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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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134 records · Page 8
All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

Silver Electrolysis for Disinfection of Spacecraft Potable Water: 2024 Update

Anodic dissolution of silver electrodes, or “silver electrolysis,” is being investigated as a means of introducing biocidal silver into potable water on exploration spacecraft. This paper provides an update on the effort to implement this technology into a spacecraft potable water system. Previous papers reported on the feasibility of the technology for this application, strategies to prevent a potential fault condition termed “electrode bridging,” results from a preliminary investigation into the cathode reaction, and preliminary multiphysics modeling of the reactor. Since then, work has begun on the design of a next-generation silver electrolysis reactor prototype that will incorporate improvements identified in previous testing and package the reactor in a more flight-like configuration. This development effort has included additional testing to optimize the reactor design for prevention of electrode bridging, further investigation into the cathode reaction (including the use of a dissolved hydrogen sensor), and an assessment of the feasibility of using the reactor in other applications, such as for microbial shock and preparation for system dormancy.

silver biocide↗
NASA NTRSDate not supplied

Modeling Logistics and Supportability for Crewed Missions Beyond Low Earth Orbit

NASA’s future missions aim to establish a sustained human presence on the lunar surface and send humans to Mars. These missions will send crews farther from home than previous missions, limiting the opportunities for resupply missions. Additionally, the use of multiple launches and reusable elements will increase mission and campaign complexity. Logistics and supportability analysis evaluates the link between mission and system characteristics and key metrics such as logistics and spares mass and volume, crew time, and risk. As missions become increasingly complex and crews are logistically isolated for longer periods of time, logistics and supportability will become more powerful drivers of risk and cost and, therefore, more important considerations during system and mission development. When logistics and supportability are considered from the beginning of system and mission development, opportunities arise to create more efficient, lower-risk systems. Design choices made without detailed consideration of logistics and supportability have the potential to result in greater risks and increased costs as all options may not have been analyzed. This paper provides an overview of a methodology used for space mission logistics and supportability analysis, including key metrics, assumptions, and required inputs. Example applications of this methodology to explore the impacts of system architecture, dormancy, and synergies between lunar and Mars missions are also presented. Conducting these holistic analyses enables informed decision-making for mission planning and system design, which can help mitigate the risk of loss of mission, vehicle, or crew. Using the knowledge of historical missions, experiences gained on the lunar surface, and logistics and supportability analyses, NASA can examine and optimize supportability characteristics for safer and more effective operations for future lunar and Mars missions.

Supportability↗
NASA NTRSDate not supplied

A Historical Review of Logistics Mass and Crew Time Demands for ISS Operations

Following over 20 years of continuously crewed operations on the International Space Station (ISS), NASA is planning to return to the Moon and eventually send humans to Mars. ISS operations provide vital data to inform mission analysts as NASA prepares for longer and more complex missions with increased mission endurance. Endurance, defined as crewed operating time between cargo deliveries (or crew launch and return to Earth), is an important metric when analyzing mission needs. NASA is developing architectures to support sustained deep-space habitats in cislunar space, the lunar surface, Mars transit, and the surface of Mars. Unlike the ISS, these systems will not be continuously crewed, and unlike the Space Shuttle, these systems will not return to Earth for regular refurbishment between missions. Lunar systems will routinely go through long uncrewed periods between crewed missions. The systems on board will need to survive these dormancy periods with no crew present to provide maintenance. Mars systems will experience significantly longer endurance than past experience. Additionally, the inability to have quick aborts to return to Earth increases the need for system reliability, redundancy, and maintainability, as well as plans for contingency operations. This paper examines the historical logistics and crew time demand for ISS operations and mission objectives and provides an overview of missions to the ISS over its operating history, the mass and items delivered with the missions, and the crew time spent during missions. These parameters provide insight and valuable data to inform logistics and crew time estimates for future long-endurance crewed exploration missions.

Crew Logistics↗
NASA NTRSDate not supplied

Silver Electrolysis for Disinfection of Spacecraft Potable Water: 2024 Update

Anodic dissolution of silver electrodes, or “silver electrolysis,” is being investigated as a means of introducing biocidal silver into potable water on exploration spacecraft. This paper provides an update on the effort to implement this technology into a spacecraft potable water system. Previous papers reported on the feasibility of the technology for this application, strategies to prevent a potential fault condition termed “electrode bridging,” results from a preliminary investigation into the cathode reaction, and preliminary multiphysics modeling of the reactor. Since then, work has begun on the design of a next-generation silver electrolysis reactor prototype that will incorporate improvements identified in previous testing and package the reactor in a more flight-like configuration. This development effort has included additional testing to optimize the reactor design for prevention of electrode bridging, further investigation into the cathode reaction (including the use of a dissolved hydrogen sensor), and an assessment of the feasibility of using the reactor in other applications, such as for microbial shock and preparation for system dormancy.

silver biocide↗
NASA NTRSDate not supplied

Modeling Logistics and Supportability for Crewed Missions Beyond Low Earth Orbit

NASA’s future missions aim to establish a sustained human presence on the lunar surface and send humans to Mars. These missions will send crews farther from home than previous missions, limiting the opportunities for resupply missions. Additionally, the use of multiple launches and reusable elements will increase mission and campaign complexity. Logistics and supportability analysis evaluates the link between mission and system characteristics and key metrics such as logistics and spares mass and volume, crew time, and risk. As missions become increasingly complex and crews are logistically isolated for longer periods of time, logistics and supportability will become more powerful drivers of risk and cost and, therefore, more important considerations during system and mission development. When logistics and supportability are considered from the beginning of system and mission development, opportunities arise to create more efficient, lower-risk systems. Design choices made without detailed consideration of logistics and supportability have the potential to result in greater risks and increased costs as all options may not have been analyzed. This paper provides an overview of a methodology used for space mission logistics and supportability analysis, including key metrics, assumptions, and required inputs. Example applications of this methodology to explore the impacts of system architecture, dormancy, and synergies between lunar and Mars missions are also presented. Conducting these holistic analyses enables informed decision-making for mission planning and system design, which can help mitigate the risk of loss of mission, vehicle, or crew. Using the knowledge of historical missions, experiences gained on the lunar surface, and logistics and supportability analyses, NASA can examine and optimize supportability characteristics for safer and more effective operations for future lunar and Mars missions.

Supportability↗
NASA NTRSDate not supplied

A Historical Review of Logistics Mass and Crew Time Demands for ISS Operations

Following over 20 years of continuously crewed operations on the International Space Station (ISS), NASA is planning to return to the Moon and eventually send humans to Mars. ISS operations provide vital data to inform mission analysts as NASA prepares for longer and more complex missions with increased mission endurance. Endurance, defined as crewed operating time between cargo deliveries (or crew launch and return to Earth), is an important metric when analyzing mission needs. NASA is developing architectures to support sustained deep-space habitats in cislunar space, the lunar surface, Mars transit, and the surface of Mars. Unlike the ISS, these systems will not be continuously crewed, and unlike the Space Shuttle, these systems will not return to Earth for regular refurbishment between missions. Lunar systems will routinely go through long uncrewed periods between crewed missions. The systems on board will need to survive these dormancy periods with no crew present to provide maintenance. Mars systems will experience significantly longer endurance than past experience. Additionally, the inability to have quick aborts to return to Earth increases the need for system reliability, redundancy, and maintainability, as well as plans for contingency operations. This paper examines the historical logistics and crew time demand for ISS operations and mission objectives and provides an overview of missions to the ISS over its operating history, the mass and items delivered with the missions, and the crew time spent during missions. These parameters provide insight and valuable data to inform logistics and crew time estimates for future long-endurance crewed exploration missions.

Crew Logistics↗
DOE OSTI2021

The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings

Dormant, disseminated tumor cells (DTCs) are thought to be the source of breast cancer metastases several years or even decades after initial treatment. To date, a selective therapy that leads to their elimination has not been discovered. While dormant DTCs resist chemotherapy, evidence suggests that this resistance is driven not by their lack of proliferation, but by their engagement of the surrounding microenvironment, via integrin-β1-mediated interactions. Because integrin-β1-targeted agents have not been translated readily to the clinic, signaling nodes downstream of integrin-β1 could serve as attractive therapeutic targets in order to sensitize dormant DTCs to therapy. By probing a number of kinases downstream of integrin-β1, we determined that PI3K inhibition with either a tool compounds or a compound (PF-05212384; aka Gedatolisib) in clinical trials robustly sensitizes quiescent breast tumor cells seeded in organotypic bone marrow cultures to chemotherapy. These results motivated the preclinical study of whether Gedatolisib—with or without genotoxic therapy—would reduce DTC burden and prevent metastases. Despite promising results in organotypic culture, Gedatolisib failed to reduce DTC burden or delay, reduce or prevent metastasis in murine models of either triple-negative or estrogen receptor-positive breast cancer dissemination and metastasis. This result held true whether analyzing Gedatolisib on its own (vs. vehicle-treated animals) or in combination with dose-dense doxorubicin and cyclophosphamide (vs. animals treated only with dose-dense chemotherapies). These data suggest that PI3K is not the node downstream of integrin-β1 that confers chemotherapeutic resistance to DTCs. More broadly, they cast doubt on the strategy to target PI3K in order to eliminate DTCs and prevent breast cancer metastasis.

60 APPLIED LIFE SCIENCES↗