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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
NASA NTRS1990

Mission and sampling analyses for atmospheric satellite experiments

Orbital analyses, instrument-viewing geometry studies, and sampling simulations are performed to define mission concepts for advanced atmospheric research satellite experiments. These analyses are conducted in collaboration with NASA Headquarters and working groups consisting of atmospheric scientists and experiment developers. Analytical techniques are developed and used to optimize geographical coverage, sensor-viewing geometries, data gathering strategies, sampling schemes, orbital characteristics, satellite launch times, and operational modes of the various experiments and mission concepts. Short-term (7 day) Shuttle Missions, the Upper Atmosphere Research Satellite (UARS), and multisatellite missions such as the Earth Observing System (EOS) are being studied. Atmospheric experiments which are being analyzed include nadir-viewing sounders, limb-emission scanners, laser systems, and solar-occultation techniques.

Harrison, Edwin F.↗
NASA NTRS2009

A New Monte Carlo Filtering Method for the Diagnosis of Mission-Critical Failures

Testing large-scale systems is expensive in terms of both time and money. Running simulations early in the process is a proven method of finding the design faults likely to lead to critical system failures, but determining the exact cause of those errors is still time-consuming and requires access to a limited number of domain experts. It is desirable to find an automated method that explores the large number of combinations and is able to isolate likely fault points. Treatment learning is a subset of minimal contrast-set learning that, rather than classifying data into distinct categories, focuses on finding the unique factors that lead to a particular classification. That is, they find the smallest change to the data that causes the largest change in the class distribution. These treatments, when imposed, are able to identify the settings most likely to cause a mission-critical failure. This research benchmarks two treatment learning methods against standard optimization techniques across three complex systems, including two projects from the Robust Software Engineering (RSE) group within the National Aeronautics and Space Administration (NASA) Ames Research Center. It is shown that these treatment learners are both faster than traditional methods and show demonstrably better results.

Gay, Gregory↗
NASA NTRS1999

A complex ligase ribozyme evolved in vitro from a group I ribozyme domain

Like most proteins, complex RNA molecules often are modular objects made up of distinct structural and functional domains. The component domains of a protein can associate in alternative combinations to form molecules with different functions. These observations raise the possibility that complex RNAs also can be assembled from preexisting structural and functional domains. To test this hypothesis, an in vitro evolution procedure was used to isolate a previously undescribed class of complex ligase ribozymes, starting from a pool of 10(16) different RNA molecules that contained a constant region derived from a large structural domain that occurs within self-splicing group I ribozymes. Attached to this constant region were three hypervariable regions, totaling 85 nucleotides, that gave rise to the catalytic motif within the evolved catalysts. The ligase ribozymes catalyze formation of a 3',5'-phosphodiester linkage between adjacent template-bound oligonucleotides, one bearing a 3' hydroxyl and the other a 5' triphosphate. Ligation occurs in the context of a Watson-Crick duplex, with a catalytic rate of 0.26 min(-1) under optimal conditions. The constant region is essential for catalytic activity and appears to retain the tertiary structure of the group I ribozyme. This work demonstrates that complex RNA molecules, like their protein counterparts, can share common structural domains while exhibiting distinct catalytic functions.

NASA Discipline Exobiology↗
NASA NTRS1973

Four-body trajectory optimization

A collection of typical three-body trajectories from the L1 libration point on the sun-earth line to the earth is presented. These trajectories in the sun-earth system are grouped into four distinct families which differ in transfer time and delta V requirements. Curves showing the variations of delta V with respect to transfer time, and typical two and three-impulse primer vector histories, are included. The development of a four-body trajectory optimization program to compute fuel optimal trajectories between the earth and a point in the sun-earth-moon system are also discussed. Methods for generating fuel optimal two-impulse trajectories which originate at the earth or a point in space, and fuel optimal three-impulse trajectories between two points in space, are presented. A brief qualitative comparison of these methods is given. An example of a four-body two-impulse transfer from the Li libration point to the earth is included.

Pu, C. L.↗
NASA NTRS1992

COINS: A composites information database system

An automated data abstraction form (ADAF) was developed to collect information on advanced fabrication processes and their related costs. The information will be collected for all components being fabricated as part of the Advanced Composite Technology (ACT) program and included in a COmposites INformation System (COINS) data base. The aim of the COINS development effort is to provide future airframe preliminary design and fabrication teams with a tool through which production cost can become a deterministic variable in the design optimization process. The effort was initiated by NASA Langley to implement the recommendations of a working group comprised of representatives from the commercial airframe companies. The principal working group recommendation was to reinstitute collection of composite part fabrication data in a format similar to the DOD/NASA Structural Composites Fabrication Guide. The fabrication information collection form was automated with current user friendly computer technology. The new automated form and features that make the form easy to use by an aircraft structural design manufacturing team are described.

Siddiqi, Shahid↗
NASA NTRS1992

Design of potent substrate-analogue inhibitors of canine renin

Through a systematic study of structure-activity relationships, we designed potent renin inhibitors for use in dog models. In assays against dog plasma renin at neutral pH, we found that, as in previous studies of rat renin inhibitors, the structure at the P2 position appears to be important for potency. The substitution of Val for His at this position increases potency by one order of magnitude. At the P3 position, potency appears to depend on a hydrophobic side chain that does not necessarily have to be aromatic. Our results also support the approach of optimizing potency in a renin inhibitor by introducing a moiety that promotes aqueous solubility (an amino group) at the C-terminus of the substrate analogue. In the design of potent dog plasma renin inhibitors, the influence of the transition-state residue 4(S)-amino-3(S)-hydroxy-5-cyclohexylpentanoic acid (ACHPA)-commonly used as a substitute for the scissile-bond dipeptide to boost potency-is not obvious, and appears to be sequence dependent. The canine renin inhibitor Ac-paF-Pro-Phe-Val-statine-Leu-Phe-paF-NH2 (compound 15; IC50 of 1.7 nM against dog plasma renin at pH 7.4; statine, 4(S)-amino-3(S)-hydroxy-6-methylheptanoic acid; paF, para-aminophenylalanine) had a potent hypotensive effect when infused intravenously into conscious, sodium-depleted, normotensive dogs. Also, compound 15 concurrently inhibited plasma renin activity and had a profound diuretic effect.

Non-NASA Center↗
NASA NTRS2005

Multivariate Parameter Sets for Optimal Synthesis of Compliant Mechanisms

This paper will propose the use of control maps along with discretized elements or meshes in the design parameter set for optimizing compliant mechanisms. The use of control maps will be demonstrated to encode the motion of groups of nodes or control points within a compliant mechanism design with simple mapping rules. The technique will serve as an alternative to increased mesh size or node wandering techniques that have been proposed to increase the number of alternative design shapes that may be considered. As an alternative approach, the proposed control map parameterization has the significant benefit that it minimizes the number of design parameters necessary (parameters increase linearly with the mesh size) in describing a given design making it computationally efficient. A limited number of tiles can produce a map that has a significant effect on the final shape. If the tiles are chosen appropriately, the problems such as material overlap and non-convex mesh elements are avoided automatically. This paper will describe the implementation of these control maps and provide several examples showing their implementation in the compliant mechanism topology synthesis process.

Shibakov, Alex↗
NASA NTRS2012

Applying Biomimetic Algorithms for Extra-Terrestrial Habitat Generation

The objective is to simulate and optimize distributed cooperation among a network of robots tasked with cooperative excavation on an extra-terrestrial surface. Additionally to examine the concept of directed Emergence among a group of limited artificially intelligent agents. Emergence is the concept of achieving complex results from very simple rules or interactions. For example, in a termite mound each individual termite does not carry a blueprint of how to make their home in a global sense, but their interactions based strictly on local desires create a complex superstructure. Leveraging this Emergence concept applied to a simulation of cooperative agents (robots) will allow an examination of the success of non-directed group strategy achieving specific results. Specifically the simulation will be a testbed to evaluate population based robotic exploration and cooperative strategies while leveraging the evolutionary teamwork approach in the face of uncertainty about the environment and partial loss of sensors. Checking against a cost function and 'social' constraints will optimize cooperation when excavating a simulated tunnel. Agents will act locally with non-local results. The rules by which the simulated robots interact will be optimized to the simplest possible for the desired result, leveraging Emergence. Sensor malfunction and line of sight issues will be incorporated into the simulation. This approach falls under Swarm Robotics, a subset of robot control concerned with finding ways to control large groups of robots. Swarm Robotics often contains biologically inspired approaches, research comes from social insect observation but also data from among groups of herding, schooling, and flocking animals. Biomimetic algorithms applied to manned space exploration is the method under consideration for further study.

Birge, Brian↗
NASA NTRS2014

A ribozyme that triphosphorylates RNA 50-hydroxyl groups

The RNA world hypothesis describes a stage in the early evolution of life in which RNA served as genome and as the only genome-encoded catalyst. To test whether RNA world organisms could have used cyclic trimetaphosphate as an energy source, we developed an in vitro selection strategy for isolating ribozymes that catalyze the triphosphorylation of RNA 50 -hydroxyl groups with trimetaphosphate. Several active sequences were isolated, and one ribozyme was analyzed in more detail. The ribozyme was truncated to 96 nt, while retaining full activity. It was converted to a transformat and reacted with rates of 0.16 min1 under optimal conditions. The secondary structure appears to contain a four-helical junction motif. This study showed that ribozymes can use trimetaphosphate to triphosphorylate RNA 50 -hydroxyl groups and suggested that RNA world organisms could have used trimetaphosphate as their energy source.

Janina E. Moretti↗
NASA NTRS1978

Design of polymeric immunomicrospheres for cell labelling and cell separation

Synthesis of several classes of hydrophylic microspheres applied to cell labeling and cell separation is described. Five classes of cross-linked microspheres with functional groups such as carboxyl, hydroxyl, amide and/or pyridine groups were synthesized. These functional groups were used to bind covalently antibodies and other proteins to the surface of the microspheres. To optimize the derivatisation technique, polyglutaraldehyde immunomicrospheres were prepared and utilized. Specific populations of human and murine lymphocytes were labelled with microspheres synthesized by the emulsion of the ionizing radiation technique. The labelling of the cells by means of microspheres containing an iron core produced successful separation of B from T lymphocytes by means of a magnetic field.

Rembaum, A.↗
NASA NTRS2005

High Frequency QRS ECG Accurately Detects Cardiomyopathy

High frequency (HF, 150-250 Hz) analysis over the entire QRS interval of the ECG is more sensitive than conventional ECG for detecting myocardial ischemia. However, the accuracy of HF QRS ECG for detecting cardiomyopathy is unknown. We obtained simultaneous resting conventional and HF QRS 12-lead ECGs in 66 patients with cardiomyopathy (EF = 23.2 plus or minus 6.l%, mean plus or minus SD) and in 66 age- and gender-matched healthy controls using PC-based ECG software recently developed at NASA. The single most accurate ECG parameter for detecting cardiomyopathy was an HF QRS morphological score that takes into consideration the total number and severity of reduced amplitude zones (RAZs) present plus the clustering of RAZs together in contiguous leads. This RAZ score had an area under the receiver operator curve (ROC) of 0.91, and was 88% sensitive, 82% specific and 85% accurate for identifying cardiomyopathy at optimum score cut-off of 140 points. Although conventional ECG parameters such as the QRS and QTc intervals were also significantly longer in patients than controls (P less than 0.001, BBBs excluded), these conventional parameters were less accurate (area under the ROC = 0.77 and 0.77, respectively) than HF QRS morphological parameters for identifying underlying cardiomyopathy. The total amplitude of the HF QRS complexes, as measured by summed root mean square voltages (RMSVs), also differed between patients and controls (33.8 plus or minus 11.5 vs. 41.5 plus or minus 13.6 mV, respectively, P less than 0.003), but this parameter was even less accurate in distinguishing the two groups (area under ROC = 0.67) than the HF QRS morphologic and conventional ECG parameters. Diagnostic accuracy was optimal (86%) when the RAZ score from the HF QRS ECG and the QTc interval from the conventional ECG were used simultaneously with cut-offs of greater than or equal to 40 points and greater than or equal to 445 ms, respectively. In conclusion 12-lead HF QRS ECG employing RAZ scoring is a simple, accurate and inexpensive screening technique for cardiomyopathy. Although HF QRS ECG is highly sensitive for cardiomyopathy, its specificity may be compromised in patients with cardiac pathologies other than cardiomyopathy, such as uncomplicated coronary artery disease or multiple coronary disease risk factors. Further studies are required to determine whether HF QRS might be useful for monitoring cardiomyopathy severity or the efficacy of therapy in a longitudinal fashion.

Schlegel, Todd T.↗
NASA NTRS2023

An Ensemble Neural Network Model for Predicting Rare-Earth Oxide and Silicate Heat Capacities at High Temperature

In this work, a neural network model was developed to predict the constant pressure heat capacity for materials in the rare-earth oxide—silica material space. Several model architectures were trained and tested on heat capacity data generated from first-principles density functional theory calculations. Hyperparameter optimization was performed, and the optimal model was selected for heat capacity predictions. The optimal model architecture was found to have a root-mean-squared error of 5.12 ± 3.37 J/mol-K. The optimal model architecture was then used in a bagging ensemble model trained using the leave-one-group-out method to provide error estimates for model predictions. The out-of-bag score for the ensemble model was 0.997. The predicted heat capacities agree well with the DFT and experimental results and were computed orders of magnitude faster than DFT simulations. Machine learning shows the potential to provide a suitable surrogate model for thermochemical property predictions for candidate environmental barrier coating materials but refining of input material features and model architectures could further improve accuracy for these models.

environmental barrier coatings↗
NASA NTRS2001

Optimizing Orbit-Instrument Configuration for Global Precipitation Mission (GPM) Satellite Fleet

Following the scientific success of the Tropical Rainfall Measuring Mission (TRMM) spearheaded by a group of NASA and NASDA scientists, their external scientific collaborators, and additional investigators within the European Union's TRMM Research Program (EUROTRMM), there has been substantial progress towards the development of a new internationally organized, global scale, and satellite-based precipitation measuring mission. The highlights of this newly developing mission are a greatly expanded scope of measuring capability and a more diversified set of science objectives. The mission is called the Global Precipitation Mission (GPM). Notionally, GPM will be a constellation-type mission involving a fleet of nine satellites. In this fleet, one member is referred to as the "core" spacecraft flown in an approximately 70 degree inclined non-sun-synchronous orbit, somewhat similar to TRMM in that it carries both a multi-channel polarized passive microwave radiometer (PMW) and a radar system, but in this case it will be a dual frequency Ku-Ka band radar system enabling explicit measurements of microphysical DSD properties. The remainder of fleet members are eight orbit-synchronized, sun-synchronous "constellation" spacecraft each carrying some type of multi-channel PMW radiometer, enabling no worse than 3-hour diurnal sampling over the entire globe. In this configuration the "core" spacecraft serves as a high quality reference platform for training and calibrating the PMW rain retrieval algorithms used with the "constellation" radiometers. Within NASA, GPM has advanced to the pre-formulation phase which has enabled the initiation of a set of science and technology studies which will help lead to the final mission design some time in the 2003 period. This presentation first provides an overview of the notional GPM program and mission design, including its organizational and programmatic concepts, scientific agenda, expected instrument package, and basic flight architecture. Following this introduction, we focus specifically on the last topic, that being an analysis which leads to an optimal flight architecture dictated in part by science requirements but constrained by allowable orbital mechanics, instrument scan patterns, and antenna aperture properties. Because the optimal architecture involves an interplay between orbit mechanics and instrument specifications, it is important to recognize that in attempting to serve various scientific themes, the final optimal architecture will represent a compromise concerning dynamic range, spatial resolution, sampling interval, pointing, beam coincidence, and measurement uncertainty. Moreover, cost becomes a major factor in seeking the optimal architecture through the pathways of antenna and instrument scan designs, as well as propulsion requirements associated with the orbit heights of various "constellation" members. Although the results presented at the IGARSS-2001 meeting will likely not be the fully refined flight architecture specifications, they are expected to be nearly complete.

Smith, Eric A.↗
NASA NTRS1995

A scientific assessment of a new technology orbital telescope

As part of a program designed to test the Alpha chemical laser weapons system in space, the Ballistic Missile Defense Organization (BMDO) developed components of an agile, lightweight, 4-meter telescope, equipped with an advanced active-optics system. BMDO had proposed to make space available in the telescope's focal plane for instrumentation optimized for scientific applications in astrophysics and planetary astronomy for a potential flight mission. Such a flight mission could be undertaken if new or additional sponsorship can be found. Despite this uncertainty, BMDO requested assistance in defining the instrumentation and other design aspects necessary to enhance the scientific value of a pointing and tracking mission. In response to this request, the Space Studies Board established the Task Group on BMDO New Technology Orbital Observatory (TGBNTOO) and charged it to: (1) provide instrumentation, data management, and science-operations advice to BMDO to optimize the scientific value of a 4-meter mission; and (2) support a space studies board assessment of the relative scientific merit of the program. This report deals with the first of these tasks, assisting the Advanced Technology Demonstrator's (ATD's) program scientific potential. Given the potential scientific aspects of the 4-meter telescope, this project is referred to as the New Technology Orbital Telescope (NTOT), or as the ATD/NTOT, to emphasize its dual-use character. The task group's basic conclusion is that the ATD/NTOT mission does have the potential for contributing in a major way to astronomical goals.

Source record↗
NASA NTRS1973

The space shuttle payload planning working groups. Volume 1: Astronomy

The space astronomy missions to be accomplished by the space shuttle are discussed. The principal instrument is the Large Space Telescope optimized for the ultraviolet and visible regions of the spectrum, but usable also in the infrared. Two infrared telescopes are also proposed and their characteristics are described. Other instruments considered for the astronomical observations are: (1) a very wide angle ultraviolet camera, (2) a grazing incidence telescope, (3) Explorer-class free flyers to measure the cosmic microwave background, and (4) rocket-class instruments which can fly frequently on a variety of missions. The stability requirements of the space shuttle for accomplishing the astronomy mission are defined.

Source record↗
NASA NTRS1975

Development of a high efficiency thin silicon solar cell

Variations in temperatures used in experimental processing and their effect on the resulting solar cell performance parameters were investigated. Diffusion temperature variation results in a fairly distinct optimum cell performance for diffusion temperatures in the immediate vicinity of 850 C. An additional effort was also devoted to redesign of the matallization gridline pattern for both minimum light blockage and minimum fill factor alteration due to series resistance. Efforts on improvement of tantalum oxide antireflection coatings were undertaken. Fifty 2 cm x 2 cm cells having a range of thicknesses have been submitted as the first sample group. These cells were processed under conditions tentatively identified during this first contractual quarter's experiments as being optimal for resulting cell performance.

Lindmayer, J.↗