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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 145 records · Page 8

Kilowatt-Class Fission Power Systems for Science and Human Precursor Missions

Nuclear power provides an enabling capability for NASA missions that might otherwise be constrained by power availability, mission duration, or operational robustness. NASA and the Department of Energy (DOE) are developing fission power technology to serve a wide range of future space uses. Advantages include lower mass, longer life, and greater mission flexibility than competing power system options. Kilowatt-class fission systems, designated "Kilopower," were conceived to address the need for systems to fill the gap above the current 100-W-class radioisotope power systems being developed for science missions and below the typical 100-k We-class reactor power systems being developed for human exploration missions. This paper reviews the current fission technology project and examines some Kilopower concepts that could be used to support future science missions or human precursors.

Flexibility↗

Interannual Variation in Phytoplankton Class-Specific Primary Production at a Global Scale

We used the NASA Ocean Biogeochemical Model (NOBM) combined with remote sensing data via assimilation to evaluate the contribution of 4 phytoplankton groups to the total primary production. First we assessed the contribution of each phytoplankton groups to the total primary production at a global scale for the period 1998-2011. Globally, diatoms were the group that contributed the most to the total phytoplankton production (50, the equivalent of 20 PgC y-1. Coccolithophores and chlorophytes each contributed to 20 (7 PgC y-1 of the total primary production and cyanobacteria represented about 10 (4 PgC y(sub-1) of the total primary production. Primary production by diatoms was highest in high latitude (45) and in major upwelling systems (Equatorial Pacific and Benguela system). We then assessed interannual variability of this group-specific primary production over the period 1998-2011. Globally the annual relative contribution of each phytoplankton groups to the total primary production varied by maximum 4 (1-2 PgC y-1. We assessed the effects of climate variability on the class-specific primary production using global (i.e. Multivariate El Nio Index, MEI) and regional climate indices (e.g. Southern Annular Mode (SAM), Pacific Decadal Oscillation (PDO) and North Atlantic Oscillation (NAO)). Most interannual variability occurred in the Equatorial Pacific and was associated with climate variability as indicated by significant correlation (p 0.05) between the MEI and the class-specific primary production from all groups except coccolithophores. In the Atlantic, climate variability as indicated by NAO was significantly correlated to the primary production of 2 out of the 4 groups in the North Central Atlantic (diatomscyanobacteria) and in the North Atlantic (chlorophytes and coccolithophores). We found that climate variability as indicated by SAM had only a limited effect on the class-specific primary production in the Southern Ocean. These results provide a modeling and data assimilation perspective to phytoplankton partitioning of primary production and contribute to our understanding of the dynamics of the carbon cycle in the oceans at a global scale.

Chl-a↗

Mission Architecture and Technology Options for a Flagship Class Venus In Situ Mission

Venus, as part of the inner triad with Earth and Mars, represents an important exploration target if we want to learn more about solar system formation and evolution. Comparative planetology could also elucidate the differences between the past, present, and future of these three planets, and can help with the characterization of potential habitable zones in our solar system and, by extension, extrasolar systems. A long lived in situ Venus mission concept, called the Venus Mobile Explorer, was prominently featured in NASA's 2006 SSE Roadmap and supported in the community White Paper by the Venus Exploration Analysis Group (VEXAG). Long-lived in situ missions are expected to belong to the largest (Flagship) mission class, which would require both enabling and enhancing technologies beside mission architecture options. Furthermore, extreme environment mitigation technologies for Venus are considered long lead development items and are expected to require technology development through a dedicated program. To better understand programmatic and technology needs and the motivating science behind them, in this fiscal year (FY08) NASA is funding a Venus Flaghip class mission study, based on key science and technology drivers identified by a NASA appointed Venus Science and Technology Definition Team (STDT). These mission drivers are then assembled around a suitable mission architecture to further refine technology and cost elements. In this paper we will discuss the connection between the final mission architecture and the connected technology drivers from this NASA funded study, which - if funded - could enable a future Flagship class Venus mission and potentially drive a proposed Venus technology development program.

Balint, Tibor S.↗

Class D Management Implementation Approach of the First Orbital Mission of the Earth Venture Series

A key element of the National Research Council's Earth Science and Applications Decadal Survey called for the creation of the Venture Class line of low-cost research and application missions within NASA (National Aeronautics and Space Administration). One key component of the architecture chosen by NASA within the Earth Venture line is a series of self-contained stand-alone spaceflight science missions called "EV-Mission". The first mission chosen for this competitively selected, cost and schedule capped, Principal Investigator-led opportunity is the CYclone Global Navigation Satellite System (CYGNSS). As specified in the defining Announcement of Opportunity, the Principal Investigator is held responsible for successfully achieving the science objectives of the selected mission and the management approach that he/she chooses to obtain those results has a significant amount of freedom as long as it meets the intent of key NASA guidance like NPR 7120.5 and 7123. CYGNSS is classified under NPR 7120.5E guidance as a Category 3 (low priority, low cost) mission and carries a Class D risk classification (low priority, high risk) per NPR 8705.4. As defined in the NPR guidance, Class D risk classification allows for a relatively broad range of implementation strategies. The management approach that will be utilized on CYGNSS is a streamlined implementation that starts with a higher risk tolerance posture at NASA and that philosophy flows all the way down to the individual part level.

Wells, James E.↗

Structural Design Considerations for a 50 kW-Class Solar Array for NASA's Asteroid Redirect Mission

NASA is planning an Asteroid Redirect Mission (ARM) to take place in the 2020s. To enable this multi-year mission, a 40 kW class solar electric propulsion (SEP) system powered by an advanced 50 kW class solar array will be required. Powered by the SEP module (SEPM), the ARM vehicle will travel to a large near-Earth asteroid, descend to its surface, capture a multi-metric ton (t) asteroid boulder, ascend from the surface and return to the Earth-moon system to ultimately place the ARM vehicle and its captured asteroid boulder into a stable distant orbit. During the years that follow, astronauts flying in the Orion multipurpose crew vehicle (MPCV) will dock with the ARM vehicle and conduct extra-vehicular activity (EVA) operations to explore and sample the asteroid boulder. This paper will review the top structural design considerations to successfully implement this 50 kW class solar array that must meet unprecedented performance levels. These considerations include beyond state-of-the-art metrics for specific mass, specific volume, deployed area, deployed solar array wing (SAW) keep in zone (KIZ), deployed strength and deployed frequency. Analytical and design results are presented that support definition of stowed KIZ and launch restraint interface definition. An offset boom is defined to meet the deployed SAW KIZ. The resulting parametric impact of the offset boom length on spacecraft moment of inertias and deployed SAW quasistatic and dynamic load cases are also presented. Load cases include ARM spacecraft thruster plume impingement, asteroid surface operations and Orion docking operations which drive the required SAW deployed strength and damping. The authors conclude that to support NASA's ARM power needs, an advanced SAW is required with mass performance better than 125 W/kg, stowed volume better than 40 kW/cu m, a deployed area of 200 sq m (100 sq m for each of two SAWs), a deployed SAW offset distance of nominally 3-4 m, a deployed SAW quasistatic strength of nominally 0.1 g in any direction, a deployed loading displacement under 2 m, a deployed fundamental frequency above 0.1 Hz and deployed damping of at least 1%. These parameters must be met on top of challenging mission environments and ground testing requirements unique to the ARM project.

solar arrays↗

Manufacturing Challenges and Benefits When Scaling the HIAD Stacked-Torus Aeroshell to a 15 Meter Class System

Over a decade of work has been conducted in the development of NASA's Hypersonic Inflatable Aerodynamic Decelerator (HIAD) deployable aeroshell technology. This effort has included multiple ground test campaigns and flight tests culminating in the HIAD project's second generation (Gen-2) aeroshell system. The HIAD project team has developed, fabricated, and tested stacked-torus inflatable structures (IS) with flexible thermal protection systems (F-TPS) ranging in diameters from 3-6 meters, with cone angles of 60 and 70 degrees. To meet NASA and commercial near-term objectives, the HIAD team must scale the current technology up to 12-15 meters in diameter. Therefore, the HIAD project's experience in scaling the technology has reached a critical juncture. Growing from a 6-meter to a 15-meter class system will introduce many new structural and logistical challenges to an already complicated manufacturing process. Although the general architecture and key aspects of the HIAD design scale well to larger vehicles, details of the technology will need to be reevaluated and possibly redesigned for use in a 15-meter-class HIAD system. These include: layout and size of the structural webbing that transfers load throughout the IS, inflatable gas barrier design, torus diameter and braid construction, internal pressure and inflation line routing, adhesives used for coating and bonding, and F-TPS gore design and seam fabrication. The logistics of fabricating and testing the IS and the F-TPS also become more challenging with increased scale. Compared to the 6-meter aeroshell (the largest HIAD built to date), a 12-meter aeroshell has four times the cross-sectional area, and a 15-meter one has over six times the area. This means that fabrication and test procedures will need to be reexamined to account for the sheer size and weight of the aeroshell components. This will affect a variety of steps in the manufacturing process, such as: stacking the tori during assembly, stitching the structural webbing, initial inflation of tori, and stitching of F-TPS gores. Additionally, new approaches and hardware will be required for handling and ground testing of both individual tori and the fully assembled HIADs. There are also noteworthy benefits of scaling up the HIAD aeroshell to a 15m-class system. Two complications in working with handmade textile structures are the non-linearity of the material components and the role of human accuracy during fabrication. Larger, more capable, HIAD structures should see much larger operational loads, potentially bringing the structural response of the material components out of the non-linear regime and into the preferred linear response range. Also, making the reasonable assumption that the magnitude of fabrication accuracy remains constant as the structures grow, the relative effect of fabrication errors should decrease as a percentage of the textile component size. Combined, these two effects improve the predictive capability and the uniformity of the structural response for a 12-15-meter HIAD. In this presentation, a handful of the challenges and associated mitigation plans will be discussed, as well as an update on current manufacturing and testing that addressing these challenges.

Infatables↗

Manufacturing Challenges and Benefits when Scaling the HIAD Stacked-Torus Aeroshell to a 15m-Class System

Over a decade of work has been conducted in the development of NASAs Hypersonic Inflatable Aerodynamic Decelerator (HIAD) deployable aeroshell technology. This effort has included multiple ground test campaigns and flight tests culminating in the HIAD projects second generation (Gen-2) aeroshell system. The HIAD project team has developed, fabricated, and tested stacked-torus inflatable structures (IS) with flexible thermal protection systems (F-TPS) ranging in diameters from 3-6m, with cone angles of 60 and 70 deg. To meet NASA and commercial near term objectives, the HIAD team must scale the current technology up to 12-15m in diameter. Therefore, the HIAD projects experience in scaling the technology has reached a critical juncture. Growing from a 6m to a 15m-class system will introduce many new structural and logistical challenges to an already complicated manufacturing process.Although the general architecture and key aspects of the HIAD design scale well to larger vehicles, details of the technology will need to be reevaluated and possibly redesigned for use in a 15m-class HIAD system. These include: layout and size of the structural webbing that transfers load throughout the IS, inflatable gas barrier design, torus diameter and braid construction, internal pressure and inflation line routing, adhesives used for coating and bonding, and F-TPS gore design and seam fabrication. The logistics of fabricating and testing the IS and the F-TPS also become more challenging with increased scale. Compared to the 6m aeroshell (the largest HIAD built to date), a 12m aeroshell has four times the cross-sectional area, and a 15m one has over six times the area. This means that fabrication and test procedures will need to be reexamined to ac-count for the sheer size and weight of the aeroshell components. This will affect a variety of steps in the manufacturing process, such as: stacking the tori during assembly, stitching the structural webbing, initial inflation of tori, and stitching of F-TPS gores. Additionally, new approaches and hardware will be required for handling and ground testing of both individual tori and the fully assembled HIADs.There are also noteworthy benefits of scaling up the HIAD aeroshell to a 15m-class system. Two complications in working with handmade textile structures are the non-linearity of the material components and the role of human accuracy during fabrication. Larger, more capable, HIAD structures should see much larger operational loads, potentially bringing the structural response of the material components out of the non-linear regime and into the preferred linear response range. Also, making the reasonable assumption that the magnitude of fabrication accuracy remains constant as the structures grow, the relative effect of fabrication errors should decrease as a percentage of the textile component size. Combined, these two effects improve the predictive capability and the uniformity of the structural response for a 12-15m HIAD.In this presentation, a handful of the challenges and associated mitigation plans will be discussed, as well as an update on current 12m aeroshell manufacturing and testing that is addressing these challenges

Infatables↗

Low Cost, Upper Stage-Class Propulsion

The low cost, upper stage-class propulsion (LCUSP) element will develop a high strength copper alloy additive manufacturing (AM) process as well as critical components for an upper stage-class propulsion system that will be demonstrated with testing. As manufacturing technologies have matured, it now appears possible to build all the major components and subsystems of an upper stage-class rocket engine for substantially less money and much faster than traditionally done. However, several enabling technologies must be developed before that can happen. This activity will address these technologies and demonstrate the concept by designing, manufacturing, and testing the critical components of a rocket engine. The processes developed and materials' property data will be transitioned to industry upon completion of the activity. Technologies to enable the concept are AM copper alloy process development, AM post-processing finishing to minimize surface roughness, AM material deposition on existing copper alloy substrate, and materials characterization.

Vickers, John↗

Two-Year Cosmology Large Angular Scale Surveyor (CLASS) Observations: 40GHz Telescope Pointing, Beam Profile, Window Function, and Polarization Performance

The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array that observes the cosmic microwave background (CMB) over 75% of the sky from the Atacama Desert, Chile, at frequency bands centered near 40, 90, 150, and 220 GHz. CLASS measures the large angular scale (1°~< θ >=90°) CMB polarization to constrain the tensor-to-scalar ratio at the r ∼ 0.01 level and the optical depth to last scattering to the sample variance limit. This paper presents the optical characterization of the 40 GHz telescope during its first observation era, from 2016 September to 2018 February. High signal-to-noise observations of the Moon establish the pointing and beam calibration. The telescope boresight pointing variation is <0°. 023 (<1.6% of the beam’s full width at half maximum (FWHM)). We estimate beam parameters per detector and in aggregate, as in the CMB survey maps. The aggregate beam has an FWHM of 1°.579 ± 0°.001 and a solid angle of 838 ± 6 μsr, consistent with physical optics simulations. The corresponding beam window function has a sub-percent error per multipole at ℓ < 200. An extended 90° beam map reveals no significant far sidelobes. The observed Moon polarization shows that the instrument polarization angles are consistent with the optical model and that the temperature-to-polarization leakage fraction is <10(exp −4) (95% C.L.). We find that the Moon-based results are consistent with measurements of M42, RCW 38, and Tau A from CLASS’s CMB survey data. In particular, Tau A measurements establish degree- level precision for instrument polarization angles.

Xu, Zhilei↗

Evidence for Magnetic Activity at Starbirth: a Powerful X-ray Flare From the Class 0 Protostar HOPS 383

Context. Class 0 protostars represent the earliest evolutionary stage of solar-type stars, during which the majority of the system mass resides in an infalling envelope of gas and dust and not yet in the central, nascent star. Although X-rays are a key signature of magnetic activity in more evolved protostars and young stars, whether such magnetic activity is present at the Class 0 stage is still debated. Aims. We aim to detect a bona fide Class 0 protostar in X-rays. Methods. We observed HOPS 383 in 2017 December in X-rays with the Chandra X-ray Observatory (~84 ks) and in near-infrared imaging with the Southern Astrophysical Research Telescope (SOAR). Results. HOPS 383 was detected in X-rays during a powerful flare. This hard (E > 2 keV) X-ray counterpart was spatially coincident with the northwest 4-cm component of HOPS 383, which would be the base of the radio thermal jet launched by HOPS 383. The flare duration was ~3.3 h; at the peak, the X-ray luminosity reached ~4 x 10(exp 31) erg/s in the 2–8 keV energy band, a level at least an order of magnitude larger than that of the undetected quiescent emission from HOPS 383. The X-ray flare spectrum is highly absorbed (N(H) ~ 7 x 10(exp 23) per sq.cm), and displays a 6.4 keV emission line with an equivalent width of ~1:1 keV, arising from neutral or low-ionization iron. Conclusions. The detection of a powerful X-ray flare from HOPS 383 constitutes direct proof that magnetic activity can be present at the earliest formative stages of solar-type stars.

Nicolas Grosso↗

Comparing X-ray Color Selection in Separating X-ray Binary Classes using Color-Color-Intensity Diagrams

X-ray binaries exhibit a wide range of properties but there are few accepted methods to determine the nature of the compact object. Color-Color-Intensity diagrams have been suggested as a means of distinguishing between systems containing black holes from those containing neutron stars. However, this technique has been verified with data from only one instrument (RXTE/ASM) with a single set of X-ray colors defined using data available only in pre-determined energy bands. We test a selection of X-ray colors with a more sensitive instrument to determine the reliability of this method. We use data from the MAXI/Gas Slit Camera, which allows users to specify energy-bands. We test X-ray colors that have been previously defined in the literature as well as ones that we define specifically in this paper. A representative set of systems are used to construct Color-Color-Intensity diagrams in each set of colors to determine which are best for separating different classes. For studying individual sources certain bands are more effective than others. For a specified energy range, the separation of soft states in black hole binaries was possible only where both soft and hard colors included information from the lowest energy band. We confirm that Color-Color-Intensity diagrams can distinguish between systems containing black holes or neutron stars in all X-ray colors tested; this suggests an universality in the accretion processes governing these different classes. We suggest possible physical processes driving different classes of X-ray binaries to different locations in Color-Color-Intensity diagrams.

N Islam↗

Ensuring Safe Decision-Making on the Moon and Mars: Cognitive Performance Assessment for Exploration Class Mission EVA

Extravehicular activity (EVA) is one of the most dangerous and cognitively demanding actions that astronauts can execute, and the cognitive demands associated with future partial gravity EVA on the Moon and Mars are expected to be higher compared to microgravity EVA currently conducted from the International Space Station (ISS). Decrements in cognitive performance present an important risk to crew safety during exploration mission class EVA. Yet there is currently insufficient data to characterize cognitive performance prior to, during, and following EVA. Furthermore, it is still unclear which cognitive domains are most important for conducting mission critical decisions with crew safety implications. To address this gap, we conducted a cognitive task analysis (CTA) of EVA to characterize the procedures, the cognitive demands required, and the critical safety decisions associated with decrements in cognitive performance. We used the applied cognitive task analysis method as outlined by Militello and Hutton (1998) and conducted interviews with subject matter experts (SMEs) in EVA at NASA Johnson Space Center in summer 2024. Interviews focused on exploration EVA and elicited feedback from SMEs on the cognitive skills required for specific EVA tasks including cognitive strategies, critical cues, and decision-making strategies. A cognitive demands table was assembled to consolidate and synthesize the information from all interviews. The information from this cognitive task analysis will inform ongoing work to identify the key cognitive domains for safe decision-making during exploration mission class EVA on the Moon and Mars. This work will importantly provide a link between cognitive domains identified in the cognitive task analysis and operationally-relevant performance metrics collected during spaceflight and simulation EVA that can be tracked and assessed by NASA mission operations. Ultimately, this work will aid in the development and application of exploration class cognitive performance monitoring capabilities to improve safe decision-making and inform EVA planning on future spaceflight missions to the Moon and Mars.

Steven R Anderson↗

Aerocapture Solutions for Uranus Flagship-class Orbiter and Probe

Recent planetary mission assessments, such as the 2022 Planetary Science Decadal Survey released by the National Academies of Science, have focused on the need for a flagship-class mission to the Ice Giant planets, particularly Uranus. The Uranus Orbit and Probe mission proposal was used by the National Academies of Science as the baseline while making its recommendation as the top flagship-class mission for NASA in the 2020-2030\'s. This mission which was based on a launch date of 2031 or 2032, used a fully-propulsive orbit insertion maneuver at Uranus (requiring 60-70% of total mass for propellant), and reached the planet after 13 years of interplanetary cruise before the 2049 equinox, a goal of the science community. A pre-2033 launch date is required to conduct a necessary Jupiter fly-by as the giant planet will be not be in the proper alignment for a later launch date. However, as the budget constraints of the NASA budget have pushed back the start date of a Uranus mission, a launch date of a flagship mission before 2033 seems unreasonable. Aerocapture, an orbit insertion maneuver that uses the atmosphere to decelerate, can reduce the propellant load needed for a captured orbit. Additionally, the aerocapture maneuver can decelerate safely while approaching the planet at higher arrival velocities, thus allowing a mission to use a highly energetic trajectory and reduce the cruise time by several years. An aerocapture-enabled solution has launch opportunities in the mid 2030's, including as late as 2038 to reach Uranus by 2049. This paper will discuss the feasibility of an aerocapture option for a Flagship-class mission to Uranus.

Soumyo Dutta↗

Aerocapture Solutions for Uranus Flagship-class Orbiter and Probe

Recent planetary mission assessments, such as the 2022 Planetary Science Decadal Survey released by the National Academies of Science, have focused on the need for a flagship-class mission to the Ice Giant planets, particularly Uranus. The Uranus Orbit and Probe mission proposal was used by the National Academies of Science as the baseline while making its recommendation as the top flagship-class mission for NASA in the 2020-2030\'s. This mission which was based on a launch date of 2031 or 2032, used a fully-propulsive orbit insertion maneuver at Uranus (requiring 60-70% of total mass for propellant), and reached the planet after 13 years of interplanetary cruise before the 2049 equinox, a goal of the science community. A pre-2033 launch date is required to conduct a necessary Jupiter fly-by as the giant planet will be not be in the proper alignment for a later launch date. However, as the budget constraints of the NASA budget have pushed back the start date of a Uranus mission, a launch date of a flagship mission before 2033 seems unreasonable. Aerocapture, an orbit insertion maneuver that uses the atmosphere to decelerate, can reduce the propellant load needed for a captured orbit. Additionally, the aerocapture maneuver can decelerate safely while approaching the planet at higher arrival velocities, thus allowing a mission to use a highly energetic trajectory and reduce the cruise time by several years. An aerocapture-enabled solution has launch opportunities in the mid 2030's, including as late as 2038 to reach Uranus by 2049. This paper will discuss the feasibility of an aerocapture option for a Flagship-class mission to Uranus.

Soumyo Dutta↗

Possible $ν$ Source Class: 3-sigma Detection of High-Energy Neutrinos from Supermassive Black Hole Binary Candidates

Identifying the sources of high-energy (TeV-PeV) astrophysical neutrinos is crucial for studies in both astrophysics and particle physics. Despite extensive searches for more than a decade, which revealed several individual potential sources and only one potential source class, the origins of these neutrinos remain largely unresolved; thus, more source classes should be investigated. In this work, we conduct the first search for high-energy neutrino emission from a new source class, supermassive black hole binaries (SMBHBs), which are also theoretically motivated. We perform an unbinned maximum-likelihood-ratio analysis on our constructed catalog of 693 SMBHB candidates and 10 years of IceCube public data. Our results show positive correlations, with higher significance in more physically motivated scenarios and the highest significance at 3.0$σ$. In addition, we also study potential connections between SMBHBs' high-energy neutrino and nano-Hz gravitational-wave emissions, the latter being the main target of pulsar timing arrays. Our results provide the first evidence of SMBHBs being high-energy neutrino emitters.

Pugazhendhi A. D, Pugazhendhi D [Bangalore, Indian↗

FY25 status report on the addition of candidate materials in Class B Code Case

This report provides the time-dependent allowable stress calculation strategy leveraging the limited creep rupture tests data generated to support the allowable stress for 100,000 hours in American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (BPVC), Section II, Part D. A variable confidence index procedure to extrapolate material properties to support 500,000 hours design life is discussed. Time-dependent allowable stresses for Class B component design and analysis are presented for Grade 1 and Grade 2 of Alloy 625. The presented data extrapolation and allowable stress calculation method will support new material addition using limited creep rupture data in the new ASME Boiler and BPVC, Section III, Division 5, Class B rules.

Part D↗

Standardized Residue Numbering and Secondary Structure Nomenclature in the Class D β-Lactamases

Over 1370 class D β-lactamases are currently known, and they pose a serious threat to the effective treatment of many infectious diseases, particularly in some pathogenic bacteria where evolving carbapenemase activity has been reported. Detailed understanding of their molecular biology, enzymology, and structural biology are critically important, but the lack of a standardized residue numbering scheme and inconsistent secondary structure annotation has made comparative analyses sometimes difficult and cumbersome. Compounding this, in the post-AlphaFold world where we currently find ourselves, an extraordinary wealth of detailed structural information on these enzymes is literally at our fingertips; therefore it is vitally important that a standard numbering system is in place to facilitate the accurate and straightforward analysis of their structures. In conclusion, here we present a residue numbering and secondary structure scheme for the class D enzymes based on the sequence and structure of OXA-48 and apply it to test targets to demonstrate the ease with which it can be used.

59 BASIC BIOLOGICAL SCIENCES↗

Staphylococcus-mediated T-cell activation and spontaneous natural killer cell activity in the absence of major histocompatibility complex class II molecules

We used major histocompatibility complex class II antigen-deficient transgenic mice to show that in vitro natural killer cell cytotoxicity and T-cell activation by staphylococcal exotoxins (superantigens) are not dependent upon the presence of major histocompatibility complex class II molecules. T cells can be activated by exotoxins in the presence of exogenously added interleukin 1 or 2 or in the presence of specific antibody without exogenously added cytokines.

Non-NASA Center↗