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A national survey of policies on disclosure of conflicts of interest in biomedical research

BACKGROUND: Conflicts of interest pose a threat to the integrity of scientific research. The current regulations of the U.S. Public Health Service and the National Science Foundation require that medical schools and other research institutions report the existence of conflicts of interest to the funding agency but allow the institutions to manage conflicts internally. The regulations do not specify how to do so. METHODS: We surveyed all medical schools (127) and other research institutions (170) that received more than $5 million in total grants annually from the National Institutes of Health or the National Science Foundation; 48 journals in basic science and clinical medicine; and 17 federal agencies in order to analyze their policies on conflicts of interest. RESULTS: Of the 297 institutions, 250 (84 percent) responded by March 2000, as did 47 of the 48 journals and 16 of the 17 federal agencies. Fifteen of the 250 institutions (6 percent)--5 medical schools and 10 other research institutions--reported that they had no policy on conflicts of interest. Among the institutions that had policies, there was marked variation in the definition and management of conflicts. Ninety-one percent had policies that adhered to the federal threshold for disclosure ($10,000 in annual income or equity in a relevant company or 5 percent ownership), and 9 percent had policies that exceeded the federal guidelines. Only 8 percent had policies requiring disclosure to funding agencies, only 7 percent had such policies regarding journals, and only 1 percent had policies requiring the disclosure of information to the relevant institutional review boards or to research subjects. Twenty journals (43 percent) reported that they had policies requiring disclosure of conflicts of interest. Only four federal agencies had policies that explicitly addressed conflicts of interest in extramural research, and all but one of the agencies relied primarily on institutional discretion. CONCLUSIONS: There is substantial variation among policies on conflicts of interest at medical schools and other research institutions. This variation, combined with the fact that many scientific journals and funding agencies do not require disclosure of conflicts of interest, suggests that the current standards may not be adequate to maintain a high level of scientific integrity.

Human↗

The United States COVID-19 Forecast Hub dataset

Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, the United States Centers for Disease Control and Prevention (CDC) partnered with an academic research lab at the University of Massachusetts Amherst to create the US COVID-19 Forecast Hub. Launched in April 2020, the Forecast Hub is a dataset with point and probabilistic forecasts of incident cases, incident hospitalizations, incident deaths, and cumulative deaths due to COVID-19 at county, state, and national, levels in the United States. Included forecasts represent a variety of modeling approaches, data sources, and assumptions regarding the spread of COVID-19. The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data can be used to develop ensemble models, communicate forecasts to the public, create visualizations, compare models, and inform policies regarding COVID-19 mitigation. These open-source data are available via download from GitHub, through an online API, and through R packages.

60 APPLIED LIFE SCIENCES↗

The Communications Technology Satellite and the associated ground terminals for experiments

The CTS project is a joint effort between the Communications Research Centre in Canada and National Aeronautics and Space Administration in the United States with both nations equally sharing available spacecraft communication time. The CTS spacecraft will be placed in synchronous orbit at 116 deg west longitude. General spacecraft operational characteristics are discussed with particular emphasis on communication system parameters. The associated Canadian and United States user ground terminals are reviewed with particular emphasis on wideband communications. In Canada the experimenter (user) ground terminal communication equipment is government owned whereas in the United States the user terminal equipment is the responsibility of each user.

Wright, D. L.↗

The orbital debris program of the United States

The policy of the U.S. government relative to orbital debris, as it is set out in recent national space policy, is reviewed. The objectives of the orbital debris program are to: ensure the current and future safe use of the space environment; ensure the safety of human space flight; promote a scientific understanding of the space environment; minimize the creation of orbital debris, and promote the adoption of appropriate debris minimization practices by international spacefaring organizations. The problem is stated and the national and international activities are described. The five recommendations of the 1995 interagency report on orbital debris are presented together with the proposed response of the U.S. government to these recommendations.

Levin, George M.↗

NASA-UK STAP: A technology applications program to aid government and industry in Kentucky

There is a need for a well-defined partnership between universities, and the business and industrial community to promote the transfer of technology. In an effort to foster such a partnership, the Space Systems Program, administered by NASA, has established information dissemination centers in cooperation with various universities throughout the country. As a result of limited success in the transfer of technology to state and local units of government NASA felt that new stimuli and new approaches were needed in the public sector area. NASA selected the University of Kentucky, a land grant institution with a significant research dissemination and service role, as the site for the new program. An annual report of this program at the University of Kentucky is presented.

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Applied Remote Sensing Program (ARSP) to state and local government

Environmental surveys of arid land areas (Arizona) in the United States are presented. Maps of soils, vegetation, drainage patterns, and land use are shown. The distribution of uranium deposits, oil and gas pools, is also shown. Legislation pertaining to the preservation of natural resources is discussed.

Johnson, J. D.↗

Evolution of Government and Industrial Partnerships to Open the Space Frontier

If the logical extension of the current exploration program is to develop self-sustaining settlements on the Moon and Mars over the next few centuries, then there is a path that takes civilization from its current one planet existence to a multi-world future. By considering the far term goal of space settlements as a desired endpoint and using the current state as a starting point, the policy drivers and potential pathways to the goal of sustainable space settlements can be explored. This paper describes a three-phased evolution of government and industrial partnerships from current day relationships to a time when there are sustainable settlements in space. Phase I details the current state government-led exploration while Phase III describes a desired endpoint of self-sufficient settlements in space. Phase II is an important transition phase, which acts as a bridge between now and the future. This paper discusses the critical evolution that must take place in two key areas to ensure a thriving future in space; space transportation and the right to use space property and resources. This paper focuses on the enabling role of government necessary to achieve United States (U.S.) goals for space exploration and open the frontier.

Martin, Gary L.↗

Meeting of the Minds Summary Report: Emergent Cyber R&D Priorities Beyond 2020

On May 26, 2021, Sandia National Laboratories (SNL) convened a diverse group of experts spanning private industry, academia, the United States military and federal government, and the national laboratories, and hosted a series of panels to gain their insight on critical emergent research and capability development needs to support national cyber strategy objectives. Two panelists of experts presented their prepared remarks, followed by open discussion from over 250 audience members.

97 MATHEMATICS AND COMPUTING↗

The Galilean Satellite Geological Mapping Program, 1984

About 40 investigators from various universities, research institutes, and government offices in the United States, England, Germany, and Italy are compiling maps of the Galilean satellites. All maps are at a scale of 1:5 million except for three of the Io maps, where high resolution pictures permit compilation of selected areas at larger scales. Guidelines for mapping Ganymede are discussed.

Lucchitta, B. K.↗

The Galilean satellite geological mapping program, 1986

The Galilean Satellite Geological Mapping Program was established to illuminate detailed geologic relations on the four large satellites of Jupiter. The program involves some 40 investigators from various universities, research institutes, and government offices in the United States, U.K., West Germany, and Italy. A total of 24 researchers was assigned to map 15 quadrangles on Ganymede, 15 to map 6 quadrangles on Io, and 3 to map 2 quadrangles on Europa. Maps of these three bodies are at a scale of 1:5 M except for three on Io that cover selected areas where high-resolution pictures permit compilation at 1:2 and 1:1 M scales. A 1:15,000,000 scale map of Callisto has been assigned; from it, quadrangles containing useful geologic information will be extracted later for mapping at a scale of 1:5,000,000.

Lucchitta, B. K.↗

CFD in design - A government perspective

Some of the research programs involving the use of CFD in the aerodynamic design process at government laboratories around the United States are presented. Technology transfer issues and future directions in the discipline or CFD are addressed. The major challengers in the aerosciences as well as other disciplines that will require high-performance computing resources such as massively parallel computers are examined.

Kutler, Paul↗

The Chandra X-Ray Observatory

The Chandra X-Ray Observatory is the X-ray component of NASA's Great observatories which also includes the recently decommissioned Compton Gamma Ray Observatory, the Hubble Space Telescope, and the soon to be launched Space Infra Red Telescope Facility. Chandra is a unique X-ray astronomy facility for high-resolution imaging and for high-resolution spectroscopy. Chandra's performance advantage over other X-ray observatories is analogous to that of the Hubble Space Telescope over ground-based observatories. Chandra is a NASA facility that provides scientific data to the international astronomical community in response to proposals for its use. Data becomes public one year after the observation. The Observatory is the product of the efforts of many commercial, academic, and government organizations in the United States and Europe. NASA's Marshall Space Flight Center (MSFC) manages the Project and provides Project Science; TRW Space and Electronics Group served as prime contractor responsible for providing the spacecraft, the telescope, and assembling and testing the observatory; the Smithsonian Astrophysical Observatory (SAO) provides technical support and is responsible for ground operations.

Weisskopf, M. C.↗

Three Years of Operation of the Chandra X-Ray Observatory

The Chandra X-Ray Observatory is a NASA facility that provides scientific data to the international astronomical community in response to proposals for its use. Data becomes public at most one year after the observation. The Observatory is the product of the efforts of many commercial, academic, and government organizations in the United States and Europe. NASA's Marshall Space Flight Center (MSFC) manages the Project and provides Project Science TRW Space and Electronics Group served as prime contractor responsible for providing the spacecraft, the telescope, and assembling and testing the observatory the Smithsonian Astrophysical Observatory (SAO) provides technical support and is responsible for around operations including the Chandra X Ray Center (CXC).

Weisskopf, Martin C.↗

NASA's Management and Utilization of the Small Business Innovative Research (SBIR) Program

The United Space Congress established the SBIR program in 1982 for the following purposes: ( 1) Stimulate technological innovation (2) Increase private-sector commercialization derived from federal R&D (3) Use small business to meet federal R&D needs (4) Foster and encourage participation by disadvantaged persons and women in technological innovation The STTR program was established in 1992 with the additional requirement of having a small business partner with a research institution (usually a university) for the purpose of transferring intellectual property from the research institution to the small business concern for enabling a government technical need and furthering the technological development for the purpose of developing commercial products. The government of Japan has established a program that models portions of the U.S. SBIR and STTR programs. They are very interested in how NASA has been so successful in fulfilling the Congressional objectives of these programs. In particular, they want to understand the management practices and incentives that are provided to enable partnerships between business enterprises, academia and government. The speech will also focus on some of the many successful technologies (on a conceptual level) that have been developed through NASA s SBIR and STTR programs and mechanisms used to promote cooperation between small businesses, large businesses, academia and government agencies within the United States. The speech is on a conceptual level, focusing on U.S. and NASA policies and management implementation practices. No enabling technical discussion will be held.

Mexcur, Winfield Paul↗

Ultra-Compact Neuroprocessor for Automotive Diagnostic and Control

Demands on the performance of vehicle control and diagnostic systems are steadily increasing as a consequence of stiff global competition and government mandates. In the United States, light trucks and passenger cars are required both to meet strict emission standards and to perform continuous diagnostics of all emissions systems operating in the vehicle.

Neuroprocessor automotive diagnostics↗

Reliability and Integrity Management Program Implementation Approach

Nuclear energy is the most reliable and environmentally sustainable energy source available today. In the United States, nuclear-generated power accounts for approximately 20% of total electricity and over 55% of clean energy. New advanced reactors have enormous potential to help further decarbonize the energy market, enhance grid resiliency, create new jobs, and build a stronger economy. More than 50 new reactors are being developed in the United States, and the federal government realizes an urgent need to deploy nuclear technologies to meet the country’s energy, environmental, and national security goals. As such, the U.S. Department of Energy launched multiple programs to support advanced reactor deployment. The research described in this paper explores implementation strategies for the Reliability and Integrity Management Program that directly supports the U.S. Department of Energy goal to enable the near-term deployment of the advanced reactor technologies. The project is conducted under the Regulatory Development Program for advanced reactors sponsored by the U.S. Department of Energy.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Large Area Crop Inventory Experiment (LACIE). Phase 2 evaluation report

Documentation of the activities of the Large Area Crop Inventory Experiment during the 1976 Northern Hemisphere crop year is presented. A brief overview of the experiment is included as well as phase two area, yield, and production estimates for the United States Great Plains, Canada, and the Union of Soviet Socialist Republics spring winter wheat regions. The accuracies of these estimates are compared with independent government estimates. Accuracy assessment of the United States Great Plains yardstick region based on a through blind sight analysis is given, and reasons for variations in estimating performance are discussed. Other phase two technical activities including operations, exploratory analysis, reporting, methods of assessment, phase three and advanced system design, technical issues, and developmental activities are also included.

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Encouraging voluntary government action via a solar-friendly designation program to promote solar energy in the United States

Sustainable development requires an accelerated transition toward renewable energy. In particular, substantially scaling up solar photovoltaics (PV) adoption is a crucial component of reducing the impacts of climate change and promoting sustainable development. However, it is challenging to convince local governments to take action. This study uses a combination of propensity score matching (PSM) and difference-in-differences (DID) models to assess the effectiveness of a voluntary environmental program (VEP) called SolSmart that targets local governments to engage in solar-friendly practices to promote the local solar PV market in the United States. Via specific designation requirements and technical assistance, SolSmart simplifies the process of acting on interest in being solar friendly, has a wide coverage of basic solar-friendly actions with flexible implementation, and motivates completion with multiple levels of designation. We find that a local government’s participation in SolSmart is associated with an increased installed capacity of 18 to 19%/mo or with less statistical significance, an increased number of installations of 17%/mo in its jurisdiction. However, SolSmart has not shown a statistically significant impact on soft cost reductions to date. In evaluating the impact of the SolSmart program, this study improves our understanding of the causation between a VEP that encourages solar-friendly local government practices and multiple solar market outcomes. VEPs may be able to promote shifts toward sustainable development at the local level. Our findings have several implications for the design of VEPs that promote local sustainability.

14 SOLAR ENERGY↗