Multi-architecture Monte-Carlo (MC) simulation of soft coarse-grained polymeric materials: SOft coarse grained Monte-Carlo Acceleration (SOMA)
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Abstract Detailed and location-aware distribution grid information is a prerequisite for various power system applications such as renewable energy integration, wildfire risk assessment, and infrastructure planning. However, a generalizable and scalable approach to obtain such information is still lacking. In this work, we develop a machine-learning-based framework to map both overhead and underground distribution grids using widely-available multi-modal data including street view images, road networks, and building maps. Benchmarked against the utility-owned distribution grid map in California, our framework achieves > 80% precision and recall on average in the geospatial mapping of grids. The framework developed with the California data can be transferred to Sub-Saharan Africa and maintain the same level of precision without fine-tuning, demonstrating its generalizability. Furthermore, our framework achieves a R 2 of 0.63 in measuring the fraction of underground power lines at the aggregate level for estimating grid exposure to wildfires. We offer the framework as an open tool for mapping and analyzing distribution grids solely based on publicly-accessible data to support the construction and maintenance of reliable and clean energy systems around the world.
In preparation for the NISAR launch and data collection in 2024, the NISAR Project Science Team is building workflows for each Science Team discipline (Ecosystems, Cryosphere, and Solid Earth). This abstract focuses on the Ecosystem disciplines and the development of on-demand cloud-processing workflows for wetlands inundation, forest biomass, agricultural active crop area, and forest disturbance. The workflow simulates NISAR data using UAVSAR or ALOS-2 Single Look Complex data, which are processed to Level 2 geocoded polarimetric covariance matrix products using InSAR Scientific Computing Environment 3.0 software and to Level 3 science products using the Algorithm Theoretical Basis Documents. In this presentation, we describe these workflows and efforts to improve efficiency and data accessibility by using a cloud processing system. We present preliminary sample products from each Ecosystem discipline: inundation, forest biomass, crop area, and forest disturbance.
With the recent introduction of heterogeneity correction algorithms for brachytherapy, the AAPM community is still unclear on how to commission and implement these into clinical practice. The recently-published AAPM TG-186 report discusses important issues for clinical implementation of these algorithms. A charge of the AAPM-ESTRO-ABG Working Group on MBDCA in Brachytherapy (WGMBDCA) is the development of a set of well-defined test case plans, available as references in the software commissioning process to be performed by clinical end-users. In this practical medical physics course, specific examples on how to perform the commissioning process are presented, as well as descriptions of the clinical impact from recent literature reporting comparisons of TG-43 and heterogeneity-based dosimetry. Learning Objectives: Identify key clinical applications needing advanced dose calculation in brachytherapy. Review TG-186 and WGMBDCA guidelines, commission process, and dosimetry benchmarks. Evaluate clinical cases using commercially available systems and compare to TG-43 dosimetry.
With the recent introduction of heterogeneity correction algorithms for brachytherapy, the AAPM community is still unclear on how to commission and implement these into clinical practice. The recently-published AAPM TG-186 report discusses important issues for clinical implementation of these algorithms. A charge of the AAPM-ESTRO-ABG Working Group on MBDCA in Brachytherapy (WGMBDCA) is the development of a set of well-defined test case plans, available as references in the software commissioning process to be performed by clinical end-users. In this practical medical physics course, specific examples on how to perform the commissioning process are presented, as well as descriptions of the clinical impact from recent literature reporting comparisons of TG-43 and heterogeneity-based dosimetry. Learning Objectives: Identify key clinical applications needing advanced dose calculation in brachytherapy. Review TG-186 and WGMBDCA guidelines, commission process, and dosimetry benchmarks. Evaluate clinical cases using commercially available systems and compare to TG-43 dosimetry.
With the recent introduction of heterogeneity correction algorithms for brachytherapy, the AAPM community is still unclear on how to commission and implement these into clinical practice. The recently-published AAPM TG-186 report discusses important issues for clinical implementation of these algorithms. A charge of the AAPM-ESTRO-ABG Working Group on MBDCA in Brachytherapy (WGMBDCA) is the development of a set of well-defined test case plans, available as references in the software commissioning process to be performed by clinical end-users. In this practical medical physics course, specific examples on how to perform the commissioning process are presented, as well as descriptions of the clinical impact from recent literature reporting comparisons of TG-43 and heterogeneity-based dosimetry. Learning Objectives: Identify key clinical applications needing advanced dose calculation in brachytherapy. Review TG-186 and WGMBDCA guidelines, commission process, and dosimetry benchmarks. Evaluate clinical cases using commercially available systems and compare to TG-43 dosimetry.
Purpose: To develop and validate more robust methods for automated lung, spine, and hardware detection in AP/PA chest images. This work is part of a continuing effort to automatically characterize the perceptual image quality of clinical radiographs. [Y. Lin et al. Med. Phys. 39, 7019–7031 (2012)] Methods: Our previous implementation of lung/spine identification was applicable to only one vendor. A more generalized routine was devised based on three primary components: lung boundary detection, fuzzy c-means (FCM) clustering, and a clinically-derived lung pixel probability map. Boundary detection was used to constrain the lung segmentations. FCM clustering produced grayscale- and neighborhood-based pixel classification probabilities which are weighted by the clinically-derived probability maps to generate a final lung segmentation. Lung centerlines were set along the left-right lung midpoints. Spine centerlines were estimated as a weighted average of body contour, lateral lung contour, and intensity-based centerline estimates. Centerline estimation was tested on 900 clinical AP/PA chest radiographs which included inpatient/outpatient, upright/bedside, men/women, and adult/pediatric images from multiple imaging systems. Our previous implementation further did not account for the presence of medical hardware (pacemakers, wires, implants, staples, stents, etc.) potentially biasing image quality analysis. A hardware detection algorithm was developed using a gradient-based thresholding method. The training and testing paradigm used a set of 48 images from which 1920 51×51 pixel{sup 2} ROIs with and 1920 ROIs without hardware were manually selected. Results: Acceptable lung centerlines were generated in 98.7% of radiographs while spine centerlines were acceptable in 99.1% of radiographs. Following threshold optimization, the hardware detection software yielded average true positive and true negative rates of 92.7% and 96.9%, respectively. Conclusion: Updated segmentation and centerline estimation methods in addition to new gradient-based hardware detection software provide improved data integrity control and error-checking for automated clinical chest image quality characterization across multiple radiography systems.
Purpose: Development of an in-house program facilitates a workflow that allows Electronic Portal Imaging Device (EPID) patient specific quality assurance (QA) measurements to be acquired and analyzed in the Portal Dosimetry Application (Varian Medical Systems, Palo Alto, CA) using a non-Aria Record and Verify (R&V) system (MOSAIQ, Elekta, Crawley, UK) to deliver beams in standard clinical treatment mode. Methods: Initial calibration of an in-house software tool includes characterization of EPID dosimetry parameters by importing DICOM images of varying delivered MUs to determine linear mapping factors in order to convert image pixel values to Varian-defined Calibrated Units (CU). Using this information, the Portal Dose Image Prediction (PDIP) algorithm was commissioned by converting images of various field sizes to output factors using the Eclipse Scripting Application Programming Interface (ESAPI) and converting a delivered configuration fluence to absolute dose units. To verify the algorithm configuration, an integrated image was acquired, exported directly from the R&V client, automatically converted to a compatible, calibrated dosimetric image, and compared to a PDIP calculated image using Varian’s Portal Dosimetry Application. Results: For two C-Series and one TrueBeam Varian linear accelerators, gamma comparisons (global 3% / 3mm) of PDIP algorithm predicted dosimetric images and images converted via the inhouse system demonstrated agreement for ≥99% of all pixels, exceeding vendor-recommended commissioning guidelines. Conclusion: Combinations of a programmatic image conversion tool and ESAPI allow for an efficient and accurate method of patient IMRT QA incorporating a 3rd party R&V system.
Purpose: Evaluate a large-field MRI phantom for assessment of geometric distortion in whole-body MRI for real-time MR guided radiation therapy. Methods: A prototype CIRS large-field MRI distortion phantom consisting of a PMMA cylinder (33 cm diameter, 30 cm length) containing a 3D-printed orthogonal grid (3 mm diameter rods, 20 mm apart), was filled with 6 mM NiCl{sub 2} and 30 mM NaCl solution. The phantom was scanned at 1.5T and 3.0T on a GE HDxt and Discovery MR750, respectively, and at 0.35T on a ViewRay system. Scans were obtained with and without 3D distortion correction to demonstrate the impact of such corrections. CT images were used as a reference standard for analysis of geometric distortion, as determined by a fully automated gradient-search method developed in Matlab. Results: 1,116 grid points distributed throughout a cylindrical volume 28 cm in diameter and 16 cm in length were identified and analyzed. With 3D distortion correction, average/maximum displacements for the 1.5, 3.0, and 0.35T systems were 0.84/2.91, 1.00/2.97, and 0.95/2.37 mm, respectively. The percentage of points with less than (1.0, 1.5, 2.0 mm) total displacement were (73%, 92%, 97%), (54%, 85%, 97%), and (55%, 90%, 99%), respectively. A reduced scan volume of 20 × 20 × 10 cm{sup 3} (representative of a head and neck scan volume) consisting of 420 points was also analyzed. In this volume, the percentage of points with less than (1.0, 1.5, 2.0 mm) total displacement were (90%, 99%, 100%), (63%, 95%, 100%), and (75%, 96%, 100%), respectively. Without 3D distortion correction, average/maximum displacements were 1.35/3.67, 1.67/4.46, and 1.51/3.89 mm, respectively. Conclusion: The prototype large-field MRI distortion phantom and developed software provide a thorough assessment of 3D spatial distortions in MRI. The distortions measured were acceptable for RT applications, both for the high field strengths and the system configuration developed by ViewRay.
Increased use of SBRT and hypofractionation in radiation oncology practice has posted a number of challenges to medical physicist, ranging from planning, image-guided patient setup and on-treatment monitoring, to quality assurance (QA) and dose delivery. This symposium is designed to provide current knowledge necessary for the safe and efficient implementation of SBRT in various linac platforms, including the emerging digital linacs equipped with high dose rate FFF beams. Issues related to 4D CT, PET and MRI simulations, 3D/4D CBCT guided patient setup, real-time image guidance during SBRT dose delivery using gated/un-gated VMAT/IMRT, and technical advancements in QA of SBRT (in particular, strategies dealing with high dose rate FFF beams) will be addressed. The symposium will help the attendees to gain a comprehensive understanding of the SBRT workflow and facilitate their clinical implementation of the state-of-art imaging and planning techniques. Learning Objectives: Present background knowledge of SBRT, describe essential requirements for safe implementation of SBRT, and discuss issues specific to SBRT treatment planning and QA. Update on the use of multi-dimensional and multi-modality imaging for reliable guidance of SBRT. Discuss treatment planning and QA issues specific to SBRT. Provide a comprehensive overview of emerging digital linacs and summarize the key geometric and dosimetric features of the new generation of linacs for substantially improved SBRT. NIH/NCI; Varian Medical Systems; F. Yin, Duke University has a research agreement with Varian Medical Systems. In addition to research grant, I had a technology license agreement with Varian Medical Systems.
Support Vector Machines (SVM) is a popular machine learning technique, which has been applied to a wide range of domains such as science, finance, and social networks for supervised learning. MaTEx undertakes the challenge of designing a scalable parallel SVM training algorithm for large scale systems, which includes commodity multi-core machines, tightly connected supercomputers and cloud computing systems. Several techniques are proposed for improved speed and memory space usage including adaptive and aggressive elimination of samples for faster convergence , and sparse format representation of data samples. Several heuristics for earliest possible to lazy elimination of non-contributing samples are considered in MaTEx. In many cases, where an early sample elimination might result in a false positive, low overhead mechanisms for reconstruction of key data structures are proposed. The proposed algorithm and heuristics are implemented and evaluated on various publicly available datasets
Abstract The recently introduced coupled cluster (CC) downfolding techniques for reducing the dimensionality of quantum many-body problems recast the CC formalism in the form of the renormalization procedure allowing, for the construction of effective (or downfolded) Hamiltonians in small-dimensionality sub-space, usually identified with the so-called active space, of the entire Hilbert space. The resulting downfolded Hamiltonians integrate out the external (out-of-active-space) Fermionic degrees of freedom from the internal (in-the-active-space) parameters of the wave function, which can be determined as components of the eigenvectors of the downfolded Hamiltonians in the active space. This paper will discuss the extension of non-Hermitian (associated with standard CC formulations) and Hermitian (associated with the unitary CC approaches) downfolding formulations to composite quantum systems commonly encountered in materials science and chemistry. The non-Hermitian formulation can provide a platform for developing local CC approaches, while the Hermitian one can serve as an ideal foundation for developing various quantum computing applications based on the limited quantum resources. We also discuss the algorithm for extracting the semi-analytical form of the inter-electron interactions in the active spaces.
Focal Area: (2) Predictive modeling using AI techniques and AI-derived model components; use of AI and other tools to design a prediction system comprising of a hierarchy of models
Major topics covered include radiation monitoring instrumentation, nuclear circuits and systems, biomedical applications of nuclear radiation in diagnosis and therapy, plasma research for fusion power, reactor control and instrumentation, nuclear power standards, and applications of digital computers in nuclear power plants. Systems and devices for space applications are described, including the Apollo alpha spectrometer, a position sensitive detection system for UV and X-ray photons, a 4500-volt electron multiplier bias supply for satellite use, spark chamber systems, proportional counters, and other devices. Individual items are announced in this issue.
This paper discusses the NASA aeronautics research and technology program from the viewpoint of the aircraft designer. The program spans the range from fundamental research to the joint validation with industry of technology for application into product development. Examples of recent developments in structures, materials, aerodynamics, controls, propulsion systems, and safety technology are presented as new additions to the designer's handbook. Finally, the major thrusts of NASA's current and planned programs which are keyed to revolutionary advances in materials science, electronics, and computer technology are addressed.
A system for calibrating both electron and ion imaging particle spectrometers was devised to calibrate flight instruments in a large vacuum facility in the Space Science Laboratory at the Marshall Space Flight Center. An IBM-compatible computer was used to control, via an IEEE 488 buss protocol, a two-axis gimbled table, constructed to fit inside the tank. Test settings of various diagnostic voltages were also acquired via the buss. These spectrometers constructed by the author at UCSD were calibrated in an automatic procedure programmed on the small computer. Data was up-loaded to the SSL VAX where a program was developed to plot the results.
This bibliography lists 647 reports, articles, and other documents introduced into the NASA scientific and technical information system in June, 1991. Subject coverage includes: aerodynamics, air transportation safety, aircraft communication and navigation, aircraft design and performance, aircraft instrumentation, aircraft propulsion, aircraft stability and control, research facilities, astronautics, chemistry and materials, engineering, geosciences, computer sciences, physics, and social sciences.
This report summarizes the range of computer science-related activities undertaken by CESDIS for NASA in the twelve months from July 1, 1998 through June 30, 1999. These activities address issues related to accessing, processing, and analyzing data from space observing systems through collaborative efforts with university, industry, and NASA space and Earth scientists. The sections of this report which follow, detail the activities undertaken by the members of each of the CESDIS branches. This includes contributions from university faculty members and graduate students as well as CESDIS employees. Phone numbers and e-mail addresses appear in Appendix F (CESDIS Personnel and Associates) to facilitate interactions and new collaborations.