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At least 145 records · Page 8

Gender-related Changes in Dorsal Hand and Foot Vein Function Following 60 Days of Head Down Bed Rest

It is well known that female astronauts are more likely to experience post-flight orthostatic hypotension and presyncope compared to male astronauts. It has been suggested that the disproportionally higher incidence of presyncope (83% of female vs. 20% male crewmembers) may be due to sex-related differences in vascular function between the upper and lower limbs. However, much of this evidence is specific to changes in resistance vessels. Given that more than 70% of the circulating blood volume resides in compliance vessels, it is conceivable that even small changes in venous function may contribute to post-flight orthostatic hypotension. In spite of this, little is currently known regarding the influence of microgravity exposure on venous function between males and females. PURPOSE: To determine the influence of 60 days of HDBR on dorsal foot and hand vein function between healthy males (M) and females (F). METHODS: Using 2-D ultrasound, dorsal hand and foot vein diameter responses to intravenous infusions phenylephrine (PE), acetylcholine (ACh), and nitroglycerine (NTG) were determined in 26 adults; 10 females (age:37 +/- 2 yr ) and 16 males (age:34 +/- 2 yr ). Changes in venous function were calculated as the difference between diameter at baseline and following each venoactive drug. Differences in venous function between limb and sexes across HDBR were determined using mixed-effects linear regression. RESULTS: In response to 60 days of HDBR, the change in venousconstrictor response to PE in the dorsal hand veins was not significantly different between M and F. Interestingly, the change in constrictor response in the dorsal foot veins (compared to pre HDBR) was approximately 30% greater in the F, whereas the constrictor response was approximately 45% less in the M (p=0.026). HDBR had no influence on the change in dilator response to ACh, or NTG between M and F and between vascular beds. CONCLUSION: These results demonstrate that 60 days of HDBR contributes to sex-related differences in venous function. Importantly, the changes are specific to dorsal foot veins and do not appear to be related to changes in endothelial or smooth muscle function. Previous data from our laboratory indicate that females have an impaired sympathetic response following HDBR. However, the results from the current investigation imply that F maintain the ability to respond to sympathetic stimulation but may not be able to adequately activate a proper response following HDBR.

Westby, Christian M.↗

Development of Countermeasures to Aid Functional Egress from the Crew Exploration Vehicle Following Long Duration Spaceflight

Astronauts experience disturbances in sensorimotor function following their return to Earth due to adaptive responses that occur during exposure to the microgravity conditions of space flight. As part of the Crew Exploration Vehicle design requirements, the crewmember adapted to the microgravity state may need to egress the vehicle within a few minutes for safety and operational reasons in various sea state conditions following a water landing. The act of emergency egress includes and is not limited to rapid motor control tasks (including both fine motor such as object manipulation and gross motor such as opening a hatch) and visual acuity tasks while maintaining spatial orientation and postural stability in time to escape safely. Exposure to even low frequency motions (0.2-2.0 Hz) induced by sea conditions surrounding a vessel can cause significant fine and gross motor control problems affecting critical functions. These motion frequencies coupled with the varying sea state conditions (frequencies ranging from 0.125-0.5 Hz) cause performance deficits by affecting the efficacy of motor and visual acuity dependent skills in tasks critical to emergency egress activities such as visual monitoring of displays, actuating discrete controls, operating auxiliary equipment and communicating with Mission Control and recovery teams. Thus, during exploration class missions the sensorimotor disturbances due to the crewmember's adaptation to microgravity may lead to disruption in the ability to maintain postural stability and perform functional egress tasks during the initial introduction to the Earth's gravitational environment. At present, the functional implication of the interactions between a debilitated crewmember during readaptation to Earth s gravity and the environmental constraints imposed by a water landing scenario is not defined and no operational countermeasure has been implemented to mitigate this risk. Stochastic resonance (SR) is a mechanism whereby noise can assist and hence enhance the response of neural systems to relevant, subthreshold sensory signals. Application of subthreshold stochastic resonance noise coupled to sensory input either through the proprioceptive, visual or vestibular sensory systems, has been shown to improve motor function. Crew members who have adapted to microgravity have acquired new sensorimotor strategies that take time to discard. We hypothesize that detection of time-critical subthreshold sensory signals will play a crucial role in improving strategic responses and thus the rate of skill re-acquisition will be faster, leading to faster recovery of function during their re-adaptation to Earth G. Therefore, we expect the use of stochastic resonance mechanisms will enhance the acquisition of new strategic abilities. This process should ensure rapid restoration of functional egress capabilities during the initial return to Earth G after prolonged space flight. Therefore, the overall goals of this project are to investigate performance of motor and visual tasks during varying sea state conditions and develop a countermeasure based on stochastic resonance that could be implemented to enhance sensorimotor capabilities with the aim of facilitating rapid adaptation to Earth s gravity, allowing rapid CEV egress on water in varying sea states following long-duration space flight.

Mulavara, Ajitkumar↗

Bone Density Following Long Duration Space Flight and Recovery

At approx.12 months, Bone Mineral Density (BMD) at most sites in men remained lower than would be predicted, raising concerns for long-term bone health consequences following space flight. Additional analyses based on longer follow-up are being conducted. Although the N is too small for definitive conclusions, women had lower rates of loss at load-bearing sites of the hip and spine immediately post-flight relative to men and smaller differences between observed vs. predicted BMD at most sites, both immediately and 12 months post-flight, relative to men. The role of other exposures/risk factors need to be explored to further understand these possible gender differences in BMD loss and recovery following long-duration space flight.

Amin, Shreyasee↗

Comparison of Postural Recovery Following Short and Long Duration Spaceflights

INTRODUCTION: Post-flight postural ataxia reflects adaptive changes to vestibulo-spinal reflexes and control strategies adopted for movement in weightlessness. Quantitative measures obtained during computerized dynamic posturography (CDP) from US and Russian programs provide insight into the effect of spaceflight duration in terms of both the initial decrements and recovery of postural stability. METHODS: CDP was obtained on 117 crewmembers following Shuttle flights lasting 4-17 days, and on 64 crewmembers following long-duration missions lasting 48-380 days. Although the number and timing of sessions varied, the goal was to characterize postural recovery pooling similar measures from different research and flight medicine programs. This report focuses on eyes closed, head erect conditions with either a fixed or sway-referenced base of support. A smaller subset of subjects repeated the sway-referenced condition while making pitch head movements (+/- 20deg at 0.33Hz). Equilibrium scores were derived from peak-to-peak anterior-posterior sway. Fall probability was modeled using Bayesian statistical methods to estimate parameters of a logit function. RESULTS: The standard Romberg condition was the least sensitive. Longer duration flights led to larger decrements in stability with sway-reference support during the first 1-2 days, although the timecourse of recovery was similar across flight duration with head erect. Head movements led to increased incidence of falls during the first week, with a significantly longer recovery following long duration flights. CONCLUSIONS: The diagnostic assessment of postural instability, and differences in the timecourse of postural recovery between short and long flight durations, are more pronounced during unstable support conditions requiring active head movements.

Wood, S. J.↗

Goddard Robotic Telescope - Optical Follow-up of GRBs and Coordinated Observations of AGNs

Since it is not possible to predict when a Gamma-Ray Burst (GRB) will occur or when Active Galactic Nucleus (AGN) flaring activity starts, follow-up/monitoring ground telescopes must be located as uniformly as possible all over the world in order to collect data simultaneously with Fermi and Swift detections. However, there is a distinct gap in follow-up coverage of telescopes in the eastern U.S. region based on the operations of Swift. Motivated by this fact, we have constructed a 14" fully automated optical robotic telescope, Goddard Robotic Telescope (GRT), at the Goddard Geophysical and Astronomical Observatory. The aims of our robotic telescope are 1) to follow-up Swift/Fermi GRBs and 2) to perform the coordinated optical observations of Fermi Large Area Telescope (LAT) AGN. Our telescope system consists of off-the-shelf hardware. With the focal reducer, we are able to match the field of view of Swift narrow instruments (20' x 20'). We started scientific observations in mid-November 2008 and GRT has been fully remotely operated since August 2009. The 3(sigma) upper limit in a 30-second exposure in the R filter is approx.15.4 mag; however, we can reach to approx.18 mag in a 600-second exposures. Due to the weather condition at the telescope site. our observing efficiency is 30-40%, on average.

Sakamoto, T.↗

Robotic Follow-Up for Human Exploration

We are studying how "robotic follow-up" can improve future planetary exploration. Robotic follow-up, which we define as augmenting human field work with subsequent robot activity, is a field exploration technique designed to increase human productivity and science return. To better understand the benefits, requirements, limitations and risks associated with this technique, we are conducting analog field tests with human and robot teams at the Haughton Crater impact structure on Devon Island, Canada. In this paper, we discuss the motivation for robotic follow-up, describe the scientific context and system design for our work, and present results and lessons learned from field testing.

Fong, Terrence↗

Bone Density Following Three Years of Recovery from Long-Duration Space Flight

It is well recognized that bone mineral density [BMD] at load-bearing sites of the hip and spine sustain significant loss during space flight, estimated at approximately 0.5-1.0% per month. However, the long-term effects on bone health following return from long-duration space flight remain unclear. It is unknown whether BMD for men recovers beyond 1 year following return from space to what would be predicted or if deficits persist. Using our previously created prediction models, we compared the observed BMD of male US crew following 3 years since returning from longduration space flight with what would be predicted if they had not been exposed to microgravity.

Amin, Shreyasee↗

Path Following with Slip Compensation for a Mars Rover

A software system for autonomous operation of a Mars rover is composed of several key algorithms that enable the rover to accurately follow a designated path, compensate for slippage of its wheels on terrain, and reach intended goals. The techniques implemented by the algorithms are visual odometry, full vehicle kinematics, a Kalman filter, and path following with slip compensation. The visual-odometry algorithm tracks distinctive scene features in stereo imagery to estimate rover motion between successively acquired stereo image pairs, by use of a maximum-likelihood motion-estimation algorithm. The full-vehicle kinematics algorithm estimates motion, with a no-slip assumption, from measured wheel rates, steering angles, and angles of rockers and bogies in the rover suspension system. The Kalman filter merges data from an inertial measurement unit (IMU) and the visual-odometry algorithm. The merged estimate is then compared to the kinematic estimate to determine whether and how much slippage has occurred. The kinematic estimate is used to complement the Kalman-filter estimate if no statistically significant slippage has occurred. If slippage has occurred, then a slip vector is calculated by subtracting the current Kalman filter estimate from the kinematic estimate. This slip vector is then used, in conjunction with the inverse kinematics, to determine the wheel velocities and steering angles needed to compensate for slip and follow the desired path.

Helmick, Daniel↗

Swift Follow-Up Observations of Candidate Gravitational-Wave Transient Events

We present the first multi-wavelength follow-up observations of two candidate gravitational-wave (GW) transient events recorded by LIGO and Virgo in their 2009-2010 science run. The events were selected with low latency by the network of GW detectors (within less than 10 minutes) and their candidate sky locations were observed by the Swift observatory (within 12 hr). Image transient detection was used to analyze the collected electromagnetic data, which were found to be consistent with background. Off-line analysis of the GW data alone has also established that the selected GW events show no evidence of an astrophysical origin; one of them is consistent with background and the other one was a test, part of a "blind injection challenge." With this work we demonstrate the feasibility of rapid follow-ups of GW transients and establish the sensitivity improvement joint electromagnetic and GW observations could bring. This is a first step toward an electromagnetic follow-up program in the regime of routine detections with the advanced GW instruments expected within this decade. In that regime, multi-wavelength observations will play a significant role in completing the astrophysical identification of GW sources. We present the methods and results from this first combined analysis and discuss its implications in terms of sensitivity for the present and future instruments.

Evans, P. A.↗

A Tailward Moving Current Sheet Normal Magnetic Field Front Followed by an Earthward Moving Dipolarization Front

A case study is presented using measurements from the Cluster spacecraft and ground-based magnetometers that show a substorm onset propagating from the inner to outer plasma sheet. On 3 October 2005, Cluster, traversing an ion-scale current sheet at the near-Earth plasma sheet, detected a sudden enhancement of Bz, which was immediately followed by a series of flux rope structures. Both the local Bz enhancement and flux ropes propagated tailward. Approximately 5 min later, another Bz enhancement, followed by a large density decrease, was observed to rapidly propagate earthward. Between the two Bz enhancements, a significant removal of magnetic flux occurred, possibly resulting from the tailward moving Bz enhancement and flux ropes. In our scenario, this flux removal caused the magnetotail to be globally stretched so that the thinnest sheet formed tailward of Cluster. The thinned current sheet facilitated magnetic reconnection that quickly evolved from plasma sheet to lobe and generated the later earthward moving dipolarization front (DF) followed by a reduction in density and entropy. Ground magnetograms located near the meridian of Cluster's magnetic foot points show two-step bay enhancements. The positive bay associated with the first Bz enhancement indicates that the substorm onset signatures propagated from the inner to the outer plasma sheet, consistent with the Cluster observation. The more intense bay features associated with the later DF are consistent with the earthward motion of the front. The event suggests that current disruption signatures that originated in the near-Earth current sheet propagated tailward, triggering or facilitating midtail reconnection, thereby preconditioning the magnetosphere for a later strong substorm enhancement.

Dipolarization Front↗

Flight Phasemeter on the Laser Ranging Interferometer on the GRACE Follow-On Mission

As the first inter-spacecraft laser interferometer, the Laser Ranging Interferometer (LRI) on the GRACE Follow-On Mission will demonstrate interferometry technology relevant to the LISA mission. This paper focuses on the completed LRI Laser Ranging Processor (LRP), which includes heterodyne signal phase tracking at µcycle/vHz precision, differential wavefront sensing, offset frequency phase locking and Pound-Drever-Hall laser stabilization. The LRI design has characteristics that are similar to those for LISA: 1064nm NPRO laser source, science bandwidth in the mHz range, MHz-range intermediate frequency and Doppler shift, detected optical power of tens of picoWatts. Laser frequency stabilization has been demonstrated at a level below 30 Hz/vHz, better than the LISA requirement of 300 Hz/vHz. The LRP has completed all performance testing and environmental qualification and has been delivered to the GRACE Follow-On spacecraft. The LRI is poised to test the LISA techniques of tone-assisted time delay interferometry and arm-locking. GRACE Follow-On launches in 2017.

Bachman, B↗

Path following using visual odometry for Mars Rover in high-slip environments.

An architecture for autonomous operation of Mars rovers in high slip environments has been designed, implemented, and tested. This architecture is composed of several key technologies that enable the rover to accurately follow a designated path, compensate for slippage, and reach intended goals independent of the terrain over which it is traversing (within the mechanical constraints of the mobility system). These technologies include: visual odometry, full vehicle kinematics, a Kalman filter, and a slop compensation/path follower. Visual odometry tracks distinctive scene features in stereo imagery to estimate rover motion between successively acquired stereo image pairs using a maximum likelihood motion estimation algorithm. The full vehicle kinematics for a rocker-bogie suspension system estimates motion, with a no-slip assumption, by measuring wheel, rates, and rocker, bogie, and steering angles. The Kalman filter merges data from an Inertial Measurement Unit (IMU) and visual odometry. This merged estimate is then compared to the kinematic estimate to determining (tracking into account estimate uncertainties) if and how much slippage has occurred then a slip vector is calculated by differencing the current Kalman filter estimate from the kinematic estimate. This slip vector is then used, in conjunction with the inverse kinematics, to determine the necessary wheel velocities and steering angles to compensate for slip and follow the desired path.

Roumeliotis, Stergios I.↗

Follow-up and Validation of K2 and TESS Planetary Systems with Keck NIRC2 Adaptive Optics Imaging

High resolution imaging (HRI) is a critical part of the transiting exoplanet follow-up and validation process. HRI allows previously unresolved stellar companions and background blends to be resolved, vetting false positive signals and improving the radii measurements of true planets. Through a multi-semester Keck NIRC2 adaptive optics imaging program, we have pursued HRI of K2 and TESS candidate planet host systems to provide the transiting exoplanet community with necessary data for system validation and characterization. Here we present a summary of our ongoing program that includes an up to date list of targets observed, a description of the observations and data reduction, and a discussion of planetary systems validated by the community using these data. This observing program has been key in NASA’s K2 and TESS missions reaching their goals of identifying new exoplanets ideal for continued follow-up observations to measure their masses and investigate their atmospheres. All observations presented here are available as calibrated images and resulting contrast curves through the Exoplanet Follow-up Observing Program (ExoFOP) website. We encourage members of the exoplanet community to use these data products in their ongoing planetary system validation and characterization efforts.

Adaptive optics↗

Radio Follow-up of a Candidate γ-Ray Transient in the Sky Localization Area of GW170608

After the identification of a candidate γ-ray transient in the error region of the binary black hole (BBH) merger GW150914 by the Fermi satellite, the question of whether BBH mergers can be associated with electromagnetic counterparts remains highly debated. Here, we present radio follow-up observations of GW170608, a BBH merger that occurred during the second observing run (O2) of the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO). Our radio follow-up focused on a specific field contained in the GW170608 sky localization area, where a candidate high-energy transient was detected by the Fermi Large Area Telescope (LAT). We make use of data collected at 1.4 GHz with the Karl G. Jansky Very Large Array (VLA), as well as with the VLA Lowband Ionosphere and Transient Experiment (VLITE). Our analysis is sensitive to potential radio afterglows with luminosity densities L(1.4GHz) ≳ 6 x 10^(28) erg/sHz. In the most optimistic theoretical models, ≈20% of BBH events occurring in massive hosts could be associated with outflows as radio luminous as this. Although we find no evidence for the presence of a radio counterpart associated with the LAT candidate in the GW170608 error region, our analysis demonstrates the feasibility of future radio follow-up observations of well-localized BBHs. Comparing our radio upper limits with theoretical expectations for the radio afterglows potentially associated with jets launched in BBH mergers, we find that for jets of energy ≈10^(49) erg seen on-axis, only jet angles θ(jet)≳40° are compatible with the observations.

Kyle Artkop↗

Swift Multiwavelength Follow-up of LVC S200224ca and the Implications for Binary Black Hole Mergers

On 2020 February 24, during their third observing run (“O3”), the Laser Interferometer Gravitational-wave Observatory and Virgo Collaboration detected S200224ca: a candidate gravitational wave (GW) event produced by a binary black hole (BBH) merger. This event was one of the best-localized compact binary coalescences detected in O3 (with 50%/90% error regions of 13/72 deg2), and so the Neil Gehrels Swift Observatory performed rapid near-UV/X-ray follow-up observations. Swift-XRT and UVOT covered approximately 79.2% and 62.4% (respectively) of the GW error region, making S200224ca the BBH event most thoroughly followed-up in near-UV (u-band) and X-ray to date. No likely EM counterparts to the GW event were found by the Swift BAT, XRT, or UVOT, nor by other observatories. Here, we report on the results of our searches for an EM counterpart, both in the BAT data near the time of the merger, and in follow-up UVOT/XRT observations. We also discuss the upper limits we can place on EM radiation from S200224ca, as well as the implications these limits have on the physics of BBH mergers. Namely, we place a shallow upper limit on the dimensionless BH charge, qˆ < 1.4 x 10-4, and an upper limit on the isotropic-equivalent energy of a blast wave E<4.1×1051 erg (assuming typical GRB parameters).

N J Klinger↗

Transcriptomic Analysis of Irradiated Mouse Retina Following Readaptation

Rodent models are used as analogs for studying the effects of spaceflight. NASA GeneLab provides access to relevant omics datasets generated from spaceflight and ground-based experiments allowing for additional retrospective analysis. In this study, we used GeneLab’s GLDS-203, a dataset generated by researchers at Loma Linda University to study the impact of prolonged unloading and/or low-dose radiation on mouse retina. We analyzed transcriptomics data from retina of mice irradiated with gamma-rays for 21 days followed by 7 days, 1 month, or 4 months of readaptation. We obtained raw gene counts from GeneLab and performed differential gene expression analysis after data normalization. For each of the three timepoints, we performed differential expression analysis to compare transcriptional profiles for retina from irradiated vs. non-irradiated (controls) mice, all exposed to gravity. We observed the highest number of differentially expressed genes at 7 days, followed by 1 month and 4 months. Enrichment analysis showed top pathways (adjusted p-value < 0.05) were related to transport along microtubule and photoreceptor cell development in the 7-day readaptation group. Fewer significantly enriched pathways were observed for the 1-month group and included mRNA metabolic processes and neuron differentiation. No significantly enriched pathways were found in the 4-month group. The Gene Ontology biological processes common between the 7 days and 1-month groups include visual perception, synapse organization, and perception of light stimulus. This analysis is part of a larger effort to characterize the molecular mechanisms involved in retinal readaptation following radiation exposure. Future analyses will include other related retina datasets in GeneLab repository to assess whether gene expression patterns are consistent across different study cohorts.

Prachi Kothiyal↗

Swift/UVOT Follow-Up of Gravitational Wave Alerts in the O3 Era

In this paper, we report on the observational performance of the Swift Ultra-violet/Optical Telescope (UVOT) in response to the gravitational wave (GW) alerts announced by the Advanced Laser Interferometer Gravitational Wave Observatory and the Advanced Virgo detector during the O3 period. We provide the observational strategy for follow-up of GW alerts and provide an overview of the processing and analysis of candidate optical/UV sources. For the O3 period, we also provide a statistical overview and report on serendipitous sources discovered by Swift/UVOT. Swift followed 18 GW candidate alerts, with UVOT observing a total of 424 deg2. We found 27 sources that changed in magnitude at the 3σ level compared with archival u- or g-band catalogued values. Swift/UVOT also followed up a further 13 sources reported by other facilities during the O3 period. Using catalogue information, we divided these 40 sources into five initial classifications: 11 candidate active galactic nuclei (AGNs)/quasars, three cataclysmic variables (CVs), nine supernovae, 11 unidentified sources that had archival photometry, and six uncatalogued sources for which no archival photometry was available. We have no strong evidence to identify any of these transients as counterparts to the GW events. The 17 unclassified sources are likely a mix of AGN and a class of fast-evolving transient, and one source may be a CV.

gravitational waves↗

Maximizing Dust Devil Follow-up Observations on Mars Using Cubesats and On-board Scheduling

Several million dust devil events occur on Mars every day. These events last, on average, about 30 minutes and range in size from meters to hundreds of meters in diameter. Designing low-cost missions that will improve our knowledge of dust devil formation and evolution, and their connection to atmospheric dynamics and the dust cycle, is fundamental to informing future crewed Mars lander missions about surface conditions. In this paper we present a mission for a constellation of low orbiting Mars cubesats, each carrying imagers with agile pointing capabilities. The goal is to maximize the number of dust devil follow-up observations through real-time, on-board scheduling. We study scenarios where cubesats are equipped with a 2.5 degree boresight angle camera that accommodates five slew positions (including nadir). We assume a concept of operations where the cubesats autonomously survey the surface of Mars and can autonomously detect dust devils from their surface imagery. When a dust devil is detected, the constellation is autonomously re-tasked through an on-board distributed scheduler to capture as many follow-on images of the event as possible, so as to study its evolution. The cubesat orbits are propagated assuming two-body dynamics and the ground tracks and camera field of view are computed assuming a spherical Mars. Realistic inter-agent communication link opportunities are computed and included in our optimization, which allow for real-time event detection information to be shared within the constellation. We compare against a powerful ``omniscient'' mission which has a priori knowledge of all dust devil activity to show the gap between predicted performance and the best possible outcome. In particular, we show that the communications are especially important for acquiring follow-up observations, and that a realistic distributed scheduling mechanism is sufficient to capture nearly all dust devil observations that are possible for a given orbit configuration.

Hook, Joshua Vander↗