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Space Radiation and Risks to Human Health

The radiation environment in space poses significant challenges to human health and is a major concern for long duration manned space missions. Outside the Earth's protective magnetosphere, astronauts are exposed to higher levels of galactic cosmic rays, whose physical characteristics are distinct from terrestrial sources of radiation such as x‐rays and gamma‐rays. Galactic cosmic rays consist of high energy and high mass nuclei as well as high energy protons; they impart unique biological damage as they traverse through tissue with impacts on human health that are largely unknown. The major health issues of concern are the risks of radiation carcinogenesis, acute and late decrements to the central nervous system, degenerative tissue effects such as cardiovascular disease, as well as possible acute radiation syndromes due to an unshielded exposure to a large solar particle event. The NASA Human Research Program's Space Radiation Program Element is focused on characterization and mitigation of these space radiation health risks along with understanding these risks in context of the other biological stressors found in the space environment. In this overview, we will provide a description of these health risks and the Element's research strategies to understand and mitigate these risks.

Huff, Janice L.↗

Space Radiation and Risks to Human Health

The radiation environment in space poses significant challenges to human health and is a major concern for long duration manned space missions. Outside the Earth's protective magnetosphere, astronauts are exposed to higher levels of galactic cosmic rays, whose physical characteristics are distinct from terrestrial sources of radiation such as x‐rays and gamma‐rays. Galactic cosmic rays consist of high energy and high mass nuclei as well as high energy protons; they impart unique biological damage as they traverse through tissue with impacts on human health that are largely unknown. The major health issues of concern are the risks of radiation carcinogenesis, acute and late decrements to the central nervous system, degenerative tissue effects such as cardiovascular disease, as well as possible acute radiation syndromes due to an unshielded exposure to a large solar particle event. The NASA Human Research Program's Space Radiation Program Element is focused on characterization and mitigation of these space radiation health risks along with understanding these risks in context of the other biological stressors found in the space environment. In this overview, we will provide a description of these health risks and the Element's research strategies to understand and mitigate these risks.

Huff, Janice L.↗

Path Toward a Unifid Geometry for Radiation Transport

The Direct Accelerated Geometry for Radiation Analysis and Design (DAGRAD) element of the RadWorks Project under Advanced Exploration Systems (AES) within the Space Technology Mission Directorate (STMD) of NASA will enable new designs and concepts of operation for radiation risk assessment, mitigation and protection. This element is designed to produce a solution that will allow NASA to calculate the transport of space radiation through complex computer-aided design (CAD) models using the state-of-the-art analytic and Monte Carlo radiation transport codes. Due to the inherent hazard of astronaut and spacecraft exposure to ionizing radiation in low-Earth orbit (LEO) or in deep space, risk analyses must be performed for all crew vehicles and habitats. Incorporating these analyses into the design process can minimize the mass needed solely for radiation protection. Transport of the radiation fields as they pass through shielding and body materials can be simulated using Monte Carlo techniques or described by the Boltzmann equation, which is obtained by balancing changes in particle fluxes as they traverse a small volume of material with the gains and losses caused by atomic and nuclear collisions. Deterministic codes that solve the Boltzmann transport equation, such as HZETRN [high charge and energy transport code developed by NASA Langley Research Center (LaRC)], are generally computationally faster than Monte Carlo codes such as FLUKA, GEANT4, MCNP(X) or PHITS; however, they are currently limited to transport in one dimension, which poorly represents the secondary light ion and neutron radiation fields. NASA currently uses HZETRN space radiation transport software, both because it is computationally efficient and because proven methods have been developed for using this software to analyze complex geometries. Although Monte Carlo codes describe the relevant physics in a fully three-dimensional manner, their computational costs have thus far prevented their widespread use for analysis of complex CAD models, leading to the creation and maintenance of toolkit-specific simplistic geometry models. The work presented here builds on the Direct Accelerated Geometry Monte Carlo (DAGMC) toolkit developed for use with the Monte Carlo N-Particle (MCNP) transport code. The workflow for achieving radiation transport on CAD models using MCNP and FLUKA has been demonstrated and the results of analyses on realistic spacecraft/habitats will be presented. Future work is planned that will further automate this process and enable the use of multiple radiation transport codes on identical geometry models imported from CAD. This effort will enhance the modeling tools used by NASA to accurately evaluate the astronaut space radiation risk and accurately determine the protection provided by as-designed exploration mission vehicles and habitats

Lee, Kerry↗

Deflection of Solar Energetic Protons by an Ion Thruster

While Galactic Cosmic Rays (GCR) represent a long-term cancer risk to deep space human missions, Solar Energetic Particles (SEP) represent a significant acute radiation hazard to human spaceflight. This work investigates wave-particle interactions caused by the incidence of a beam of energetic protons, representing a notional SEP event, onto a cloud of ions representing a notional ion thruster plume. The resulting electromagnetic ion/ion instability is developed to investigate the degree to which energetic protons can be scattered out of the initial beam. This work includes investigations of deflection rate dependences on incident SEP energy and flux, ion thruster power and orientation relative to SEP incidence, plume ion species, and background plasma. Also investigated are the spectrum and angular distribution of electromagnetic radiation resulting from the wave-particle interactions. The primary objective of this investigation is to develop a technique for active mitigation of SEP radiation threats to spacecraft and crew, by exploring the wave-particle interaction of a SEP event with the plasma plume expelled from an ion thruster. Since the cost in expended fuel restricts this technique to intermittent use during interplanetary flights, effective prediction of when a SEP event might impact the mission is still important, and the observation of conditions that might lead to SEP events, human-in-the-loop space weather analyses, and development of SEP prediction models remain essential to crew safety, spacecraft function, and mission success.

Interplanetary Space Flight↗

Mitigation for the demolition of building 25-4314, radiation services, area 25, Nevada national security site, NYE county, Nevada

The purpose of this letter report is to document the mitigation of adverse effects of a proposed undertaking that would demolish Building 25-4314 in Area 25 of the Nevada National Security Site (NNSS) in compliance with the terms of the 2024 Programmatic Agreement among the U.S. Department of Energy and the Nevada State Historic Preservation Officer and the Advisory Council on Historic Preservation Concerning the Protection of Historic Properties on the Nevada National Security Site, Nye County, Nevada (NNSS PA). Building 25-4314 (State Historic Preservation Office [SHPO] Resource # B19016) is a contributing element to the Nuclear Rocket Development Station (NRDS) Historic District (SHPO Resource # D424), which has been determined eligible for listing in the National Register of Historic Places (NRHP) under Criteria A, B, C, and D (Reno et al. 2023). The proposed demolition constitutes an adverse effect. The U.S. Department of Energy (DOE) National Nuclear Security Administration Nevada Field Office (NNSA/NFO) consulted with the SHPO on an adverse effect finding for the undertaking and notified the SHPO of its intent to use the standard mitigation in the NNSS PA on December 11, 2024 (Julian to Reed). The SHPO concurred on December 30, 2024 (Reed to Julian). Therefore, NNSA/NFO has prepared mitigation pursuant to the standard mitigation in the NNSS PA Appendix D.I.A for contributing elements to recorded, NRHP-eligible districts.

#B19016↗

Dried Plum Protects From Radiation-Induced Bone Loss by Attenuating Pro-Osteoclastic and Oxidative Stress Responses

Future space explorations beyond the earths magnetosphere will increase human exposure to space radiation and associated risks to skeletal health. We hypothesize that oxidative stress resulting from radiation exposure plays a major role in progressive bone loss and dysfunction in associated tissue. In animal studies, increased free radical formation is associated with pathological changes in bone structure, enhanced bone resorption, reduced bone formation and decreased bone mineral density, which can lead to skeletal fragility. Our long-term goals are to define the mechanisms and risk of bone loss in the spaceflight environment and to facilitate the development of effective countermeasures. We had previously reported that exposure to low or high-LET radiation correlates with an acute increase in the expression of pro-osteoclastic and oxidative stress genes in bone during the early response to radiation followed by pathological changes in skeletal structure. We then conducted systematic screening for potential countermeasures against bone loss where we tested the ability of various antioxidants to mitigate the radiation-induced increase in expression of these markers. For the screen, 16-week old C57Bl6J mice were treated with a dietary antioxidant cocktail, injectable DHLA or a dried plum-enriched diet (DP). Mice were then exposed to 2Gy 137Cs radiation and one day later, marrow cells were collected and the relevant genes analyzed for expression levels. Among the candidate countermeasures tested, DP was most effective in reducing the expression of genes associated with bone loss. Furthermore, analysis of skeletal structure by microcomputed tomography (microCT) revealed that DP also prevents the radiation-induced deterioration in skeletal microarchitecture as indicated by parameters such as percent bone volume (BVTV), trabecular spacing and trabecular number. We also found that DP has similar protective effects on skeletal structure in a follow-up study using 1 Gy of sequential proton and iron, radiation species relevant to spaceflight. When cultured ex vivo under osteogenic conditions, bone marrow-derived cells from DP-fed animals exhibited increased colony numbers compared to control diet-fed animals. These findings suggest that DP exerts pro-osteogenic effects apart from its previously demonstrated anti-resorptive action, which may be one of the mechanisms underlying its radioprotective effect on bone. In conclusion, a diet enriched in certain types of antioxidants may be useful as an intervention for radiation-induced bone loss.

Bone-loss↗

Real Time Space Weather Support for Chandra X-ray Observatory Operations

NASA launched the Chandra X-ray Observatory in July 1999. Soon after first light in August 1999, however, degradation in the energy resolution and charge transfer efficiency of the Advanced CCD Imaging Spectrometer (ACIS) x-ray detectors was observed. The source of the degradation was quickly identified as radiation damage in the charge-transfer channel of the front-illuminated CCDs, by weakly penetrating ("soft", 100-500 keV) protons as Chandra passed through the Earth s radiation belts and ring currents. As soft protons were not considered a risk to spacecraft health before launch, the only on-board radiation monitoring system is the Electron, Proton, and Helium Instrument (EPHIN) which was included on Chandra with the primary purpose of monitoring energetic solar particle events. Further damage to the ACIS detector has been successfully mitigated through a combination of careful mission planning, autonomous on-board radiation protection, and manual intervention based upon real-time monitoring of the soft-proton environment. The AE-8 and AP-8 trapped radiation models and Chandra Radiation Models are used to schedule science operations in regions of low proton flux. EPHIN has been used as the primary autonomous in-situ radiation trigger; but, it is not sensitive to the soft protons that damage the front-illuminated CCDs. Monitoring of near-real-time space weather data sources provides critical information on the proton environment outside the Earth's magnetosphere due to solar proton events and other phenomena. The operations team uses data from the Geostationary Operational Environmental Satellites (GOES) to provide near-real-time monitoring of the proton environment; however, these data do not give a representative measure of the soft-proton (less than 1 MeV) flux in Chandra s high elliptical orbit. The only source of relevant measurements of sub-MeV protons is the Electron, Proton, and Alpha Monitor (EPAM) aboard the Advanced Composition Explorer (ACE) satellite at L1, with real-time data provided by NOAA's Space Weather Prediction Center. This presentation will discuss radiation mitigation against proton damage, including models and real-time data sources used to protect the ACIS detector system.

O'Dell, Stephen L.↗

Real Time Space Weather Support for Chandra X-Ray Observatory Operations

NASA launched the Chandra X-ray Observatory in July 1999. Soon after first light in August 1999, however, degradation in the energy resolution and charge transfer efficiency of the Advanced CCD Imaging Spectrometer (ACIS) x-ray detectors was observed. The source of the degradation was quickly identified as radiation damage in the charge-transfer channel of the front-illuminated CCDs, by weakly penetrating ( soft , 100 500 keV) protons as Chandra passed through the Earth s radiation belts and ring currents. As soft protons were not considered a risk to spacecraft health before launch, the only on-board radiation monitoring system is the Electron, Proton, and Helium Instrument (EPHIN) which was included on Chandra with the primary purpose of monitoring energetic solar particle events. Further damage to the ACIS detector has been successfully mitigated through a combination of careful mission planning, autonomous on-board radiation protection, and manual intervention based upon real-time monitoring of the soft-proton environment. The AE-8 and AP-8 trapped radiation models and Chandra Radiation Models are used to schedule science operations in regions of low proton flux. EPHIN has been used as the primary autonomous in-situ radiation trigger; but, it is not sensitive to the soft protons that damage the front-illuminated CCDs. Monitoring of near-real-time space weather data sources provides critical information on the proton environment outside the Earth s magnetosphere due to solar proton events and other phenomena. The operations team uses data from the Geostationary Operational Environmental Satellites (GOES) to provide near-real-time monitoring of the proton environment; however, these data do not give a representative measure of the soft-proton (< 1 MeV) flux in Chandra s high elliptical orbit. The only source of relevant measurements of sub-MeV protons is the Electron, Proton, and Alpha Monitor (EPAM) aboard the Advanced Composition Explorer (ACE) satellite at L1, with real-time data provided by NOAA s Space Weather Prediction Center. This presentation describes the radiation mitigation strategies to minimize the proton damage in the ACIS CCD detectors and the importance of real-time data sources that are used to protect the ACIS detector system from space weather events.

O'Dell, Stephen L.↗

Outline: Recent work at JPL Under MSREP

MSREP is a multi-faceted program with radiation effects in new technologies, development of testing and hardness assurance methods, continual evaluation of space and laboratory test data and support to NASA Projects. Other work in progress includes: 1) Device Scaling and New Phenomena; 2) Radiation Effects in Microprocessors; 3) Latchup Testing and Latchup Mitigation; and 4) Revised Radiation Design Approaches. This paper is in viewgraph form.

Source record↗

Developments in Radiation-Hardened Electronics Applicable to the Vision for Space Exploration

The Radiation Hardened Electronics for Space Exploration (RHESE) project develops the advanced technologies required to produce radiation hardened electronics, processors, and devices in support of the anticipated requirements of NASA's Constellation program. Methods of protecting and hardening electronics against the encountered space environment are discussed. Critical stages of a spaceflight mission that are vulnerable to radiation-induced interruptions or failures are identified. Solutions to mitigating the risk of radiation events are proposed through the infusion of RHESE technology products and deliverables into the Constellation program's spacecraft designs.

Keys, Andrew S.↗

Outcomes of a NASA Human Research Program’s (HRP) Space Radiation Element-sponsored Mini-Technical Interchange Meeting/workshop on Cardiovascular Disease Risk from Space Radiation

The NASA HRP’s Space Radiation Element funds research to characterize and mitigate adverse health outcomes from space radiation including cardiovascular risks to astronauts to enable deep space exploration and sustained human presence in space. Non-cancer effects such as damage to the cardiovascular system have been observed at clinically relevant high doses of ionizing radiation. However, an association between lower doses and risk of cardiovascular disease (CVD) remains somewhat controversial, especially in relation to the existence of low dose thresholds, radiation quality, and dose-rate effects, as well as gaps in characterizing the mechanisms and major pathways of disease. To facilitate, accelerate, and incubate new ideas to characterize and mitigate this risk, the Element is planning to organize a series of miniature technical interchange meetings (Tiny-TIMs) to provide a venue for HRP-funded investigators and thought leaders to present ongoing work and engage in open discussion on presented results, limitations of current approaches, incorporating better experimental strategies, model systems, etc. The initial Tiny-TIM held during the NASA HRP Investigators’ Workshop earlier this year – Upping the ante on characterizing and mitigating cardiovascular disease risk from space radiation exposure – aimed to stimulate discussion on the current state of scientific knowledge of CVD risk from space-like radiation exposure. The Tiny-TIM consisted of two 90-minute sessions; the first session concentrated on current knowledge of CVD risk from space radiation and the second session focused on innovative ideas, newer approaches, and techniques to accelerate research. The second session was followed by an open spirited discussion amongst peers on the current issues impeding the characterization of CVD risk from space radiation. The Element facilitated the discussion using a set of pressing open questions/gaps in knowledge that need to be addressed by the scientific community. The outcomes of the Tiny-TIM will be presented along with a plan of proposed future workshops and other initiatives of the Space Radiation Element.

Janapriya Saha↗

Planning for a Large Space Weather Event: Preparation for and Lessons Learned from the 2024 Space Weather Interagency Tabletop Exercise

On May 8-9 2024, the Space Radiation Analysis Group (SRAG) at NASA/Johnson Space Center participated in a joint exercise with DoD, FEMA, OSTP, DOE and other agencies to assess their ability to respond to a large hypothetical space weather event. SRAG is a uniquely skilled group of scientists and engineers tasked with mitigating impacts of radiation exposure to the astronaut crew aboard the International Space Station and upcoming missions beyond Low Earth Orbit (LEO). In meeting this objective, the team has developed expertise in both modeling the impacts of an enhanced space environment and in the real-time operational support of the Flight Control Team when assessing a response to the environment. Several members of SRAG worked with the Tabletop Exercise (TTX) planners to define a realistic large event and to model the resulting radiation exposure on an Artemis crew. SRAG members participating in the TTX were blinded to the results of this analysis. As the event unfolded during the TTX, SRAG provided their assessment of the likely impact on the crew and recommendations for crew actions. During the exercise, the team tracked lessons learned for their own planning, currently in work, for Artemis-II and subsequent missions.

Janet Barzilla↗

Signal and Power Integrity Design Methodology for High-Performance Flight Computing Systems

Computing capabilities of space systems have in-creased onboard performance by orders of magnitude with the use of radiation-tolerant field-programmable gate arrays (FPGA)and processors. The incorporation of signal and power integrity analysis with printed circuit board (PCB) design in reliable computing architectures for space systems has become critical to enable future mission capabilities. Developers launch high-performance processors into a breadth of orbits and missions, running varying applications that create challenges for designing reliable computing hardware. Specifically, for these designs, academic and industry research has focused on component radiation performance, fault mitigation, and reliable architectures. How-ever, other design parameters including electromagnetic interference (EMI), PCB stackup, signal integrity (SI), voltage regulator module (VRM) design, and power distribution network (PDN)are often deprioritized or disregarded as the design matures. Since these characteristics are becoming more significant in high-performance processor designs, this research presents a hardware design and analysis methodology for high-performance, space-computing systems that focuses on a holistic design approach and PDN reliability. While these challenges exist across all space hardware, the reduced PCB dimensions imposed by SmallSats and CubeSats introduce additional hurdles, specifically to VRM and decoupling design. By examining the relationship between the PDN and radiation performance, an analytical relationship is developed that incorporates Total Ionizing Dose and Single-Event Transients to ensure reliability throughout the mission duration. The presented design methodology is applied to the SpaceCube v3.0 Mini, an FPGA-based on-board science data processing system developed at NASA Goddard Space Flight Center.

Advanced avionics↗

Perspectives and challenges of ultra-high temperature ceramics for fusion plasma-facing applications

Ultra-high temperature ceramics (UHTCs) offer several potential advantages as plasma-facing components (PFCs) in fusion reactors due to their extreme melting points, tailorable thermal conductivity, and attractive unirradiated mechanical properties including fracture toughness comparable or superior to tungsten. Here, recent developments and material properties of UHTCs are briefly reviewed, along with an overview of limited studies on their responses to neutron irradiation and an evaluation of plasma-surface interactions. Five key research pathways, primarily focused on irradiation effects, for advancing UHTCs in PFC applications are discussed: (1) assessing irradiation effects on the coupled thermal–mechanical performance (2) addressing the lack of studies on irradiation, plasma-surface interactions, and their synergistic effects; (3) investigating high-temperature (>1000 °C) neutron irradiation effects critical for PFC performance; (4) optimizing multi-component UHTC compositions or composites to improve thermal or mechanical properties; (5) enhancing radiation resistance to mitigate microcracking and void swelling through strategies such as increasing sink strength by reducing grain size, introducing fine particles, and leveraging complex concentrated alloy concepts.

36 MATERIALS SCIENCE↗

Revolutionary Concepts for Helicopter Noise Reduction: SILENT Program

As part of a NASA initiative to reduce helicopter main rotor noise, a Phase 1 study has been performed of candidate noise reduction concepts. Both conventional and novel design technologies have been analyzed that reduce the community impact of helicopter operations. In this study the noise reduction potential and design implications are assessed for conventional means of noise reduction, e.g., tip speed reduction, tip shapes and airfoil tailoring, and for two innovative design concepts: modulated blade spacing and x-force control. Main rotor designs that incorporate modulated blade spacing are shown to have reduced peak noise levels in most flight operations. X-force control alters the helicopter's force balance whereby the miss distance between main rotor blades and shed vortices can be controlled. This control provides a high potential to mitigate BVI noise radiation. Each concept is evaluated using best practice design and analysis methods, achieving the study's aim to significantly reduce noise with minimal performance degradation and no vibration increase. It is concluded that a SILENT main rotor design, incorporating the modulated blade spacing concept, offers significantly reduced noise levels and the potential of a breakthrough in how a helicopter's sound is perceived and judged. The SILENT rotor represents a definite advancement in the state-of-the-art and is selected as the design concept for demonstration in Phase 2. A Phase 2 Implementation Plan is developed for whirl cage and wind tunnel evaluations of a scaled model SILENT rotor.

Edwards, Bryan↗

Chandra Radiation Environment Modeling

CRMFLX (Chandra Radiation Model of ion FluX) is a radiation environment risk mitigation tool for use as a decision aid in planning the operations times for Chandra's Advanced CCD Imaging Spectrometer (ACIS) detector. The accurate prediction of the proton flux environment with energies of 100 - 200 keV is needed in order to protect the ACIS detector against proton degradation. Unfortunately, protons of this energy are abundant in the region of space Chandra must operate, and on-board particle detectors do not measure proton flux levels of the required energy range. This presentation will describe the plasma environment data analysis and modeling basis of the CRMFLX engineering environment model developed to predict the proton flux in the solar wind, magnetosheath, and magnetosphere phenomenological regions of geospace. The recently released CRMFLX Version 2 implementation includes an algorithm that propagates flux from an observation location to other regions of the magnetosphere based on convective ExB and VB-curvature particle drift motions. This technique has the advantage of more completely filling out the database and makes maximum use of limited data obtained during high Kp periods or in areas of the magnetosphere with poor satellite flux measurement coverage.

Minow, Joseph I.↗

The Empirical Low Energy Ion Flux Model for the Terrestrial Magnetosphere

This document includes a viewgraph presentation plus the full paper presented at the conference. The Living With a Star Ion Flux Model (IFM) is a radiation environment risk mitigation tool that provides magnetospheric ion flux values for varying geomagnetic disturbance levels in the geospace environment. IFM incorporates flux observations from the Polar and Geotail spacecraft in a single statistical flux model. IFM is an engineering environment model which predicts the proton flux not only in the magnetosphere, but also in the solar wind and magnetosheath phenomenological regions. This paper describes the ion flux databases that allows for IFM output to be correlated with the geomagnetic activity level, as represented by the Kp index.

Blackwell, William C.↗