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Intrauterine Exposure to Maternal Stress Alters Bdnf IV DNA Methylation and Telomere Length in the Brain of Adult Rat Offspring

DNA methylation (addition of methyl groups to cytosines which normally represses gene transcription) and changes in telomere length (TTAGGG repeats on the ends of chromosomes) are two molecular modifications that result from stress and could contribute to the long-term effects of intrauterine exposure to maternal stress on offspring behavioral outcomes. Here, we measured methylation of Brain-derived neurotrophic factor (Bdnf), a gene important in development and plasticity, and telomere length in the brains of adult rat male and female offspring whose mothers were exposed to unpredictable and variable stressors throughout gestation. Males exposed to prenatal stress had greater methylation (Bdnf IV) in the medial prefrontal cortex (mPFC) compared to non-stressed controls. Further, prenatally-stressed males had shorter telomeres than controls in the mPFC. This study provides the first evidence in a rodent model of an association between prenatal stress exposure and subsequent shorter brain telomere length. Together findings indicate a long-term impact of prenatal stress on DNA methylation and telomere biology with relevance for behavioral and health outcomes, and contribute to a growing literature linking stress to intergenerational epigenetic alterations and changes in telomere length.

prenatal stress↗

Blood pressure responses to LBNP in nontrained and trained hypertensive rats

To study the influences of 16 wk of endurance training on the reflex regulation of resting blood pressure, nontrained (NT) and trained (T) female hypertensive rats (SHR) were subjected to conditions of lower body negative pressure (LBNP). Measurements of muscle cytochrome oxidase activity and run time to exhaustion indicated that the animals were endurance trained. The rats (NT = 6, T = 7) were tranquilized with 300-600 micrograms.kg-1 diazepam (IV) before heart rates and blood pressures were measured over a range of 2.5-10.0 mm Hg of negative pressure. When subjected to conditions of LBNP, the reflex tachycardia of the T group was greater than the NT at the lower (-2.5 and -5.0 mm Hg) negative pressures. Although arterial pressure declines were similar in both groups, the T group experienced significantly less of a decline in central venous pressure than the NT animals. When chlorisondamine was used as a ganglionic blocker (2.5 mg.kg-1, IV), the fall in CVP at 10 mm Hg negative pressure was greater for the NT group while the fall in the initial systemic arterial pressure was more for the T group. From these results we concluded that training had altered the interaction between cardiopulmonary and arterial baroreflexes in these hypertensive rats and a nonneural component had been altered such as cardiac function.

Non-NASA Center↗

Cosolvent-tuned interactions in ionic liquids: A vibrational and quantum-chemical study of ethylene glycol ratio effects

Ionic liquids (ILs) are attractive media for CO 2 capture but remain limited by viscosity and cost. Blending ILs with ethylene glycol (EG) is a practical route to mitigate these constraints, yet the molecular origins of cosolvent effects and their dependence on composition are not well resolved. We combine Fourier-transform infrared (FT-IR) spectroscopy with quantum-chemical (DFT) analysis to elucidate how the IL:EG molar ratio modulates intermolecular interactions and electronic structure. Computed vibrational frequencies enable mode assignment and deconvolution of overlapping bands, revealing systematic, ratio-dependent shifts and broadenings in (i) EG O–H stretching, (ii) cation and EG C–H stretchings (imidazolium C2–H, C4–H, C5–H, methyl and ethyl groups, -CH2 of EG), (iii) anion signature modes (e.g., CN motifs), and (iv) EG C–O and C–C stretchings, consistent with the redistribution of hydrogen-bonding networks. Molecular electrostatic potential (MESP) maps quantify attenuation of extreme potential regions with increasing EG, indicating progressive screening of cation–anion electrostatic interactions. Quantum Theory of Atoms in Molecules (QTAIM) identifies emergent bond critical points between EG and the IL ions, while Reduced Density Gradient–Noncovalent Interaction (RDG–NCI) analysis differentiates strong directional hydrogen bonds from dispersive contacts across compositions. Together, these results show that EG fraction controls a switch from predominantly ion–ion to mixed ion–EG coordination, altering local polarity and polarizability that underlie the observed FT-IR trends. The framework provides composition–structure–spectrum relationships that can guide rational selection of IL:EG ratios to balance favorable molecular interactions with practical performance targets in scalable CO 2 capture systems.

DAC↗

Report of Industry Panel Group

A final report is presented from the industry panel group. The contents include: 1) General comments; 2) Positive progress since Minnowbrook IV; 3) Industry panel outcome; 4) Prioritized turbine projects; 5) Prioritized compressor projects; and 6) Miscellaneous.

Gallimore, Simon↗

Virtual International Satellite Training Experiences for Weather, Marine, Climate, and Environmental Applications

Since January 2020, National Oceanic and Atmospheric Administration, its Cooperative Institutes, and international partners provided over 15,000 hours of virtual satellite focused on user engagement. The training provides and guides users to analyze a large variety of satellite data for weather, climate, and environmental applications and decision support. The training team reached users in over 50 countries via monthly Regional Focus Group and special topic sessions, World Meteorological Organization Regional Association III and IV Workshops, and American Meteorological Society Short Courses. The training sessions were offered in both English and Spanish covering such themes as GOES-R, JPSS and other satellite capabilities, data access using GEONET Cast, data display, and user applications. The training also emphasized the operational application of satellite observations for cross-disciplinary topics like heavy rain and hail events, aviation hazards, fire and smoke detection, volcanic eruptions and ash monitoring, climate indices, monitoring coral reef health, and in tsunami preparedness. The presentation will highlight the methods used and challenges posed by the various training approaches and future modifications to adapt to the virtual environment during training sessions planned for the next year.

Satellite Training↗

Discovery and Characterization of Two Ultrafaint Dwarfs outside the Halo of the Milky Way: Leo M and Leo K

Abstract We report the discovery of two ultrafaint dwarf galaxies, Leo M and Leo K, that lie outside the halo of the Milky Way (MW). Using Hubble Space Telescope imaging of the resolved stars, we create color–magnitude diagrams reaching the oldest main-sequence turnoff of each system and (i) fit for structural parameters of the galaxies; (ii) measure their distances using the luminosity of the horizontal branch stars; (iii) estimate integrated magnitudes and stellar masses; and (iv) reconstruct the star formation histories. Based on their location in the Local Group, neither galaxy is currently within the halo of the MW although Leo K is located ∼26 kpc from the low-mass galaxy Leo T and these two systems may have had a past interaction. Leo M and Leo K have stellar masses of 1.8 − 0.2 + 0.3 × 10 4 M ⊙ and 1.2 ± 0.2 × 10 4 M ⊙ , and were quenched 10.6 − 1.1 + 2.2 Gyr and 12.8 − 4.2 + 0.1 Gyr ago, respectively. Given that the galaxies are at farther distances from the MW, it is unlikely that they were quenched by environmental processing. Instead, given their low stellar masses, their early quenching timescales are consistent with the scenario that a combination of reionization and stellar feedback shut down star formation at early cosmic times.

Astronomy & Astrophysics↗

Free-space laser communication technologies IV; Proceedings of the 4th Conference, Los Angeles, CA, Jan. 23, 24, 1992

Papers included in this volume are grouped under topics of receivers; laser transmitters; components; system analysis, performance, and applications; and beam control (pointing, acquisition, and tracking). Papers are presented on an experimental determination of power penalty contributions in an optical Costas-type phase-locked loop receiver, a resonant laser receiver for free-space laser communications, a simple low-loss technique for frequency-locking lasers, direct phase modulation of laser diodes, and a silex beacon. Particular attention is given to experimental results on an optical array antenna for nonmechanical beam steering, a potassium Faraday anomalous dispersion optical filter, a 100-Mbps resonant cavity phase modulator for coherent optical communications, a numerical simulation of a 325-Mbit/s QPPM optical communication system, design options for an optical multiple-access data relay terminal, CCD-based optical tracking loop design trades, and an analysis of a spatial-tracking subsystem for optical communications.

Begley, David L.↗

Revisiting the petrogenesis of pyroclastic glass bead deposits at the Apollo 15 and 17 sites

The Apollo 15 low-titanium and Apollo 17 high-titanium pyroclastic glass beads are amongst the most primitive magmatically derived samples obtained from the Moon. Two key samples, the low-Ti Apollo 15426 green glass clod and the high-Ti Apollo 74220 orange glass are morphologically distinct, where the Apollo 15 beads are larger (~ 107 μm along maximum axis) and more fractured, and the Apollo 17 are smaller (~42 μm) and less fractured. In this study, holohyaline beads as well as crystallized beads were examined from both samples. Crystallized beads show compositional variability in major, minor, and trace elements and enable examination of magmatic mineral fractionation processes during cooling of both deposits. The Apollo 15426 beads experienced variable olivine crystallization, whereas the Apollo 74220 beads experienced both olivine and ilmenite crystallization. Holohyaline beads from both deposits show more limited major, minor, and trace element variability than their crystallized counterparts. Trace element abundance data for individual holohyaline beads show that in Apollo 74220, they are tightly clustered at ~30 × Carbonaceous Ivuna chondrite [CI] with negative Eu anomalies and subchondritic Nb/Ta, and interpreted to reflect the presence of late-stage magma ocean cumulate overturned into an otherwise primitive mantle source. Incompatible trace element abundances for holohyaline beads in 15426 are supra-chondritic from ~8 × CI, to >80 × CI, with pronounced relative depletions in Sr and Eu for the most incompatible element enriched beads, which represent a distinct bead group within the deposit. Apollo 15426 beads have elevated Ni and Co abundances at the edges of the beads compared to their centers. These data are interpreted to reflect a more complex magmatic evolution of the 15426 deposit, beginning with: (i) initial magma generation, storage and assimilation within shallower low-Ca and high-Ca pyroxene bearing magma ocean cumulates (15B,C); (ii) mobilization of the earlier magmas by more recently generated primitive magmas (15A); (iii) eruption and crystallization of some beads (15D,E), and (iv) later jumbling of the deposit, possible impact contamination and addition of exotic bead components (J Group). In contrast, the 74220 data shows no discernable difference between Ni and Co abundances at the edges and centers supporting prior observations for limited melt fractionation and an absence of meteoritic components. It is further suggested that both deposits are likely to have been formed in the presence of a transient atmosphere. Using 74220 melt compositions from this study, post-entrapment crystallization abundances range from 266 to 1130 micrograms/g for H 2 O, 36 to 68 micrograms/g for F, 441 to 832 micrograms/g for S, and zero to 2.31 micrograms/g for Cl, consistent with prior studies and suggesting up to ~0.1 wt.% H 2 O in the melt, with considerably less in the source. The role that late-stage magma ocean cumulates rich in ilmenite, apatite and high-Ca pyroxene might play in modifying this volatile element estimate, however, casts remaining doubt on the volatile element abundance and evolution of the primitive Moon.

Moon↗

Mark IV-85 mission support planning and future mission set

The Deep Space Network (DSN) is currently involved with supporting a group of mature deep space missions, none of which was launched in the past ten years. With great anticipation, the DSN is looking forward to the return of the Space Transportation System, which is scheduled to launch four deep space missions in 1989 through 1992. The DSN also supports earth orbiting spacecraft that are not compatible with the Tracking and Data Relay Satellite System (TDRSS).

Amorose, R. J.↗

Spectroscopic CCD surveys for quasars at large redshift. 3: The Palomar Transit Grism Survey catalog

This paper reports the initial results of the Palomar Transit Grism Survey (PTGS). The PTGS was designed to produce a sample of z greater than 2.7 quasars that were identified by well-defined selection criteria. The survey consists of six narrow (approximately equal to 8.5 min wide) strips of sky; the total effective area is 61.47 sq deg. Low-resolution slitless spectra, covering the wavelength range from 4400 to 7500 A, were obtained for approximately 600 000 objects. The wavelength- and flux-calibrated spectra were searched for emission lines with an automatic software algorithm. A total to 1655 emission features in the grism data satisfied our signal-to-noise ratio and equivalent width selection criteria; subsequent slit spectroscopy of the candidates confirmed the existence of 1052 lines (928 different objects). Six groups of emission lines were detected in the survey: Lyman alpha + N V, C IV, C III1, Mg II, H Beta + (O III), and H alpha + (S II). More than two-thirds of the candidates are low-redshift (z less than 0.45) emission-line galaxies; ninety objects are high-redshift quasars (z greater than 2.7) detected via their Lyman alpha + N V emission lines. The survey contains three previously unknown quasars brighter than 17th magnitude; all three have redshifts of approximately equal to 1.3. In this paper we present the observational properties of the survey, the algorithms used to select the emission-line candidates, and the catalog of emission-line objects.

Schneider, Donald P.↗

Early Design Choices: Capture, Model, Integrate, Analyze, Simulate

I. Designs are constructed incrementally to meet requirements and solve problems: a) Requirements types: objectives, scenarios, constraints, ilities. etc. b) Problem/issue types: risk/safety, cost/difficulty, interaction, conflict, etc. II. Capture requirements, problems and solutions: a) Collect design and analysis products and make them accessible for integration and analysis; b) Link changes in design requirements, problems and solutions; and c) Harvest design data for design models and choice structures. III. System designs are constructed by multiple groups designing interacting subsystems a) Diverse problems, choice criteria, analysis methods and point solutions. IV. Support integration and global analysis of repercussions: a) System implications of point solutions; b) Broad analysis of interactions beyond totals of mass, cost, etc.

Malin, Jane T.↗

Expanding AirSTAR Capability for Flight Research in an Existing Avionics Design

The NASA Airborne Subscale Transport Aircraft Research (AirSTAR) project is an Unmanned Aerial Systems (UAS) test bed for experimental flight control laws and vehicle dynamics research. During its development, the test bed has gone through a number of system permutations, each meant to add functionality to the concept of operations of the system. This enabled the build-up of not only the system itself, but also the support infrastructure and processes necessary to support flight operations. These permutations were grouped into project phases and the move from Phase-III to Phase-IV was marked by a significant increase in research capability and necessary safety systems due to the integration of an Internal Pilot into the control system chain already established for the External Pilot. The major system changes in Phase-IV operations necessitated a new safety and failsafe system to properly integrate both the Internal and External Pilots and to meet acceptable project safety margins. This work involved retrofitting an existing data system into the evolved concept of operations. Moving from the first Phase-IV aircraft to the dynamically scaled aircraft further involved restructuring the system to better guard against electromagnetic interference (EMI), and the entire avionics wiring harness was redesigned in order to facilitate better maintenance and access to onboard electronics. This retrofit and harness re-design will be explored and how it integrates with the evolved Phase-IV operations.

Laughter, Sean A.↗

Geochemical evidences for two chondritic-like cometary or asteroidal impacts before and at the K/T boundary

A number of geological and palaeontological evidences support multiple impacts of cometary showers within a short time (approximately 1-3 Ma) and their connection with mass extinctions. Observations include clustered crater ages, stratigraphic horizons of impact ejecta closely spaced in time, and evidence for stepwise mass extinctions spanning intervals of 1-3 Ma. For the K/T boundary, three candidates, Popigai, Manson, and Yucatan, have been proposed as impact craters. Two distinct strata at the K/T boundary in western North America have been interpreted as evidence for two sequential impacts. If multiple impacts occurred within a time span of about 1 Ma then multiple Ir enrichments should be observed. DSDP Hole 577B on the Shatsky Plateau in the northern Pacific at K/T time is the first site. Samples contain approximately greater than 97 percent CaCO3, which exhibit clear chemical signals associated with asteroidal/cometary impact. Ir, Fe, and Cr data are presented. From the Th-normalized data, two satellite peaks below the major peak at 78 cm and 81 cm of 577B-1-4 are clearly shown. The major Ir peak (K/T boundary) is at 72 cm. Fe and Cr, from C1-like impactor ejecta fallout, also show two peaks at the same positions. For hole 738C on the southern Kerguelen Plateau, Ir values reach a peak concentration of 18 ppb in the clay layer at 96.0-96.2 cm in section 20R-5, and gradually tail off. In the sample 115 cm above the boundary, Ir concentrations have still not reached background levels. From the Ir peak downward to the lowermost sample analyzed at 102 cm, the Ir concentration is still as high as 1.7 ppb. From the Th-normalized data, we observe a small Ir/Th peak at 100-101 cm. Though this peak is within the error margin, the trend is clear. Fe and Cr exhibit the same pattern. The third case is Hole 690C on the Queen Maud Ridge. Again, the Ir/Th plot indicates the strong possibility of satellite peaks at approximately 52 cm. The main peak is at 39-40 cm. For the Stevns Klint K/T boundary layers, the stratification of trace elements appears threefold with peak concentrations in sublayers A1, A3, and B2 for different element groups, including Ir. C1 ratios for many siderophile elements found in combined layers III and IV, corresponding to layers A, B, C, and D, strongly support the impact hypothesis. Also, multiple Ir anomalies in the K/T section at Lattengebirge, Bavarian Alps are reported. Recent works on Ni-rich spinels and Ir at the K/T boundaries clearly establish cometary/asteroidal impacts at the K/T boundary. Lastly, cometary showers can explain the enhanced Ir contents over approximately a 1 Ma interval in Gubbio shales.

Liu, Y.-G.↗

The Crystal and Molecular Structure of Acetatochlorobis(4-methylpyridine)oxovanadium (IV)

The crystal and molecular structure of the title compound, VOCl(O2CCH3)(4-CH3C5H4N)2, has been determined by single-crystal x-ray diffraction. The material crystallizes in the space group P 1(bar) (#2) with a = 7.822(2), b = 8.023(l), c = 14.841(2) Angstroms, alpha = 99.73(l), beta = 91.41(l), and gamma = 117.13(l). The coordination geometry around the vanadium is a highly distorted octahedron. The molecule is remarkable for being a monomeric oxovanadium (IV) carboxylate. A generalized synthetic strategy is proposed for the preparation of oxovanadium (IV) monomers.

Schupp, John D.↗

Non-LTE, line-blanketed model atmospheres for late O- and early B-type stars

The use of non-LTE line-blanketed model atmospheres to analyze the spectra of hot stars is reported. The stars analyzed are members of clusters and associations, have spectral types in the range O9-B2 and luminosity classes in the range III-IV, have slow to moderate rotation, and are photometrically constant. Sampled line opacities of iron-group elements were incorporated in the radiative transfer solution; solar abundances were assumed. Good to excellent agreement is obtained between the computed profiles and essentially all the line profiles used to fix the model, and reliable stellar parameters are derived. The synthetic M II 5581 equivalent widths agree well with the observed ones at the low end of the temperature range studied, but, above 25,000 K, the synthetic line is generally stronger than the observed line. The behavior of the observed equivalent widths of N II, N III, C II and C III lines as a function of Teff is studied. Most of the lines show much scatter, with no consistent trend that could indicate abundance differences from star to star.

Grigsby, James A.↗

Transient Triamidoamine Neptunium(V)–Mono(Imido) Complexes: C–H Activations and Hydrogen Atom Transfer Driven by Effective Nuclear Charge

Metal-mono(imido) linkages have been known for seven decades, and they are found in transition metal, main group, lanthanide, thorium, and uranium complexes. However, transuranium-mono(imido) complexes remain unknown in any scenario. Here, we present evidence for transient neptunium(V)–mono(imido) complexes. Treatment of [Np III (Tren TIPS )] (1, Tren TIPS = {N(CH 2 CH 2 NSiPr i 3 ) 3 } 3– ) with N 3 R (R = SiMe 3 ; 1-adamantyl, Ad) results in N 2 evolution and dark purple solutions consistent with the formation of [Np V (Tren TIPS )(NR)] (3NpNR). However, solutions of 3NpNR rapidly turn orange, where for R = SiMe 3 the isolated 1:1 products are [Np IV (Tren TIPS ){N(H)SiMe 3 }] (4a) and [Np IV (Tren TIPS-2H ){N(H)SiMe 3 }] (4b, Tren TIPS-2H = {N(CH 2 CH 2 NS i Pri 3 ) 2 (NCH 2 CH 2 NSiPr i 2 C[Me]=CH 2 )} 3– ). The latter contains a dehydrogenated-Pr i vinyl functionality accounting for the source of the two amido H atoms. The reaction for R = Ad proceeds similarly, but only [Np IV (Tren TIPS ){N(H)Ad}] (5a) could be unequivocally confirmed, though its isolation suggests generality of the imido-to-amido functional group transformation. Complexes 4a/4b exhibit slow relaxation of their magnetization, adding to the small number of transuranium single ion magnets. Experimental and computational analysis suggests that the amido products are formed by C–H activation and two sequential hydrogen atom transfer reactions involving a three-step proton-coupled electron-transfer sequence of H • radical abstraction, electron transfer, then another H • radical abstraction step. In contrast to transient 3NpNR, the 5f 2 uranium(IV)-imido complex [K(2.2.2-cryptand)][U IV (Tren TIPS )(NSiMe 3 )] (8UNSiMe 3 ) is robust, even in boiling THF, suggesting the transience of 5f 2 3NpNR is not due to the 5f n -count but the increased effective nuclear charge of neptunium vs uranium. This work highlights divergence of uranium- and neptunium-imido stabilities, emphasizing that the latter is an inherently challenging synthetic target.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗