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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRS2013

A New Nearby Pulsar Wind Nebula Overlapping the RX J0852.0-4622 Supernova Remnant

Context. Energetic pulsars can be embedded in a nebula of relativistic leptons which is powered by the dissipation of the rotational energy of the pulsar. The object PSR J0855􀀀4644 is an energetic and fast-spinning pulsar (E' = 1.1 x 10(exp 36) erg/s, P=65 ms) discovered near the South-East rim of the supernova remnant (SNR) RXJ0852.0-4622 (aka Vela Jr) by the Parkes multibeam survey. The position of the pulsar is in spatial coincidence with an enhancement in X-rays and TeV gamma-rays, which could be due to its putative pulsar wind nebula (PWN). Aims. The purpose of this study is to search for di use non-thermal X-ray emission around PSR J0855-4644 to test for the presence of a PWN and to estimate the distance to the pulsar. Methods. An X-ray observation was carried out with the XMM-Newton satellite to constrain the properties of the pulsar and its nebula. The absorption column density derived in X-rays from the pulsar and from different regions of the rim of the SNR was compared with the absorption derived from the atomic (HI) and molecular ((12)CO) gas distribution along the corresponding lines of sight to estimate the distance to the pulsar and to the SNR. Results. The observation has revealed the X-ray counterpart of the pulsar together with surrounding extended emission thus confirming the existence of a PWN. The comparison of column densities provided an upper limit to the distance of the pulsar PSR J0855-4644 and the SNR RX J0852.0-4622 (d less than or equal to 900 pc). Although both objects are at compatible distances, we rule out that the pulsar and the SNR are associated. With this revised distance, PSR J0855-4644 is the second most energetic pulsar, after the Vela pulsar, within a radius of 1 kpc and could therefore contribute to the local cosmic-ray e-/e+ spectrum.

overlapping↗
DOE OSTI2024

In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer’s disease

The molecular mechanisms underlying neuronal dysfunction in Alzheimer’s disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ) and tau deposits in the living human brain. We obtained in-vivo resting-state functional MRI (rs-fMRI), Aβ- and tau-PET for 47 cognitively unimpaired and 16 AD participants from the Translational Biomarkers in Aging and Dementia cohort. Adverse neuronal activity impacts by Aβ and tau were quantified with personalized dynamical models by fitting pathology-mediated computational signals to the participant’s real rs-fMRIs. Then, we detected robust brain-wide associations between the spatial profiles of Aβ-tau impacts and gene expression in the neurotypical transcriptome (Allen Human Brain Atlas). Within the obtained distinctive signature of in-vivo neuronal dysfunction, several genes have prominent roles in microglial activation and in interactions with Aβ and tau. Moreover, cellular vulnerability estimations revealed strong association of microglial expression patterns with Aβ and tau’s synergistic impact on neuronal activity (q < 0.001). These results further support the central role of the immune system and neuroinflammatory pathways in AD pathogenesis. Neuronal dysregulation by AD pathologies also associated with neurotypical synaptic and developmental processes. In addition, we identified drug candidates from the vast LINCS library to halt or reduce the observed Aβ-tau effects on neuronal activity. Top-ranked pharmacological interventions target inflammatory, cancer and cardiovascular pathways, including specific medications undergoing clinical evaluation in AD. Our findings, based on the examination of molecular-pathological-functional interactions in humans, may accelerate the process of bringing effective therapies into clinical practice.

60 APPLIED LIFE SCIENCES↗