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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,441 records · Page 80
All sourcesNASA NTRSDOE OSTI
DOE OSTI2012

Ultrasensitive, amplification-free assays for detecting pathogens

Hybridization of nucleic acid probes has the potential to directly detect pathogens without requiring resource-intensive amplification steps, but conventional approaches to direct hybridization are typically slow or suffer from low sensitivity. In this work, we have characterized a novel approach for rapid detection of low-abundance nucleic acids by direct hybridizati on in solution, with sensitive analysis enabled by electrophoretic preconcentration of nucleic acids at a nanoporous m embrane. We performed proof-of-concept testing of the assay using a m odel DNA virus, showing direct detection of as little as 400 amol (~240 m illion copies) with current (un optimized) hardware. We extensively char acterized the preconcentration process for DNA, and determ ined rates of preconcentrat ion and efficiency of recovery as a function of preconcentration conditions, membrane formulation, and DNA size. The membrane preconcentration device also en ables rapid, ultra-sensitive size-based separation of nucleic acids, and has been demonstrated for multiplex PCR analysis of drug resistance genes in bacteria.

Meagher, Robert J.↗
DOE OSTI2013

Low-power multichannel ASIC for Gamma-ray Medical Imager

In this CRADA BNL agreed to revise the design and layout of a prototype low-noise multi-channel front-end ASIC for use in Digirad’s new generation of gamma cameras based on CsI-Si pixel sensors. The ASIC must provide low-noise charge amplification, photon-counting and amplitude/timing resolving capability, multiplexed readout. Starting from the first prototype developed in 2011 CRADA BNL-C-10-10 BNL agreed on the following modifications.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2013

Time-resolved broadband cavity-enhanced absorption spectroscopy for chemical kinetics.

Experimental measurements of elementary reaction rate coefficients and product branching ratios are essential to our understanding of many fundamentally important processes in Combustion Chemistry. However, such measurements are often impossible because of a lack of adequate detection techniques. Some of the largest gaps in our knowledge concern some of the most important radical species, because their short lifetimes and low steady-state concentrations make them particularly difficult to detect. To address this challenge, we propose a novel general detection method for gas-phase chemical kinetics: time-resolved broadband cavity-enhanced absorption spectroscopy (TR-BB-CEAS). This all-optical, non-intrusive, multiplexed method enables sensitive direct probing of transient reaction intermediates in a simple, inexpensive, and robust experimental package.

Sheps, Leonid↗
DOE OSTI2014

Dynamic Optimized Advanced Scheduling of Bandwidth Demands for Large-Scale Science Applications (Final Report)

In this project, developed scheduling frameworks for dynamic bandwidth demands for large-scale science applications. In particular, we developed scheduling algorithms for dynamic bandwidth demands in this project. Apart from theoretical approaches such as Integer Linear Programming, Tabu Search and Genetic Algorithm heuristics, we have utilized practical data from ESnet OSCARS project (from our DOE lab partners) to conduct realistic simulations of our approaches. We have disseminated our work through conference paper presentations and journal papers and a book chapter. In this project we addressed the problem of scheduling of lightpaths over optical wavelength division multiplexed (WDM) networks. We published several conference papers and journal papers on this topic. We also addressed the problems of joint allocation of computing, storage and networking resources in Grid/Cloud networks and proposed energy-efficient mechanisms for operation optical WDM networks.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2014

Radar Channel Balancing with Commutation

When multiple channels are employed in a pulse-Doppler radar, achieving and maintaining balance between the channels is problematic. In some circumstances the channels may be commutated to achieve adequate balance. Commutation is the switching, trading, toggling, or multiplexing of the channels between signal paths. Commutation allows modulating the imbalance energy away from the balanced energy in Doppler, where it can be mitigated with filtering.

42 ENGINEERING↗
DOE OSTI2016

High Efficiency, Low Emission Refrigeration System

Supermarket refrigeration systems account for approximately 50% of supermarket energy use, placing this class of equipment among the highest energy consumers in the commercial building domain. In addition, the commonly used refrigeration system in supermarket applications is the multiplex direct expansion (DX) system, which is prone to refrigerant leaks due to its long lengths of refrigerant piping. This leakage reduces the efficiency of the system and increases the impact of the system on the environment. The high Global Warming Potential (GWP) of the hydrofluorocarbon (HFC) refrigerants commonly used in these systems, coupled with the large refrigerant charge and the high refrigerant leakage rates leads to significant direct emissions of greenhouse gases into the atmosphere. Methods for reducing refrigerant leakage and energy consumption are available, but underutilized. Further work needs to be done to reduce costs of advanced system designs to improve market utilization. In addition, refrigeration system retrofits that result in reduced energy consumption are needed since the majority of applications address retrofits rather than new stores. The retrofit market is also of most concern since it involves large-volume refrigerant systems with high leak rates. Finally, alternative refrigerants for new and retrofit applications are needed to reduce emissions and reduce the impact on the environment. The objective of this Collaborative Research and Development Agreement (CRADA) between the Oak Ridge National Laboratory and Hill Phoenix is to develop a supermarket refrigeration system that reduces greenhouse gas emissions and has 25 to 30 percent lower energy consumption than existing systems. The outcomes of this project will include the design of a low emission, high efficiency commercial refrigeration system suitable for use in current U.S. supermarkets. In addition, a prototype low emission, high efficiency supermarket refrigeration system will be produced for laboratory and field testing. Laboratory and field testing will demonstrate the high energy efficiency and low environmental impact of the refrigeration system developed in this project.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2016

Rapid Detection and Characterization of Emerging Foreign Animal Disease Pathogens

To best safeguard human and animal health requires early detection and characterization of disease events. This must include effective surveillance for emerging infectious diseases. Both deliberate and natural outbreaks have enormous economic and public health impacts, and can present serious threats to national security. In this project, we developed novel next generation detection technologies to protect the agricultural economy and biosecurity. The first technology is a multiplexed assay to simultaneously detection 10 swine viral and bacterial pathogens. The second one is the Lawrence Livermore Microbial Detection Array (LLMDA) which can detect more than 10,000 microbial species including 4219 viruses, 5367 bacteria, 265 fungi, 117 protozoa and 293 archaea. We analyzed a series of swine clinical samples from past disease events to demonstrate the utility of the assays for faster and cheaper detection of emerging and foreign animal disease pathogens, and their utility as s routine diagnosis and surveillance tool. A second goal of the study is to better understand mechanisms of African swine fever virus (ASFV) infection in pigs to aid the development of countermeasures and diagnostics. There is no vaccine available for ASF. ASF outbreak is on the rise on several European countries. Though ASF is not currently in the U.S., a potential outbreak in the U.S. would be detrimental to the swine industry and the US agricultural economy. We pursued a genome-wide approach to characterize the pig immune responses after ASFV infection. We used RNA sequencing and bioinformatics methods to identify genes and pathways that are affected during ASF infection. We have identified a list of most differentially expressed genes that are in the immune response pathways.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2017

Spatial and Temporal Analysis of Bias HAST System Temperature

High-reliability components for high-consequence systems require detailed testing of operation after having undergone highly accelerated stress testing (HAST) under unusual conditions of high-temperature and humidity. This paper describes the design and operation of a system called "Wormwood" that is a highly multiplexed temperature measurement system that is designed to operate under HAST conditions to allow measurement of the temperature as a function of time and position in a HAST chamber. HAST chambers have single-point temperature measurements that can be traceable to NIST standards. The objective of these "Wormwood" measurements is to verify the uniformity and stability of the remaining volume of the HAST chamber with respect to the single traceable standard.

42 ENGINEERING↗
DOE OSTI2017

Microwave Readout Techniques for Very Large Arrays of Nuclear Sensors

During this project, we transformed the use of microwave readout techniques for nuclear sensors from a speculative idea to reality. The core of the project consisted of the development of a set of microwave electronics able to generate and process large numbers of microwave tones. The tones can be used to probe a circuit containing a series of electrical resonances whose frequency locations and widths depend on the state of a network of sensors, with one sensor per resonance. The amplitude and phase of the tones emerging from the circuit are processed by the same electronics and are reduced to the sensor signals after two demodulation steps. This approach allows a large number of sensors to be interrogated using a single pair of coaxial cables. We successfully developed hardware, firmware, and software to complete a scalable implementation of these microwave control electronics and demonstrated their use in two areas. First, we showed that the electronics can be used at room temperature to read out a network of diverse sensor types relevant to safeguards or process monitoring. Second, we showed that the electronics can be used to measure large numbers of ultrasensitive cryogenic sensors such as gamma-ray microcalorimeters. In particular, we demonstrated the undegraded readout of up to 128 channels and established a path to even higher multiplexing factors. These results have transformed the prospects for gamma-ray spectrometers based on cryogenic microcalorimeter arrays by enabling spectrometers whose collecting areas and count rates can be competitive with high purity germanium but with 10x better spectral resolution.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2017

Low Global Warming Potential Refrigerants for Commercial Refrigeration Systems

Supermarket refrigeration systems account for approximately 50% of supermarket energy use, placing this class of equipment among the highest energy consumers in the commercial building domain. In addition, the commonly used refrigeration system in supermarket applications is the multiplex direct expansion (DX) system, which is prone to refrigerant leaks due to its long lengths of refrigerant piping. This leakage reduces the efficiency of the system and increases the impact of the system on the environment. The high Global Warming Potential (GWP) of the hydrofluorocarbon (HFC) refrigerants commonly used in these systems, coupled with the large refrigerant charge and the high refrigerant leakage rates leads to significant direct emissions of greenhouse gases into the atmosphere. Environmental concerns are driving regulations for the heating, ventilating, air-conditioning and refrigeration (HVAC&R) industry towards lower GWP alternatives to HFC refrigerants. Existing lower GWP refrigerant alternatives include hydrocarbons, such as propane (R-290) and isobutane (R-600a), as well as carbon dioxide (R-744), ammonia (R-717), and R-32. In addition, new lower GWP refrigerant alternatives are currently being developed by refrigerant manufacturers, including hydrofluoro-olefin (HFO) and unsaturated hydrochlorofluorocarbon (HCFO) refrigerants. The selection of an appropriate refrigerant for a given refrigeration application should be based on several factors, including the GWP of the refrigerant, the energy consumption of the refrigeration system over its operating lifetime, and leakage of refrigerant over the system lifetime. For example, focusing on energy efficiency alone may overlook the significant environmental impact of refrigerant leakage; while focusing on GWP alone might result in lower efficiency systems that result in higher indirect impact over the equipment lifetime. Thus, the objective of this Collaborative Research and Development Agreement (CRADA) between Honeywell and the Oak Ridge National Laboratory (ORNL) is to develop a Life Cycle Climate Performance (LCCP) modeling tool for optimally designing HVAC&R equipment with lower life cycle greenhouse gas emissions, and the selection of alternative working fluids that reduce the greenhouse gas emissions of HVAC&R equipment. In addition, an experimental evaluation program is used to measure the coefficient of performance (COP) and refrigerating capacity of various refrigerant candidates, which have differing GWP values, in commercial refrigeration equipment. Through a cooperative effort between industry and government, alternative working fluids will be chosen based on maximum reduction in greenhouse gases at minimal cost impact to the consumer. This project will ultimately result in advancing the goals of reducing greenhouse gas emissions through the use of low GWP working fluids and technologies for HVAC&R and appliance equipment, resulting in cost-competitive products and systems.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2017

Particle integrity, sampling, and application of a DNA-tagged tracer for aerosol transport studies

Aerosols are an ever-present part of our daily environment and have extensive effects on both human and environmental health. Particles in the inhalable range (1-10 μm diameter) are of particular concern because their deposition in the lung can lead to a variety of illnesses including allergic reactions, viral or bacterial infections, and cancer. Understanding the transport of inhalable aerosols across both short and long distances is necessary to predict human exposures to aerosols. To assess the transport of hazardous aerosols, surrogate tracer particles are required to measure their transport through occupied spaces. These tracer particles must not only possess similar transport characteristics to those of interest but also be easily distinguished from the background at low levels and survive the environmental conditions of the testing environment. A previously-developed DNA-tagged particle (DNATrax), composed of food-grade sugar and a DNA oligonucleotide as a “barcode” label, shows promise as a new aerosol tracer. Herein, the use of DNATrax material is validated for use in both indoor and outdoor environments. Utilizing passive samplers made of materials commonly found in indoor environments followed by quantitative polymerase chain reaction (qPCR) assay for endpoint particle detection, particles detection was achieved up to 90 m from the aerosolization location and across shorter distances with high spatial resolution. The unique DNA label and PCR assay specificity were leveraged to perform multiple simultaneous experiments. This allowed the assessment of experimental reproducibility, a rare occurrence among aerosol field tests. To transition to outdoor testing, the solid material provides some protection of the DNA label when exposed to ultraviolet (UV) radiation, with 60% of the DNA remaining intact after 60 minutes under a germicidal lamp and the rate of degradation declining with irradiation time. Additionally, exposure of the DNATrax material using formulations of two different food-grade sugars (maltodextrin and erythritol) to humidity as high as 66% had no significant effect on the DNA label’s degradation or the particle’s aerodynamic diameter, confirming particle stability under such conditions. In summary, confirmation of the DNATrax particles’ size and label integrity under variable conditions combined with experiment multiplexing and high resolution sampling provides a powerful experimental design for modeling aerosol transport through occupied indoor and outdoor locations.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2017

Fast Switching Magnet for Heavy Ion Beam Separation

Fast magnets for multiplexing ion beams between different beamlines are technologically challenging and expensive, but there is an ever-growing need to develop such systems for beam separation at research and industrial facilities. For example, The Argonne Tandem Linac Accelerator System (ATLAS) is planning to expand its operations as a multi-user facility and there is a clear need, presently unmet by the industry, for a switching magnet system with the sub-millisecond transient times.In response to this problem, RadiaBeam Technologies is developing a novel pulsed switching magnet system capable of producing a 1.1T peak field over 45 cm length with a short (<1 ms) rise and fall time. The key enabling innovation in this project is an introduction of a solid-state interposed modulator architecture, which enables to improve magnet performance and reliability and reduce the cost to a practical level.

43 PARTICLE ACCELERATORS↗
DOE OSTI2017

Optical Encoding Technology for Viral Screening Panels Final Report CRADA No TC02132.0

This was a collaborative effort between Lawrence Livermore National Security, LLC, Lawrence Livermore National Laboratory (LLNL) and Parallel Synthesis Technologies, Inc. (PSTI), to develop Optical Encoding Technology for Viral Screening Panels. The goal for this effort was to prepare a portable bead reader system that would enable the development of viral and bacterial screening panels which could be used for the detection of any desired set of bacteria or viruses in any location. The main objective was to determine if the combination of a bead-based, PCR suspension array technology, formulated from Parallume encoded beads and PSTI’s multiplex assay reader system (MARS), could provide advantages in terms of the number of simultaneously measured samples, portability, ruggedness, ease of use, accuracy, precision or cost as compared to the Luminexbased system developed at LLNL. The project underwent several no cost extensions however the overall goal of demonstrating the utility of this new system was achieved. As a result of the project a significant change to the type of bead PSTI used for the suspension system was implemented allowing better performance than the commercial Luminex system.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2017

A Full Mesh ATCA-based General Purpose Data Processing Board (Pulsar II)

The Pulsar II is a custom ATCA full mesh enabled FPGA-based processor board which has been designed with the goal of creating a scalable architecture abundant in flexible, non-blocking, high bandwidth interconnections. The design has been motivated by silicon-based tracking trigger needs for LHC experiments. In this technical memo we describe the Pulsar II hardware and its performance, such as the performance test results with full mesh backplanes from different vendors, how the backplane is used for the development of low-latency time-multiplexed data transfer schemes and how the inter-shelf and intra-shelf synchronization works.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2018

Next Generation Qualification: Guralp Systems Affinity Digitizer Evaluation

Sandia National Laboratories has tested and evaluated a new digitizer, the Affinity, manufactured by Guralp Systems Ltd. These digitizers are used to record sensor output for seismic and infrasound monitoring applications. The purpose of the digitizer evaluation was to measure the performance characteristics in such areas as power consumption, input impedance, sensitivity, full scale, self-noise, dynamic range, system noise, response, passband, and timing. The Affinity digitizer is Guralp's latest release in their digitizer product line. The Affinity is available with either 4 or 8 channels at 24 bit resolution. In addition to the 24 bit channels, 16 multiplexed low resolution channels are provided. Other features include the means to accept multiple types of timing sources (e.g. GPS, NTP and PTP) and a web page interface for command and control of the unit.

47 OTHER INSTRUMENTATION↗
DOE OSTI2018

Time Dependent Analysis of Laser Heating of Metal Parts in Contact with HE

We consider the time dependent heat transfer of laser energy impinging on metal parts that are in contact with high explosives (HE). The predecessor to this calculation was TN-J4-17-2109, “Heat Transfer Analysis from Laser Energy on Metal Parts in Contact with HE”, which considered the time independent heat transfer and compared to experimental results. The intent here is to extend those results to the time dependent case. The steady-state results were developed because they were the “worst case” from a safety perspective: the steady state represents the highest possible temperature excursion. However, we found that the temperatures achieved were well above the safety limits established by the DOE High Explosives Safety Manual. Moreover, they were well above the safety limit published by the LANL / Weapons Facilities Operations (WFO) in WFO-OS-ES-48, which establishes an upper temperature limit of 70°C for metal in contact with High Explosive (HE). The J-4 response to the original results was to design, build, and deploy an interlock system for DARHT that would ensure no laser energy on the firing point when both personnel and HE were present. This system was tested and proved effective, refer TP-DARHT-1150, (12/19/2016). It was reviewed and approved by the LANL Explosives Instrumentation Review Committee, refer PRES-J4-16-2140, “DARHT Laser Diagnostics Interlock System: Presentation to the EIRC”, (2016). Although the interlock system prevented personnel from being on the firing point under conditions where the diagnostic lasers would heat metal above the WFO limit, the WFO limit was still exceeded during the Multiplexed Photonic Doppler Velocimetry (MPDV) tuning process. The only practical solution is to limit the amount of time that the MPDV lasers are engaged at full power. The diagnostics interlock system was implemented with laser shutters that can fully interrupt the beams, and these shutters can be used to limit the amount of time that the lasers will impinge on the hydrotest assembly. It is the purpose of this paper to provide quantitative guidance on what length of time can be permitted during this tuning process. Therefore, we will solve the time-dependent heat transfer equation to determine the temperature increase as a function of time. This function can be inverted to determine the maximum allowable time for energizing the lasers based on the maximum allowable temperature at the metal to HE interface.

42 ENGINEERING↗
DOE OSTI2018

Vibro-acoustic Testing for Microstructure Characterization and Metrology: Technology Commercialization Fund—Fiscal Year 2017

There is a need in nuclear reactors to inspect irradiated materials and structures. A portable scanning infrastructure for a material characterization technique called vibro acoustography (VA) is being developed by the Idaho National laboratory for nuclear applications to characterize fuel, cladding materials, and structures. The proposed VA technology is based on ultrasound and acoustic waves; however, it provides information beyond what is available from the traditional ultrasound techniques and can expand the knowledge on nuclear material characterization and microstructure evolution. VA technique has several advantages over traditional characterization techniques. VA is a non-contact submersion technique that is inherently wireless transmission and reception (from the ultrasonic transmitter to the acoustic receiver). The transmission medium can be most liquids used for reactor cooling such as water and sodium. For nuclear in-pile applications, the Ultrasonic Transducer (UT) will need to have a line of sight location that is within lower radiation flux zones. Multiple UT sources can be frequency multiplexed to allow a single hydrophone receiver to monitor several locations. The reactor structure can also be an integral part of the transmission system acting as waveguides to deliver the acoustic signal to an acoustic receiver. Because of the long wavelength of the acoustic signal, the acoustic receiver does not have to be line of sight with respect to the component under test. The focusing and generation of the acoustic beat frequency from two ultrasonic waves allows for the potential to ultrasonically image complex shapes. These features will significantly reduce experiment complexity, installation times and cost while being safe and easy to use.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2018

Laser-Driven Megavolt X-Ray and Neutron Source Optimization

This 4-month feasibility study assessed the options, trade-offs and major issues in using National Ignition Facility (NIF) and Advanced Radiographic Capability (ARC)-class laser beams for multipulse MeV x-ray and neutron radiography of high explosives (HE) driven experiments. It was performed in close collaboration with a second FS evaluating future HE radiography requirements and expected laser-based source data quality with respect to existing and alternate radiography sources. The study first reviewed the existing published data on MeV x-ray and neutron sources compared to requirements on yield (10 14 /sr for X-rays, > 10 13 /sr for neutrons), spot size (< 1 mm) and duration (< 20 ns). For MeV neutron sources, the preferred options are DTfilled exploding pusher targets or stagnating DT plasmas, each source requiring 50 kJ level. few ns beam irradiation at 0.5 or 0.35 micron wavelength. The preferred X-ray MeV source option to be fully assessed by a follow-up SI is an angularly and temporally-multiplexed multi-burst version of a Bremsstrahlung source (Courtois et al. 2011) irradiated by up to 7 10 ps, kJ-class 1 micron wavelength lasers beams. This multi-burst laser mode, submitted as an ROI and patent, should increase final laser optics damage energy thresholds based on 2 pulse tests and hence allow near full extraction of the 15 kJ of 1 micron laser energy available on a NIF beamline. Hydrodynamic simulations were used to evaluate the effects of preceding pulse irradiation on target integrity, and show that this can be mitigated by using 3D structured targets.

47 OTHER INSTRUMENTATION↗