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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,459 records · Page 81
All sourcesNASA NTRSDOE OSTI
DOE OSTI2014

Phases 1 & 2—Coal-Based Oxy-Fuel System Evaluation and Combustor Development and Phase 2A—Recovery Act: Oxy-Fuel Turbomachinery Development for Energy Intensive Industrial Applications (Final Report, Rev.1)

Clean Energy Systems, Inc. (CES) partnered with the U.S. Department of Energy’s National Energy Technology Laboratory in 2005 to study and develop a competing technology for use in future fossil-fueled power generation facilities that could operate with near zero emissions. CES’s background in oxy-fuel (O-F) rocket technology lead to the award of Cooperative Agreement DE-FC26-05NT42645, “Coal-Based Oxy-Fuel System Evaluation and Combustor Development,” where CES was to first evaluate the potential of these O-F power cycles, then develop the detailed design of a commercial-scale O-F combustor for use in these clean burning fossil-fueled plants. Throughout the studies, CES found that in order to operate at competitive cycle efficiencies a high-temperature intermediate pressure turbine was required. This led to an extension of the Agreement for, “Oxy-Fuel Turbomachinery Development for Energy Intensive Industrial Applications” where CES was to also develop an intermediate-pressure O-F turbine (OFT) that could be deployed in O-F industrial plants that capture and sequester >99% of produced CO 2 , at competitive cycle efficiencies using diverse fuels. The following report details CES’ activities from October 2005 through March 2013, to evaluate O-F power cycles, develop and validate detailed designs of O-F combustors (main and reheat), and to design, manufacture, and test a commercial-scale OFT, under the three-phase Cooperative Agreement.

01 COAL, LIGNITE, AND PEAT↗
DOE OSTI2016

Development of Xe and Kr empirical potentials for CeO 2 , ThO 2 , UO 2 and PuO 2 , combining DFT with high temperature MD

In this study, the development of embedded atom method (EAM) many-body potentials for actinide oxides and associated mixed oxide (MOX) systems has motivated the development of a complementary parameter set for gas-actinide and gas-oxygen interactions. A comprehensive set of density functional theory (DFT) calculations were used to study Xe and Kr incorporation at a number of sites in CeO 2 , ThO 2 , UO 2 and PuO 2 . These structures were used to fit a potential, which was used to generate molecular dynamics (MD) configurations incorporating Xe and Kr at 300 K, 1500 K, 3000 K and 5000 K. Subsequent matching to the forces predicted by DFT for these MD configurations was used to refine the potential set. This fitting approach ensured weighted fitting to configurations that are thermodynamically significant over a broad temperature range, while avoiding computationally expensive DFT-MD calculations. The resultant gas potentials were validated against DFT trapping energies and are suitable for simulating combinations of Xe and Kr in solid solutions of CeO 2 , ThO 2 , UO 2 and PuO 2 , providing a powerful tool for the atomistic simulation of conventional nuclear reactor fuel UO 2 as well as advanced MOX fuels.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2024

High phenotypic and genotypic plasticity among strains of the mushroom-forming fungus Schizophyllum commune

Schizophyllum commune is a mushroom-forming fungus notable for its distinctive fruiting bodies with split gills. It is used as a model organism to study mushroom development, lignocellulose degradation and mating type loci. It is a hypervariable species with considerable genetic and phenotypic diversity between the strains. In this study, we systematically phenotyped 16 dikaryotic strains for aspects of mushroom development and 18 monokaryotic strains for lignocellulose degradation. There was considerable heterogeneity among the strains regarding these phenotypes. The majority of the strains developed mushrooms with varying morphologies, although some strains only grew vegetatively under the tested conditions. Growth on various carbon sources showed strain-specific profiles. The genomes of seven monokaryotic strains were sequenced and analyzed together with six previously published genome sequences. Moreover, the related species Schizophyllum fasciatum was sequenced. Although there was considerable genetic variation between the genome assemblies, the genes related to mushroom formation and lignocellulose degradation were well conserved. These sequenced genomes, in combination with the high phenotypic diversity, will provide a solid basis for functional genomics analyses of the strains of S. commune.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1996

Comparison of lightning observations from the KSC LDAR system with radar observations from the NCAR CP-2 radar

This grant supported observations of thunderstorms at Kennedy Space Center during the summer of 1995. In particular, we obtained detailed observations of lightning-producing storms over KSC with the CP2 radar of the National Center for Atmospheric Research (NCAR), for the purpose of comparing these with observations from KSC's Lightning Detection and Ranging (LDAR) system. The NCAR radar was a special purpose dual-polarization system for studying the development of precipitation in storms and was at KSC for another project, the Small Cumulus Microphysics Study - SCMS. We used the radar on a non-interference basis to obtain the desired observations. In addition we recorded the electrostatic field change of the lightning discharges at two locations. Subsequent to the field observational period we compared the LDAR lightning observations with the storm structure as indicated by the radar. The results obtained to date are summarized briefly as follows: (1) The initial lightning sequence in a small developing storm was observed to occur in a region of the storm where supercooled raindrops had frozen within the previous few minutes. This is consistent with the idea that the storm electrification is produced by interactions between ice particles. (2) The lightning discharges tended to avoid regions of supercooled liquid raindrops, possibly indicating that corona from the drops reduces any electrification in the vicinity of the drops. (3) 'Bilevel' lightning discharges within storms have been confirmed to be between the level of negative charge at mid-levels in the storm and the upper storm level. This is consistent with and expands upon our understanding that storms have a basic dipolar charge structure. (4) The upward channels of the intracloud lightning discharges are often aligned with shafts of strong precipitation, and often begin just above the upper extent of 40 dBZ reflectivity in the precipitation shaft. This is consistent with a precipitation-based mechanism of electrification.

Krehbiel, Paul↗
NASA NTRS2017

Time Resolved Stereo Particle Image Velocimetry Measurements of the Instabilities Downstream of a Backward-Facing Step in a Swept-Wing Boundary Layer

Time-resolved particle image velocimetry (TRPIV) measurements are performed down-stream of a swept backward-facing step, with a height of 49% of the boundary-layer thickness. The results agree well qualitatively with previously reported hotwire measurements, though the amplitudes of the fluctuating components measured using TRPIV are higher. Nonetheless, the low-amplitude instabilities in the flow are fairly well resolved using TR- PIV. Proper orthogonal decomposition is used to study the development of the traveling cross flow and Tollmien-Schlichting (TS) instabilities downstream of the step and to study how they interact to form the large velocity spikes that ultimately lead to transition. A secondary mode within the traveling cross flow frequency band develops with a wavelength close to that of the stationary cross flow instability, so that at a certain point in the phase, it causes an increase in the spanwise modulation initially caused by the stationary cross flow mode. This increased modulation leads to an increase in the amplitude of the TS mode, which, itself, is highly modulated through interactions with the stationary cross flow. When the traveling cross flow and TS modes align in time and space, the large velocity spikes occur. Thus, these three instabilities, which are individually of low amplitude when the spikes start to occur (U'rms/Ue <0.03), interact and combine to cause a large flow disturbance that eventually leads to transition.

Eppink, Jenna L.↗
DOE OSTI2023

BlueSTEAl: A pair of silicon arrays and a zero-degree phoswich detector for studies of scattering and reactions in inverse kinematics

BlueSTEAl, the Blue (aluminum chamber of) Silicon TElescope Arrays for light nuclei, has been developed to study direct reactions in inverse kinematics, as well as scattering and breakup reactions using radioactive ion beams. It is a detector system consisting of a pair of annular silicon detector arrays and a zero-degree phoswich plastic scintillator. For typical binary reaction studies in inverse kinematics, light ions are detected by the Si array in coincidence with heavy recoils detected by the phoswich placed at the focal-plane of a zero-degree magnetic spectrometer. The Si array can also be used to detect light nuclei such as beryllium and carbon with clear isotope separation, while the phoswich can also be placed at zero degrees without a spectrometer and used as a high-efficiency beam counting monitor with particle identification capability at the rate of up to ~5 × 10 4 particles per second. This paper reports on the capabilities of BlueSTEAl as determined by recent experiments performed at the Texas A&M Cyclotron Institute. Furthermore, the device is also anticipated to be used in future experiments at other radioactive ion beam facilities.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
NASA NTRS1975

Design definition study of a lift/cruise fan technology V/STOL airplane: Summary

A two-engine three-fan V/STOL airplane was designed to fulfill naval operational requirements. A multimission airplane was developed from study of specific point designs. Based on the multimission concept, airplanes were designed to demonstrate and develop the technology and operational procedures for this class of aircraft. Use of interconnected variable pitch fans led to a good balance between high thrust with responsive control and efficient thrust at cruise speeds. The airplanes and their characteristics are presented.

Zabinsky, J. M.↗
NASA NTRS2022

Mission Planning for Trident: Discovery proposal to Neptune’s moon, Triton

Trident was one of the four Discovery-class Step-1 mission proposals selected by NASA in 2020 for further development and study; however, in 2021, the Step-2 proposal was not down-selected to transition into the next phase of mission development, i.e., a mission for flight.Neptune’s largest moon, Triton, was the primary focus of study for Trident. Triton’s physical and orbital characteristics make it a unique planetary target for scientific exploration, providing opportunities for investigations in a wide variety of scientific fields, including geomorphological, atmospheric, geophysical, magnetospheric, and ionospheric studies. The science objectives of the Trident mission encompassed an in-depth interior-to-exterior set of objectives, focused on multiple outstanding questions resulting from the 1989 encounter of Voyager 2, and subsequent analysis.Ball Aerospace Corp. was tasked with building the Trident spacecraft, with JPL responsible for providing Engineering Support (Mission Design & Navigation, Mission Planning, Flight Operations, Ground Data Systems, Systems Engineering) and leading Project Management. The observatory would carry a wide-ranging suite of scientific instruments onboard, including an Infrared Spectrometer (IRS) and Narrow Angle Camera (NAC) to be provided by Ball Aerospace Corp., a Wide Angle Camera (WAC) from JPL, a Magnetometer from UCLA, a contributed Plasma Science Suite from IRF (Sweden), and a contributed Radio Science instrument from ASI (Italy). All of these instruments would be used to collect unique datasets during the Triton encounter. Trident would have taken advantage of an ~13-yr, nearly-ballistic trajectory to Triton, utilizing a timely Jupiter Gravity Assist, to execute a 10-day long encounter in the Neptunian system. Launch was planned for October 2025, with Triton arrival scheduled for December 2038. The timeline for this mission would have been sub-divided into seven major phases: Launch, Commissioning, Inner Planet Cruise, Outer Planet Cruise, Approach, Encounter, and Science Data Return. Multiple planetary flybys were planned to be performed during the cruise, including three Earth flybys and one Venus flyby in the Inner Planet Cruise phase, and one Jupiter flyby in the Outer Planet Cruise phase. Along with conventional (Range and Doppler) tracking data, Delta-DOR and Optical Navigation data were also to be acquired to assist with spacecraft navigation during the Approach and Encounter phases. A 3 meter X-Band High Gain Antenna would allow playback of all science data at 1 kbps within 1 year after the Triton Encounter. The Mission Planning element on Trident encompassed and informed multiple aspects of this proposal, ranging from science observation planning during the Triton Encounter phase, to generation of activity timelines for all mission phases; performing ground coverage analysis for science observations to be acquired by all instruments and tracing them to science requirements; evaluation of spacecraft resources including data volume stored onboard, power/energy consumption, telecom (commanding/telemetry) requirements, and overall, working at the interface of science and engineering teams on the mission. All of these functions that were performed by the Mission Planning team on this proposal are discussed in this paper.

Prockter, Louise↗
NASA NTRS1976

A study of some effects of vertical shear on thunderstorms

Evidence is presented for the existence of vortices and vortex pairs in thunderstorms. A preliminary parameterized model of the nonthermal generation of thunderstorm vortices derived from field observations of storms and laboratory observations of a jet in crossflow is reported, together with an explanation of how such a model might be used to guide analysis of mesoscale rawinsonde, radar, and satellite data toward an improved capability for prediction of thunderstorm motion and growth. Preliminary analyses of radar and satellite data from Atmospheric Variability Experiment IV are used with available rawinsonde data to develop a correlation between wind shears, instability, and thunderstorm motion and development. Specific studies are recommended for best development of concepts and utilization of data from Atmospheric Variability and Atmospheric Variability Severe Storms Experiments.

Connell, J.↗
DOE OSTI2014

NMR spin relaxation in proteins: The patterns of motion that dissipate power to the bath

We developed in recent years the two-body coupled-rotator slowly relaxing local structure (SRLS) approach for the analysis of NMR relaxation in proteins. The two bodies/rotators are the protein (diffusion tensor D{sub 1}) and the spin-bearing probe, e.g., the {sup 15}N−{sup 1}H bond (diffusion tensor, D{sub 2}), coupled by a local potential (u). A Smoluchowski equation is solved to yield the generic time correlation functions (TCFs), which are sums of weighted exponentials (eigenmodes). By Fourier transformation one obtains the generic spectral density functions (SDFs) which underlie the experimental relaxation parameters. The typical paradigm is to characterize structural dynamics in terms of the best-fit values of D{sub 1}, D{sub 2}, and u. Additional approaches we pursued employ the SRLS TCFs, SDFs, or eigenmodes as descriptors. In this study we develop yet another perspective. We consider the SDF as function of the angular velocity associated with the fluctuating fields underlying NMR relaxation. A parameter called j-fraction, which represents the relative contribution of eigenmode, i, to a given value of the SDF function at a specific frequency, ω, is defined. j-fraction profiles of the dominant eigenmodes are derived for 0 ≤ ω ≤ 10{sup 12} rad/s. They reveal which patterns of motion actuate power dissipation at given ω-values, what are their rates, and what is their relative contribution. Simulations are carried out to determine the effect of timescale separation, D{sub 1}/D{sub 2}, axial potential strength, and local diffusion axiality. For D{sub 1}/D{sub 2} ≤ 0.01 and strong local potential of 15 k{sub B}T, power is dissipated by global diffusion, renormalized (by the strong potential) local diffusion, and probe diffusion on the surface of a cone (to be called cone diffusion). For D{sub 1}/D{sub 2} = 0.1, power is dissipated by mixed eigenmodes largely of a global-diffusion-type or cone-diffusion-type, and a nearly bare renormalized-local-diffusion eigenmode. For D{sub 1}/D{sub 2} > 0.1, most eigenmodes are of a mixed type. The analysis is affected substantially by reducing the potential strength from 15 to 5 k{sub B}T, and/or allowing for axial D{sub 2} with D{sub 2,∥}/D{sub 2,⊥} = 10. The scheme developed is applied to {sup 15}N−{sup 1}H relaxation from the β-sheet residue K19 and the α-helix residue A34 of the third immunoglobulin-binding domain of streptococcal protein G. Previous studies revealed rhombic local potentials with different rhombicity around C{sub i−1}{sup α}−C{sub i}{sup α}, and different timescale separation (0.047 for K19 and 0.102 for A34). Here, we find that K19 and A34 dissipate power to the bath through global diffusion, mixed cone-diffusion-related and mixed renormalized-local-diffusion-related motions. At small ω-values, A34 is more effective than K19 in dissipating power. In general, it executes faster cone-diffusion-type, and slower renormalized-local-diffusion-type and local-probe-fluctuation-type motions. K19 experiences faster N−H fluctuations than A34. Eigenmode clustering, experienced by K19 to a larger extent, is observed in the fast-probe-fluctuation regime. New information on the effect of the structural context on N−H bond dynamics has been obtained. The patterns of motion that dissipate NMR-relaxation-related power illuminate protein dynamics from a new perspective. They constitute yet another qualifier of N−H bond dynamics. This study sets the stage for developing ways for enhancing the contribution of desired pathways for power dissipation at selected angular velocities.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2016

Development and performance of a suprathermal electron spectrometer to study auroral precipitations

The design, development, and performance of Medium-energy Electron SPectrometer (MESP), dedicated to the in situ observation of suprathermal electrons in the auroral ionosphere, are summarized in this paper. MESP employs a permanent magnet filter with a light tight structure to select electrons with proper energies guided to the detectors. A combination of two avalanche photodiodes and a large area solid-state detector (SSD) provided 46 total energy bins (1 keV resolution for 3−20 keV range for APDs, and 7 keV resolution for >20 keV range for SSDs). Multi-channel ultra-low power application-specific integrated circuits are also verified for the flight operation to read-out and analyze the detector signals. MESP was launched from Poker Flat Research Range on 3 March 2014 as a part of ground-to-rocket electrodynamics-electrons correlative experiment (GREECE) mission. MESP successfully measured the precipitating electrons from 3 to 120 keV in 120-ms time resolution and characterized the features of suprathermal distributions associated with auroral arcs throughout the flight. The measured electrons were showing the inverted-V type spectra, consistent with the past measurements. In addition, investigations of the suprathermal electron population indicated the existence of the energetic non-thermal distribution corresponding to the brightest aurora.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
NASA NTRS2016

Development and Performance of a Suprathermal Electron Spectrometer to Study Auroral Precipitations

The design, development, and performance of Medium-energy Electron SPectrometer (MESP), dedicated to the in situ observation of suprathermal electrons in the auroral ionosphere, are summarized in this paper. MESP employs a permanent magnet filter with a light tight structure to select electrons with proper energies guided to the detectors. A combination of two avalanche photodiodes and a large area solid-state detector (SSD) provided 46 total energy bins (1 keV resolution for 3-20 keV range for APDs, and 7 keV resolution for greater than 20 keV range for SSDs). Multi-channel ultra-low power application-specific integrated circuits are also verified for the flight operation to read-out and analyze the detector signals. MESP was launched from Poker F1at Research Range on 3 March 2014 as a part of ground-to-rocket electrodynamics-electrons correlative experiment (GREECE) mission. MESP successfully measured the precipitating electrons from 3 to 120 keV in 120-ms time resolution and characterized the features of suprathermal distributions associated with auroral arcs throughout the flight. The measured electrons were showing the inverted-V type spectra, consistent with the past measurements. In addition, investigations of the suprathermal electron population indicated the existence of the energetic non-thermal distribution corresponding to the brightest aurora.

Ogasawara, Keiichi↗
NASA NTRS1985

Remote Sensing of Earth Terrain

The objective of this research is to develop theoretical models that are useful and practical in the remote sensing of the Earth environment including the Earth terrain, the lower and the upper atmospheres. Various models applicable to the microwave remote sensing of vegetation, snow-ice, and atmospheric precipitation have been developed. Such studies shall be extended to the higher frequency range to unify the optical band and the microwave theoretical foundations. The study, which had an emphasis on vegetation canopy to include all terrain media, and the whole Earth environment will be extended. A data base will be developed to generate scene radiation characteristics which will benefit the studies of global inhabitability, meteorological applications, and crop yield.

Kong, J. A.↗
DOE OSTI2026

A Sensitivity-driven Wide Area Protection (SWAP) Coordination Tool for High Penetration of Inverter-based Resources (IBR)

Traditionally, power system generation sources have been composed of synchronous generators, of which the fault current behavior is understood with minimal differences between generation size and types due to the physics of their construction. Present protection schemes and modeling methods are based upon these understood characteristics. Most renewable generation is composed of inverter-based resources (IBR), in which fault current is determined by switching control software and hardware limitations, each of which can vary between manufacturers and even between models of the same manufacturer. The resulting fault current is low in magnitude, low in negative-sequence current, unpredictable phase angles, and is a challenge to model. These characteristics also result in a challenge to traditional protection schemes and fault simulation software. To address several of these concerns, the project has the following goals: 1. Improve IBR models: Improve IBR models used in short circuit (SC) programs to accurately capture the response of IBRs at the bulk power system (BPS) level for fault and protection studies. 2. Develop automation tool: Develop an automation tool that allows engineers to identify protection coordination and sensitivity issues by performing SC and protection coordination studies in a high IBR-penetrated grid by applying variations to the IBR models, faults, contingencies, etc. 3. Develop schemes: Develop new protection mitigation solution schemes that complement the existing protection systems to ensure safe operation of the BPS with higher IBR penetration levels. The project team did not achieve this final goal, as the Department of Energy (DOE) stopped the project early due to changes in DOE funding priorities. The termination notice came at the beginning of the final project phase, while the team was identifying and beginning to investigate protection issues. It should be noted that the team discussed a 100% penetration scenario. However, this scenario would require the use of grid-forming IBR models that are not presently available. Since developing these models requires additional effort, the 100% penetration scenario was not pursued during this project. In the future, developing the methodology and models for the 100% scenario could benefit the industry.

14 SOLAR ENERGY↗
DOE OSTI2016

Dry Pretreatment of Used Nuclear Fuel for Tritium Removal: A Review

Virtually all the elements in the periodic chart are generated as a result of atomic fission in nuclear fuel. Several of the elements are volatile or can readily react with other chemicals to form volatile molecules that can be released during the processing of used nuclear fuel for the recovery of the valuable products. Among the volatile fission products, {sup 129}I, {sup 14}C, {sup 3}H, {sup 85}Kr, and {sup 79}Se constitute the main environmental concern for uncontrolled release. Storage of used fuel allows the short-lived isotopes to decay significantly (e.g., {sup 3}H decays in half every 12.32 years and {sup 85}Kr every 10.76 years). However, depending on regulatory limits they may remain an environmental concern up to about 50-100 years of fuel storage. In contrast, the concern for environmental release of the highly mobile {sup 129}I and {sup 14}C remains for geological times (half-lives of 15.7 million years for {sup 129}I and 5730 years for {sup 14}C). Processing of used commercial nuclear fuel requires significant head-end operations to remove the fuel from the protective coverings (e.g., assemblies). The current industrial process includes cropping the end caps of the fuel assemblies, chopping of the fuel pins and/or bundles into short segments, and prolonged leaching of the segments using concentrated nitric acid (HNO{sub 3}). The infrastructure, processes, and waste treatment systems in the head-end operations, including the associated off-gas system, are some of the larger and more costly components of the entire plant. The bulk of the volatile fission products are released to the off-gas during the leaching and dissolution. However, a small but significant amount will transfer to the following steps of processing such as solvent extraction and will show up in many different waste streams. The effective capture of {sup 3}H and iodine throughout the different processes and disposition of associated waste streams is costly and complicated. Up-front removal and capture is highly desirable. Currently, at the U.S. Department of Energy national laboratories and internationally, several dry pretreatment technologies are being studied and developed with the potential to simplify and increase the safety of subsequent storage or chemical recycling processes. These studies include (1) alternative decladding methods, (2) oxidation of exposed fuel following either conventional shearing or chemical decladding, and (3) the collection and stabilization of released volatile radionuclides. Several dry processes are being developed for the up-front removal of tritium and other fission products. They can be combined with different decladding alternatives and, in general, produce a fine powder that can be fed to aqueous or pyrochemical separations processes. (authors)

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2015

Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types

Safety pharmacology studies that evaluate new drug entities for potential cardiac liability remain a critical component of drug development. Current studies have shown that in vitro tests utilizing human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) may be beneficial for preclinical risk evaluation. We recently demonstrated that an in vitro multi-parameter test panel assessing overall cardiac health and function could accurately reflect the associated clinical cardiotoxicity of 4 FDA-approved targeted oncology agents using hiPS-CM. The present studies expand upon this initial observation to assess whether this in vitro screen could detect cardiotoxicity across multiple drug classes with known clinical cardiac risks. Thus, 24 drugs were examined for their effect on both structural (viability, reactive oxygen species generation, lipid formation, troponin secretion) and functional (beating activity) endpoints in hiPS-CM. Using this screen, the cardiac-safe drugs showed no effects on any of the tests in our panel. However, 16 of 18 compounds with known clinical cardiac risk showed drug-induced changes in hiPS-CM by at least one method. Moreover, when taking into account the Cmax values, these 16 compounds could be further classified depending on whether the effects were structural, functional, or both. Overall, the most sensitive test assessed cardiac beating using the xCELLigence platform (88.9%) while the structural endpoints provided additional insight into the mechanism of cardiotoxicity for several drugs. These studies show that a multi-parameter approach examining both cardiac cell health and function in hiPS-CM provides a comprehensive and robust assessment that can aid in the determination of potential cardiac liability. - Highlights: • 24 drugs were tested for cardiac liability using an in vitro multi-parameter screen. • Changes in beating activity were the most sensitive in predicting cardiac risk. • Structural effects add in-depth insight towards mechanism of cardiac toxicity. • Testing functional and structural endpoints enhances early cardiac risk assessment.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron

The analysis of clinical use of neutron therapy with 6 MeV fast neutrons compared to conventional radiation therapy was carried out. The experience of using neutron and mixed neutron and photon therapy in patients with different radio-resistant malignant tumors shows the necessity of further studies and development of the novel approaches to densely-ionizing radiation. The results of dosimetry and radiobiological studies have been the basis for planning clinical programs for neutron therapy. Clinical trials over the past 30 years have shown that neutron therapy successfully destroys radio-resistant cancers, including salivary gland tumors, adenoidcystic carcinoma, inoperable sarcomas, locally advanced head and neck tumors, and locally advanced prostate cancer. Radiation therapy with 6.3 MeV fast neutrons used alone and in combination with photon therapy resulted in improved long-term treatment outcomes in patients with radio-resistant malignant tumors.

62 RADIOLOGY AND NUCLEAR MEDICINE↗