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At least 1,495 records · Page 83
All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

TU-F-CAMPUS-T-03: Enhancing the Tumor Specific Radiosensitization Using Molecular Targeted Gold Nanorods

Purpose: Gold nanoparticle (GNP) mediated radiosensitization has gained significant attention in recent years. However, the widely used passive targeting strategy requires high concentration of GNPs to induce the desired therapeutic effect, thus dampening the enthusiasm for clinical translation. The purpose of this study is to utilize a molecular targeting strategy to minimize the concentration of GNPs injected while simultaneously enhancing the tumor specific radiosensitization for an improved therapeutic outcome. Methods: Cetuximab (antibody specific to the epidermal growth factor receptor that is over-expressed in tumors) conjugated gold nanorods (cGNRs) was used for the tumor targeting. The binding affinity, internalization, and in vitro radiosensitization were evaluated using dark field microscopy, transmission electron microscopy, and clonogenic cell survival assay, respectively. In vivo biodistribution in tumor (HCT116-colorectal cancer cells) bearing mice were quantified using inductively coupled plasma mass spectrometry. In vivo radiosensitization potential was tested using 250-kVp x-rays and clinically relevant 6-MV radiation beams. Results: cGNRs displayed excellent cell-surface binding and internalization (∼31,000 vs 12,000/cell) when compared to unconjugated GNRs (pGNRs). In vitro, the dose enhancement factor at 10% survival (DEF10) was estimated as 1.06 and 1.17, respectively for both 250-kVp and 6-MV beams. In vivo biodistribution analysis revealed enhanced uptake of cGNRs in tumor (1.3 µg/g of tumor tissue), which is ∼1000-fold less than the reported values using passive targeting strategy. Nonetheless, significant radiosensitization was observed in vivo with cGNRs when compared to pGNRs, when irradiated with 250-kVp (tumor volume doubling time 35 days vs 25 days; p=0.002) and 6 MV (17 days vs 13 days; p=0.0052) beams. Conclusion: The enhanced radiosensitization effect observed with very low intratumoral concentrations of gold and megavoltage x-rays using the active targeting strategy holds promise for clinical translation of this strategy from a toxicity and cost-effectiveness perspective and could evolve as a paradigm-changing approach in the field of radiation oncology.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

Fundamentals and Applications of Hybrid LWFA-PWFA

Fundamental similarities and differences between laser-driven plasma wakefield acceleration (LWFA) and particle-driven plasma wakefield acceleration (PWFA) are discussed. The complementary features enable the conception and development of novel hybrid plasma accelerators, which allow previously not accessible compact solutions for high quality electron bunch generation and arising applications. Very high energy gains can be realized by electron beam drivers even in single stages because PWFA is practically dephasing-free and not diffraction-limited. These electron driver beams for PWFA in turn can be produced in compact LWFA stages. In various hybrid approaches, these PWFA systems can be spiked with ionizing laser pulses to realize tunable and high-quality electron sources via optical density downramp injection (also known as plasma torch) or plasma photocathodes (also known as Trojan Horse) and via wakefield-induced injection (also known as WII). These hybrids can act as beam energy, brightness and quality transformers, and partially have built-in stabilizing features. They thus offer compact pathways towards beams with unprecedented emittance and brightness, which may have transformative impact for light sources and photon science applications. Furthermore, they allow the study of PWFA-specific challenges in compact setups in addition to large linac-based facilities, such as fundamental beam–plasma interaction physics, to develop novel diagnostics, and to develop contributions such as ultralow emittance test beams or other building blocks and schemes which support future plasma-based collider concepts.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2016

Fermilab Recycler Collimation System Design

To provide 700 kW proton beams for neutrino production in the NuMI facility, we employ slip stacking in the Recycler with transfer to the Main Injector for recapture and acceleration. Slip stacking with 12 Booster batches per 1.33 sec cycle of the Main Injector has been implemented and briefly tested while extensive operation with 8 batches and 10 batches per MI cycle has been demonstrated. Operation in this mode since 2013 shows that loss localization is an essential component for long term operation. Beam loss in the Recycler will be localized in a collimation region with design capability for absorbing up to 2 kW of lost protons in a pair of 20-Ton collimators (absorbers). This system will employ a two stage collimation with a thin molybdenum scattering foil to define the bottom edge of both the injected and decelerated-for-slipping beams. Optimization and engineering design of the collimator components and radiation shielding are based on comprehensive MARS15 simulations predicting high collimation efficiency as well as tolerable levels of prompt and residual radiation. The system installation during the Fermilab 2016 facility shutdown will permit commissioning in the subsequent operating period.

43 PARTICLE ACCELERATORS↗
DOE OSTI2016

Cross-scale observations of the 2015 St. Patrick's day storm: THEMIS, Van Allen Probes, and TWINS

In this paper, we present cross-scale magnetospheric observations of the 17 March 2015 (St. Patrick's Day) storm, by Time History of Events and Macroscale Interactions during Substorms (THEMIS), Van Allen Probes (Radiation Belt Storm Probes), and Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS), plus upstream ACE/Wind solar wind data. THEMIS crossed the bow shock or magnetopause 22 times and observed the magnetospheric compression that initiated the storm. Empirical models reproduce these boundary locations within 0.7 R E . Van Allen Probes crossed the plasmapause 13 times; test particle simulations reproduce these encounters within 0.5 R E . Before the storm, Van Allen Probes measured quiet double-nose proton spectra in the region of corotating cold plasma. About 15 min after a 0605 UT dayside southward turning, Van Allen Probes captured the onset of inner magnetospheric convection, as a density decrease at the moving corotation-convection boundary (CCB) and a steep increase in ring current (RC) proton flux. During the first several hours of the storm, Van Allen Probes measured highly dynamic ion signatures (numerous injections and multiple spectral peaks). Sustained convection after ~1200 UT initiated a major buildup of the midnight-sector ring current (measured by RBSP A), with much weaker duskside fluxes (measured by RBSP B, THEMIS a and THEMIS d). A close conjunction of THEMIS d, RBSP A, and TWINS 1 at 1631 UT shows good three-way agreement in the shapes of two-peak spectra from the center of the partial RC. A midstorm injection, observed by Van Allen Probes and TWINS at 1740 UT, brought in fresh ions with lower average energies (leading to globally less energetic spectra in precipitating ions) but increased the total pressure. Finally, the cross-scale measurements of 17 March 2015 contain significant spatial, spectral, and temporal structure.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2018

High Wear-Resistant Aluminum Matrix Composite Layer Fabricated by MIG Welding with Lateral B{sub 4}C Powder Injection

In this work, a low-cost technique combining MIG welding and lateral powder injection was developed to fabricate B{sub 4}C particles-reinforced aluminum matrix composite (AMC) layer on a T6 heat-treated 7075 aluminum alloy (AA7075-T6) substrate. The AMC layer was 6-7 mm thick and well bonded to the substrate. The B{sub 4}C particles were dispersed throughout the AMC layer with an average content of approximately 7 vol.%. No significant reaction products existed either at the particle–matrix interface or in the Al-matrix. In pin-on-disk dry sliding wear tests against Al{sub 2}O{sub 3} grinding wheels, the AMC layer exhibited excellent wear resistance with volume wear rate approximately 1/10-3/10 that of the quenched AISI 1045 steel and only approximately 2-7% that of the AA7075-T6 alloy under the same wear conditions. A small addition of ceramic particles can greatly improve wear resistance, suggesting that this technique has good prospects for a wide variety of applications.

36 MATERIALS SCIENCE↗
DOE OSTI2018

Pressure transient analysis during CO 2 push-pull tests into faults for EGS characterization

Here, with the goal of detecting and characterizing faults and fractures in enhanced geothermal systems (EGS), a new technology involving CO 2 push-pull testing, active-source geophysical imaging, and well logging has recently been proposed. This technique takes advantage of (1) the contrasting properties of supercritical CO 2 and water which cause CO 2 to appear distinct from surrounding brine in seismic and other geophysical logging approaches, (2) the non-wetting nature of CO 2 which keeps it localized to the faults and fractures to create contrast potentially sufficient for active seismic and well-logging approaches to image faults and fracture zones at EGS sites. In this study, we evaluate the feasibility of using pressure transient monitoring during CO 2 push-pull tests to complement active seismic and wireline well logging for EGS characterization. For this purpose, we developed a 2D model of a prototypical geothermal site (Desert Peak, NV) that includes a single fault. The fault zone consists of a slip plane, fault gouge, and damage zone, and is bounded by the surrounding matrix of the country rock. Through numerical simulation using iTOUGH2, we found that the pressure transient at the monitoring wells in the fault gouge shows unique traits due to the multiphase flow conditions developed by CO 2 injection, and varies sensitively on the arrival of the CO 2 plume and the degree of CO 2 saturation. A sensitivity analysis shows the pressure transient is most sensitive to the fault gouge permeability, but also depends on multiphase flow parameters and the boundary conditions of the fault. Lastly, an inversion study reveals that the fault gouge permeability can be best estimated with the pressure transient data, whereas additional CO 2 saturation data do not improve the accuracy of the inversion significantly.

58 GEOSCIENCES↗
DOE OSTI2021

A large dataset of detection and submeter-accurate 3-D trajectories of juvenile Chinook salmon

Abstract Acoustic telemetry has been used extensively to study the behavior of aquatic animals. The Juvenile Salmon Acoustic Telemetry System (JSATS) is one such system; it was developed for studying juvenile salmonids but has been used to study numerous species. A recent innovation of the JSATS system is an acoustic transmitter that is small enough to be implanted through injection or small incision that doesn’t require sutures. Use of the JSATS system involves deploying cabled acoustic receivers at hydroelectric dams, or other structures, and autonomous acoustic receivers in free-flowing sections of a river. The raw detections from acoustic-tagged fish are processed to remove potential false positives. The clean detections (5,147,996 total) are used to generate detection events and to compute 3-D trajectories (403,900 total), which are used to assign fish to a passage route through a dam. Controlled field testing involving a high-accuracy Global Positioning System receiver is done to validate the submeter accuracy of the trajectories. The JSATS dataset could be reused for expanding the understanding of near-dam fish behavior.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Hubble Frontier Field Clusters and Their Parallel Fields: Photometric and Photometric Redshift Catalogs

We present a multiband analysis of the six Hubble Frontier Field clusters and their parallel fields, producing catalogs with measurements of source photometry and photometric redshifts. We release these catalogs to the public along with maps of intracluster light and models for the brightest galaxies in each field. This rich data set covers a wavelength range from 0.2 to 8 μm, utilizing data from the Hubble Space Telescope, Keck Observatories, Very Large Telescope array, and Spitzer Space Telescope. We validate our products by injecting into our fields and recovering a population of synthetic objects with similar characteristics to those in real extragalactic surveys. The photometric catalogs contain a total of over 32,000 entries, with 50% completeness at a threshold of mag AB ~ 29.1 for unblended sources and magAB ~ 29 for blended ones, in the IR-weighted detection band. Photometric redshifts were obtained by means of template fitting and have an average outlier fraction of 10.3% and scatter σ = 0.067 when compared to spectroscopic estimates. The software we devised, after being tested in the present work, will be applied to new data sets from ongoing and future surveys.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2014

Superconducting magnet performance for 28 GHz electron cyclotron resonance ion source developed at the Korea Basic Science Institute

A superconducting magnet for use in an electron cyclotron resonance ion source was developed at the Korea Basic Science Institute. The superconducting magnet is comprised of three solenoids and a hexapole magnet. According to the design value, the solenoid magnets can generate a mirror field, resulting in axial magnetic fields of 3.6 T at the injection area and 2.2 T at the extraction region. A radial field strength of 2.1 T can also be achieved by hexapole magnet on the plasma chamber wall. NbTi superconducting wire was used in the winding process following appropriate techniques for magnet structure. The final assembly of the each magnet involved it being vertically inserted into the cryostat to cool down the temperature using liquid helium. The performance of each solenoid and hexapole magnet was separately verified experimentally. The construction of the superconducting coil, the entire magnet assembly for performance testing and experimental results are reported herein.

43 PARTICLE ACCELERATORS↗
DOE OSTI2019

Experimental Investigation on Additively Manufactured Transpiration and Film Cooling Structures

The last 50 years has witnessed significant improvement in film cooling technologies while transpiration cooling is still not implemented in turbine airfoil cooling. Although transpiration cooling could provide higher cooling efficiency with less coolant consumption compared to film cooling, the fine pore structure and high porosity in transpiration cooling metal media always raised difficulties in conventional manufacturing. Recently, the rapid development of additive manufacturing (AM) has provided a new perspective to address such challenge. With the capability of the innovative powder bed selective laser metal sintering (SLMS) AM technology, the complex geometries of transpiration cooling part could be precisely fabricated and endued with improved mechanical strength. This study utilized the SLMS AM technology to fabricate the transpiration cooling and film cooling structures with Inconel 718 superalloy. Five different types of porous media including two perforated plates with different hole pitches, metal sphere packing, metal wire mesh, and blood vessel shaped passages for transpiration cooling were fabricated by EOS M290 system. One laidback fan-shaped film cooling coupon was also fabricated with the same printing process as the control group. Heat transfer tests under three different coolant mass flow rates and four different mainstream temperatures were conducted to evaluate the cooling performance of the printed coupons. The effects of geometry parameters including porosity, surface outlet area ratio, and internal solid–fluid interface area ratio were investigated as well. The results showed that the transpiration cooling structures generally had higher cooling effectiveness than film cooling structure. The overall average cooling effectiveness of blood vessel-shaped transpiration cooling reached 0.35, 0.5, and 0.57, respectively, with low (1.2%), medium (2.4%), and high (3.6%) coolant injection ratios. The morphological parameters analysis showed the major factor that affected the cooling effectiveness most was the internal solid–fluid interface area ratio for transpiration cooling. This study showed that additive manufactured transpiration cooling could be a promising alternative method for turbine blade cooling and worthwhile for further investigations.

Engineering↗
DOE OSTI2020

A novel active optimization approach for rapid and efficient design space exploration using ensemble machine learning

In this work, a novel design optimization technique based on active learning, which involves dynamic exploration and exploitation of the design space of interest using an ensemble of machine learning algorithms, is presented. In this approach, a hybrid methodology incorporating an explorative weak learner (regularized basis function model) which fits high-level information about the response surface, and an exploitative strong learner (based on committee machine) that fits finer details around promising regions identified by the weak learner, is employed. For each design iteration, an aristocratic approach is used to select a set of nominees, where points that meet a threshold merit value as predicted by the weak learner are selected to be evaluated using expensive function evaluation. In addition to these points, the global optimum as predicted by the strong learner is also evaluated to enable rapid convergence to the actual global optimum once the most promising region has been identified by the optimizer. This methodology is first tested by applying it to the optimization of a two-dimensional multi-modal surface. The performance of the new active learning approach is compared with traditional global optimization methods, namely micro-genetic algorithm (pGA) and particle swarm optimization (PSO). It is demonstrated that the new optimizer is able to reach the global optimum much faster with a significantly fewer number of function evaluations. Subsequently, the new optimizer is also applied to a complex internal combustion (IC) engine combustion optimization case with nine control parameters related to fuel injection, initial thermodynamic conditions, and in-cylinder flow. It is again found that the new approach significantly lowers the number of function evaluations that are needed to reach the optimum design configuration (by up to 80%) when compared to particle swarm and genetic algorithm-based optimization techniques.

Machine learning, active learning, design optimiza↗
DOE OSTI2022

Space Charge Driven Emittance Growth and the Effect of Octupoles in IOTA

The Integrable Optics Test Accelerator (IOTA) at Fermilab is a small machine dedicated to a broad frontier accelerator physics program. An important aspect of this program is to investigate the potential benefits of the resonance free tune spread achievable with integrable optics to store and accelerate high intensity proton beams for which space charge is significant. In this context, a good understanding of proton beam emittance growth and particle loss mechanisms is essential. Assuming nominal design parameters, simulations show that for a bunched beam, the bulk of emittance growth takes place immediately following injection, typically within tens of turns. We attempt to account for this growth using a simplified RMS mismatch theory; some of its limitations and possible improvements are briefly discussed. We then compare theoretical predictions to simulations performed using the PIC code pyORBIT. Further exploring ways to mitigate emittance growth and reduce particle loss, we compare two beam matching strategies: (1) matching at the injection point (2) matching at the center of the nonlinear (octupole) insertion region where $\beta_x = \beta_y$. To observe how nonlinearity affects emittance growth and whether it dominates growth due to mismatch, we track two different distributions. Finally, we explore the potential of using octupoles in a quasi-integrable configuration to mitigate growth using a variety of initial distributions both at reduced and full intensities.

43 PARTICLE ACCELERATORS↗
DOE OSTI2016

Long-term Sustainability of Fracture Conductivity in Geothermal Systems using Proppants

Long-term sustainability of fracture conductivity is critical for commercial success of engineered geothermal system (EGS) and hydrogeothermal field sites. The injection of proppants has been suggested as a means to enhance the conductivity in these systems. Several studies have examined the chemical behavior of proppants that are not at chemical equilibrium with the reservoir rock and water. These studies have suggested that in geothermal systems, geochemical reactions can lead to enhance proppant dissolution and deposition alteration minerals. We hypothesize that proppant dissolution will decrease the strength of the proppant and can potentially reduce the conductivity of the fracture. To examine the geomechanical strength of proppants, we have performed modified crushing tests of proppants and reservoir rock material that was subjected to geothermal reservoir temperature conditions. The batch reactor experiments heated crushed quartz monzonite rock material, proppants (either quartz sand, sintered bauxite or kryptospheres) with Raft River geothermal water to 250 ºC for a period of 2 months. Solid and liquid samples were shipped to University of Utah for chemical characterization with ICP-OES, ICP-MS, and SEM. A separate portion of the rock/proppant material was subjected to a modified American Petroleum Institute ISO 13503-2 proppant crushing test. This test is typically used to determine the maximum stress level that can be applied to a proppant pack without the occurrence of unacceptable proppant crushing. We will use the test results to examine potential changes in proppant/reservoir rock geomechanical properties as compared to samples that have not been subjected to geothermal conditions. These preliminary results will be used to screen the proppants for long term use in EGS and hot hydrogeothermal systems.

fracture sustainability↗
DOE OSTI2017

Phase I Project: Fiber Optic Distributed Acoustic Sensing for Periodic Hydraulic Tests

The extraction of heat from hot rock requires circulation of fluid through fracture networks. Because the geometry and connectivity of these fractures determines the efficiency of fluid circulation, many tools are used to characterize fractures before and after development of the reservoir. Under this project, a new tool was developed that allows hydraulic connectivity between geothermal boreholes to be identified. Nanostrain in rock fractures is measured using fiber optic distributed acoustic sensing (DAS). This strain is measured in one borehole in response to periodic pressure pulses induced in another borehole. The strain in the fractures represents hydraulic connectivity between wells. DAS is typically used at frequencies of Hz to kHz, but strain at mHz frequencies were measured for this project. The tool was demonstrated in the laboratory and in the field. In the laboratory, strain in fiber optic cables was measured in response to compression due to oscillating fluid pressure. DAS recorded strains as small as 10 picometer/m in response to 1 cm of water level change. At a fractured crystalline rock field site, strain was measured in boreholes. Fiber-optic cable was mechanically coupled borehole walls using pressured flexible liners. In one borehole 30 m from the oscillating pumping source, pressure and strain were measured simultaneously. The DAS system measured fracture displacement at frequencies of less than 1 mHz (18 min periods) and amplitudes of less than 1 nm, in response to fluid pressure changes of less 20 Pa (2 mm of water). The attenuation and phase shift of the monitored strain signal is indicative of the permeability and storage (compliance) of the fracture network that connects the two wells. The strain response as a function of oscillation frequency is characteristic of the hydraulic structure of the formation. This is the first application of DAS to the measurement of low frequency strain in boreholes. It has enormous potential for monitoring geothermal reservoirs for purposes of understanding reservoir compliance and for assuring security of injection fluids. Periodic pressure pulses can be induced by oscillating injection or pumping during operation so the system could provide real time reservoir data. DAS cable may already be installed at a site as it is becoming increasingly used for seismic observation. Simulations conducted for this project indicate that strain should be propagated through borehole cements, so observations can be made outside of well casing. In uncased holes, the cable would need to be mechanically coupled to the borehole wall to provide measurements. One option would be to install fiber into cemented and abandoned boreholes to extend their utility.

15 GEOTHERMAL ENERGY↗
DOE OSTI2024

A full-scope, high-fidelity simulator-based hardware-in-the-loop testbed for comprehensive nuclear power plant cybersecurity research

Nuclear power plant (NPP) cybersecurity research often relies on hardware-in-the-loop (HIL) testbeds that integrate real hardware components into simulated environments. These testbeds allow researchers to identify vulnerabilities, evaluate attack impacts, and test security measures in a controlled setting. Furthermore, previous HIL testbeds lacked fidelity to accurately represent real nuclear systems, limiting the scope of cybersecurity analysis. This study presents the creation of a HIL testbed, devised upon a full-scope, high-fidelity NPP simulator, to facilitate realistic and comprehensive cybersecurity research. To demonstrate its capabilities, the control logic for the steam generator water level was migrated from the simulator to an external programmable logic controller. As a practical application of the developed testbed, supply chain attack scenarios were simulated by injecting malicious code into the controller logic, and the effects of manipulating sensor inputs and control commands were observed. While this HIL testbed provides more detailed simulations, enhanced realism, and wider applicability compared to other options utilizing a less complex simulator, it is also more intricate and costly. For this reason, we include a detailed comparison with some alternative architectures to aid fellow researchers and practitioners in the selection of a suitable HIL architecture based on specific research objectives.

47 OTHER INSTRUMENTATION↗
DOE OSTI2014

Integrated modeling of temperature profiles in L-mode tokamak discharges

Simulations of doublet III-D, the joint European tokamak, and the tokamak fusion test reactor L-mode tokamak plasmas are carried out using the PTRANSP predictive integrated modeling code. The simulation and experimental temperature profiles are compared. The time evolved temperature profiles are computed utilizing the Multi-Mode anomalous transport model version 7.1 (MMM7.1) which includes transport associated with drift-resistive-inertial ballooning modes (the DRIBM model [T. Rafiq et al., Phys. Plasmas 17, 082511 (2010)]). The tokamak discharges considered involved a broad range of conditions including scans over gyroradius, ITER like current ramp-up, with and without neon impurity injection, collisionality, and low and high plasma current. The comparison of simulation and experimental temperature profiles for the discharges considered is shown for the radial range from the magnetic axis to the last closed flux surface. The regions where various modes in the Multi-Mode model contribute to transport are illustrated. In the simulations carried out using the MMM7.1 model it is found that: The drift-resistive-inertial ballooning modes contribute to the anomalous transport primarily near the edge of the plasma; transport associated with the ion temperature gradient and trapped electron modes contribute in the core region but decrease in the region of the plasma boundary; and neoclassical ion thermal transport contributes mainly near the center of the discharge.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2015

MRI reconstruction of multi-image acquisitions using a rank regularizer with data reordering

Purpose: To improve rank constrained reconstructions for undersampled multi-image MRI acquisitions. Methods: Motivated by the recent developments in low-rank matrix completion theory and its applicability to rapid dynamic MRI, a new reordering-based rank constrained reconstruction of undersampled multi-image data that uses prior image information is proposed. Instead of directly minimizing the nuclear norm of a matrix of estimated images, the nuclear norm of reordered matrix values is minimized. The reordering is based on the prior image estimates. The method is tested on brain diffusion imaging data and dynamic contrast enhanced myocardial perfusion data. Results: Good quality images from data undersampled by a factor of three for diffusion imaging and by a factor of 3.5 for dynamic cardiac perfusion imaging with respiratory motion were obtained. Reordering gave visually improved image quality over standard nuclear norm minimization reconstructions. Root mean squared errors with respect to ground truth images were improved by ∼18% and ∼16% with reordering for diffusion and perfusion applications, respectively. Conclusions: The reordered low-rank constraint is a way to inject prior image information that offers improvements over a standard low-rank constraint for undersampled multi-image MRI reconstructions.

60 APPLIED LIFE SCIENCES↗