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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
NASA NTRS2001

Progress on the International Space Station - We're Part Way up the Mountain

The first phase of the International Space Station construction has been completed, and research has begun. Russian, U.S., and Canadian hardware is on orbit, and Italian logistics modules have visited often. With the delivery of the U.S. Laboratory, Destiny, significant research capability is in place, and dozens of U.S. and Russian experiments have been conducted. Crew members have been on orbit continuously since November 2000. Several "bumps in the road" have occurred along the way, and each has been systematically overcome. Enormous amounts of hardware and software are being developed by the International Space Station partners and participants around the world and are largely on schedule for launch. Significant progress has been made in the testing of completed elements at launch sites in the United States and Kazakhstan. Over 250,000 kilograms of flight hardware have been delivered to the Kennedy Space Center and integrated testing of several elements wired together has progressed extremely well. Mission control centers are fully functioning in Houston, Moscow, and Canada, and operations centers Darmstadt, Tsukuba, Turino, and Huntsville will be going on line as they are required. Extensive coordination efforts continue among the space agencies of the five partners and two participants, involving 16 nations. All of them continue to face their own challenges and have achieved significant successes. This paper will discuss the contributions of the International Space Station partners and participants, their accomplished milestones, and upcoming events. The International Space Station program, the largest and most complicated peacetime project in history, has progressed part way up the mountain, and the partners are continuing their journey to the top. The International Space Station (ISS) is unprecedented in its technological, engineering, and management complexity, and is one of the largest international collaborations ever undertaken. The ISS is a dramatic example of the ability of nations to work together as a team toward common goals and dreams. The challenges encountered and overcome by the international ISS team have been likened to climbing a mountain. Construction of the ISS has progressed rapidly in the past year. ISS is now a functioning microgravity laboratory in space hosting a permanent human presence, prompting the characterization that we are "part way up the mountain, and the team continues its climb."

Fortenberry, Lindy↗
NASA NTRS2016

Progressive Damage Modeling of Notched Composites

There is an increased interest in using non-crimp fabric reinforced composites for primary and secondary structural weight savings in high performance automobile applications. However, one of the main challenges in implementing these composites is the lack of understanding of damage progression under a wide variety of loading conditions for general configurations. Towards that end, researchers at GM and NASA are developing new damage models to predict accurately the progressive failure of these composites. In this investigation, the developed progressive failure analysis model was applied to study damage progression in center-notched and open-hole tension specimens for various laminate schemes. The results of a detailed study with respect to the effect of element size on the analysis outcome are presented.

Aitharaju, Venkat↗
NASA NTRS2018

Climate Reanalysis: Progress and Future Prospects

Reanalysis is the process whereby an unchanging data assimilation system is used to provide a consistent reprocessing of observations, typically spanning an extended segment of the historical data record. The process relies on an underlying model to combine often-disparate observations in a physically consistent manner, enabling production of gridded data sets for a broad range of applications including the study of historical weather events, preparation of climatologies, business sector development and, more recently, climate monitoring. Over the last few decades, several generations of reanalyses of the global atmosphere have been produced by various operational and research centers, focusing more or less on the period of regular conventional and satellite observations beginning in the mid to late twentieth century. There have also been successful efforts to extend atmospheric reanalyses back to the late nineteenth and early twentieth centuries, using mostly surface observations. Much progress has resulted from (and contributed to) advancements in numerical weather prediction, especially improved models and data assimilation techniques, increased computing capacity, the availability of new observation types and efforts to recover and improve the quality of historical ones. The recent extension of forecast systems that allow integrated modeling of meteorological, oceanic, land surface, and chemical variables provide the basic elements for coupled data assimilation. This has opened the door to the development of a new generation of coupled reanalyses of the Earth system, or integrated Earth system analyses (IESA). Evidence so far suggests that this approach can improve the analysis of currently uncoupled components of the Earth system, especially at their interface, and lead to increased predictability. However, extensive analysis coupling as envisioned for IESA, while progressing, still presents significant challenges. These include model biases that can be exacerbated when coupled, component systems with different physical characteristics and different spatial and temporal scales, and component observations in different media with different spatial and temporal frequencies and different latencies. Quantification of uncertainty in reanalyses is also a critical challenge and is important for expanding their utility as a tool for climate change assessment. This talk provides a brief overview of the progress of reanalysis development during recent decades, and describes remaining challenges in the progression toward coupled Earth system reanalyses.

IES↗
NASA NTRS2019

Benchmarking Mixed Mode Failure in Progressive Damage and Failure Analysis Methods

The verification and validation of progressive-damage-analysis finite element methods are difficult but critical tasks to undertake during their development. Verification exercises assess whether a predictive analysis tool produces results that are consistent with the fundamental concepts and assumptions of the tool under evaluation. Ideally, closed-form analytical solutions can be derived for which method verification results can be compared. Problems selected for computational tool verification are often simple and isolate individual features of the tool. In the case of progressive damage finite element methods, verifications should be performed to evaluate the ability of the model to predict the initiation of damage and its growth through the finite element mesh under a variety of conditions. Mabson et al. proposed a test case of a unidirectional, fiber-reinforced plate with a center crack subjected to tensile loads to evaluate matrix crack propagation predictions. The problem was modeled using the Abaqus Hashin continuum damage mechanics (CDM) model for fiber-reinforced composites. Different combinations of matrix strengths and element sizes were used in the simulations, and the results were compared to a closed-form solution based on linear elastic fracture mechanics (LEFM). It was determined that the Abaqus CDM model could predict the LEFM solution of Mode I cracks only when the finite element mesh density met specific requirements based on the material properties. This paper presents closed-form LEFM solutions for a center notch mixed mode (CNMM) verification problem. Parametric finite element analyses were developed using progressive damage analysis methods of both the Discrete Damage Mechanics (DDM) and CDM classes. The progressive damage analysis methods applied in the analyses of the CNMM problem include CompDam and the Floating Node Method. Analyses were conducted with various mode mixities and element sizes to verify that the damage models were working as intended and to identify any limits of applicability.

Leone, Frank↗
NASA NTRSDate not supplied

NASA's Exploration and In-Space Services (NExIS) Division OSAM-1 Propellant Transfer Subsystem Progress 2020

National Aeronautics and Space Administration (NASA)’s Exploration and In-Space Services (NExIS) Division of Goddard Space Flight Center has been developing technology for the On-orbit Servicing, Assembly and Manufacturing Mission 1 (OSAM-1) to robotically refuel heritage and new satellites on-orbit. OSAM-1, formerly known as Restore-L, successfully passed an important NASA milestone called Key Decision Point-C (KDP-C), receiving agency-level approval for its implementation. The decision point also establishes the mission’s official schedule and budget. The OSAM-1 spacecraft, Servicing Payload and the Space Infrastructure Dexterous Robot (SPIDER) payload will refuel a satellite in space, assemble a communications antenna and manufacture a beam. By demonstrating these capabilities, the mission is advancing never-before tested technologies for use in future missions (by NASA and other government organizations and private industry). The mission is funded by the Technology Demonstration Missions program within NASA’s Space Technology Mission Directorate. This paper covers a review of servicing extensibility and critical technologies that are being developed within NExIS with a focus on the fluid transfer refueling technology within the framework of the Propellant Transfer Subsystem (PTS). An overview of the planned initial technology demonstration servicing mission via the OSAM-1 Space Vehicle is provided as an extension of the technology development progress reported in 20181, and 20192. The general objectives, challenges, and key technologies are presented as an introduction to the context of the OSAM-1 mission, and a precursor to the OSAM-1 PTS specific development status. Development and progress of the Hose Management Assembly (HMA) and Propellant Transfer Assembly (PTA) are discussed. HMA risk reduction test results including those of thermal vacuum testing are presented. Important analytical results are discussed and progress of drawings and procedures developed for the fabrication and testing phase are shown. A summary of the PTS overall verification status and design activities prepared for the critical design peer review are presented. Procurement progress is shown with status on long, medium, and short term efforts to acquire the hardware required to support the mission objectives. Technology development, challenges, and testing status are discussed with particular regard to the OSAM-1 specific key assemblies including the PTA and HMA along with the overall integrated flight mockup of the spacecraft to client fluid transfer testing conducted in the servicing testbeds. The paper concludes with key milestones leading to the goal of on-orbit refueling to be demonstrated in 2024. The overall mission Launch Readiness Date (LRD) has been realigned to accommodate budget profiles and incorporation of additional on-orbit assembly and manufacturing demonstration efforts.

Propellant transfer, satellite servicing↗
NASA NTRSDate not supplied

NASA’s Space Launch System Stands Ready on Doorstep of Maiden Voyage Launch and Progress Made to Future Missions

NASA and its partners made significant progress towards the Artemis I launch in 2022. The integrated Space Launch System (SLS)vehicleand Orion spacecraft were first rolled out of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center (KSC) in March. SLS is a super heavy-lift vehicle to send large, strategic payloads to the Moon, Mars, and beyond. It isthebackbone of the Artemis human lunar exploration program. Rollout transported the vehicle to Launch Pad 39B for a series of tests, including the wet dress rehearsal (WDR). Multiple attempts were required to complete WDR, each building on the one before. Following the WDR campaign, NASA teams refined hardware and launch procedures, and the vehicle was prepared for its first launch attempt scheduled for August 29. Challenges with the weather and hardware resulted in a scrub on the 29th, and the second attempt was set for Sept. 3. A hydrogen leak on the tail service mast umbilical forced a scrub. NASA teams completed repairs and testing on the vehicle on Launch Pad 39B to preserve a launch attempt at the end of September. Managers chose to return the vehicle to the VAB to protect it fromthe threat of Hurricane Ian. Within the VAB, NASA further inspected and prepared SLS for selected November windows. In addition to progress to the Artemis I mission, significant progress was made on the Artemis II and Artemis III rockets. Progress was also made towards on the Block 1B and Block 2 variants, beginning on the fourth and ninth flight, respectively. Both variants will provide significant improvements in both launch mass and mission flexibility to multiple destinations. This paper will discuss Artemis I vehicle integration, testing, and available results from the launch campaign to date.

Bruce Askins↗
NASA NTRSDate not supplied

Design and Hardware Progress on a Magnetically-Geared Actuator for Extremely Cold Lunar Environments

Introduction: Under the Motors for Dusty and Extremely Cold Environments (MDECE) Project, NASA Glenn Research Center is developing a magnetically-geared actuator for extremely cold space environments to avoid the wiring and significant efficiency penalty associated with heating grease-lubricated actuators as well as the stringent life and loading constraints imposed by dry film lubricated mechanical gears. The heating penalty can be equivalent to up to a 90% efficiency reduction in permanently shadowed regions on the Moon. This poster or presentation will summarize the progress made over the past 6-12 months on designing the fully-functional actuator and building a proof-of-concept actuator and testing it in an ambient environment. Design Progress: A critical design review was successfully completed at the end of June 2023. This presentation will touch on the key highlights from that review in the areas of electro-magnetic design and optimization, bearing optimization, thermal analysis, structural analysis, and mechanical design and manufacturing. The predicted technical performance measures of the actuator will be mentioned. The team is currently finishing some actions from the review and finalizing the drawing package in preparation for hardware procurement. Hardware Progress: Despite some significant delays in receiving fabricated parts and magnetic subassemblies, progress was made in manufacturing and assembling a proof-of-concept version of both the actuator’s magnetically-geared motor (Fig. 1) and the actuator’s cycloidal-type output magnetic gear stage (Fig. 2) [3]. The presentation will mention key lessons learned to date from the fabrication, assembly, and testing of the proof of concept.

Lunar surface↗
DOE OSTI2020

Quarterly Technical Progress Report Piperazine Advanced Stripper (PZAS™) Front End Engineering Design

EXECUTIVE SUMMARY This document summarizes the status of Cooperative Agreement DE-FE0031844, “Piperazine Advanced Stripper (PZAS™) Front-End Engineering Design,” during the reporting period of January 1 through March 31, 2020. The objective of this project is to develop accurate installed costs by conducting a Front-End Engineering Design (FEED) of PZAS™ at Golden Spread Electric Cooperative’s (GSEC) Mustang Station located in Denver City, TX. Complementary benefits include positioning the technology for a commercial project with the 45Q tax credits, qualifying PZAS™ for use on a Natural Gas Combined Cycle (NGCC) Cogen facility, and to provide cost detail to optimize PZAS™ and help guide R&D of second-generation solvent CO2 capture technologies. Results from the FEED will be used to evaluate the economic feasibility of the process at Mustang Station. This project is funded by the U.S. DOE National Energy Technology Laboratory under the aforementioned Cooperative Agreement. Exxon, Total, Chevron, UOP-Honeywell, and the University of Texas (UT) are project co-funders. AECOM and Trimeric are project team members; UT is the prime contractor. Summary of Progress Cooperative Agreement DE-FE0031844 was established in October 2019. The current reporting period, January 1 through March 31, 2020, is the second technical progress reporting period for the project. Several milestones were accomplished during this reporting period, including: • Kickoff Meeting with DOE on February 3, 2020. • Kickoff Meeting with GSEC on March 30, 2020. (Note: Due to Covid-19 travel restrictions and shelter-in-place guidelines, the kickoff meeting was conducted remotely via videoconferencing. See attached notes from that telecon.) • Updated Project Management Plan March 2020, submitted with this quarterly report Other activities during the quarter included progress on contracting and other legal agreements (e.g., non-disclosure agreements), internal kickoff meetings at both AECOM and Trimeric, and development of a Technical Implementation Plan (TIP). The TIP will help the team to make critical, early process decisions and, ultimately, to develop a project and process design basis. Note that all agreements between project team participants are complete as of this submittal, except the vendor agreement with Kiewit (steam cycle modeling). Plans for Next Reporting Period Activities during the next reporting period (April 1, 2020 through June 30, 2020) include: the completion of the Project Design Basis and progress towards the Process Design Basis/Process Design Package (PDP). The Project Design Basis is due as a deliverable and milestone during the next reporting period.

Rochelle, Gary T.↗
DOE OSTI2019

Panel Session 62: Progress on Deep Repository Programs Around the World

This panel session focused on the progress of deep repository programs, worldwide. While efforts on a deep geological repository for SNF/UNF and HLW in the USA were terminated in 2010, several other repository programs continue to make considerable progress and deserve to be recognized. Panelists were invited from national, multi-national, and international repository programs and organizations to report upon the status and future as well as the perceived reasons underlying the success and the failure of components of their respective repository program. This panel provided a forum for interested parties to present, exchange, and take advantage of, as appropriate, repository progress, challenges, concepts/designs and other lessons learned around the world, including site characterization, site selection, research and development, licensing, construction, operation, and public acceptance and participation. Presentations proposed include: 1 - Cigeo (French Deep Geological Repository Project) update 2018 (Daniel Delort, Andra (France)); 2 - Progress on Deep Geological Repository Programs Around the World (Bruce McKirdy, Radioactive Waste Management (United Kingdom)); 3 - Geological disposal facility in Belgium (Didier Leonard, ONDRAF/NIRAS (Belgium))

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2017

An alpha-synuclein MRM assay with diagnostic potential for Parkinson's disease and monitoring disease progression

Aim: The alpha-synuclein (α-syn) level in human cerebrospinal fluid (CSF), as measured by immunoassays, is promising as a Parkinson’s disease (PD) biomarker. However, the levels of total α-syn are inconsistent among studies with large cohorts and different measurement platforms. Total α-syn level also does not correlate with disease severity or progression. Here, we developed a highly sensitive Multiple Reaction Monitoring (MRM) method to measure absolute CSF α-syn peptide concentrations without prior enrichment or fractionation, aiming to discover new candidate biomarkers. Results: Six peptides covering 73% of protein sequence were reliably identified, and two were consistently quantified in cross-sectional and longitudinal cohorts. Absolute concentration of α-syn in human CSF was determined to be 2.1ng/mL. A unique α-syn peptide, TVEGAGSIAAATGFVK (81-96), displayed excellent correlation with previous immunoassay results in two independent PD cohorts (p < 0.001), correlated with disease severity, and its changes significantly tracked the disease progression longitudinally. Conclusions: An MRM assay to quantify human CSF α-syn was developed and optimized. Sixty clinical samples from cross-sectional and longitudinal PD cohorts were analyzed with this approach. Although further larger-scale validation is needed, the results suggest that α-syn peptide could serve as a promising biomarker in PD diagnosis and progression.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Impact of HIV-1 subtype and Korean Red Ginseng on AIDS progression: comparison of subtype B and subtype D

To date, no study has described disease progression in Asian patients infected with HIV-1 subtype D. To determine whether the disease progression differs in patients infected with subtypes D and B prior to starting combination antiretroviral therapy, the annual decline (AD) in CD4 + T cell counts over 96 59 months was retrospectively analyzed in 163 patients and compared in subtypes D and B based on the nef gene. CD4 + T cell AD was significantly higher in the six subtype D-infected patients than in the 157 subtype B-infected patients irrespective of Korean Red Ginseng (KRG) treatment (p < 0.001). Of these, two subtype D-infected patients and 116 subtype B-infected patients had taken KRG. AD was significantly lower in patient in the KRG-treated group than in those in the KRG-naïve group irrespective of subtype (p < 0.05). To control for the effect of KRG, patients not treated with KRG were analyzed, with AD found to be significantly greater in subtype D-infected patients than in subtype B-infected patients (p < 0.01). KRG treatment had a greater effect on AD in subtype D-infected patients than in subtype B-infected patients (4.5-fold vs. 1.6-fold). Mortality rates were significantly higher in both the 45 KRG-naïve (p < 0.001) and all 163 (p < 0.01) patients infected with subtype D than subtype B. Subtype D infection is associated with a >2-fold higher risk of death and a 2.9-fold greater rate of progression than subtype B, regardless of KRG treatment.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

Application usability levels: a framework for tracking project product progress

The space physics community continues to grow and become both more interdisciplinary and more intertwined with commercial and government operations. This has created a need for a framework to easily identify what projects can be used for specific applications and how close the tool is to routine autonomous or on-demand implementation and operation. We propose the Application Usability Level (AUL) framework and publicizing AULs to help the community quantify the progress of successful applications, metrics, and validation efforts. This framework will also aid the scientific community by supplying the type of information needed to build off of previously published work and publicizing the applications and requirements needed by the user communities. In this paper, we define the AUL framework, outline the milestones required for progression to higher AULs, and provide example projects utilizing the AUL framework. This work has been completed as part of the activities of the Assessment of Understanding and Quantifying Progress working group which is part of the International Forum for Space Weather Capabilities Assessment.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS2021

Semantic Segmentation of High-Resolution Satellite Imagery using Generative Adversarial Networks with Progressive Growing

With increase in urbanization and Earth Sciences research into urban areas, the need to quickly and accurately segment urban rooftop maps has never been greater. Cur-rent machine learning techniques struggle to produce high accuracy maps in dense urban zones where there is high image noise and foot print overlap. In this paper, we evaluate a training methodology for pixel-wise segmentation for high resolution satellite imagery using progressive growing of generative adversarial networks as a solution. We apply our model to segmenting building rooftops and compare these results to conventional methods for rooftop segmentation. We evaluate our approach using the SpaceNet version 2 and xView datasets. Our experiments show that for SpaceNet, progressive Generative Adversarial Network (GAN) training achieved a test accuracy of 93% compared to 89% for traditional GAN training and 87% for U-Net architecture, while for xView, we achieved 71% accuracy using progressive GAN training compared to 69% through traditional GAN training and 65% using U-Net.

Semantic↗
DOE OSTI2023

A General Autofluorescence Method to Characterize Polymerization Progress

Abstract An autofluorescence technique to characterize polymerization progress in real time/in line was developed, which functioned in the absence of typical fluorogenic groups on the monomer or polymer. The monomer dicyclopentadiene and polymer polydicyclopentadiene are hydrocarbons that lack traditional functional groups for fluorescence spectroscopy. Here, the autofluorescence of formulations containing this monomer and polymer during ruthenium‐catalyzed ring‐opening metathesis polymerization (ROMP) was harnessed for reaction monitoring. The methods fluorescence recovery after photobleaching (FRAP) and here‐developed fluorescence lifetime recovery after photobleaching (FLRAP) characterized polymerization progress in these native systems—without requiring exogenous fluorophore. (Auto)fluorescence lifetime recovery changes during polymerization correlated linearly to degree of cure, providing a quantitative link with reaction progress. These changing signals also provided relative rates of background polymerization, enabling comparison of 10 different catalyst‐inhibitor‐stabilized formulations. Multiple‐well analysis demonstrated suitability for future high‐throughput evaluation of formulations for thermosets. The central concept of the combined autofluorescence and FLRAP/FRAP method may be extendable to monitoring other polymerization reactions previously overlooked for lack of an obvious fluorescence handle.

López, Pía A.↗
DOE OSTI2023

A General Autofluorescence Method to Characterize Polymerization Progress

An autofluorescence technique to characterize polymerization progress in real time/in line was developed, which functioned in the absence of typical fluorogenic groups on the monomer or polymer. The monomer dicyclopentadiene and polymer polydicyclopentadiene are hydrocarbons that lack traditional functional groups for fluorescence spectroscopy. Here, the autofluorescence of formulations containing this monomer and polymer during ruthenium-catalyzed ring-opening metathesis polymerization (ROMP) was harnessed for reaction monitoring. The methods fluorescence recovery after photobleaching (FRAP) and here-developed fluorescence lifetime recovery after photobleaching (FLRAP) characterized polymerization progress in these native systems—without requiring exogenous fluorophore. (Auto)fluorescence lifetime recovery changes during polymerization correlated linearly to degree of cure, providing a quantitative link with reaction progress. These changing signals also provided relative rates of background polymerization, enabling comparison of 10 different catalyst–inhibitor-stabilized formulations. Multiple-well analysis demonstrated suitability for future high-throughput evaluation of formulations for thermosets. Furthermore, the central concept of the combined autofluorescence and FLRAP/FRAP method may be extendable to monitoring other polymerization reactions previously overlooked for lack of an obvious fluorescence handle.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2024

NCAPH drives breast cancer progression and identifies a gene signature that predicts luminal a tumour recurrence

Luminal A tumours generally have a favourable prognosis but possess the highest 10-year recurrence risk among breast cancers. Additionally, a quarter of the recurrence cases occur within 5 years post-diagnosis. Identifying such patients is crucial as long-term relapsers could benefit from extended hormone therapy, while early relapsers might require more aggressive treatment. We conducted a study to explore non-structural chromosome maintenance condensin I complex subunit H’s (NCAPH) role in luminal A breast cancer pathogenesis, both in vitro and in vivo, aiming to identify an intratumoural gene expression signature, with a focus on elevated NCAPH levels, as a potential marker for unfavourable progression. Our analysis included transgenic mouse models overexpressing NCAPH and a genetically diverse mouse cohort generated by backcrossing. A least absolute shrinkage and selection operator (LASSO) multivariate regression analysis was performed on transcripts associated with elevated intratumoural NCAPH levels. We found that NCAPH contributes to adverse luminal A breast cancer progression. The intratumoural gene expression signature associated with elevated NCAPH levels emerged as a potential risk identifier. Transgenic mice overexpressing NCAPH developed breast tumours with extended latency, and in Mouse Mammary Tumor Virus (MMTV)-NCAPH ErbB2 double-transgenic mice, luminal tumours showed increased aggressiveness. High intratumoural Ncaph levels correlated with worse breast cancer outcome and subpar chemotherapy response. A 10-gene risk score, termed Gene Signature for Luminal A 10 (GSLA10), was derived from the LASSO analysis, correlating with adverse luminal A breast cancer progression. The GSLA10 signature outperformed the Oncotype DX signature in discerning tumours with unfavourable outcomes, previously categorised as luminal A by Prediction Analysis of Microarray 50 (PAM50) across three independent human cohorts. This new signature holds promise for identifying luminal A tumour patients with adverse prognosis, aiding in the development of personalised treatment strategies to significantly improve patient outcomes.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

The correlation between the incidence of adverse events and progression-free survival in patients treated with cabozantinib for metastatic renal cell carcinoma (mRCC)

Clinical practice shows significant differences in treatment outcomes across patients treated with cabozantinib for metastatic renal cell carcinoma (mRCC). It is not known whether cabozantinib-induced adverse events are predictive factors of survival as in case of drugs such as sunitinib or axitinib. The study participants were 30 adult patients with mRCC treated with cabozantinib as a second- or further line setting. All adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Progression-free survival (PFS) values were calculated by taking the beginning of cabozantinib treatment as the start date and either disease progression or death as the end date. PFS were estimated using the Kaplan–Meier method, and compared using the log-rank test. We identified independent PFS predictors using multiple Cox proportional hazards models and reported hazard ratios (HR) with 95% confidence intervals. The median observation time cabozantinib treatment was 7.5 months, with a range of 2–15 months. During that time, 11 (37%) of the patients had mRCC progression. Median PFS on cabozantinib was not reached, and lower quartile was 6 months. All patients developed at least one adverse event in the course of cabozantinib therapy. Hypertension, hypothyroidism and HFS were observed most frequently, in about two-thirds of the patients. The co-incidence of multiple adverse events was common. Hypertension, hypothyroidism, diarrhea and liver toxicity were significantly associated with longer PFS values. Patients with three or more side effects had significantly longer PFS than those with two or fewer. Even though this study was conducted in a small patient sample and the observation time was relatively short our results confirm the predictive value of the incidence of adverse events during cabozantinib treatment in mRCC patients. To the best of our knowledge, this is the first study of this kind conducted in this group of patients.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2017

MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1

Aberrant expression of microRNAs contributes to the initiation and progression of numerous human cancers. The underlying effects and molecular mechanisms of microRNA-187 (miR-187) in gastric cancer (GC) remain unclear. The present study reports that miR-187 was significantly overexpressed in GC tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis (P = 0.048), and TNM stage (P = 0.035). Additionally, miR-187 promoted tumor growth in vivo, and significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells. It was found that collapsin response mediator protein 1 (CRMP1), a tumor suppressor, was a direct downstream target of miR-187 in GC. Furthermore, CRMP1 silencing resulted in similar effects on cell proliferation, migration, and apoptosis as those of miR-187 overexpressing GC cells. Additionally, the effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation. In summary, miR-187 promotes tumor progression by regulating CRMP1 expression in GC and may thus be a potential prognostic marker and a therapeutic target in GC. - Highlights: • miR-187 was significantly overexpressed in GC tissues and associated with malignant clinical factors. • miR-187 significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells. • CRMP1 tumor suppressor is a direct target of miR-187 in GC. • Overexpression of miR-187 promoted GC progression by targeting tumor suppressor gene CRMP1.

60 APPLIED LIFE SCIENCES↗