm } b$ with $H^{\pm } \rightarrow cs$, is presented. This search targets the production of top-quark pairs $t\bar{t} \rightarrow WbH^{\pm } b$, with $W \rightarrow ℓv(ℓ = e, μ)$, resulting in a lepton-plus-jets final state characterised by an isolated electron or muon and at least four jets. The search exploits b-quark and c-quark identification techniques as well as multivariate methods to suppress the dominant $t\bar{t}$ background. The data analysed correspond to 140 fb -1 of $pp$ collisions at $\sqrt{s}$ = 13 TeV recorded with the ATLAS detector at the LHC between 2015 and 2018. Observed (expected) 95% confidence-level upper limits on the branching fraction $\mathscr{B}(t \rightarrow H^{\pm } b)$, assuming $\mathscr{B}(t \rightarrow Wb) + \mathscr{B}(t \rightarrow H^{\pm }(\rightarrow cs)b$, are set between 0.066% (0.077%) and 3.6% (2.3%) for a charged Higgs boson with a mass between 60 and 168 GeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Computational tools and data integration to accelerate vaccine development: challenges, opportunities, and future directions

The development of effective vaccines is crucial for combating current and emerging pathogens. Despite significant advances in the field of vaccine development there remain numerous challenges including the lack of standardized data reporting and curation practices, making it difficult to determine correlates of protection from experimental and clinical studies. Significant gaps in data and knowledge integration can hinder vaccine development which relies on a comprehensive understanding of the interplay between pathogens and the host immune system. In this review, we explore the current landscape of vaccine development, highlighting the computational challenges, limitations, and opportunities associated with integrating diverse data types for leveraging artificial intelligence (AI) and machine learning (ML) techniques in vaccine design. We discuss the role of natural language processing, semantic integration, and causal inference in extracting valuable insights from published literature and unstructured data sources, as well as the computational modeling of immune responses. Furthermore, we highlight specific challenges associated with uncertainty quantification in vaccine development and emphasize the importance of establishing standardized data formats and ontologies to facilitate the integration and analysis of heterogeneous data. Through data harmonization and integration, the development of safe and effective vaccines can be accelerated to improve public health outcomes. Looking to the future, we highlight the need for collaborative efforts among researchers, data scientists, and public health experts to realize the full potential of AI-assisted vaccine design and streamline the vaccine development process.

60 APPLIED LIFE SCIENCES↗

Hard solar flare X-ray bursts on 8 December 1970

Hard X-ray bursts have been observed from two 1B flares located in the same sunspot region and separated in time by about 70 minutes on Dec. 8, 1970. The bursts are composed by many 'flashes' of 2 to 20 seconds duration. Power spectrum analysis reveals no strong periodicities although a significant peak appears at 7.5 sec. The characteristic times of 2 to 20 sec do not seem likely to be electron transit times since the flare size is so small. These times are evidently connected with the acceleration of the electrons. Fitting Takakura's model of the radio noise region to the observations, this region is found to be small, but the density of electrons above 100 keV is high, on the order of 10 million per cu cm.

Anderson, K. A.↗

Measurements of the production cross-sections of a Higgs boson in association with a vector boson and decaying into WW * with the ATLAS detector at $\sqrt{s}$ = 13 TeV

Measurements of the total and differential Higgs boson production cross-sections, via WH and ZH associated production using H → WW* → ℓνℓν and H → WW* → ℓνjj decays, are presented. The analysis uses proton-proton events delivered by the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector between 2015 and 2018. The data correspond to an integrated luminosity of 140 fb −1 . The sum of the WH and ZH cross-sections times the H → WW* branching fraction is measured to be ${0.44}_{-0.09}^{+0.10}$ (stat.)$_{-0.05}^{+0.06}$ (syst.) pb, in agreement with the Standard Model prediction. Higgs boson production is further characterised through measurements of the differential cross-section as a function of the transverse momentum of the vector boson and in the framework of Simplified Template Cross-Sections.

hadron-hadron scattering↗

Combination of searches for singly produced vectorlike top quarks in 𝑝⁢𝑝 collisions at $\sqrt{𝑠}$ =13 TeV with the ATLAS detector

A combination of searches for the single production of vectorlike top quarks (𝑇) is presented. These analyses are based on proton-proton collisions at $\sqrt{𝑠}$ = 13 TeV recorded in 2015–2018 with the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb −1 . The 𝑇 decay modes considered in this combination are into a top quark and either a Standard Model Higgs boson or a 𝑍 boson (𝑇 → 𝐻⁡𝑡 and 𝑇 → 𝑍⁢𝑡). The individual searches used in the combination are differentiated by the number of leptons (𝑒, 𝜇) in the final state. The observed data are found to be in good agreement with the Standard Model background prediction. Interpretations are provided for a range of masses and couplings of the vectorlike top quark for benchmark models and generalized representations in terms of 95% confidence level limits. For a benchmark signal prediction of a vectorlike top quark SU(2) singlet with electroweak coupling, 𝜅, of 0.5, masses below 2.1 TeV are excluded, resulting in the most restrictive limits to date.

Composite models↗

Measurement of the associated production of a top-antitop-quark pair and a Higgs boson decaying into a $b\bar{b}$ pair in pp collisions at $\sqrt{s} = 13$ TeV using the ATLAS detector at the LHC

This paper reports the measurement of Higgs boson production in association with a $t\bar{t}$ pair in the $H$ → $b\bar{b}$ decay channel. The analysis uses 140 fb -1 of 13 TeV proton–proton collision data collected with the ATLAS detector at the Large Hadron Collider. The final states with one or two electrons or muons are employed. An excess of events over the expected background is found with an observed (expected) significance of 4.6 (5.4) standard deviations. The $t\bar{t}$ $H$ cross-section is $σ_{t\bar{t} H}$ = $411^{+101}_{-92}$ fb = $411 ± 54$ (stat.) $^{+85}_{-75}$ (syst.) fb for a Higgs boson mass of 125.09 GeV, consistent with the prediction of the Standard Model of $507^{+35}_{-75}$ fb. The cross-section is also measured differentially in bins of the Higgs boson transverse momentum within the simplified template cross-section framework.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for light neutral particles decaying promptly into collimated pairs of electrons or muons in pp collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector

A search for a dark photon, a new light neutral particle, which decays promptly into collimated pairs of electrons or muons is presented. The search targets dark photons resulting from the exotic decay of the Standard Model Higgs boson, assuming its production via the dominant gluon-gluon fusion mode. The analysis is based on 140 fb -1 of data collected with the ATLAS detector at the Large Hadron Collider from proton-proton collisions at a center-of-mass energy of 13 TeV. Events with collimated pairs of electrons or muons are analysed and background contributions are estimated using data-driven techniques. No significant excess in the data above the Standard Model background is observed. Upper limits are set at 95% confidence level on the branching ratio of the Higgs boson decay into dark photons between 0.001% and 5%, depending on the assumed dark photon mass and signal model.

Aad, G. [Aix-Marseille Université] (ORCID:00000002↗

Search for $t\bar{t}H/A \rightarrow t\bar{t}t\bar{t}$ production in proton–proton collisions at $\sqrt{s}=13$ $\text {TeV}$ with the ATLAS detector

A search is presented for a heavy scalar (H) or pseudo-scalar (A) predicted by the two-Higgs-doublet models, where the H/A is produced in association with a top-quark pair $(t\bar{t}H/A),$ and with the H/A decaying into a $t\bar{t}$ pair. The full LHC Run 2 proton–proton collision data collected by the ATLAS experiment is used, corresponding to an integrated luminosity of $139~\text {fb}^{-1}.$ Events are selected requiring exactly one or two opposite-charge electrons or muons. Data-driven corrections are applied to improve the modelling of the $t\bar{t}$ +jets background in the regime with high jet and b-jet multiplicities. These include a novel multi-dimensional kinematic reweighting based on a neural network trained using data and simulations. An H/A-mass parameterised graph neural network is trained to optimise the signal-to-background discrimination. In combination with the previous search performed by the ATLAS Collaboration in the multilepton final state, the observed upper limits on the $t\bar{t}H/A \rightarrow t\bar{t}t\bar{t}$ production cross-section at 95% confidence level range between 14 fb and 5.0 fb for an H/A with mass between 400 GeV and 1000 GeV , respectively. Assuming that both the H and A contribute to the $t\bar{t}t\bar{t}$ cross-section, tan β values below 1.7 or 0.7 are excluded for a mass of 400 GeV or 1000 GeV , respectively. The results are also used to constrain a model predicting the pair production of a colour-octet scalar, with the scalar decaying into a $t\bar{t}$ pair.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A precise measurement of the jet energy scale derived from single-particle measurements and in situ techniques in proton–proton collisions at $\sqrt{s}=$ 13 TeV with the ATLAS detector

The jet energy calibration and its uncertainties are derived from measurements of the calorimeter response to single particles in both data and Monte Carlo simulation using proton–proton collisions at $\sqrt{s} = 13$ TeV collected with the ATLAS detector during Run 2 at the Large Hadron Collider. The jet calibration uncertainty for anti-$k_T$ jets with a jet radius parameter of R$_\textrm{jet} = 0.4$ and in the central jet rapidity region is about 2.5% for transverse momenta ($p_{\text {T}}$) of 20 $\text {GeV}$ , about 0.5% for $p_{\text {T}} = 300$ GeV and 0.7% for $p_{\text {T}} = 4$ TeV . Excellent agreement is found with earlier determinations obtained from -balance based in situ methods ($Z/\gamma$ +jets). The combination of these two independent methods results in the most precise jet energy measurement achieved so far with the ATLAS detector with a relative uncertainty of 0.3% at $p_\textrm{T} = 300$ GeV and 0.6% at 4 TeV. The jet energy calibration is also derived with the single-particle calorimeter response measurements separately for quark- and gluon-induced jets and furthermore for jets with R jet varying from 0.2 to 1.0 retaining the correlations between these measurements. Differences between inclusive jets and jets from boosted top-quark decays, with and without grooming the soft jet constituents, are also studied.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A continuous calibration of the ATLAS flavour-tagging classifiers via optimal transportation maps

A calibration of the ATLAS flavour-tagging algorithms using a new calibration procedure based on optimal transportation maps is presented. Simultaneous, continuous corrections to the b-jet, c-jet, and light-flavour jet classification probabilities from jet-tagging algorithms in simulation are derived for b-jets using $t\bar{t} \rightarrow e\mu \nu \nu bb$ data. After application of the derived calibration maps, closure between simulation and observation is achieved for jet flavour observables used in ATLAS analyses of Large Hadron Collider (LHC) Run 2 proton-proton collision data. This continuous calibration opens up new possibilities for the future use of jet flavour information in LHC analyses and also serves as a guide for deriving high-dimensional corrections to simulation via transportation maps, an important development for a broad range of inference tasks.

Aad, G. [Aix-Marseille Université] (ORCID:00000002↗

30- to 100-keV protons upstream from the earth's bow shock

Protons of 30 to 100 keV are found upstream from the bow shock whenever interplanetary magnetic fields connect the spacecraft and bow shock. The protons do not appear upstream of a boundary determined by the solar wind speed (the speed at which the interplanetary field is being convected) and an effective upstreaming velocity of 2.5 to 3 times the solar wind speed along the field lines. It is believed that (1) the lower-energy (3-4 keV) protons accelerated and reflected by the bow shock and (2) the Alfven waves observed upstream are in some way responsible for the origin of the 30- to 100-keV protons in very large regions upstream from the bow shock.

Lin, R. P.↗

Disruption of postural readaptation by inertial stimuli following space flight

Postural instability (relative to pre-flight) has been observed in all shuttle astronauts studied upon return from orbital missions. Postural stability was more closely examined in four shuttle astronaut subjects before and after an 8 day orbital mission. Results of the pre- and post-flight postural stability studies were compared with a larger (n = 34) study of astronauts returning from shuttle missions of similar duration. Results from both studies indicated that inadequate vestibular feedback was the most significant sensory deficit contributing to the postural instability observed post flight. For two of the four IML-1 astronauts, post-flight postural instability and rate of recovery toward their earth-normal performance matched the performance of the larger sample. However, post-flight postural control in one returning astronaut was substantially below mean performance. This individual, who was within normal limits with respect to postural control before the mission, indicated that recovery to pre-flight postural stability was also interrupted by a post-flight pitch plane rotation test. A similar, though less extreme departure from the mean recovery trajectory was present in another astronaut following the same post-flight rotation test. The pitch plane rotation stimuli included otolith stimuli in the form of both transient tangential and constant centripetal linear acceleration components. We inferred from these findings that adaptation on orbit and re-adaptation on earth involved a change in sensorimotor integration of vestibular signals most likely from the otolith organs.

NASA Center JSC↗