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At least 145 records · Page 8

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NASA NTRS2000

Chromosomal instability induced by heavy ion irradiation

PURPOSE: To establish the dose-response relationship for the induction of chromosomal instability in GM10115 cells exposed to high-energy iron ions (1 GeV/nucleon, mean LET 146 keV/microm) and gold ions (11 GeV/nucleon, mean LET 1450 keV/microm). Past work has established that sparsely ionizing X-rays can induce a long-lived destabilization of chromosomes in a dose-dependent manner at an incidence of approximately 3% per gray. The present investigation assesses the capacity of High-Z and High-energy (HZE) particles to elicit this same endpoint. MATERIALS AND METHODS: Clonal populations derived from single progenitor cells surviving heavy-ion irradiation were analyzed cytogenetically to identify those clones showing a persistent destablization of chromosomes. RESULTS: Dose-response data, with a particular emphasis at low dose (< 1.0 Gy), indicate a frequency of approximately 4% per gray for the induction of chromosomal instability in clones derived from single progenitor cells surviving exposure to iron ions. The induction of chromosomal instability by gold ions was, however, less responsive to applied dose, as the observed incidence of this phenotype varied from 0 to 10% over 1-8 Gy. Both iron and gold ions gave dose-dependent increases in the yield of chromosomal aberrations (both chromosome- and chromatid-type) measured at the first mitosis following irradiation, as well as shoulderless survival curves having D0=0.87 and 1.1 Gy respectively. CONCLUSIONS: Based on the present dose-response data, the relative biological effectiveness of iron ions is 1.3 for the induction of chromosomal instability, and this indicates that heavy ions are only slightly more efficient than X-rays at eliciting this delayed phenotype.

Non-NASA Center↗

NASA NTRS2021

Comparison of Single-Event Transients in an Epitaxial Silicon Diode Resulting from Heavy Ion-, Focused X-Ray-, and Pulsed Laser-Induced Charge Generation

Heavy ion, focused X-ray, pulsed laser single event transient experiments are performed on a silicon epitaxial diode. Collected charge, transient rise times, and transient fall times are calculated and compared between the different sources. The transient shape characteristics depend on the source (ion, X-ray, or laser), even when similar amounts of charge are generated. The observed differences are examined and explained in terms of basic charge collection mechanisms.

Heavy ions↗

NASA NTRS2001

Shielded Heavy-Ion Environment Linear Detector (SHIELD): an experiment for the Radiation and Technology Demonstration (RTD) Mission

Radiological assessment of the many cosmic ion species of widely distributed energies requires the use of theoretical transport models to accurately describe diverse physical processes related to nuclear reactions in spacecraft structures, planetary atmospheres and surfaces, and tissues. Heavy-ion transport models that were designed to characterize shielded radiation fields have been validated through comparison with data from thick-target irradiation experiments at particle accelerators. With the RTD Mission comes a unique opportunity to validate existing radiation transport models and guide the development of tools for shield design. For the first time, transport properties will be measured in free-space to characterize the shielding effectiveness of materials that are likely to be aboard interplanetary space missions. Target materials composed of aluminum, advanced composite spacecraft structure and other shielding materials, helium (a propellant) and tissue equivalent matrices will be evaluated. Large solid state detectors will provide kinetic energy and charge identification for incident heavy-ions and for secondary ions created in the target material. Transport calculations using the HZETRN model suggest that 8 g cm -2 thick targets would be adequate to evaluate the shielding effectiveness during solar minimum activity conditions for a period of 30 days or more.

NASA Center LaRC↗

NASA NTRS1986

The effect of heavy ions on the formation and structure of cometary bow shocks

A hybrid simulation model is used to investigate the effects of heavy cometary ions on the formation and structure of a cometary bow shock. The calculations are carried out over various Mach numbers and heavy ion velocity distribution functions. The model is based on previous formulations for phenomena in the solar wind and at the earth's bow shock. The generation of the shock is described in terms of particles injected from one side of the simulation field and reflected from the other end of the field, i.e., a solid wall boundary model. This technique permits the steep buildup of the ion density near the cometary nucleus, followed by coupling of the incident and reflected ion streams to produce a shock. It is shown that at low Mach numbers (up to Mach 2) the shock is transitory and periodically formed by protons, then destroyed by heavy ions (O+). Slightly higher Mach numbers lead to a true stationary shock. An examination of coupling effects between the solar wind and the heavy ions at low Mach numbers by using the Rankine-Hugoniot relations reveals that the ions and the solar wind protons cannot be treated as a single fluid calculating the shock characteristics.

Omidi, N.↗

NASA NTRS1991

Heavy ion measurement on LDEF

The Kiel Long Duration Exposure Facility (LDEF) experiment M0002, mounted on experiment tray E6, was designed to measure the heavy ion environment by means of CR-39 plastic solid state track detectors. The detector stack with a size of 40x34x4.5 cu cm was exposed in vacuum covered by thermal protection foils with a total thickness of approx. 14 mg/sq cm. After etching small samples of the detector foils tracks with Z greater than or = 6 could be easily detected on a background of small etch pits, which were probably produced by secondaries from proton interactions. The LDEF orientation with respect to the magnetic field lines within the South Atlantic Anomaly (SAA) is expected to be constant during the mission. Therefore, the azimuth angle distribution was measured on the detector foils for low energy stopping particles. All detected arrival directions are close to a plane perpendicular to the magnetic field line of -20 deg declination and -40 deg inclination at location 34 deg W and 27 deg S. Together with the steep energy spectrum, this spatial distribution close to the mirror plane in the SAA is an evidence that heavy ions were detected from a radiation belt population.

Beaujean, R.↗

NASA NTRS1992

The production of He-3 and heavy ion enrichment in He-3-rich flares by electromagnetic hydrogen cyclotron waves

A new model is presented for the production of He-3 and heavy ion enrichments in He-3-rich flares using a direct single-stage mechanism. In analogy with the production of electromagnetic hydrogen cyclotron waves in earth's aurora by electron beams, it is suggested that such waves should exist in the electron acceleration region of impulsive solar flares. Both analytic and test-particle models of the effect of such waves in a nonuniform magnetic field show that these waves can selectively accelerate He-3 and heavy ions to MeV energies in a single-stage process, in contrast to other models which require a two-stage mechanism.

Temerin, M.↗

NASA NTRS1992

Heavy ion measurement on LDEF

A stack of CR-39 and Kodak CN track detectors was exposed on the NASA satellite LDEF and recovered after almost six years in space. The quick look analysis yielded heavy ion tracks on a background of low energy secondaries from proton interaction. The detected heavy ions show a steep energy spectrum which indicates a radiation belt origin.

Beaujean, R.↗

NASA NTRS1980

Energy dependence and temporal evolution of the He-3/He-4 ratios in heavy-ion-rich energetic particle events

A study is presented of the energy dependence of the He-3/He-4 between 0.44 and 4.1 MeV per nucleon for six heavy-ion-rich events observed in 1974 and 1976. The observations were made using the low-energy dE/dx vs E Ultralow-Energy Particle telescope on IMP 8. It was found that all selected heavy-ion-rich events are also enriched in He-3: that the He-3/He-4 ratio decreases with decreasing energies; and that a rapid temporal evolution of the He-3/He-4 and the Fe/(H + He) ratios is strongly correlated during one event with the maximum value at the onset. These results are analyzed in terms of a model based on the preferential injection of He-3 and Fe resulting from turbulent ion heating and subsequent Fermi acceleration.

Moebius, E.↗

NASA NTRS1983

The composition of heavy ions in solar energetic particle events

Recent advances in determining the elemental, charge state, and isotopic composition of or approximate to 1 to or approximate to 20 MeV per nucleon ions in solar energetic particle (SEP) events and outline our current understanding of the nature of solar and interplanetary processes which may explain the observations. Average values of relative abundances measured in a large number of SEP events were found to be roughly energy independent in the approx. 1 to approx. 20 MeV per nucleon range, and showed a systematic deviation from photospheric abundances which seems to be organized in terms of the first ionization potential of the ion. Direct measurements of the charge states of SEPs revealed the surprisingly common presence of energetic He(+) along with heavy ion with typically coronal ionization states. High resolution measurements of isotopic abundance ratios in a small number of SEP events showed these to be consistent with the universal composition except for the puzzling overabundance of the SEP(22)Ne/(20)Ne relative to this isotopes ratio in the solar wind. The broad spectrum of observed elemental abundance variations, which in their extreme result in composition anomalies characteristic of (3)He rich, heavy ion rich and carbon poor SEP events, along with direct measurements of the ionization states of SEPs provided essential information on the physical characteristics of, and conditions in the source regions, as well as important constraints to possible models for SEP production.

Fan, C. Y.↗

NASA NTRS1984

The composition of heavy ions in solar energetic particle events

Fan, C. Y.↗

NASA NTRS1981

Energetic heavy ions with nuclear charge Z greater than or equal to 4 in the equatorial radiation belts of the earth - Magnetic storms

Direct in situ observations of trapped energetic heavy ions with nuclear charge Z greater than or equal to 4 at energies in the lower MeV range made with Explorer 45 during the period June-December 1972 are presented. It is noted that all measurements were carried out in the vicinity of the geomagnetic equatorial plane and that the data show the varying effects of four major magnetic storm periods. Orders of magnitude increases in the trapped heavy ion population are seen deep within the radiation belts following the August 1972 solar flare and magnetic storm events. Fluxes of the Z greater than or equal to 4 ions are found to decay faster than those of helium ions of comparable energies; typical decay times for these ions are found to be 24-40 days at L less than or equal to 4 and shorter at higher L shells. The observations are compared with the expected post-injection long-term behavior of atomic oxygen ions deduced from charge exhange, radial diffusive transport, and Coulomb collisions. Good agreement is found between theory and observations.

Spjeldvik, W. N.↗

NASA NTRS1995

Cosmic ray heavy ion penetration deep into the magnetosphere: Results from S81-1 and CRRES

In spite of strong magnetic shielding by the geomagnetic field, small fractions (1-10 %) of the total high energy, heavy ion intensities of solar and galactic cosmic rays have been observed at energies below theoretical cutoffs for direct entry into the earth's magnetosphere from interplanetary space. We report on measurements of these heavy ions at 10 to 500 MeV/nucleon by cosmic ray composition experiments on the S81-1 satellite in polar orbit during 1982 and on the Combined Release and Radiation Effects Satellite (CRRES) satellite in geosynchronous transfer orbit during 1990-1991.

Cooper, J. F.↗

NASA NTRS1984

The solar flare heavy ion environment for single-event upsets - A summary of observations over the last solar cycle, 1973-1983

A summary of observations of the flux of 25 to 400 MeV/nucleon heavy ions from solar flares is presented covering the period from late 1973 to early 1984. Distributions of flare occurrence frequency versus fluence, energy spectra, and composition are presented for the 30 events observed during this period, to quantify the variability of the heavy ion environment. A comparison of these data to a model environment suggests some refinements to the model. LET spectra based on the worst case flare observed are presented to illustrate the significance of the flare ion distribution and the importance of accurate shielding estimates.

Chenette, D. L.↗

NASA NTRS2012

Late Effects of Heavy Ion Irradiation on Ex Vivo Osteoblastogenesis and Cancellous Bone Microarchitecture

Prolonged spaceflight causes degeneration of skeletal tissue with incomplete recovery even after return to Earth. We hypothesize that heavy ion irradiation, a component of Galactic Cosmic Radiation, damages osteoblast progenitors and may contribute to bone loss during long duration space travel beyond the protection of the Earth's magnetosphere. Male, 16 week old C57BL6/J mice were exposed to high LET (56 Fe, 600MeV) radiation using either low (5 or 10cGy) or high (50 or 200cGy) doses at the NASA Space Radiation Lab and were euthanized 3 - 4, 7, or 35 days later. Bone structure was quantified by microcomputed tomography (6.8 micron pixel size) and marrow cell redox assessed using membrane permeable, free radical sensitive fluorogenic dyes. To assess osteoblastogenesis, adherent marrow cells were cultured ex vivo, then mineralized nodule formation quantified by imaging and gene expression analyzed by RT PCR. Interestingly, 3 - 4 days post exposure, fluorogenic dyes that reflect cytoplasmic generation of reactive nitrogen/oxygen species (DAF FM Diacetate or CM H2DCFDA) revealed irradiation (50cGy) reduced free radical generation (20-45%) compared to sham irradiated controls. Alternatively, use of a dye showing relative specificity for mitochondrial superoxide generation (MitoSOX) revealed an 88% increase compared to controls. One week after exposure, reactive oxygen/nitrogen levels remained lower(24%) relative to sham irradiated controls. After one month, high dose irradiation (200 cGy) caused an 86% decrement in ex vivo nodule formation and a 16-31% decrement in bone volume to total volume and trabecular number (50, 200cGy) compared to controls. High dose irradiation (200cGy) up regulated expression of a late osteoblast marker (BGLAP) and select genes related to oxidative metabolism (Catalase) and DNA damage repair (Gadd45). In contrast, lower doses (5, 10cGy) did not affect bone structure or ex vivo nodule formation, but did down regulate iNOS by 0.54 - 0.58 fold. Thus, both low and high doses of heavy ion irradiation cause time dependent, adaptive changes in redox state within marrow cells but only high doses (50, 200cGy) inhibit osteoblastogenesis and cause cancellous bone loss. We conclude space radiation has the potential to cause persistent damage to bone marrow derived stem and progenitor cells for osteoblasts despite adaptive changes in cellular redox state.

Tran, Luan Hoang↗

NASA NTRS2017

Failure Analysis of Heavy-Ion-Irradiated Schottky Diodes

In this paper, we use high- and low-magnification optical microscope images, thermal infrared camera images, and scanning electron microscope images to identify failure locations in heavy-ion-irradiated Schottky diodes. After failures have been identified, the parts were cross-sectioned to describe the structure of the failures and energy dispersive x-ray spectroscopy was used to characterize the materials in the failure structures.

Radiation effects↗

NASA NTRS1984

Neoplastic cell transformation by energetic heavy ions and its modification with chemical agents

One of the major deleterious late effects of ionizing radiation is related to the induction of neoplasms. In the present report recent experimental results on neoplastic cell transformation by heavy ions are presented, and possible means to circumvent the carcinogenic effect of space radiation are discussed. Biological effects observed in experiments involving the use of energetic heavy ions accelerated at the Bevalac suggest that many of the biological effects observed in earlier space flight experiments may be due to space radiation, particularly cosmic rays. It is found that the effect of radiation on cell transformation is dose-rate dependent. The frequency of neoplastic transformation for a given dose decreases with a decrease of dose rate of Co-60 gamma rays. It is found that various chemical agents give radiation protection, including DMSO.

Yang, T. C.↗

NASA NTRS1983

Heavy-ion total and absorption cross sections above 25 MeV/nucleon

Within the context of a double-folding optical potential approximation to the exact nucleus-nucleus multiple-scattering series, eikonal scattering theory is used to generate tables of heavy ion total and absorption cross sections at incident kinetic energies above 25 MeV/nucleon for use in cosmic ray high-energy heavy ion transport and shielding studies. Comparisons of predictions with nucleus-nucleus experimental data show excellent agreement except at the lowest energies, where the eikonal approximation may not be completely valid. Even at the lowest energies, however, agreement is typically within 20 percent.

Townsend, L. W.↗

NASA NTRS1984

An abrasion-ablation model description of galactic heavy-ion fragmentation

The fragmentation of high-energy galactic heavy ions by nuclear interactions with arbitrary target nuclei is described within the context of a simple abrasion-ablation fragmentation model. The abrasion part of the theory utilizes a quantum-mechanical formalism based upon an optical model potential approximation to the exact nucleus-nucleus multiple-scattering series. Nuclear charge distributions of the excited prefragments are calculated using either a hypergeometric distribution or a method based upon the zero-point oscillations of the giant dipole resonance. The excitation energy of the prefragment is estimated from the geometric clean-cut abrasion-ablation model. The decay probabilities for the various particle emission channels, in the ablation stage of the fragmentation, are obtained from the EVAP-4 Monte Carlo computer program. Elemental production cross sections for 1.88-GeV/nucleon iron colliding with carbon, silver, and lead targets are calculated and compared with experimental data and with the predictions from the semiempirical relations of Silberberg and Tsao.

Townsend, L. W.↗