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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,495 records · Page 83
All sourcesNASA NTRSDOE OSTI
DOE OSTI2026

Data for Metabolic Engineering of Nonmodel Yeast Issatchenkia orientalis SD108 for 5-Aminolevulinic Acid Production

Biological production of 5‐aminolevulinic acid (5‐ALA) has received growing attentionover theyears.However, thereis the tradeoff between 5‐ALA biosynthesis and cell growth because the fermentation broth will become acidic due to the production of 5‐ALA. To address this limitation, we engineered an acid‐tolerant yeast, Issatchenkia orientalis SD108, for 5‐ALA production. We first discovered that the cell growth rate of I. orientalis SD108 was boosted by 5‐ALA and its endogenous ALA synthetase (ALAS) showed higher activity than those homologs from other yeasts. The titer of 5‐ALA was improved from 28mg/L to 120‐, 150‐, and 300mg/L, by optimizing plasmid design, overexpressing a transporter, and increasing gene copy number, respectively. After redirecting the metabolic flux using the pyruvate decarboxylase (PDC) knockout strain (SD108ΔPDC) and culturing with urea, we increased the titer of 5‐ALA to 510mg/L, a 13‐fold enhancement, proving the importance of the newly identified IoALAS with higher activity and the strategic selection of nitrogen sources for knockout strains. This study demonstrates the acid‐tolerant I. orientalis SD108ΔPDC has a high potential for 5‐ALA production at a large scale in the future.

Bioproducts↗
DOE OSTI2019

Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers

The cardiogenic transcription factors (TFs) Mef2c, Gata4, and Tbx5 can directly reprogram fibroblasts to induced cardiac-like myocytes (iCLMs), presenting a potential source of cells for cardiac repair. While activity of these TFs is enhanced by Hand2 and Akt1, their genomic targets and interactions during reprogramming are not well studied. We performed genome-wide analyses of cardiogenic TF binding and enhancer profiling during cardiac reprogramming. We found that these TFs synergistically activate enhancers highlighted by Mef2c binding sites and that Hand2 and Akt1 coordinately recruit other TFs to enhancer elements. Intriguingly, these enhancer landscapes collectively resemble patterns of enhancer activation during embryonic cardiogenesis. We further constructed a cardiac reprogramming gene regulatory network and found repression of EGFR signaling pathway genes. Consistently, chemical inhibition of EGFR signaling augmented reprogramming. Thus, by defining epigenetic landscapes these findings reveal synergistic transcriptional activation across a broad landscape of cardiac enhancers and key signaling pathways that govern iCLM reprogramming.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1985

Biogeochemical factors which regulate the formation and fate of sulfide in wetlands

Coastal wetland areas occupy a small percentage of the terrestrial environment yet are extremely productive regions which support rapid rates of below ground bacterial activity. Wetlands appear to be significant as biogenic sources of gaseous sulfur, carbon, and nitrogen. These gases are important as tracers of man's activities, and they influence atmospheric chemistry. The interactions among wetland biogeochemical processes regulate the anaerobic production of reduced gases and influence the fate of these volatiles. Therefore, spatial and temporal variations in hydrology, salinity, temperature, and speciation and growth of vegetation affect the type and magnitude of gas emissions thus hindering predictive estimates of gas flux. The research is divided into two major parts, the first is the biogeochemical characterization of a selected tidal wetland area in terms of factors likely to regulate sulfide flux; the second is a direct measurement of gaseous sulfur flux as related to changes in these biogeochemical conditions. Variant factors affecting sulfide flux include the wetlands' tidal range, seasonal salinity, and other hydrological conditions, grass species and plant growth, soil composition, and microbial activity.

Hines, Mark E.↗
NASA NTRS1992

Biogeochemical factors which regulate the formation and fate of sulfide in wetlands

Coastal wetland areas occupy a small percentage of the terrestrial environment yet are extremely productive regions which support rapid rates of belowground bacterial activity. Wetlands appear to be significant as biogenic sources of gaseous sulfur, carbon, and nitrogen. These gases are important as tracers of man's activities, and they influence atmospheric chemistry. The interactions among wetland biogeochemical processes regulate the anaerobic production of reduced gases and influence the fate of these volatiles. Therefore, spatial and temporal variations in hydrology, salinity, temperature and specification, and growth of vegetation affect the type and magnitude of gas emissions thus hindering predictive estimates of gas flux. Our research is divided into two major components, the first is the biogeochemical characterization of a selected tidal wetland area in terms of factors likely to regulate sulfide flux; the second is a direct measurement of gaseous sulfur flux as related to changes in these biogeochemical conditions. Presently, we are near completion of phase one.

Hines, Mark E.↗
DOE OSTI2014

Subaru adaptive-optics high-spatial-resolution infrared K- and L'-band imaging search for deeply buried dual AGNs in merging galaxies

We present the results of infrared K- (2.2 μm) and L'-band (3.8 μm) high-spatial-resolution (<0.''2) imaging observations of nearby gas- and dust-rich infrared luminous merging galaxies, assisted by the adaptive optics system on the Subaru 8.2 m telescope. We investigate the presence and frequency of red K – L' compact sources, which are sensitive indicators of active galactic nuclei (AGNs), including AGNs that are deeply buried in gas and dust. We observed 29 merging systems and confirmed at least one AGN in all but one system. However, luminous dual AGNs were detected in only four of the 29 systems (∼14%), despite our method's being sensitive to buried AGNs. For multiple nuclei sources, we compared the estimated AGN luminosities with supermassive black hole (SMBH) masses inferred from large-aperture K-band stellar emission photometry in individual nuclei. We found that mass accretion rates onto SMBHs are significantly different among multiple SMBHs, such that larger-mass SMBHs generally show higher mass accretion rates when normalized to SMBH mass. Our results suggest that non-synchronous mass accretion onto SMBHs in gas- and dust-rich infrared luminous merging galaxies hampers the observational detection of kiloparsec-scale multiple active SMBHs. This could explain the significantly smaller detection fraction of kiloparsec-scale dual AGNs when compared with the number expected from simple theoretical predictions. Our results also indicate that mass accretion onto SMBHs is dominated by local conditions, rather than by global galaxy properties, reinforcing the importance of observations to our understanding of how multiple SMBHs are activated and acquire mass in gas- and dust-rich merging galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2012

Plans for an Integrated Front-End Test Stand at the Spallation Neutron Source

A spare Radio-Frequency Quadrupole (RFQ) is presently being fabricated by industry with delivery to Oak Ridge National Laboratory planned in late 2012. The establishment of a test stand at the Spallation Neutron Source site is underway so that complete acceptance testing can be performed during the winter of 2012-2013. This activity is the first step in the establishment of an integrated front-end test stand that will include an ion source, low-energy beam transport (LEBT), RFQ, medium-energy beam transport, diagnostics, and a beam dump. The test stand will be capable of delivering an H- ion beam of up to 50 mA with a pulse length of 1 ms and a repetition rate of 60 Hz or a proton beam of up to 50 mA, 100us, 1Hz. The test stand will enable the following activities: complete ion source characterization; development of a magnetic LEBT chopper; development of a two-source layout; development of beam diagnostics; and study of beam dynamics of high intensity beam.

Champion, Mark S↗
DOE OSTI2017

A Spherical Active Coded Aperture for 4π Gamma-ray Imaging

Gamma-ray imaging facilitates the efficient detection, characterization, and localization of compact radioactive sources in cluttered environments. Fieldable detector systems employing active planar coded apertures have demonstrated broad energy sensitivity via both coded aperture and Compton imaging modalities. But, planar configurations suffer from a limited field-of-view, especially in the coded aperture mode. In order to improve upon this limitation, we introduce a novel design by rearranging the detectors into an active coded spherical configuration, resulting in a 4pi isotropic field-of-view for both coded aperture and Compton imaging. This work focuses on the low- energy coded aperture modality and the optimization techniques used to determine the optimal number and configuration of 1 cm 3 CdZnTe coplanar grid detectors on a 14 cm diameter sphere with 192 available detector locations.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
NASA NTRS1976

Thermodynamic history of a solar active region observed in X-rays

The structure and energy content of an active coronal volume during its early history are investigated using soft X-ray images secured with the glancing-incidence telescope on Skylab. During the late stages of emerging-flux-region activity, the maximum temperatures exceeded 6.5 million K. At that time, the temporal rate of change in thermal energy content was about 10 to the 25th power ergs/s and was comparable to the rate of energy loss by radiation. Fluctuations in the energy content of the X-ray source region imply that this coronal active region was probably not in energy equilibrium during the five days of observation.

Teske, R. G.↗
DOE OSTI2019

Enhanced p-Type Doping in Polycrystalline CdTe Films: Deposition and Activation

An in situ nonequilibrium method to increase hole density in polycrystalline CdTe thin films to 10 16 cm -3 using group V substitution on Te is presented. Single-phase CdTe films doped with P, As, and Sb were deposited at 550 degrees C at 100-200 nm/s onto moving cadmium sulfide/high resistance transparent buffer layer/transparent conductive oxide /glass superstrates by vapor transport deposition in Cd overpressure from high purity compound sources. Doping levels before and after activation were determined by capacitance-voltage analysis of diagnostic devices. Secondary ion mass spectrometry depth profiling confirmed dopant incorporation levels of 10 17 -10 18 atoms/cm 3 in as-deposited films. Electronic activation was carried out by post-deposition annealing in Cd or CdCl 2 vapor with fast cooling, increasing acceptor concentrations to >10 15 cm -3 for P and >10 16 cm -3 for As and Sb, compared with mid -10 14 cm -3 acceptor levels for undoped CdTe films. The activation methods are compatible with post-deposition processing presently used for high-efficiency CdTe solar cells. For the dopants As and Sb, the acceptor concentration increased by substitutional As Te and Sb Te formation, respectively, which was validated by cathodoluminescence spectroscopy.

14 SOLAR ENERGY↗
DOE OSTI2014

mJIVE-20: A survey for compact mJy radio objects with the very long baseline array

We present the description and early results of the mJy Imaging VLBA Exploration at 20 cm (mJIVE-20). mJIVE-20 is a large project on the Very Long Baseline Array which is systematically inspecting a large sample of mJy radio sources, pre-selected from the Faint Images of the Radio Sky at Twenty cm (FIRST) survey made with the Very Large Array, to identify any compact emission that may be present. The survey is being undertaken using filler time on the VLBA, which utilizes short segments scheduled in bad weather and/or with a reduced number of antennas, during which no highly rated science projects can be scheduled. The newly available multifield capability of the VLBA makes it possible for us to inspect of the order of 100 sources per hour of observing time with a 6.75σ detection sensitivity of approximately 1 mJy beam{sup –1}. The results of the mJIVE-20 survey are made publicly available as soon as the data are calibrated. After 18 months of observing, over 20,000 FIRST sources have been inspected, with 4336 very long baseline interferometry detections. These initial results suggest that within the range 1-200 mJy, fainter sources are somewhat more likely to be dominated by a very compact component than brighter sources. Over half of all arcsecond-scale mJy radio sources contain a compact component, although the fraction of sources that are dominated by milliarcsecond scale structure (where the majority of the arcsecond scale flux is recovered in the mJIVE-20 image) is smaller at around 30%-35%, increasing toward lower flux densities. Significant differences are seen depending on the optical classification of the source. Radio sources with a stellar/point-like counterpart in the Sloan Digital Sky Survey (SDSS) are more likely to be detected overall, but this detection likelihood appears to be independent of the arcsecond-scale radio flux density. The trend toward higher radio compactness for fainter sources is confined to sources that are not detected in SDSS or that have counterparts classified as galaxies. These results are consistent with a unification model of active galactic nuclei in which less luminous sources have on average slower radio jets, with lower Doppler suppression of compact core emission over a wider range of viewing angles.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2023

Cell Extracts from Bacteria and Yeast Retain Metabolic Activity after Extended Storage and Repeated Thawing

Cell-free synthetic biology enables rapid prototyping of biological parts and synthesis of proteins or metabolites in the absence of cell growth constraints. Cell-free systems are frequently made from crude cell extracts, where composition and activity can vary significantly based on source strain, preparation and processing, reagents, and other considerations. This variability can cause extracts to be treated as black boxes for which empirical observations guide practical laboratory practices, including a hesitance to use dated or previously thawed extracts. To better understand the robustness of cell extracts over time, we assessed the activity of cell-free metabolism during storage. As a model, we studied conversion of glucose to 2,3-butanediol. We found that cell extracts from Escherichia coli and Saccharomyces cerevisiae subjected to an 18-month storage period and repeated freeze-thaw cycles retain consistent metabolic activity. Here this work gives users of cell-free systems a better understanding of the impacts of storage on extract behavior.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2011

Investigating the Nuclear Activity of Barred Spiral Galaxies: The Case of NGC 1672

We have performed an X-ray study of the nearby barred spiral galaxy NGC 1672, primarily to ascertain the effect of the bar on its nuclear activity. We use both Chandra and XMM-Newton observations to investigate its X-ray properties, together with supporting high-resolution optical imaging data from the Hubble Space Telescope (HST) infrared imaging from the Spitzer Space Telescope, and Australia Telescope Compact Array ground-based radio data. We detect 28 X-ray sources within the D25 area of the galaxy; many are spatially correlated with star formation in the bar and spiral arms, and two are identified as background galaxies in the HST images. Nine of the X-ray sources are ultraluminous X-ray sources, with the three brightest (LX 5 * 10(exp 39) erg s(exp -1)) located at the ends of the bar. With the spatial resolution of Chandra, we are able to show for the first time that NGC 1672 possesses a hard (1.5) nuclear X-ray source with a 2-10 keV luminosity of 4 * 10(exp 38) erg s(exp -1). This is surrounded by an X-ray-bright circumnuclear star-forming ring, comprised of point sources and hot gas, which dominates the 2-10 keV emission in the central region of the galaxy. The spatially resolved multiwavelength photometry indicates that the nuclear source is a low-luminosity active galactic nucleus (LLAGN), but with star formation activity close to the central black hole. A high-resolution multiwavelength survey is required to fully assess the impact of both large-scale bars and smaller-scale phenomena such as nuclear bars, rings, and nuclear spirals on the fueling of LLAGN.

COLOR FIGURES↗
DOE OSTI2019

Modelling Environmental Impacts of Cesium-137 Under a Hypothetical Release of Radioactive Waste

Waste tanks at the nuclear facility located at Sellafield, UK, represent a nuclear source which could release radionuclides to the atmosphere. A model chain which combines atmospheric transport, deposition as well as riverine transport to sea has been developed to predict the riverine activity concentrations of {sup 137}Cs. The source term was estimated to be 9 × 10{sup 4} TBq of {sup 137}Cs, or 1% of the assumed total {sup 137}Cs inventory of the HAL (Highly Active Liquid) storage tanks. Air dispersion modelling predicted {sup 137}Cs deposition reaching 127 kBq m{sup −2} at the Vikedal catchment in Western Norway. Thus, the riverine transport model predicted that the activity concentration of {sup 137}Cs in water at the river outlet could reach 9000 Bq m{sup −3} in the aqueous phase and 1000 Bq kg{sup −1} in solid phase at peak level. The lake and river reaches showed different transport patterns due to the buffering effects caused by dilution and slowing down of water velocity.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2016

The gamma-ray-emitting quasar 0202+149: a CSS revisited

PKS 0202+149 is a low-power radio source with blazar-like, γ-ray active galactic nucleus (AGN) characteristics. We investigate its properties and classification in relation to its γ-ray characteristics. This source shows a hint of low-frequency turnover at about 200 MHz. Radio imaging data of 0202+149 at different frequencies show differing morphologies on both kiloparsec (kpc) and parsec (pc) scales. The overall source shows a triple structure of a core and double lobes with a total projected size of ∼1.3 kpc. The compact source structure of 0202+149 is reminiscent of a compact steep spectrum (CSS) source. At pc scales, a core-jet structure extends ∼25 pc (in projection) at a position angle perpendicular to the kpc-scale structure. The curved pc-scale structure with a jet and inner lobe suggests that the CSS nuclear activity has recently re-started, although its power has been decreasing, while the kpc-scale lobes are relics of earlier activity. A maximum apparent superluminal motion of ∼16 c is detected in the jet components, indicating a highly relativistic jet flow. The brightness temperature of the core is lower than the average value found for highly beamed, γ-ray AGNs, indicating a lower radio power and a relatively lower Doppler boosting factor. The CSS radio classification indicates that blazar-like γ-ray properties can also be manifested in low-power CSS radio sources with the appropriate jet and beaming properties.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2022

Synthesis and Exploratory Catalysis of 3d Metals: Atom and Group-Transfer Reactions and the Activation and Functionalization of Small Molecules Including Greenhouse Gases

Determining ways to convert natural gas, with zero emissions, and to more value-added materials such as olefins is one of the main goals in my research group. Over this funding period, we explored the chemistry of early-transition metals with metal-nitrogen multiple bonds, specifically titanium and zirconium nitrides, and explored their redox properties, basicity and reactivity with small molecules including greenhouses gases such as carbon dioxide. Some of these work serve as inspiration for the chemistry of important materials such as uranium nitride along with its unprecedented basicity and ability to activate C-H bonds. Using robust chelating templates we also examined rare examples of trivalent group 4 transition metal ions, and studied these spectroscopically. Using early transition metal ions we also explored synthetic routes to new phosphide based products using the phosphaethynolate salt. In addition, we also explored the chemistry of ferrous systems, and redox active ligand that can allow us to reversibly break and make C-S as well as N-N bonds, activate dinitrogen forming unusual MNNM topologies. Our final component describes how we activate methane and dehydrocouple if with a carbene source to form ethylene. Using this information, we also discovered a simple to make iridium catalyst that activate and functionalize methane with 9:1 selectivity for mono-functionalization. We have established a pathway that leads to poisoning of the catalyst and have found optimal conditions for higher selectivity and with over 170 Turnovers.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1982

The remarkable 400 micron source NGC 6334/I/North/

Observations at 400 microns of the NGC 6334 complex have confirmed the discovery of an unusual 1000-solar mass object, NGC 6334/I(North), which was not detected by broad-band 100-micron survey observations. The results suggest that this cool source (T = 19 + or - 5 K) is an active star formation region in a very early stage of evolution. The observed infrared luminosity of the source, 7000 solar luminosities, requires the presence of one or more embedded B stars or the formation of a dense protostellar core. Derived dust and gas densities agree well with results from molecular line observations of the complex. Nearby 100 micron peaks I and V were also observed.

Gezari, D. Y.↗
NASA NTRS1990

Ultraviolet, visible, and gravity astrophysics: A plan for the 1990's

NASA's Office of Space Science and Applications (OSSA) receives advice on scientific strategy and priorities from the U.S. National Academy of Sciences. Guidance to the OSSA Astrophysics Division, in particular, is provided by dedicated academy committees, ad hoc study groups, and, at ten-year intervals, by broadly mandated astronomy and astrophysics survey committees charged with making recommendations for the coming decade. Many of the academy's recommendations have important implications for the conduct of ultraviolet and visible-light astronomy from space. Moreover, these areas are now poised for an era of rapid growth. Through technological progress, ultraviolet astronomy has already risen from a novel observational technique four decades ago to the mainstream of astronomical research today. Recent developments in space technology and instrumentation have the potential to generate comparably dramatic strides in observational astronomy within the next ten years. In 1989, the Ultraviolet and Visible Astrophysics Branch of the OSSA Astrophysics Division recognized the need for a new, long-range plan that would implement the academy's recommendations in a way that yielded the most advantageous use of new technology. NASA's Ultraviolet, Visible, and Gravity Astrophysics Management Operations Working Group was asked to develop such a plan for the 1990's. Since the branch holds programmatic responsibility for space research in gravitational physics and relativity, as well as for ultraviolet and visible-light astrophysics, missions in those areas were also included. The working group met throughout 1989 and 1990 to survey current astrophysical problems, assess the potential of new technologies, examine prior academy recommendations, and develop the implementation plan. The present report is the product of those deliberations. Key astrophysical questions to be addressed cover topics such as the structure and evolution of the early universe, energetics of active galactic nuclei, stellar winds in massive stars, sources powered by accretion, composition and state of the interstellar medium, nature of the galactic halo, chromospheric activity in cool stars, and formation of stars and planetary systems. This document provides a review of these questions, program concerns, and the recommended implementation plan for the 1990's.

Source record↗
NASA NTRS2018

The Impacts of Recent Drought on Fire, Forest Loss, and Regional Smoke Emissions in Lowland Bolivia

In the southern Amazon relationships have been established among drought, human activities that cause forest loss, fire, and smoke emissions. We explore the impacts of recent drought on fire, forest loss, and atmospheric visibility in lowland Bolivia. To assess human influence on fire, we consider climate, fire, and vegetation dynamics in an area largely excluded from human activities since 1979, Noel Kempff Mercado National Park (NK) in northeastern Bolivia. We use data from five sources: the Moderate Resolution Imaging Spectroradiometer Collection 6 active fire product (2001-2015) (MODIS C6), Global Fire Weather Database (GFWED) data (1982-2015), MODIS land cover data (2001-2010), MODIS forest loss data (2000-2012), and the regional extinction coefficient for the southwestern Amazon (i.e., B(sub ext)), which is derived from horizontal visibility data from surface stations at the World Meteorological Organization (WMO) level (1973-2015). The B(sub ext) is affected by smoke and acts as a proxy for visibility and regional fire emissions. In lowland Bolivia from 2001 to 2015, interannual Drought Code (DC) variability was linked to fire activity, while from 1982 to 2015, interannual DC variability was linked to B(sub ext). From 2001 to 2015, the B(sub ext) and MODIS C6 active fire data for lowland Bolivia captured fire seasonality, and covaried between low- and high-fire years. Consistent with previous studies, our results suggest B(sub ext)t can be used as a longer-term proxy of regional fire emissions in southwestern Amazonia. Overall, our study found drought conditions were the dominant control on interannual fire variability in lowland Bolivia, and fires within NK were limited to the Cerrado and seasonally inundated wetland biomes. Our results suggest lowland Bolivian tropical forests were susceptible to human activities that may have amplified fire during drought. Human activities and drought need to be considered in future projections of southern Amazonian fire, in regard to carbon emissions and global climate.

Forest Loss↗