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Baroreflex regulation of blood pressure during dynamic exercise

From the work of Potts et al. Papelier et al. and Shi et al. it is readily apparent that the arterial (aortic and carotid) baroreflexes are reset to function at the prevailing ABP of exercise. The blood pressure of exercise is the result of the hemodynamic (cardiac output and TPR) responses, which appear to be regulated by two redundant neural control systems, "Central Command" and the "exercise pressor reflex". Central Command is a feed-forward neural control system that operates in parallel with the neural regulation of the locomotor system and appears to establish the hemodynamic response to exercise. Within the central nervous system it appears that the HLR may be the operational site for Central Command. Specific neural sites within the HLR have been demonstrated in animals to be active during exercise. With the advent of positron emission tomography (PET) and single-photon emission computed tomography (SPECT), the anatomical areas of the human brain related to Central Command are being mapped. It also appears that the Nucleus Tractus Solitarius and the ventrolateral medulla may serve as an integrating site as they receive neural information from the working muscles via the group III/IV muscle afferents as well as from higher brain centers. This anatomical site within the CNS is now the focus of many investigations in which arterial baroreflex function, Central Command and the "exercise pressor reflex" appear to demonstrate inhibitory or facilitatory interaction. The concept of whether Central Command is the prime mover in the resetting of the arterial baroreceptors to function at the exercising ABP or whether the resetting is an integration of the "exercise pressor reflex" information with that of Central Command is now under intense investigation. However, it would be justified to conclude, from the data of Bevegard and Shepherd, Dicarlo and Bishop, Potts et al., and Papelier et al. that the act of exercise results in the resetting of the arterial baroreflex. In addition, if, as we have proposed, the cardiopulmonary baroreceptors primarily monitors and reflexly regulates cardiac filling volume, it would seem from the data of Mack et al. and Potts et al. that the cardiopulmonary baroreceptor is also reset at the beginning of exercise. Therefore, investigations of the neural mechanisms of regulation involving Central Command and cardiopulmonary afferents, similar to those being undertaken for the arterial baroreflex, need to be established.

NASA Discipline Cardiopulmonary↗

Clamp-mount device

A clamp-mount device is disclosed for mounting equipment to an associated I-beam and the like structural member of the type having oppositely extending flanges wherein the device comprises a base and a pair of oppositely facing clamping members carried diagonally on the base clamping flanges therebetween and having flange receiving openings facing one another. Lock means are carried diagonally by the base opposite the clamping members locking the flanges in the clamping members. A resilient hub is carried centrally of the base engaging and biasing a back side of the flanges maintaining tightly clamped and facilitating use on vertical as well as horizontal members. The base turns about the hub to receive the flanges within the clamping members. Equipment may be secured to the base by any suitable means such as bolts in openings. Slidable gate latches secure the hinged locks in an upright locking position. The resilient hub includes a recess opening formed in the base and a rubber-like pad carried in this opening being depressably and rotatably carried therein.

Clark, K. H.↗

The Neuroendocrinology of Thirst and Salt Appetite: Visceral Sensory Signals and Mechanisms of Central Integration

This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of body fluids, together with reflex endocrine and neural responses, are critical for reestablishing homeostasis. Like their endocrine and neural counterparts, these behaviors are under the control of both excitatory and inhibitory influences arising from changes in osmolality, endocrine factors such as angiotensin and aldosterone, and neural signals from low and high pressure baroreceptors. The excitatory and inhibitory influences reaching the brain require the integrative capacity of a neural network which includes the structures of the lamina terminalis, the amygdala, the perifornical area, and the paraventricular nucleus in the forebrain, and the lateral parabrachial nucleus (LPBN), the nucleus tractus solitarius (NTS), and the area postrema in the hindbrain. These regions are discussed in terms of their roles in receiving afferent sensory input and in processing information related to hydromineral balance. Osmoreceptors controlling thirst are located in systemic Viscera and in central structures that lack the blood-brain barrier. Angiotensin and aldosterone act on and through structures of the lamina terminalis and the amygdala to stimulate thirst and sodium appetite under conditions of hypovolemia. The NTS and LPBN receive neural signals from baroreceptors and are responsible for inhibiting the ingestion of fluids under conditions of increased volume and pressure and for stimulating thirst under conditions of bypovolemia and hypotension. The interplay of multiple facilitory influences within the brain may take the form of interactions between descending angiotensinergic systems originating in the forebrain and ascending adrenergic systems emanating from the hindbrain. Oxytocin and serotonin are additional candidate neuro- chemicals with postulated inhibitory central actions and with essential roles in the overall integration of sensory input within the neural network devoted to maintaining hydromineral balance.

Johnson, Alan Kim↗

Interplanetary Microlaser Transponders

The feasibility of an asynchronous (i.e. independently firing) interplanetary laser transponder, capable of ranging between Earth and Mars and using the automated SLR2000 Satellite Laser Ranging (SLR) system as an Earth base station, has been suggested. Since that time, we have received a small amount of discretionary funding to further explore the transponder concept and to develop and test an engineering breadboard. Candidate operational scenarios for acquiring and tracking the opposite laser terminal over interplanetary distances have been developed, and breadboard engineering parameters were chosen to reflect the requirements of an Earth-Mars link Laboratory tests have been devised to simulate the Earth- Mars link between two independent SLR2000 transceivers and to demonstrate the transfer of range and time in single photon mode. The present paper reviews the concept of the asynchronous microlaser transponder, the transponder breadboard design, an operational scenario recently developed for an asteroid rendezvous, and the laboratory test setup. The optical head of the transponder breadboard fits within a cylinder roughly 15 cm in diameter and 32 cm in length and is mounted in a commercial two axis gimbal driven by two computer-controlled stepper motors which allows the receiver optical axis to be centered on a simulated Earth image. The optical head is built around a small optical bench which supports a 14.7 cm diameter refractive telescope, a prototype 2 kHz SLR2000 microlaser transmitter, a quadrant microchannel plate photomultiplier (MCP/PMT), a CCD array camera, spatial and spectral filters, assorted lenses and mirrors, and protective covers and sun shields. The microlaser is end-pumped by a fiber-coupled diode laser array. An annular mirror is employed as a passive transmit/receive (T/R) switch in an aperture-sharing arrangement wherein the transmitted beam passes through the central hole and illuminates only the central 2.5 cm of the common telescope (adequate to achieve a 10 arcsecond full laser beam divergence) while the receiver uses the remainder of the 14.7 cm aperture. Additional electronic instrumentation includes the diode pump array and associated heat sink and current drivers, rubidium frequency standard, timing distribution module, range gate generator, a recently developed all-digital correlation range receiver, and system computer. Acquisition of the opposite transponder terminal requires a search within a three-dimensional volume determined by the initial pointing uncertainty and a maximum 500 microsecond uncertainty in the laser time of fire at the opposite terminal for totally uncorrelated Earth and spacecraft clocks. The angular search is aided by a sensitive CCD array capable of imaging the Earth, Moon, and surrounding stars within the nominal + 0.5 degree cone of uncertainty associated with the initial pointing of a spacecraft body or microwave communications dish.

Degnan, John J.↗

The application of spaceborne GPS to atmospheric limb sounding and global change monitoring

This monograph is intended for readers with minimal background in radio science who seek a relatively comprehensive treatment of the mission and technical aspects of an Earth-orbiting radio occultation satellite. Part 1 (chapters 1-6) describes mission concepts and programmatic information; Part 2 (chapters 7-12) deals with the theoretical aspects of analyzing and interpreting radio occultation measurements. In this mission concept the navigation signals from a Global Positioning System (GPS) satellite that is being occulted by the Earth's limb are observed by a GPS flight receiver on board a low Earth orbiter (LEO) satellite. This technique can be used to recover profiles of the Earth's atmospheric refractivity, pressure, and temperature using small, dedicated, and relatively low-cost space systems. Chapter 2 summarizes the basic space system concepts of the limb-sounding technique and describes a low-cost strawman demonstration mission. Chapter 3 discusses some of the scientific benefits of using radio occultation on a suite of small satellites. Chapter 4 provides a more detailed discussion of several system elements in a radio occultation mission, including the launch system for small payloads, the LEO microsat, the GPS constellation, the GPS flight receiver payload, the mission operations ground control and data receiving system, the ground-based GPS global tracking network for precision orbit determination, and the central data processing and archive system. Chapter 5 addresses the various technology readiness questions that invariably arise. Chapter 6 discusses the overall costs of a demonstration mission such as GPS/MET (meteorological) proposed by the University Navstar Consortium (UNAVCO). Chapter 7 describes a geometrical optics approach to coplanar atmospheric occultation. Chapter 8 addresses major questions regarding accuracy of the occultation techniques. Chapter 9 describes some simulations that have been performed to evaluate the sensitivity of the recovered profiles of atmospheric parameters to different error sources, such as departure from spherical symmetry, water vapor, etc. Chapter 10 discusses horizontal and vertical resolution associated with limb sounders in general. Chapter 11 treats selected Fresnel diffraction techniques that can be used in radio occultation measurements to sharpen resolution. Chapter 12 provides brief discussions on selected special topics, such as strategies for handling interference and multipath processes that may arise for rays traveling in the lower troposphere.

Melbourne, W. G.↗

Long range geoid control through the European GPS traverse: Final results

The European north-south Global Positioning System (GPS)-traverse proposed by IAG SSG 3.88, should control and improve the European geoid. This traverse follows first order leveling lines, included in the United European Leveling Network. From May to August 1986 and in July 1987, the central and northern part of this traverse (approx. 3000 km) was observed using up to four TI 4100 receivers, covering Austria, Federal Republic of Germany, Denmark, Sweden and Norway. Both traverse parts contain 71 stations with distances of about 50 km. In addition, 8 stations have been occupied for overlapping connections, and traverse links were established for connecting the fundamental stations Wettzell (VLBI and SLR) and Onsala (VLBI). Final results show a GPS observation precision of a few cm for loops of some 100 km circumference. After transformation of the GPS results to geoid heights using the leveled heights, comparisons with different existing gravimetric geoid determinations including geopotential models were performed. In addition, new geopotential models complete to degree and order 360 tailored to gravity data in Europe, and gravimetric geoid solutions using 6 x 10' mean gravity anomalies were investigated. The comparison with GPS and leveling yields rms discrepancies of + or - 0.1...0.2 m over 1000 km traverse sections for the best solutions, but a strong slope is existing in Sweden and southern Norway in almost all solutions, which is probably caused by systematic errors in the available gravity data for Scandinavia. This is confirmed by a new geoid computation at the Danish Geodetic Institute where the slope has disappeared. If this new solution is taken for the northern traverse section and the best solution for the central part, the rms discrepancy reduces to approximately + or - 0.2 m over 3000 km. Thus, a + or - 10 (exp 7) relative height accuracy seems to be achievable over long distances with the GPS/leveling and the gravimetric geoid calculation techniques, applied in this experiment.

Torge, W.↗

Disaster warning satellite study

The Disaster Warning Satellite System is described. It will provide NOAA with an independent, mass communication system for the purpose of warning the public of impending disaster and issuing bulletins for corrective action to protect lives and property. The system consists of three major segments. The first segment is the network of state or regional offices that communicate with the central ground station; the second segment is the satellite that relays information from ground stations to home receivers; the third segment is composed of the home receivers that receive information from the satellite and provide an audio output to the public. The ground stations required in this system are linked together by two, separate, voice bandwidth communication channels on the Disaster Warning Satellites so that a communications link would be available in the event of disruption of land line service.

Source record↗

Earth Observatory Satellite system definition study. Report 5: System design and specifications. Volume 6: Specification for EOS Central Data Processing Facility (CDPF)

The specifications and functions of the Central Data Processing (CDPF) Facility which supports the Earth Observatory Satellite (EOS) are discussed. The CDPF will receive the EOS sensor data and spacecraft data through the Spaceflight Tracking and Data Network (STDN) and the Operations Control Center (OCC). The CDPF will process the data and produce high density digital tapes, computer compatible tapes, film and paper print images, and other data products. The specific aspects of data inputs and data processing are identified. A block diagram of the CDPF to show the data flow and interfaces of the subsystems is provided.

Source record↗

Statistical analysis of power-size-redshift distributions of extragalactic jets

This paper investigates whether a hot, sparse, yet cosmologically significant intergalactic medium is consistent with data collected from extragalactic radio sources. This is done by use of Monte Carlo simulations which employ previously run pseudohydrodynamical simulations to cover an observational parameter space. These observational parameters include the scale height, central density, and temperature of a (isothermal) galactic halo, and the power of the central engine which drives the jet. The Monte Carlo simulations generate distribution of sizes in bins of (received) power and redshift, which have been compared with observational data using Kolmogorov-Smirnov tests. Results of this analysis are consistent with the existence of an IGM with temperature and density mentioned above. In addition, this analysis suggests that the active lifetime of powerful extragalactic radio sources decreases with increasing power.

Rosen, Alexander↗

Coolness in the tropical Pacific during an El Nino episode

The response of radiation budgets to changes in water vapor and clouds in an El Nino episode is investigated using the analyzed sea surface temperature (SST) and satellite-derived clouds and the earth radiation budgets for the tropical Pacific (30 deg N-30 deg S, 100 deg E-100 deg W). Analyses are performed for April 1985 and April 1987. The former is a non-El Nino year and the latter is an El Nino year. Compared to April 1985, when the SST over the central and eastern equatorial Pacific is approximately 2 C lower, the high-level cloudiness in April 1987 increases in the central and eastern equatorial Pacific. Corresponding to the increase in cloudiness, the outgoing longwave radiation and the net downward solar radiation at the top of the atmosphere decrease. The patterns of these changes are reversed in the western tropical Pacific and the Northern Hemispheric (NH) subsidence region centered at approximately 20 deg N, indicating an eastward shift of the convection center from the maritime continents to the central equatorial Pacific and a strengthened NH Hadley circulation. The earth-atmosphere system in the region receives less radiative energy by 4 W/sq m in the warmer month of April 1987 than in the month of April 1985, which is primarily caused by a reduced atmospheric clear sky greenhouse effect in the NH tropical Pacific in April 1987. Clouds have strong effects on both the IR and solar radiation, but the net effect on the radiation budget at the top of the atmopshere changes only slightly between April 1985 and April 1987. The results are consistent with Lindzen's hypothesis that reduced upper-tropospheric water vapor in the vicinity of the enhanced convection region produces cooling that counteracts warming in the Tropics.

Chou, Ming-Dah↗

Vestibulospinal adaptation to microgravity

Human balance control is known to be transiently disrupted after spaceflight; however, the mechanisms responsible for postflight postural ataxia are still under investigation. In this report, we propose a conceptual model of vestibulospinal adaptation based on theoretical adaptive control concepts and supported by the results from a comprehensive study of balance control recovery after spaceflight. The conceptual model predicts that immediately after spaceflight the balance control system of a returning astronaut does not expect to receive gravity-induced afferent inputs and that descending vestibulospinal control of balance is disrupted until the central nervous system is able to cope with the newly available vestibular otolith information. Predictions of the model are tested using data from a study of the neurosensory control of balance in astronauts immediately after landing. In that study, the mechanisms of sensorimotor balance control were assessed under normal, reduced, and/or altered (sway-referenced) visual and somatosensory input conditions. We conclude that the adaptive control model accurately describes the neurobehavioral responses to spaceflight and that similar models of altered sensory, motor, or environmental constraints are needed clinically to predict responses that patients with sensorimotor pathologies may have to various visual-vestibular or changing stimulus environments.

manned↗

NASA Kennedy Space Center: Contributions to Sea Turtle Science and Conservation

The National Aeronautics and Space Administration (NASA) is a United States (US) federal agency that oversees US space exploration and aeronautical research. NASA's primary launch site, Kennedy Space Center (KSC) is located along the east coast of Florida, on Cape Canaveral and the western Atlantic Ocean. The natural environment within KSC's large land boundaries, not only functions as an extensive safety buffer-area, it performs simultaneously as a wildlife refuge and a national seashore. In the early 1960s, NASA was developing KSC for rocket launches and the US was establishing an awareness of, and commitment to protecting the environment. The US began creating regulations that required the consideration of the environment when taking action on federal land or with federal funds. The timing of the US Endangered Species Act (1973), the US National Environmental Policy Act (1972), coincided with the planning and implementation of the US Space Shuttle Program. This resulted in the first efforts to evaluate the impacts of space launch operation operations on waterways, air quality, habitats, and wildlife. The first KSC fauna and flora baseline studies were predominantly performed by University of Central Florida (then Florida Technological University). Numerous species of relative importance were observed and sea turtles were receiving regulatory review and protection as surveys by Dr. L Ehrhart (UCF) from 1973-1978 described turtles nesting along the KSC beaches and foraging in the KSC lagoon systems. These data were used in the first NASA Environmental Impact Statement for the Space Transportation System (shuttle program) in 1980. In 1982, NASA began a long term ecological monitoring program with contracted scientists on site. This included efforts to track sea turtle status and trends at KSC and maintain protective measures for these species. Many studies and collaborations have occurred on KSC over these last 45 years with agencies (USFWS, NOAA, NAVY), students, and universities (UCF, University of Toronto, Texas A&M, UF). This presentation will review the various studies and collaborations on sea turtles at KSC that include: nest distributions and success, stranding network development, aerial survey testing for nest counts, predator control assessments, the earliest baseline blood chemistry health determinations on nesting females, stress hormones in nesting females, multi-year study of hatchling sex ratios, genetics, species composition, abundance and distribution of in-water juveniles, turtle cold stun response, exterior lighting impacts and control, and satellite tag tracking of post-nesting turtles in the vicinity of near shore shoals and sand mining sites. Through these studies, monitoring, and recommendations, KSC has provided excellent stewardship and protection of the local environment. While conducting its space program mission, KSC has also made significant contributions of information for agencies charged with the conservation and management of these species

Provancha, Jane A.↗

Spatial frequency response of an optical heterodyne receiver

The principles of transfer function analysis are applied to a passive optical heterodyne receiver to obtain the modulation transfer function (MTF). MTF calculations are performed based on an optical platform which is imaging vertically varying profiles at worst case shuttle orbit altitudes. An analysis of the derogatory effects of sampling (aliasing) and central obscurations on both resolution and heterodyne efficiency is given. It is found that the cascading property of MTF analysis must be carefully applied since the coherent transfer function of the optical receiver and that due to the local oscillator-detector combination are not separable but are related by the convolution of their products. Application of these results to the specific case of a space-lab type optical heterodyne receiver shows that resolutions of the order of 1.5-2.0 Km are possible for worst-case type orbital scenarios. Further, comparison of obscured-type receivers (e.g., Cassegrains) with unobscured receivers shows that both resolution and efficiency are severely degraded in an obscured-type receiver and consequently should not be used for a passive heterodyne detection scheme.

Fales, C. L.↗

Central and South America GPS geodesy - CASA Uno

In January 1988, scientists from over 25 organizations in 13 countries and territories cooperated in the largest GPS campaign in the world to date. A total of 43 GPS receivers collected approximately 590 station-days of data in American Samoa, Australia, Canada, Colombia, Costa Rica, Ecuador, New Zealand, Norway, Panama, Sweden, United States, West Germany, and Venezuela. The experiment was entitled CASA Uno. Scientific goals of the project include measurements of strain in the northern Andes, subduction rates for the Cocos and Nazca plates beneath Central and South America, and relative motion between the Caribbean plate and South America. A second set of measurements are planned in 1991 and should provide preliminary estimates of crustal deformation and plate motion rates in the region.

Kellogg, James N.↗

Neurophysiological findings relevant to echolocation in marine animals

A review of echolocation mechanisms in marine mammals, chiefly porpoises, is given. Data cover peripheral auditory and central neurophysiological specializations favorable to the analysis of echolocating clicks and their echoes. Conclusions show (1) signals are received from 50 up to at least 135 kHz, (2) sound is received through the mandible skin, and (3) the midbrain sites are insensitive to low frequencies (below 6 kHz).

Bullock, T. H.↗

Lunar Surface Network Relay Terminal: A Lunar Communications Platform

This paper will discuss the development of a Lunar Surface Relay that will serve as a central terminal for lunar surface wireless communications (e.g., 3GPP, Wi-Fi) for surface assets to transmit and receive data back-and-forth with Earth through lunar orbital relays or direct with Earth. Four variations of a wireless surface terminal were designed with varying concepts of operation to assess mass, power, cost drivers, and trade-offs. The designs entailed one stationary platform and three mobile which provided interesting trade-offs. The terminals are powered for operation with either a radioisotope/battery power system or solar array/battery power system.

WiFi↗

Analysis of Pulsed Airborne Lidar Measurements of Atmospheric CO2 Column Absorption from 3-13 km Altitudes

We have developed a pulsed lidar technique for measuring the tropospheric CO2 concentrations as a candidate for NASA's ASCENDS space mission [1]. It uses two pulsed laser transmitters allowing simultaneous measurement of a CO2 absorption line in the 1575 nm band, O2 extinction in the Oxygen A-band, surface height and backscatter profile. The lasers are precisely stepped in wavelength across the CO2 line and an O2 line region during the measurement. The direct detection receiver measures the energies of the laser echoes from the surface along with the range profile of scattering in the path. The column densities for the CO2 and O2 gases are estimated from the ratio of the on- and off-line signals via the integrated path differential absorption (IPDA) technique. The time of flight of the laser pulses is used to estimate the height of the scattering surface and to reject laser photons scattered in the atmosphere. We developed an airborne lidar to demonstrate an early version of the CO2 measurement from the NASA Glenn Lear-25 aircraft. The airborne lidar stepped the pulsed laser's wavelength across the selected CO2 line with 20 wavelength steps per scan. The line scan rate is 450 Hz, the laser pulse widths are 1 usec, and laser pulse energy is 24 uJ. The time resolved laser backscatter is collected by a 20 cm telescope, detected by a NIR photomultiplier and is recorded on every other reading by a photon counting system [2]. During August 2009 we made a series of 2.5 hour long flights and measured the atmospheric CO2 absorption and line shapes using the 1572.33 nm CO2 line. Measurements were made at stepped altitudes from 3-13 km over locations in the US, including the SGP ARM site in Oklahoma, central Illinois, north-eastern North Carolina, and over the Chesapeake Bay and the eastern shore of Virginia. Although the received signal energies were weaker than expected for ASCENDS, clear CO2 line shapes were observed at all altitudes, and some measurements were made through thin clouds. The Oklahoma and east coast flights were coordinated with a LaRC/ITT CO2 lidar on the LaRC UC-12 aircraft, and in-situ measurements were made using its CO2 sensor and radiosondes. We have conducted an analysis of the ranging and IPDA lidar measurements from these four flights. Most flights had 5-6 altitude steps with 200-300 seconds of recorded measurements per step. We used a cross-correlation approach to process the laser echo records. This was used to estimate the range to the scattering surface, to define the edges of the laser pulses and to determine echo pulse energy at each wavelength. We used a minimum mean square approach to fit an instrument response function and to solve for the best-fit CO2 absorption line shape. We then calculated the differential optical depth (DOD) of the fitted CO2 line. We computed its statistics at the various altitude steps, and compare them to the DODs calculated from spectroscopy based on HITRAN 2008 and the column conditions calculated from the airborne in-situ readings. The results show the lidar and in-situ measurements have very similar DOD change with altitude and greater than 10 segments per flight where the scatter in the lidar measurements are less than or equal to 1ppm. We also present the results from subsequent CO2 column absorption measurements, which were made with stronger detected signals during three flights on the NASA DC-8 over the southwestern US in during July 2010.

Abshire, James B.↗

Analysis of bioelectric records and fabrication of phototype sleep analysis equipment

A computer-analysis technique was used to evaluate the changes in the waking EEGs of 5 normal subjects which occurred during the oral administration of flurazepam hydrochloride (Dalmane). While the subjects were receiving the drug, there was an increase in the amount of beta (14-38 c/sec) activity in fronto-central EEG leads in all 5 subjects. This increase in beta activity was characterized by a highly consistent increase in the number of waves that occurred during an EEG recording interval of fixed duration and by a less consistent increase in average wave amplitude. There was no detectable change in mean EEG wavelength (frequency) within the beta frequency range. The EEG patterns reverted to their baseline condition during 2-3 weeks after withdrawal of the drug. Analysis of the alpha, theta and delta components of the EEG indicated no changes during or following administration of the drug. This study clearly illustrates the usefulness of specific computer-analysis techniques in the characterization and quantification of sleep-promoting drugs upon the EEG of the normal young adults in the waking state. Two preamplifiers and 150 EEG monitoring caps with electrodes were delivered to MSC.

Kellaway, P.↗