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Orbits for 18 Visual Binaries and Two Double-line Spectroscopic Binaries Observed with HRCAM on the CTIO SOAR 4 m Telescope, Using a New Bayesian Orbit Code Based on Markov Chain Monte Carlo

We present orbital elements and mass sums for 18 visual binary stars of spectral types B to K (five of which are new orbits) with periods ranging from 20 to more than 500 yr. For two double-line spectroscopic binaries with no previous orbits, the individual component masses, using combined astrometric and radial velocity data, have a formal uncertainty of ∼0.1 M{sub ⊙}. Adopting published photometry and trigonometric parallaxes, plus our own measurements, we place these objects on an H-R diagram and discuss their evolutionary status. These objects are part of a survey to characterize the binary population of stars in the Southern Hemisphere using the SOAR 4 m telescope+HRCAM at CTIO. Orbital elements are computed using a newly developed Markov chain Monte Carlo (MCMC) algorithm that delivers maximum-likelihood estimates of the parameters, as well as posterior probability density functions that allow us to evaluate the uncertainty of our derived parameters in a robust way. For spectroscopic binaries, using our approach, it is possible to derive a self-consistent parallax for the system from the combined astrometric and radial velocity data (“orbital parallax”), which compares well with the trigonometric parallaxes. We also present a mathematical formalism that allows a dimensionality reduction of the feature space from seven to three search parameters (or from 10 to seven dimensions—including parallax—in the case of spectroscopic binaries with astrometric data), which makes it possible to explore a smaller number of parameters in each case, improving the computational efficiency of our MCMC code.

79 ASTRONOMY AND ASTROPHYSICS↗

Automatic information extraction from neutron radiography imaging to estimate axial fuel expansion in $\mathrm{EBR-II}$

Approximately 130,000 metal fuel pins were irradiated in the Experimental Breeder Reactor II (EBR-II) during its 30 years of operation to develop and characterize existing and prospective fuels. For many of the metal fuel irradiation experiments, neutron radiography imaging was performed to characterize fuel behavior, like fuel swelling. However, due to the lack of technology or resources, many of the images have not been processed or were processed manually through visual examination. This paper represents first-attempt to develop an image processing algorithm capable of automatically extracting information regarding the degree of fuel swelling from neutron radiography imaging. The algorithm was applied to 120 images of three different metallic fuel pin compositions—U-10Zr, U-8Pu-10Zr, and U-19Pu-10Zr. The algorithm performs operations of image intensity adjustment, image binarization, region finding, and labeling to extract information about fuel swelling. The average growth for U-10Zr was found to be 8.49% with 95% Confidence Interval (CI) [8.33 –8.66%], for U-8Pu-10Zr — 7.50% with 95% CI [7.23 – 7.78%], and for U-19Pu-10Zr — 3.15%, with 95% CI [2.40 – 3.91%]. The results obtained by applying this automatic image processing algorithm are consistent with previously reported studies of the same types of fuels. The automatic image processing algorithm will be expanded to include thousands of available neutron radiography images and different types of fuels to investigate empirical dependencies of fuel swelling, which can be subsequently applied to advanced fuel modeling. Results from this study can later be compared to BISON simulations to further benchmark modeling efforts and develop assessment cases.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

CANDELS: THE CORRELATION BETWEEN GALAXY MORPHOLOGY AND STAR FORMATION ACTIVITY AT z {approx} 2

We discuss the state of the assembly of the Hubble sequence in the mix of bright galaxies at redshift 1.4 < z {<=} 2.5 with a large sample of 1671 galaxies down to H{sub AB} {approx} 26, selected from the HST/ACS and WFC3 images of the GOODS-South field obtained as part of the GOODS and CANDELS observations. We investigate the relationship between the star formation properties and morphology using various parametric diagnostics, such as the Sersic light profile, Gini (G), M{sub 20}, concentration (C), asymmetry (A), and multiplicity ({Psi}) parameters. Our sample clearly separates into massive, red, and passive galaxies versus less massive, blue, and star-forming ones, and this dichotomy correlates very well with the galaxies' morphological properties. Star-forming galaxies show a broad variety of morphological features, including clumpy structures and bulges mixed with faint low surface brightness features, generally characterized by disky-type light profiles. Passively evolving galaxies, on the other hand, very often have compact light distribution and morphology typical of today's spheroidal systems. We also find that artificially redshifted local galaxies have a similar distribution with z {approx} 2 galaxies in a G-M{sub 20} plane. Visual inspection between the rest-frame optical and UV images show that there is a generally weak morphological k-correction for galaxies at z {approx} 2, but the comparison with non-parametric measures show that galaxies in the rest-frame UV are somewhat clumpier than rest-frame optical. Similar general trends are observed in the local universe among massive galaxies, suggesting that the backbone of the Hubble sequence was already in place at z {approx} 2.

79 ASTRONOMY AND ASTROPHYSICS↗

Reservoir Characterization of Bridgeport and Cypress Sandstones in Lawrence Field Illinois to Improve Petroleum Recovery by Alkaline-Surfactant-Polymer Flood

Within the Illinois Basin, most of the oilfields are mature and have been extensively waterflooded with water cuts that range up to 99% in many of the larger fields. In order to maximize production of significant remaining mobile oil from these fields, new recovery techniques need to be researched and applied. The purpose of this project was to conduct reservoir characterization studies supporting Alkaline-Surfactant-Polymer Floods in two distinct sandstone reservoirs in Lawrence Field, Lawrence County, Illinois. A project using alkaline-surfactantpolymer (ASP) has been established in the century old Lawrence Field in southeastern Illinois where original oil in place (OOIP) is estimated at over a billion barrels and 400 million barrels have been recovered leaving more than 600 million barrels as an EOR target. Radial core flood analysis using core from the field demonstrated recoveries greater than 20% of OOIP. While the lab results are likely optimistic to actual field performance, the ASP tests indicate that substantial reserves could be recovered even if the field results are 5 to 10% of OOIP. Reservoir characterization is a key factor in the success of any EOR application. Reservoirs within the Illinois Basin are frequently characterized as being highly compartmentalized resulting in multiple flow unit configurations. The research conducted on Lawrence Field focused on characteristics that define reservoir compartmentalization in order to delineate preferred target areas so that the chemical flood can be designed and implemented for the greatest recovery potential. Along with traditional facies mapping, core analyses and petrographic analyses, conceptual geological models were constructed and used to develop 3D geocellular models, a valuable tool for visualizing reservoir architecture and also a prerequisite for reservoir simulation modeling. Cores were described and potential permeability barriers were correlated using geophysical logs. Petrographic analyses were used to better understand porosity and permeability trends in the region and to characterize barriers and define flow units. Diagenetic alterations that impact porosity and permeability include development of quartz overgrowths, sutured quartz grains, dissolution of feldspar grains, formation of clay mineral coatings on grains, and calcite cementation. Many of these alterations are controlled by facies. Mapping efforts identified distinct flow units in the northern part of the field showing that the Pennsylvanian Bridgeport consists of a series of thick incised channel fill sequences. The sandstones are about 75-150 feet thick and typically consist of medium grained and poorly sorted fluvial to distributary channel fill deposits at the base. The sandstones become indistinctly bedded distributary channel deposits in the main part of the reservoir before fining upwards and becoming more tidally influenced near their top. These channel deposits have core permeabilities ranging from 20 md to well over 1000 md. The tidally influenced deposits are more compartmentalized compared to the thicker and more continuous basal fluvial deposits. Fine grained sandstones that are laterally equivalent to the thicker channel type deposits have permeabilities rarely reaching above 250 md. Most of the unrecovered oil in Lawrence Field is contained in Pennsylvanian Age Bridgeport sandstones and Mississippian Age Cypress sandstones. These reservoirs are highly complex and compartmentalized. Detailed reservoir characterization including the development of 3-D geologic and geocellular models of target areas in the field were completed to identify areas with the best potential to recover remaining reserves including unswept and by-passed oil. This project consisted of tasks designed to compile, interpret, and analyze the data required to conduct reservoir characterization for the Bridgeport and Cypress sandstones in pilot areas in anticipation of expanded implementation of ASP flooding in Lawrence Field. Geologic and geocellular modeling needed for reservoir characterization and reservoir simulation were completed as prerequisites for design of efficient ASP flood patterns. Characterizing the complex reservoir geology that identifies the geologic conditions that will optimize oil recoveries for expansion of the ASP pilots in the Bridgeport and Cypress sandstones to other areas of Lawrence Field is the primary objective of this project. It will permit evaluation of efficiency of oil recovery from Bridgeport and Cypress sandstone reservoirs using ASP technology. Additionally evaluation of similar Pennsylvanian and Chesterian reservoirs shows that it is likely that ASP flood technology can be successfully applied to similar reservoirs in the Illinois Basin as well as to other U.S. reservoirs. Chemical flooding was introduced in stages with the first flood initiated in 2010 and a second offset pilot project initiated during 2011. Rex Energy Corporation is reporting a positive response on its ASP Middagh pilot project in the Pennsylvanian Bridgeport B reservoir, Lawrence Field. Oil response in the 15 acre flood has continued to show an increase in oil cut from 1% to 12%. Total pattern production increased from 16 BOPD and stabilized at a range of 65-75 BOPD in the last three months of 2011. Peak production rose to 100 + BOPD. Oil cut in the pilot increased for 1.0% to ~ 12.0% with an individual well showing oil cuts greater than 20%. A second, 58 acre pilot (Perkins-Smith) adjacent to and likely in communication with the Middagh pilot has been initiated. Preliminary brine injection has been implemented and ASP injection was initiated in mid-2012. Response is expected by mid-2013 with peak recovery expected by late 2013. Rex Energy is projecting full scale expansion with the next step of development being a 351 acre project scheduled to begin in mid-2013. Preliminary development has been initiated in this Delta Unit area located in the south half of section 32, T4N, R12W.

02 PETROLEUM↗

Visualization and prediction of supercritical CO 2 distribution in sandstones during drainage: An in situ synchrotron X-ray micro-computed tomography study

Pore-scale distribution of supercritical CO 2 (scCO 2 ) exerts significant control on a variety of key hydrologic as well as geochemical processes, including residual trapping and dissolution. Despite such importance, only a small number of experiments have directly characterized the three-dimensional distribution of scCO 2 in geologic materials during the invasion (drainage) process. Here, we present a study which couples dynamic high-resolution synchrotron X-ray micro-computed tomography imaging of a scCO 2 /brine system at in situ pressure/temperature conditions with quantitative pore-scale modeling to allow direct validation of a pore-scale description of scCO2 distribution. The experiment combines high-speed synchrotron radiography with tomography to characterize the brine saturated sample, the scCO 2 breakthrough process, and the partially saturated state of a sandstone sample from the Domengine Formation, a regionally extensive unit within the Sacramento Basin (California, USA). The availability of a 3D dataset allowed us to examine correlations between grains and pores morphometric parameters and the actual distribution of scCO 2 in the sample, including the examination of the role of small-scale sedimentary structure on CO2 distribution. The segmented scCO 2 /brine volume was also used to validate a simple computational model based on the local thickness concept, able to accurately simulate the distribution of scCO 2 after drainage. The same method was also used to simulate Hg capillary pressure curves with satisfactory results when compared to the measured ones. Finally, this predictive approach, requiring only a tomographic scan of the dry sample, proved to be an effective route for studying processes related to CO 2 invasion structure in geological samples at the pore scale.

3D quantitative morphometric analysis↗

SU-F-T-275: A Correlation Study On 3D Fluence-Based QA and 2D Dose Measurement-Based QA

Purpose: The aim of this paper was to demonstrate the feasibility and creditability of computing and verifying 3D fluencies to assure IMRT and VMAT treatment deliveries, by correlating the passing rates of the 3D fluence-based QA (P(ά)) to the passing rates of 2D dose measurementbased QA (P(Dm)). Methods: 3D volumetric primary fluencies are calculated by forward-projecting the beam apertures and modulated by beam MU values at all gantry angles. We first introduce simulated machine parameter errors (MU, MLC positions, jaw, gantry and collimator) to the plan. Using passing rates of voxel intensity differences (P(Ir)) and 3D gamma analysis (P(γ)), calculated 3D fluencies, calculated 3D delivered dose, and measured 2D planar dose in phantom from the original plan are then compared with those from corresponding plans with errors, respectively. The correlations of these three groups of resultant passing rates, i.e. 3D fluence-based QA (P(ά,Ir) and P(ά,γ)), calculated 3D dose (P(Dc,Ir) and P(Dc,γ)), and 2D dose measurement-based QA (P(Dm,Ir) and P(Dm,γ)), will be investigated. Results: 20 treatment plans with 5 different types of errors were tested. Spearman’s correlations were found between P(ά,Ir) and P(Dc,Ir), and also between P(ά,γ) and P(Dc,γ), with averaged p-value 0.037, 0.065, and averaged correlation coefficient ρ-value 0.942, 0.871 respectively. Using Matrixx QA for IMRT plans, Spearman’s correlations were also obtained between P(ά,Ir) and P(Dm,Ir) and also between P(ά,γ) and P(Dm,γ), with p-value being 0.048, 0.071 and ρ-value being 0.897, 0.779 respectively. Conclusion: The demonstrated correlations improve the creditability of using 3D fluence-based QA for assuring treatment deliveries for IMRT/VMAT plans. Together with advantages of high detection sensitivity and better visualization of machine parameter errors, this study further demonstrates the accuracy and feasibility of 3D fluence based-QA in pre-treatment QA and daily QA. Research reported in this study is supported by the Agency for Healthcare Research and Quality (AHRQ) under award 1R01HS0222888. The senior author received research grants from ViewRay Inc. and Varian Medical System.

60 APPLIED LIFE SCIENCES↗

Hofmann Stability Charts Revisited for PIP-II: From Classical Theory to Assumption-Free and ML-Driven Maps

The Hofmann stability chart remains a standard for visualizing parametric resonances in space-charge–dominated linacs, but its use typically relies on non-oscillatory Vlasov dispersion relations with simplifying assumptions (continuous focusing, KV phase space, linear optics, limited transverse–longitudinal coupling). We revisit the chart for the PIP-II linac along three tracks. (1) We reproduce the conventional maps in the (νz/νx, νx/ν0x) plane for relevant εz/εx, providing a validated reference. (2) We remove key assumptions by deriving stability surfaces directly from multi-particle tracking with realistic lattice discreteness, RF defocusing, solenoid/quad optics, and bunched-beam dynamics; local tunes and early-time growth rates are estimated from envelope oscillations and projected to the same coordinates. These assumption-reduced maps recover the canonical stopbands while revealing shifts and broadenings driven by tune modulation, non-KV distributions, and transverse–longitudinal coupling at PIP-II intensities. (3) We train a compact machine-learning surrogate that emulates the growth surface from zero-current optics, tune depression, emittance ratio, bunching factor, and selected lattice descriptors, enabling rapid scans and online working-point selection. We compare the three representations on representative PIP-II sections and discuss implications for commissioning guard bands, resonance avoidance, and routine operations.

Pathak, Abhishek [Fermilab] (ORCID:000000021704208↗

Enhanced magnetic flux density mapping using coherent steady state equilibrium signal in MREIT

Measuring the z-component of magnetic flux density B = (B{sub x}, B{sub y}, B{sub z}) induced by transversally injected current, magnetic resonance electrical impedance tomography (MREIT) aims to visualize electrical property (current density and/or conductivity distribution) in a three-dimensional imaging object. For practical implementations of MREIT technique, it is critical to reduce injection of current pulse within safety requirements. With the goal of minimizing the noise level in measured B{sub z} data, we propose a new method to enhance the measure B{sub z} data using steady-state coherent gradient multi-echo (SSC-GME) MR pulse sequence combining with injection current nonlinear encoding (ICNE) method in MREIT, where the ICNE technique injects current during a readout gradient to maximize the signal intensity of phase signal including B{sub z}. The total phase offset in SSC-GME includes additional magnetic flux density due to the injected current, which is different from the phase signal for the conventional spoiled MR pulse sequence. We decompose the magnetization precession phase from the total phase offset including B{sub z} and optimize B{sub z} data using the steady-state equilibrium signal. Results from a real phantom experiment including different kinds of anomalies demonstrated that the proposed method enhanced B{sub z} comparing to a conventional spoiled pulse sequence.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

THE CFHTLS-STRONG LENSING LEGACY SURVEY (SL2S): INVESTIGATING THE GROUP-SCALE LENSES WITH THE SARCS SAMPLE

We present the Strong Lensing Legacy Survey-ARCS (SARCS) sample compiled from the final T0006 data release of the Canada-France-Hawaii Telescope Legacy Survey (CFHTLS) covering a total non-overlapping area of 159 deg{sup 2}. We adopt a semi-automatic method to find gravitational arcs in the survey that makes use of an arc-finding algorithm. The candidate list is pruned by visual inspection and ranking to form the final SARCS sample. This list also includes some serendipitously discovered lens candidates which the automated algorithm did not detect. The SARCS sample consists of 127 lens candidates which span arc radii {approx}2''-18'' within the unmasked area of {approx}150 deg{sup 2}. Within the sample, 54 systems are promising lenses among which, we find 12 giant arcs (length-to-width ratio {>=}8). We also find two radial arc candidates in SL2SJ141447+544704. From our sample, we detect a systematic alignment of the giant arcs with the major axis of the baryonic component of the putative lens in concordance with previous studies. This alignment is also observed for all arcs in the sample and does not vary significantly with increasing arc radius. The mean values of the photometric redshift distributions of lenses corresponding to the giant arcs and all arcs sample are at z {approx} 0.6. Owing to the large area and depth of the CFHTLS, we find the largest sample of lenses probing mass scales that are intermediate to cluster and galaxy lenses for the first time. We compare the observed image separation distribution (ISD) of our arcs with theoretical models. A two-component density profile for the lenses which accounts for both the central galaxy and the dark matter component is required by the data to explain the observed ISD. Unfortunately, current levels of uncertainties and degeneracies accommodate models both with and without adiabatic contraction. We also show the effects of changing parameters of the model that predict the ISD and that a larger lens sample might constrain relations such as the concentration-mass relation, mass-luminosity relation, and the faint-end slope of the luminosity function.

79 ASTRONOMY AND ASTROPHYSICS↗

Visualizing Oxidation Mechanisms in Few-Layered Black Phosphorus via In Situ Transmission Electron Microscopy

Layered two-dimensional (2D) black phosphorus (BP) exhibits novel semiconducting properties including a tunable bandgap and high electron mobility. However, the poor stability of BP in ambient environment severely limits potential for application in future electronic and optoelectronic devices. While passivation or encapsulation of BP using inert materials/polymers has emerged as a plausible solution, a detailed fundamental understanding of BP's reaction with oxygen is imperative to rationally advance its use in applications. Here, we use in situ environmental transmission electron microscopy to elucidate atomistic structural changes in mechanically exfoliated few-layered BP during exposure to varying partial pressures of oxygen. An amorphous oxide layer is seen on the actively etching BP edges, and the thickness of this layer increases with increasing oxygen partial pressure, indicating that oxidation proceeds via initial formation of amorphous P x O y species which sublime to result in the etching of the BP crystal. We observe that while few-layered BP is stable under the 80 kV electron beam (e-beam) in vacuum, the lattice oxidizes and degrades at room temperature in the presence of oxygen only in the region under the e-beam. The oxidative etch rate also increases with increasing e-beam dosage, suggesting the presence of an energy barrier for the oxidation reaction. Preferential oxidative etching along the [0 0 1] and [0 0 1] crystallographic directions is observed, in good agreement with density functional theory calculations showing favorable thermodynamic stability of the oxidized BP (0 0 $\bar{1}$) planes compared to the (1 0 0) planes. Finally, we expect the atomistic insights and fundamental understanding obtained here to aid in the development of novel approaches to integrate BP in future applications.

2D materials↗

Scalable Contour Tree Computation by Data Parallel Peak Pruning

As data sets grow to exascale, automated data analysis and visualization are increasingly important, to intermediate human understanding and to reduce demands on disk storage via in situ analysis. Trends in architecture of high performance computing systems necessitate analysis algorithms to make effective use of combinations of massively multicore and distributed systems. One of the principal analytic tools is the contour tree, which analyses relationships between contours to identify features of more than local importance. Unfortunately, the predominant algorithms for computing the contour tree are explicitly serial, and founded on serial metaphors, which has limited the scalability of this form of analysis. While there is some work on distributed contour tree computation, and separately on hybrid GPU-CPU computation, there is no efficient algorithm with strong formal guarantees on performance allied with fast practical performance. Furthermore, we report the first shared SMP algorithm for fully parallel contour tree computation, with formal guarantees of O(lg V lg t) parallel steps and O(V lg V) work for data with V samples and t contour tree supernodes, and implementations with more than 30× parallel speed up on both CPU using TBB and GPU using Thrust and up 70× speed up compared to the serial sweep and merge algorithm.

97 MATHEMATICS AND COMPUTING↗

SU-F-R-44: Modeling Lung SBRT Tumor Response Using Bayesian Network Averaging

Purpose: The prediction of tumor control after a patient receives lung SBRT (stereotactic body radiation therapy) has proven to be challenging, due to the complex interactions between an individual’s biology and dose-volume metrics. Many of these variables have predictive power when combined, a feature that we exploit using a graph modeling approach based on Bayesian networks. This provides a probabilistic framework that allows for accurate and visually intuitive predictive modeling. The aim of this study is to uncover possible interactions between an individual patient’s characteristics and generate a robust model capable of predicting said patient’s treatment outcome. Methods: We investigated a cohort of 32 prospective patients from multiple institutions whom had received curative SBRT to the lung. The number of patients exhibiting tumor failure was observed to be 7 (event rate of 22%). The serum concentration of 5 biomarkers previously associated with NSCLC (non-small cell lung cancer) was measured pre-treatment. A total of 21 variables were analyzed including: dose-volume metrics with BED (biologically effective dose) correction and clinical variables. A Markov Chain Monte Carlo technique estimated the posterior probability distribution of the potential graphical structures. The probability of tumor failure was then estimated by averaging the top 100 graphs and applying Baye’s rule. Results: The optimal Bayesian model generated throughout this study incorporated the PTV volume, the serum concentration of the biomarker EGFR (epidermal growth factor receptor) and prescription BED. This predictive model recorded an area under the receiver operating characteristic curve of 0.94(1), providing better performance compared to competing methods in other literature. Conclusion: The use of biomarkers in conjunction with dose-volume metrics allows for the generation of a robust predictive model. The preliminary results of this report demonstrate that it is possible to accurately model the prognosis of an individual lung SBRT patient’s treatment.

60 APPLIED LIFE SCIENCES↗

Evaluation of Immunocompetent Mouse Models for Borrelia miyamotoi Infection

Borrelia miyamotoi is a relapsing fever spirochete that is harbored by Ixodes spp. ticks and is virtually uncharacterized, compared to other relapsing fever Borrelia vectored by Ornithodoros spp. ticks. There is not an immunocompetent mouse model for studying B. miyamotoi infection in vivo or for transmission in the vector-host cycle. Our goal was to evaluate B. miyamotoi infections in multiple mouse breeds/strains as a prelude to the ascertainment of the best experimental infection model. Two B. miyamotoi strains, namely, LB-2001 and CT13-2396, as well as three mouse models, namely, CD-1, C3H/HeJ, and BALB/c, were evaluated. We were unable to observe B. miyamotoi LB-2001 spirochetes in the blood via darkfield microscopy or to detect DNA via real-time PCR post needle inoculation in the CD-1 and C3H/HeJ mice. However, LB-2001 DNA was detected via real-time PCR in the blood of the BALB/c mice after needle inoculation, although spirochetes were not observed via microscopy. CD-1, C3H/HeJ, and BALB/c mice generated an antibody response to B. miyamotoi LB-2001 following needle inoculation, but established infections were not detected, and the I. scapularis larvae failed to acquire spirochetes from the exposed CD-1 mice. In contrast, B. miyamotoi CT13-2396 was visualized in the blood of the CD-1 and C3H/HeJ mice via darkfield microscopy and detected by real-time PCR post needle inoculation. Both mouse strains seroconverted. However, no established infection was detected in the mouse organs, and the I. scapularis larvae failed to acquire Borrelia after feeding on CT13-2396 exposed CD-1 or C3H/HeJ mice. Furthermore, these findings underscore the challenges in establishing an experimental B. miyamotoi infection model in immunocompetent laboratory mice.

60 APPLIED LIFE SCIENCES↗

Neurobehavioral effects of arsenic exposure among secondary school children in the Kandal Province, Cambodia

The research was carried out at 3 study sites with varying groundwater arsenic (As) levels in the Kandal Province of Cambodia. Kampong Kong Commune was chosen as a highly contaminated site (300–500 μg/L), Svay Romiet Commune was chosen as a moderately contaminated site (50–300 μg/L) and Anlong Romiet Commune was chosen as a control site. Neurobehavioral tests on the 3 exposure groups were conducted using a modified WHO neurobehavioral core test battery. Seven neurobehavioral tests including digit symbol, digit span, Santa Ana manual dexterity, Benton visual retention, pursuit aiming, trail making and simple reaction time were applied. Children's hair samples were also collected to investigate the influence of hair As levels on the neurobehavioral test scores. The results from the inductively coupled plasma-mass spectrometry (ICP-MS) analyses of hair samples showed that hair As levels at the 3 study sites were significantly different (p<0.001), whereby hair samples from the highly contaminated site (n=157) had a median hair As level of 0.93 μg/g, while the moderately contaminated site (n=151) had a median hair As level of 0.22 μg/g, and the control site (n=214) had a median hair As level of 0.08 μg/g. There were significant differences among the 3 study sites for all the neurobehavioral tests scores, except for digit span (backward) test. Multiple linear regression clearly shows a positive significant influence of hair As levels on all the neurobehavioral test scores, except for digit span (backward) test, after controlling for hair lead (Pb), manganese (Mn) and cadmium (Cd). Children with high hair As levels experienced 1.57–4.67 times greater risk of having lower neurobehavioral test scores compared to those with low hair As levels, after adjusting for hair Pb, Mn and Cd levels and BMI status. In conclusion, arsenic-exposed school children from the Kandal Province of Cambodia with a median hair As level of 0.93 µg/g among those from the highly contaminated study site, showed clear evidence of neurobehavioral effects. - Highlights: • We measured the level of arsenic concentration in school secondary school children's hair. • As contamination in groundwater is the major source effect on the neurobehavioral performance of school children. • School children in highly and moderately contaminated sites are at risk of As exposure.

54 ENVIRONMENTAL SCIENCES↗

Automated identification of local contamination in remote atmospheric composition time series

Abstract. Atmospheric observations in remote locations offer a possibility of exploring trace gas and particle concentrations in pristine environments. However, data from remote areas are often contaminated by pollution from local sources. Detecting this contamination is thus a central and frequently encountered issue. Consequently, many different methods exist today to identify local contamination in atmospheric composition measurement time series, but no single method has been widely accepted. In this study, we present a new method to identify primary pollution in remote atmospheric datasets, e.g., from ship campaigns or stations with a low background signal compared to the contaminated signal. The pollution detection algorithm (PDA) identifies and flags periods of polluted data in five steps. The first and most important step identifies polluted periods based on the derivative (time derivative) of a concentration over time. If this derivative exceeds a given threshold, data are flagged as polluted. Further pollution identification steps are a simple concentration threshold filter, a neighboring points filter (optional), a median, and a sparse data filter (optional). The PDA only relies on the target dataset itself and is independent of ancillary datasets such as meteorological variables. All parameters of each step are adjustable so that the PDA can be “tuned” to be more or less stringent (e.g., flag more or fewer data points as contaminated). The PDA was developed and tested with a particle number concentration dataset collected during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition in the central Arctic. Using strict settings, we identified 62 % of the data as influenced by local contamination. Using a second independent particle number concentration dataset also collected during MOSAiC, we evaluated the performance of the PDA against the same dataset cleaned by visual inspection. The two methods agreed in 94 % of the cases. Additionally, the PDA was successfully applied to a trace gas dataset (CO2), also collected during MOSAiC, and to another particle number concentration dataset, collected at the high-altitude background station Jungfraujoch, Switzerland. Thus, the PDA proves to be a useful and flexible tool to identify periods affected by local contamination in atmospheric composition datasets without the need for ancillary measurements. It is best applied to data representing primary pollution. The user-friendly and open-access code enables reproducible application to a wide suite of different datasets. It is available at https://doi.org/10.5281/zenodo.5761101 (Beck et al., 2021).

54 ENVIRONMENTAL SCIENCES↗

Transformational Challenge Reactor – On the Application of Design for Additive Manufacturing (DfAM) Techniques to the Conception of Nuclear Core

Additive manufacturing (AM) technologies are radically changing the way objects are designed and manufactured. They allow building by deposition and solidification of material layer by layer, enabling the possibility to create simple and complex features alike, almost seamlessly. Generally, the design optimization process requires to define objectives, design variables and constraints. Additive manufacturing does not challenge this process per se but does allow designers to completely redefine the constraints space as the ones originating from fabrication can be considerably relaxed compared to more “traditional” manufacturing. Thus, design optimization becomes naturally far more responsive to the actual physics being solved and considerably less influenced by fabrication limitations, leading to dramatically different designs. To take advantage of these new opportunities, so-called Designing for Additive Manufacturing (DfAM) techniques are emerging. Development of design techniques specifically tailored for additive manufacturing is warranted because, considering AM, the design space is typically considerably larger than with traditional manufacturing. The ability to explore the design space efficiently is of paramount importance for designers. This study proposes to investigate and apply some of these DfAM techniques to the conception of nuclear core. The goal being to assess if these new methods can be applied to core design and if core design could benefits from additive manufacturing technologies. After a brief investigation on the pertinence of some DfAM techniques for core design, algorithms are proposed and a workflow is established to carry neutronics and steady-state thermal-hydraulics analyses. To diminish the work load, the workflow has been automated using python modules. These modules allow the rapid creation of input files, post-treatment of output files and visualization. To test the pertinence of the proposed workflow, three test cases have been investigated: a research and test reactor, a micro-reactor and a space propulsion reactor. These test cases offered a variety of objectives, constraints and operating conditions. It is observed that the proposed workflow is capable of converging quickly and efficiently to valid design solutions. It is then concluded that DfAM techniques can be applied to core design.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

STRUCTURAL EVOLUTION OF EARLY-TYPE GALAXIES TO z = 2.5 IN CANDELS

Projected axis ratio measurements of 880 early-type galaxies at redshifts 1 < z < 2.5 selected from CANDELS are used to reconstruct and model their intrinsic shapes. The sample is selected on the basis of multiple rest-frame colors to reflect low star-formation activity. We demonstrate that these galaxies as an ensemble are dust-poor and transparent and therefore likely have smooth light profiles, similar to visually classified early-type galaxies. Similar to their present-day counterparts, the z > 1 early-type galaxies show a variety of intrinsic shapes; even at a fixed mass, the projected axis ratio distributions cannot be explained by the random projection of a set of galaxies with very similar intrinsic shapes. However, a two-population model for the intrinsic shapes, consisting of a triaxial, fairly round population, combined with a flat (c/a {approx} 0.3) oblate population, adequately describes the projected axis ratio distributions of both present-day and z > 1 early-type galaxies. We find that the proportion of oblate versus triaxial galaxies depends both on the galaxies' stellar mass, and-at a given mass-on redshift. For present-day and z < 1 early-type galaxies the oblate fraction strongly depends on galaxy mass. At z > 1, this trend is much weaker over the mass range explored here (10{sup 10} < M{sub *}/M{sub Sun} < 10{sup 11}), because the oblate fraction among massive (M{sub *} {approx} 10{sup 11} M{sub Sun }) was much higher in the past: 0.59 {+-} 0.10 at z > 1, compared to 0.20 {+-} 0.02 at z {approx} 0.1. When combined with previous findings that the number density and sizes of early-type galaxies substantially increase over the same redshift range, this can be explained by the gradual emergence of merger-produced elliptical galaxies, at the expense of the destruction of pre-existing disks that were common among their high-redshift progenitors. In contrast, the oblate fraction among low-mass early-type galaxies (log (M{sub *}/M{sub Sun }) < 10.5) increased toward the present, from z = 0 to 0.38 {+-} 0.11 at z > 1 to 0.72 {+-} 0.06 at z = 0. We speculate that this lower incidence of disks at early cosmic times can be attributed to two factors: low-mass, star-forming progenitors at z > 1 were not settled into stable disks to the same degree as at later cosmic times, and the stripping of gas from star-forming disk galaxies in dense environments is an increasingly important process at lower redshifts.

79 ASTRONOMY AND ASTROPHYSICS↗

SU-E-I-78: Improving Prostatic Delineation Using Dual-Energy CT

Purpose: Visual prostatic definition is difficult using conventional CT. This is because the prostate is surrounded closely with tissue of similar electron density. Definition is further hindered when the region contains high-Z material (such as fiducial markers). Dual-energy CT (DECT) is a technique where images are rendered using two tube voltages during a single scan session. This study evaluates DECT as a means of improving prostatic volume delineation for radiation oncology. Methods: The patients were scanned using a Definition AS20 (Siemens Healthcare, Malvern, PA). This device uses a single-tube configuration, where two scans of differing energies are performed in serial. The scans are acquired with tube voltage of 80kVp and 140kVp. Following acquisition, these scan data were used to generate effective monoenergetic scans ranging from 40keV to 190keV. In the current study, the data were presented to observers using a novel program, which allows real-time adjustment of window, level, and effective keV; all while scrolling through volumetric slices. Three patients were scanned, each with a different high-contrast material in or around the prostate: I-125 seeds, gold fiducial markers, and prostatic calcifications. These images are compared to a weighted average of the 80kVp and 140kVP scans, which yield a scan similar to that of a 120 kVp scan, which is a common tube voltage in radiation oncology. Results: Prostatic definition improved in each case. Differentiation of soft tissue from surrounding adipose improved with lower keV, while higher keV provided a reduction of high-z artifacts. Furthermore, the dynamic adjustment of the keV allowed observers to better recognize regions of differing tissue composition within this relatively homogeneous area. Conclusion: By simultaneously providing the observer with the benefits of high-energy images and low-energy images, and allowing adjustment in real-time, improved imaging in highly homogeneous regions such as the male pelvis is achievable.

60 APPLIED LIFE SCIENCES↗