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REVISED MASS-TO-LIGHT RATIOS FOR NEARBY GALAXY GROUPS AND CLUSTERS

We present a detailed investigation of the cluster stellar mass-to-light (M*/L) ratio and cumulative stellar masses, derived on a galaxy-by-galaxy basis, for 12 massive (M {sub 500} ∼ 10{sup 14}-10{sup 15} M {sub ☉}), nearby clusters with available optical imaging data from the Sloan Digital Sky Survey Data Release 10 and X-ray data from the Chandra X-ray Observatory. Our method involves a statistical cluster membership using both photometric and spectroscopic redshifts when available to maximize completeness while minimizing contamination effects. We show that different methods of estimating the stellar mass-to-light ratio from observed photometry result in systematic discrepancies in the total stellar masses and average mass-to-light ratios of cluster galaxies. Nonetheless, all conversion methodologies point to a lack of correlation between M*/L{sub i} and total cluster mass, even though low-mass groups contain relatively more blue galaxies. We also find no statistically significant correlation between M*/L{sub i} and the fraction of blue galaxies (g – i < 0.85). For the mass range covered by our sample, the assumption of a Chabrier initial mass function (IMF) yields an integrated M*/L{sub i} ≅ 1.7 ± 0.2 M {sub ☉}/L {sub i,} {sub ☉}, a lower value than used in most similar studies, though consistent with the study of low-mass galaxy groups by Leauthaud et al. A light (diet) Salpeter IMF would imply a ∼60% increase in M*/L{sub i}.

79 ASTRONOMY AND ASTROPHYSICS↗

Combining RNA-SEQ Datasets from NASA GENELAB: An Evaluation of Correction Methods

Background: Conducting space biology experiments aboard the International Space Station, particularly those utilizing complex model organisms like mice, is expensive and difficult due to limited crew availability, hardware, and space. As a result, sample numbers from these studies are low, reducing the statistical power of any one experiment. Aggregating spaceflight datasets serves as a method to increase sample numbers, allowing for novel insights through bioinformatic analysis of ‘omics data from merged datasets. However, aggregating datasets can introduce unwanted variation including 1) differences in sample handling, processing, and sequencing platforms between datasets (technical variation) as well as 2) differences in experimental design between datasets. Methods: In the present study, NASA GeneLab-hosted RNAseq datasets from mouse liver tissues were used to evaluate several statistical methods to correct for this unwanted variation through two approaches, reference-based and standard. The following correction algorithms were applied with (reference-based) and/or without (standard) considering Universal Mouse RNA Reference samples: ComBat and ComBat_seq from the SVA package, the median polish, empirical Bayes, and ANOVA-based algorithms from the MBatch package, and negative binomial regression normalization in the DESeq2 package. For each approach, after the correction algorithm was applied, differential gene expression (DGE) analysis of flight and ground control samples was performed with the combined data. The robustness of each tool was evaluated using BatchQC to determine statistical differences between datasets before and after correction, Principal Component Analysis to evaluate global gene expression in samples before and after correction, and by comparing DGE analysis of individual datasets and combined datasets before and after correction. Results: The results showed that the reference-based approach introduced several additional (and likely artificial) differentially expressed genes when compared with the respective standard approach. Conclusions: Of the methods tested, standard ComBat_seq and DESeq2 were identified as the most robust correction methods for combining spaceflight mouse liver RNAseq datasets hosted on GeneLab.

Finsam Samson↗

Exascale granular microstructure reconstruction in 3D volumes of arbitrary geometries with generative learning

Reconstructing 3D granular microstructures within volumes of arbitrary geometries from limited 2D image data is crucial for predicting the material properties, as well as performances of structural components accounting for material microstructural effects. We present a novel generative learning framework that enables exascale reconstruction of granular microstructures within complex 3D geometric volumes. Building upon existing transfer learning techniques using pre-trained convolutional neural networks (CNN), we introduce several key innovations to overcome the difficulties inherent in arbitrary geometries. Our framework incorporates periodic boundary conditions using circular padding techniques, ensuring continuity and representativeness of the reconstructed microstructures. We also introduce a novel seamless transition reconstruction (STR) method that creates statistically equivalent transition zones to integrate multiple pre-existing 3D microstructure volumes. Based on STR, we propose a cost-effective strategy for reconstructing microstructures within complex geometric volumes, minimizing computational waste. Validation through numerical experiments using kinetic Monte Carlo simulations demonstrates accurate reproduction of grain statistics, including grain size distributions and morphology. A case study involving the reconstruction of a 4-blade propeller microstructure illustrates the method’s capability to efficiently handle complex geometries. In conclusion, the proposed framework significantly reduces computational demands while maintaining high reconstruction quality, paving the way for scalable microstructure reconstruction in materials design and analysis.

36 MATERIALS SCIENCE↗

Inferring Viral Transmission Time from Phylogenies for Known Transmission Pairs

When the time of an HIV transmission event is unknown, methods to identify it from virus genetic data can reveal the circumstances that enable transmission. We developed a single-parameter Markov model to infer transmission time from an HIV phylogeny constructed of multiple virus sequences from people in a transmission pair. Our method finds the statistical support for transmission occurring in different possible time slices. We compared our time-slice model results to previously described methods: a tree-based logical transmission interval, a simple parsimony-like rules-based method, and a more complex coalescent model. Across simulations with multiple transmitted lineages, different transmission times relative to the source’s infection, and different sampling times relative to transmission, we found that overall our time-slice model provided accurate and narrower estimates of the time of transmission. We also identified situations when transmission time or direction was difficult to estimate by any method, particularly when transmission occurred long after the source was infected and when sampling occurred long after transmission. Applying our model to real HIV transmission pairs showed some agreement with facts known from the case investigations. We also found, however, that uncertainty on the inferred transmission time was driven more by uncertainty from time calibration of the phylogeny than from the model inference itself. Encouragingly, comparable performance of the Markov time-slice model and the coalescent model—which make use of different information within a tree—suggests that a new method remains to be described that will make full use of the topology and node times for improved transmission time inference.

59 BASIC BIOLOGICAL SCIENCES↗

The Past, Present and Future of Structural Health Monitoring: An Overview of Three Ages

This paper presents an overview of the discipline of structural health monitoring (SHM), organised in terms of three proposed ages. The first age is delineated by the prehistory of SHM and the period where nondestructing testing methods evolved into an organised set of principles built upon physics-based models; this age ended when the model-based approaches reached an impasse in terms of their ability to properly deal with real-world problems. The second age of SHM began with a transition to data-based methods based on statistical pattern recognition, which provided a holistic approach to SHM problems for the first time. This age arguably ended when the methods foundered in situations where the necessary training data were scarce. It is argued here that the third age began with the development of population-based SHM, which has been designed to overcome the problem of data scarcity. As there is very limited space in a single article to provide a comprehensive overview, an appendix has been provided here that gives a very systematic bibliography of SHM reviews—a meta-bibliography.

60 APPLIED LIFE SCIENCES↗

SU-D-207-06: Clinical Validations of Shading Correction for Cone-Beam CT Using Planning CT as a Prior

Purpose: Current cone-beam CT (CBCT) images contain severe shading artifacts mainly due to scatter, hindering their quantitative use in current radiation therapy. We have previously proposed an effective shading correction method for CBCT using planning CT (pCT) as prior knowledge. In this work, we investigate the method robustness via statistical analyses on studies of a large patient group and compare the performance with that of a state-of-the-art method implemented on the current commercial radiation therapy machine -- the Varian Truebeam system. Methods: Since radiotherapy patients routinely undergo multiple-detector CT (MDCT) scans in the planning procedure, we use the high-quality pCT as “free” prior knowledge for CBCT image improvement. The CBCT image with no correction is first spatially registered with the pCT. Primary CBCT projections are estimated via forward projections of the registered image. The low frequency errors in the projections, which stem from mainly scatter, are estimated by filtering the difference between original line integral and the estimated scatter projections. The corrected CBCT image is then reconstructed from the scatter corrected projections. The proposed method is evaluated on 40 cancer patients. Results: On all patient images, we compare errors on CT number, spatial non-uniformity (SNU) and image contrast, using pCT as the ground truth. T-tests show that our algorithm improves over the Varian method on CBCT accuracies of CT number and SNU with 90% confident. The average CT number error is reduced from 54.8 HU on the Varian method to 40.9 HU, and the SNU error is reduced from 7.7% to 3.8%. There is no obvious improvement on image contrast. Conclusion: Large-group patient studies show that the proposed pCT-based algorithm outperforms the Varian method of the Truebeam system on CBCT shading correction, by providing CBCT images with higher CT number accuracy and greater image uniformity.

60 APPLIED LIFE SCIENCES↗

Classification of Photovoltaic Failures with Hidden Markov Modeling, an Unsupervised Statistical Approach

Failure detection methods are of significant interest for photovoltaic (PV) site operators to help reduce gaps between expected and observed energy generation. Current approaches for field-based fault detection, however, rely on multiple data inputs and can suffer from interpretability issues. In contrast, this work offers an unsupervised statistical approach that leverages hidden Markov models (HMM) to identify failures occurring at PV sites. Using performance index data from 104 sites across the United States, individual PV-HMM models are trained and evaluated for failure detection and transition probabilities. This analysis indicates that the trained PV-HMM models have the highest probability of remaining in their current state (87.1% to 93.5%), whereas the transition probability from normal to failure (6.5%) is lower than the transition from failure to normal (12.9%) states. A comparison of these patterns using both threshold levels and operations and maintenance (O&M) tickets indicate high precision rates of PV-HMMs (median = 82.4%) across all of the sites. Although additional work is needed to assess sensitivities, the PV-HMM methodology demonstrates significant potential for real-time failure detection as well as extensions into predictive maintenance capabilities for PV.

classification↗

The impact of detection rate changes and correlations on random-coincidence background measurements

Coincidence detection of multiple particles emitted during an experiment can yield a new depth of understanding of the underlying process under study. However, the probability of detecting particles that are generated from the same physical event within a given coincidence time window is generally much lower than that of detecting particles that appear in the same coincidence time window, but were not created from the same physical event, and are therefore detected randomly in coincidence with each other. Thus, accurate and precise methods of measuring this random-coincidence background are essential for a wide variety of fields of science. A method to determine this background directly using the data themselves without any additional experimental run time or fake signals introduced in the data was recently established (O’Donnell, 2016). This method yields a statistical uncertainty on the random-coincidence background that is orders of magnitude smaller than that of the true coincidence data, though the potential for systematic errors of backgrounds from this method was never explored. In this work, we discuss common varieties of correlated and uncorrelated changes in the detection rates of each particle detected in an experiment. Here we demonstrate here that a correlation between particle detection rates from, for example, an incident particle beam that initiates a physical process of interest, creates systematic errors in the random-coincidence background measurement. We also discuss the impact of a variety of other realistic scenarios for rate changes in experiments. Lastly, a method is introduced to correct for errors in the random-coincidence background from any source, yielding an optimization between statistical precision and eliminating potential lingering systematic errors.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Experiments, Statistical Analysis, and Modeling to Evaluate the Porosity Influence in SPS Coatings

Suspension plasma spray (SPS) is far more complicated than conventional plasma spray and requires a deep knowledge about the influence of process parameters and their correlations. In this study, YSZ coatings were manufactured by SPS with six different process parameters such as plasma power, suspension mass load, original powder size, substrate surface topology, spray distance, and spray step. Then, the porosity of as-prepared coatings was investigated by image method and X-ray transmission technique. A multivariate analysis on the collected experimental data was carried out by employing mathematical statistics methods. The results showed that: 1) Coating porosity has a negative correlation with plasma power and suspension mass load and a positive correlation with the original powder size, spray distance, spray step, and substrate roughness; 2) Spraying distance is the main factor affecting to coating porosity, followed by suspension mass load and substrate surface roughness, respectively. A linear model for porosity prediction was developed and was verified by experiments. Furthermore, the mechanism by which process parameters influence coating porosity is additionally discussed.

36 MATERIALS SCIENCE↗

MIRO Continuum Calibration for Asteroid Mode

MIRO (Microwave Instrument for the Rosetta Orbiter) is a lightweight, uncooled, dual-frequency heterodyne radiometer. The MIRO encountered asteroid Steins in 2008, and during the flyby, MIRO used the Asteroid Mode to measure the emission spectrum of Steins. The Asteroid Mode is one of the seven modes of the MIRO operation, and is designed to increase the length of time that a spectral line is in the MIRO pass-band during a flyby of an object. This software is used to calibrate the continuum measurement of Steins emission power during the asteroid flyby. The MIRO raw measurement data need to be calibrated in order to obtain physically meaningful data. This software calibrates the MIRO raw measurements in digital units to the brightness temperature in Kelvin. The software uses two calibration sequences that are included in the Asteroid Mode. One sequence is at the beginning of the mode, and the other at the end. The first six frames contain the measurement of a cold calibration target, while the last six frames measure a warm calibration target. The targets have known temperatures and are used to provide reference power and gain, which can be used to convert MIRO measurements into brightness temperature. The software was developed to calibrate MIRO continuum measurements from Asteroid Mode. The software determines the relationship between the raw digital unit measured by MIRO and the equivalent brightness temperature by analyzing data from calibration frames. The found relationship is applied to non-calibration frames, which are the measurements of an object of interest such as asteroids and other planetary objects that MIRO encounters during its operation. This software characterizes the gain fluctuations statistically and determines which method to estimate gain between calibration frames. For example, if the fluctuation is lower than a statistically significant level, the averaging method is used to estimate the gain between the calibration frames. If the fluctuation is found to be statistically significant, a linear interpolation of gain and reference power is used to estimate the gain between the calibration frames.

Lee, Seungwon↗

Probabilistic evolution of stochastic dynamical systems: A meso-scale perspective

Stochastic dynamical systems arise naturally across nearly all areas of science and engineering. Typically, a dynamical system model is based on some prior knowledge about the underlying dynamics of interest in which probabilistic features are used to quantify and propagate uncertainties associated with the initial conditions, external excitations, etc. From a probabilistic modeling standing point, two broad classes of methods exist, i.e. macro-scale methods and micro-scale methods. Classically, macro-scale methods such as statistical moments-based strategies are usually too coarse to capture the multi-mode shape or tails of a non-Gaussian distribution. Micro-scale methods such as random samples-based approaches, on the other hand, become computationally very challenging in dealing with high-dimensional stochastic systems. In view of these potential limitations, a meso-scale scheme is proposed here that utilizes a meso-scale statistical structure to describe the dynamical evolution from a probabilistic perspective. The significance of this statistical structure is twofold. First, it can be tailored to any arbitrary random space. Second, it not only maintains the probability evolution around sample trajectories but also requires fewer meso-scale components than the micro-scale samples. To demonstrate the efficacy of the proposed meso-scale scheme, a set of examples of increasing complexity are provided. Connections to the benchmark stochastic models as conservative and Markov models along with practical implementation guidelines are presented.

97 MATHEMATICS AND COMPUTING↗

Parameter estimation techniques based on optimizing goodness-of-fit statistics for structural reliability

New methods are presented that utilize the optimization of goodness-of-fit statistics in order to estimate Weibull parameters from failure data. It is assumed that the underlying population is characterized by a three-parameter Weibull distribution. Goodness-of-fit tests are based on the empirical distribution function (EDF). The EDF is a step function, calculated using failure data, and represents an approximation of the cumulative distribution function for the underlying population. Statistics (such as the Kolmogorov-Smirnov statistic and the Anderson-Darling statistic) measure the discrepancy between the EDF and the cumulative distribution function (CDF). These statistics are minimized with respect to the three Weibull parameters. Due to nonlinearities encountered in the minimization process, Powell's numerical optimization procedure is applied to obtain the optimum value of the EDF. Numerical examples show the applicability of these new estimation methods. The results are compared to the estimates obtained with Cooper's nonlinear regression algorithm.

Starlinger, Alois↗

A Minority Report Submitted as an Addendum to the Report of the Mars 2020 Organic Contamination Panel

This Minority Report (MR) presents seven findings in addition to or contrary to the main OCP report: 1. Contamination control for the Mars 2020 cache must be strict. Mars’ surface is known to be organics-poor from laboratory studies, Mars meteorite analyses, and from four previous NASA missions. It is imperative that contamination control measures are enacted that enable reliable and robust detection of potential biomarker compounds at the ppb level. 2. Since Mars 2020 is a sample return mission and analyses of samples in the returnable cache are expected to occur after return to Earth, positive controls are not recommended for flight on Mars 2020 unless a compelling case can be made for their use. 3. The findings of previous panels dedicated to organic compound analysis in Martian samples (OCSSG, ND-SAG, SDT) recommend TOC limits between 10-40 ppb. The MR finds that the lower limit of 10 ppb is recommended and that insufficient justification is given by the OCP Panel Report (PR) to raise the TOC limit to 40 ppb. 4. Analytical capability is sufficiently advanced that analytical capability is an irrelevant consideration with respect to differentiating between 10 and 40 ppb TOC. 5. Perceived contamination control challenges are an irrelevant consideration for raising the TOC contamination limit from 10 to 40 ppb since those challenges, and the procedures to ameliorate them, will exist regardless of whether the limit is 10 or 40 ppb. 6. The “dilution cleaning” method has not been adequately proven for utilization on the Mars 2020 mission. Shortcomings have been identified in terms of peer review, method verification, analytical and testing approach, application to space flight hardware, and performance under Martian conditions. The method should be revisited and independently tested using statistically and analytically robust methods, and scrutinized in a rigorous peer review process. 7. The Mars 2020 mission claims considerable heritage from the Mars Science Laboratory (MSL) mission, but MSL contamination control efforts contain significant errors and implementation discrepancies that would imperil the Mars 2020 caching mission were they repeated. A standing contamination control panel should be formed to provide independent oversight for the Mars 2020 mission.

Mars Sample Return↗

Transmission overhaul and replacement predictions using Weibull and renewel theory

A method to estimate the frequency of transmission overhauls is presented. This method is based on the two-parameter Weibull statistical distribution for component life. A second method is presented to estimate the number of replacement components needed to support the transmission overhaul pattern. The second method is based on renewal theory. Confidence statistics are applied with both methods to improve the statistical estimate of sample behavior. A transmission example is also presented to illustrate the use of the methods. Transmission overhaul frequency and component replacement calculations are included in the example.

Savage, M.↗

Transmission overhaul and replacement predictions using Weibull and renewal theory

A method to estimate the frequency of transmission overhauls is presented. This method is based on the two-parameter Weibull statistical distribution for component life. A second method is presented to estimate the number of replacement components needed to support the transmission overhaul pattern. The second method is based on renewal theory. Confidence statistics are applied with both methods to improve the statistical estimate of sample behavior. A transmission example is also presented to illustrate the use of the methods. Transmission overhaul frequency and component replacement calculations are included in the example.

Savage, M.↗

Topological data analysis and machine learning for recognizing atmospheric river patterns in large climate datasets

Identifying weather patterns that frequently lead to extreme weather events is a crucial first step in understanding how they may vary under different climate change scenarios. Here, we propose an automated method for recognizing atmospheric rivers (ARs) in climate data using topological data analysis and machine learning. The method provides useful information about topological features (shape characteristics) and statistics of ARs. We illustrate this method by applying it to outputs of version 5.1 of the Community Atmosphere Model version 5.1 (CAM5.1) and the reanalysis product of the second Modern-Era Retrospective Analysis for Research and Applications (MERRA-2). An advantage of the proposed method is that it is threshold-free – there is no need to determine any threshold criteria for the detection method – when the spatial resolution of the climate model changes. Hence, this method may be useful in evaluating model biases in calculating AR statistics. Further, the method can be applied to different climate scenarios without tuning since it does not rely on threshold conditions. We show that the method is suitable for rapidly analyzing large amounts of climate model and reanalysis output data.

54 ENVIRONMENTAL SCIENCES↗

Estimating Bidirectional Reflectance and Monitoring Stability of SNPP-VIIRS Reflective Solar Bands Using A Deep Neural Network

The NASA Clouds and the Earth's Radiant Energy System project provides the scientific community with observed top-of-atmosphere shortwave and longwave fluxes for climate monitoring and climate model validation. To provide consistent VIIRS cloud retrievals, the CERES Imager and Geostationary Calibration Group (IGCG) must understand and quantify the stability of the VIIRS instruments. To achieve this, the IGCG utilizes tropical deep convective clouds (DCCs) as invariant targets. Proper seasonal characterization of the DCC bidirectional reflectance distribution function (BRDF) is key to the success of DCC-based calibration methods, particularly for shortwave infrared (SWIR) bands. This article proposes the use of a deep neural network (DNN) to characterize VIIRS solar reflective band BRDF reflectance, with which individual channel trends are isolated by manipulating the DNN time input. Initial results show that the DNN method can extract statistically significant SNPP-VIIRS band trends, using only SNPP-VIIRS inputs, that are correlative to and match the magnitude of significant trends determined using methods that rely on an external angular distribution model. It may be possible to apply this approach to actively monitor the stability of new instruments without the need for predetermined seasonal BRDF corrections.

Benjamin Scarino↗