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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,459 records · Page 81
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

Molecular mechanism of secreted amyloid-β precursor protein in binding and modulating GABABR1a

A recent phenomenal study discovered that the extension domain of secreted amyloid-β precursor protein (sAPP) can bind to the intrinsically disordered sushi 1 domain of the γ-aminobutyric acid type B receptor subunit 1a (GABA B R1a) and modulate its synaptic transmission. The work provided an important structural foundation for the modulation of GABA B R1a; however, the detailed molecular interaction mechanism, crucial for future drug design, remains elusive. Here, we further investigated the dynamical interactions between sAPP peptides and the natively unstructured sushi 1 domain using all-atom molecular dynamics simulations, for both the 17-residue sAPP peptide (APP 17-mer) and its minimally active 9 residue segment (APP 9-mer). We then explored mutations of the APP 9-mer with rigorous free energy perturbation (FEP) calculations. Our in silico mutagenesis studies revealed key residues (D4, W6, and W7) responsible for the binding with the sushi 1 domain. More importantly, one double mutation based on different vertebrate APP sequences from evolution exhibited a stronger binding (ΔΔG = -1.91 ± 0.66 kcal mol -1 ), indicating a potentially enhanced GABA B R1a modulator. These large-scale simulations may provide new insights into the binding mechanism between sAPP and the sushi 1 domain, which could open new avenues in the development of future GABA B R1a-specific therapeutics.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2020

Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism

Metabolites control immune cell functions, and delivery of these metabolites in a sustained manner may be able to modulate function of the immune cells. In this study, alpha-ketoglutarate (aKG) and diol based polymeric-microparticles (termed paKG MPs) were synthesized to provide sustained release of aKG and promote an immunosuppressive cellular phenotype. Notably, after association with dendritic cells (DCs), paKG MPs modulated the intracellular metabolic-profile/pathways, and decreased glycolysis and mitochondrial respiration in vitro. These metabolic changes resulted in modulation of MHC-II, CD86 expression in DCs, and altered the frequency of regulatory T cells (Tregs), and T-helper type-1/2/17 cells in vitro. In conclusion, this unique strategy of intracellular delivery of key-metabolites in a sustained manner provides a new direction in immunometabolism field-based immunotherapy with potential applications in different diseases associated with immune disorders.

36 MATERIALS SCIENCE↗
DOE OSTI2021

Doping-modulated strain control of bifunctional electrocatalysis for rechargeable zinc–air batteries

Changes in the local atomic arrangement in a crystal caused by lattice-mismatch-induced strain can efficiently regulate the performance of electrocatalysts for zinc–air batteries (ZABs) in many manners, mainly due to modulated electronic structure configurations that affect the adsorption energies for oxygen-intermediates formed during oxygen reduction and evolution reactions (ORR and OER). However, the application of strain engineering in electrocatalysis has been limited by the strain relaxation caused by structural instability such as dissolution and destruction, leading to insufficient durability towards the ORR/OER. In this work, we propose a doping strategy to modulate the phase transition and formation of self-supported cobalt fluoride–sulfide (CoFS) nanoporous films using a low amount of copper (Cu) as a dopant. This well-defined Cu–CoFS heterostructure overcomes the obstacle of structural instability. Our study of the proposed Cu–CoFS also helps establish the structure–property relationship of strained electrocatalysts by unraveling the role of local strain in regulating the electronic structure of the catalyst. As a proof-of-concept, the Cu–CoFS electrocatalyst with doping-modulated strain exhibited superior onset potentials of 0.91 V and 1.49 V for the ORR and OER, respectively, surpassing commercial Pt/C@RuO 2 and benchmarking non-platinum group metal (non-PGM) catalysts. ZABs with the Cu–CoFS catalyst delivered excellent charge/discharge cycling performance with an extremely low voltage gap of 0.5 V at a current density of 10 mA cm –2 and successively 0.93 V at a high current density of 100 mA cm –2 and afforded an outstanding peak power density of 255 mW cm –2 .

25 ENERGY STORAGE↗
DOE OSTI2010

The effects of nonadiabatic dust charge variation and ultraviolet irradiation on the modulational instability of dust ion acoustic waves

The effects of nonadiabatic dust charge fluctuation on the nonlinear propagation of the dust ion acoustic (DIA) waves in the dusty plasma with positively charged dust grains have been investigated. By using the reductive perturbation technique, a three-dimensional modified nonlinear Schroedinger equation (mNLSE) governing the nonlinear envelope DIA waves was derived and the approximate solitary wave solution of the mNLSE was also obtained in the weak effect of nonadiabatic dust charge fluctuation limit, which shows that the amplitude of the DIA solitary wave exponentially decreases with time due to the collisionless dissipation caused by the nonadiabatic dust charge variation. The frequency, instability growth rate, and the critical modulational wave number of the small amplitude modulation are all dependent on photoelectron generated by ultraviolet irradiation and time due to the presence of nonadiabatic dust charge variation. The transverse perturbation plays an important role in the modulational instability region.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2010

Excitation of surface plasma waves by a density-modulated electron beam in a magnetized plasma cylinder

A density-modulated electron beam propagating through a plasma cylinder excites surface plasma waves (SPWs) via Cerenkov and fast cyclotron interaction. A nonlocal theory of this process has been developed. Numerical calculations of the growth rate and unstable mode frequencies have been carried out for the typical parameters of the SPWs. The growth rate {gamma} (in rad/s) of the unstable wave instability increases with the modulation index {Delta} and has the largest value for {Delta}{approx}1 in addition to when the frequency and wave number of the modulation are comparable to that of the unstable wave. For {Delta}=0, {gamma} turns out to be {approx}6.06x10{sup 9} rad/s for Cerenkov interaction and {approx}5.47x10{sup 9} rad/s for fast cyclotron interaction. The growth rate of the instability increases with the beam density and scales as one-third power of the beam density in Cerenkov interaction and is proportional to the square root of beam density in fast cyclotron interaction. The real part of the frequency of the unstable wave increases as almost the square root of the beam voltage. The results of the theory are applied to explain some of the experimental observations.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2011

Modulational instability of ion-acoustic waves in plasmas with superthermal electrons

Using the reductive perturbation technique, the modulational instability of ion- acoustic waves in a plasma containing superthermal electrons is studied. It is found that the presence of superthermal electrons significantly changes the instability domain. A Lorentzian (kappa) velocity distribution function is used to model superthermal electrons. It is shown that the presence of superthermal electrons reduces the critical frequency of the modulational instability of ion-acoustic waves. Besides, due to the presence of the superthermal electrons, ion-acoustic waves are unstable on a vaster region. Moreover, the modulational instability growth rate is larger for a larger population of superthermal electrons.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2011

Modulational instability and nonlinear evolution of two-dimensional electrostatic wave packets in ultra-relativistic degenerate dense plasmas

We consider the nonlinear propagation of electrostatic wave packets in an ultra-relativistic (UR) degenerate dense electron-ion plasma, whose dynamics is governed by the nonlocal two-dimensional nonlinear Schroedinger-like equations. The coupled set of equations is then used to study the modulational instability (MI) of a uniform wave train to an infinitesimal perturbation of multidimensional form. The condition for the MI is obtained, and it is shown that the nondimensional parameter, {beta}{proportional_to}{lambda}{sub C}n{sub 0}{sup 1/3} (where {lambda}{sub C} is the reduced Compton wavelength and n{sub 0} is the particle number density) associated with the UR pressure of degenerate electrons, shifts the stable (unstable) regions at n{sub 0{approx}}10{sup 30}cm{sup -3} to unstable (stable) ones at higher densities, i.e., n{sub 0} > or approx. 7x10{sup 33}. It is also found that the higher the values of n{sub 0}, the lower is the growth rate of MI with cut-offs at lower wave numbers of modulation. Furthermore, the dynamical evolution of the wave packets is studied numerically. We show that either they disperse away or they blowup in a finite time, when the wave action is below or above the threshold. The results could be useful for understanding the properties of modulated wave packets and their multidimensional evolution in UR degenerate dense plasmas, such as those in the interior of white dwarfs and/or pre-Supernova stars.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2011

Quantum stochastic processes for maps on Hilbert C*-modules

We discuss pairs ({phi}, {Phi}) of maps, where {phi} is a map between C*-algebras and {Phi} is a {phi}-module map between Hilbert C*-modules, which are generalization of representations of Hilbert C*-modules. A covariant version of Stinespring's theorem for such a pair ({phi}, {Phi}) is established, and quantum stochastic processes constructed from pairs ({l_brace}{phi}{sub t{r_brace}}, {l_brace}{Phi}{sub t{r_brace}}) of families of such maps are studied. We prove that the quantum stochastic process J={l_brace}J{sub t{r_brace}} constructed from a {phi}-quantum dynamical semigroup {Phi}={l_brace}{Phi}{sub t{r_brace}} is a j-map for the quantum stochastic process j={l_brace}j{sub t{r_brace}} constructed from the given quantum dynamical semigroup {phi}={l_brace}{phi}{sub t{r_brace}}, and that J is covariant if the {phi}-quantum dynamical semigroup {Phi} is covariant.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2012

Test particle simulation of direct laser acceleration in a density-modulated plasma waveguide

Direct laser acceleration (DLA) of electrons by the use of the intense axial electric field of an ultrafast radially polarized laser pulse is a promising technique for future compact accelerators. Density-modulated plasma waveguides can be implemented for guiding the propagation of the laser pulse to extend the acceleration distance and for the quasi-phase-matching between the accelerated electrons and the laser pulse. A test particle model is developed to study the optimal axial density modulation structure of plasma waveguides for laser pulses to efficiently accelerate co-propagating electrons. A simple analytical approach is also presented, which can be used to estimate the energy gain in DLA. The analytical model is validated by the test particle simulation. The effect of injection phase and acceleration of electrons injected at various radial positions are studied. The results indicate that a positively chirped density modulation of the waveguide structure is required to accelerate electron with low initial energies, and can be effectively optimized. A wider tolerance on the injection phase and radial distance from the waveguide axis exists for electrons injected with a higher initial energy.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2013

Electronic and magnetic tunability of Sr{sub 2}CrReO{sub 6} films by growth-mediated oxygen modulation

Highly ordered epitaxial films of ferrimagnetic semiconductor Sr{sub 2}CrReO{sub 6} (SCRO) have been fabricated by off-axis magnetron sputtering, and characterized as a function of the oxygen partial pressure. In this Letter, we report 18 000% modulation in electrical resistivity at T = 7K (60% at room temperature) from a 1% modulation in the oxygen partial pressure during film growth. The growth window was centered at peak saturation magnetization, which drops due to both increasing and decreasing oxygen growth pressure. The results suggest that n-type doping due to oxygen vacancies plays a dominant role in the electrical properties and modulation of Sr{sub 2}CrReO{sub 6} thin films.

36 MATERIALS SCIENCE↗
DOE OSTI2013

Physics basis of Multi-Mode anomalous transport module

The derivation of Multi-Mode anomalous transport module version 8.1 (MMM8.1) is presented. The MMM8.1 module is advanced, relative to MMM7.1, by the inclusion of peeling modes, dependence of turbulence correlation length on flow shear, electromagnetic effects in the toroidal momentum diffusivity, and the option to compute poloidal momentum diffusivity. The MMM8.1 model includes a model for ion temperature gradient, trapped electron, kinetic ballooning, peeling, collisionless and collision dominated magnetohydrodynamics modes as well as model for electron temperature gradient modes, and a model for drift resistive inertial ballooning modes. In the derivation of the MMM8.1 module, effects of collisions, fast ion and impurity dilution, non-circular flux surfaces, finite beta, and Shafranov shift are included. The MMM8.1 is used to compute thermal, particle, toroidal, and poloidal angular momentum transports. The fluid approach which underlies the derivation of MMM8.1 is expected to reliably predict, on an energy transport time scale, the evolution of temperature, density, and momentum profiles in plasma discharges for a wide range of plasma conditions.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2013

G-equivariant {phi}-coordinated quasi modules for quantum vertex algebras

This is a paper in a series to study quantum vertex algebras and their relations with various quantum algebras. In this paper, we introduce a notion of T-type quantum vertex algebra and a notion of G-equivariant {phi}-coordinated quasi module for a T-type quantum vertex algebra with an automorphism group G. We refine and extend several previous results and we obtain a commutator formula for G-equivariant {phi}-coordinated quasi modules. As an illustrating example, we study a special case of the deformed Virasoro algebra Vir{sub p,q} with q=-1, to which we associate a Clifford vertex superalgebra and its G-equivariant {phi}-coordinated quasi modules.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2013

Combined Opto-Acoustical sensor modules for KM3NeT

KM3NeT is a future multi-cubic-kilometre water Cherenkov neutrino telescope currently entering a first construction phase. It will be located in the Mediterranean Sea and comprise about 600 vertical structures called detection units. Each of these detection units has a length of several hundred metres and is anchored to the sea bed on one side and held taut by a buoy on the other side. The detection units are thus subject to permanent movement due to sea currents. Modules holding photosensors and additional equipment are equally distributed along the detection units. The relative positions of the photosensors has to be known with an uncertainty below 20 cm in order to achieve the necessary precision for neutrino astronomy. These positions can be determined with an acoustic positioning system: dedicated acoustic emitters located at known positions and acoustic receivers along each detection unit. This article describes the approach to combine an acoustic receiver with the photosensors inside one detection module using a common power supply and data readout. The advantage of this approach lies in a reduction of underwater connectors and module configurations as well as in the compactification of the detection units integrating the auxiliary devices necessary for their successful operation.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2013

Modulational instability of spin modified quantum magnetosonic waves in Fermi-Dirac-Pauli plasmas

A theoretical and numerical study of the modulational instability of large amplitude quantum magnetosonic waves (QMWs) in a relativistically degenerate plasma is presented. A modified nonlinear Schrödinger equation is derived by using the reductive perturbation method. The modulational instability regions of the QMWs and the corresponding growth rates are significantly affected by the relativistic degeneracy parameter, the Pauli spin magnetization effects, and the equilibrium magnetic field. The dynamics and nonlinear saturation of the modulational instability of QMWs are investigated numerically. It is found that the increase of the relativistic degeneracy parameter can increase the growth rate of the instability, and the system is saturated nonlinearly by the formation of envelope solitary waves. The current investigation may have relevance to astrophysical magnetized compact objects, such as white dwarfs and pulsar magnetospheres.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2013

Spatially addressable design of gradient index structures through spatial light modulator based holographic lithography

In this paper, we present an achievable gradient refractive index in bi-continuous holographic structures that are formed through five-beam interference. We further present a theoretic approach for the realization of gradient index devices by engineering the phases of the interfering beams with a pixelated spatial light modulator. As an example, the design concept of a gradient index Luneburg lens is verified through full-wave electromagnetic simulations. These five beams with desired phases can be generated through programming gray level super-cells in a diffractive spatial light modulator. As a proof-of-concept, gradient index structures are demonstrated using synthesized and gradient phase patterns displayed in the spatial light modulator.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2014

The high Beta cryo-modules and the associated cryogenic system for the HIE-ISOLDE upgrade at CERN

The major upgrade of the energy and intensity of the existing ISOLDE and REX-ISOLDE radioactive ion beam facilities at CERN requires the replacement of most of the existing ISOLDE post-acceleration equipment by a superconducting linac based on quarter-wave resonators housed together with superconducting solenoids in a series of four high-β and two low-β cryo-modules. As well as providing optimum conditions for physics, the cryo-modules need to function under stringent vacuum and cryogenic conditions. We present the detail design and expected cryogenic performance of the high- β cryo-module together with the cryogenic supply and distribution system destined to service the complete superconducting linac.

43 PARTICLE ACCELERATORS↗
DOE OSTI2014

Graded Hilbert C*-modules

The notion of Hilbert C*-modules graded by a semilattice was first introduced in the study of many-body systems. We show the relationship between these Hilbert C*-modules and their homogeneous subspaces. We study the stability of graded Hilbert C*-modules under tensor products and crossed products.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2014

Modulational instability of electrostatic acoustic waves in an electron-hole semiconductor quantum plasma

The modulational instability of quantum electrostatic acoustic waves in electron-hole quantum semiconductor plasmas is investigated using the quantum hydrodynamic model, from which a modified nonlinear Schrödinger equation with damping effects is derived using the reductive perturbation method. Here, we consider the combined effects of quantum recoil, quantum degenerate pressures, as well as the exchange-correlation effect standing for the electrons (holes) spin. The modulational instability for different semiconductors (GaAs, GaSb, and InP) is discussed. The collision between electron (hole) and phonon is also investigated. The permitted maximum time for modulational instability and the damping features of quantum envelope solitary wave are all determined by the collision. The approximate solitary solution with damping effects is presented in weak collision limit. The damping properties were discussed by numerical method.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗