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At least 163 records · Page 9

High School Citizen Scientists Use AI/ML to Predict Intra-Ocular Pressure From Gene Expression Data for Spaceflown Mice

Artificial Intelligence (AI) and Machine Learning (ML) have increasingly become pivotal in biological and biomedical research, largely due to the culture of open data sharing and its associated benefits. The methodologies inherent in AI/ML are particularly adept at identifying and forecasting biological phenotypes from the vast amounts of data generated by next-generation sequencing technologies. These techniques offer substantial promise for advancing research in space biosciences and for the development of automated systems for monitoring space health. Nevertheless, there are crucial aspects to consider when training, validating, and testing machine learning models in both biological research and clinical contexts. It is essential that Open Science principles, including data sharing and the availability of open-source code, are complemented by high-quality, publicly accessible training resources. These resources should focus on best practices and include modules based on real-world scientific cases and data to ensure that future AI/ML practitioners gain practical experience with genuine problems. Addressing this knowledge gap, we have designed, developed, and delivered both interactive and self-paced training programs for citizen scientists worldwide, enabling them to utilize AI/ML for space biology research. This initiative was made possible through generous funding from a Transformation to Open Science Training grant. The interactive training sessions, conducted this summer, utilized AI/ML techniques to analyze data from the Open Science Data Repository, specifically targeting the effects of spaceflight on ocular structure and function. The dataset OSD-583, from the Rodent Research 9 mission, provides experimental data detailing the ocular responses of mice subjected to a 35-day spaceflight, compared with ground control counterparts. Using OSD-583 as observational data, our summer training participants applied AI/ML methods to predict intraocular pressure from RNA-seq data and identify the genes most predictive of the observed responses. Further analysis through pathway enrichment and gene set enrichment revealed that these genes are involved in molecular and cellular processes contributing to retinal degeneration.

James Casaletto↗

Soil Salinity Level Assessment and Prediction Integrating UAV-borne Hyperspectral Imaging and Machine Learning Algorithms to Combat Desertification

In response to the ongoing global food crisis, the United Nations has identified “Zero Hunger” as one of its Sustainable Development Goals. A central contributor to the crisis is the process in which agricultural lands go through desertification. Research has shown a direct correlation between soil salinity and desertification - increased salinity levels indicate a higher risk for desertification. Furthermore, researchers have explored various techniques to map soil salinity, but these methods are oftentimes inefficient and don’t address future salinity predictions. To improve desertification monitoring, soil salinity can be observed via hyperspectral imaging on unmanned aerial vehicles (UAVs) to predict the risk of agricultural desertification using artificial intelligence (AI) and machine learning (ML) techniques. A significant gap exists in past research that applies ML and imaging techniques to soil salinity: convolutional neural networks (CNNs) and regression models are rarely leveraged together, despite the efficiency and accuracy of these models. To compensate for this gap, the proposed system leverages the use of these AI and ML models to improve soil assessment and prediction techniques. This approach involves three steps - data collection, image analysis, and future prediction. Using hyperspectral cameras on UAVs to collect the data from the region, a trained CNN model will output estimated soil salinity levels at a specific time. The estimations will then be analyzed by a regression model to assess the accuracy of future soil salinity predictions. The proposed system will identify regions at risk of desertification to help farmers mitigate agricultural loss, in turn helping alleviate the food crisis.

UAV systems↗

Optimizing Air Traffic - Integrating Artificial Intelligence and Machine Learning in Flight Path Planning and 3D Airspace Visualization for Air Traffic Control

Air Traffic Control (ATC) systems are vital components of the National Airspace System (NAS). ATC, Airport Traffic Control Towers (ATCT), and Terminal Radar Approach Control (TRACON) are responsible for directing all flights departing from and arriving at airports, managing our nation’s airspace, preventing potential accidents, and ensuring that every flight is accounted for. However, these systems often face challenges in effectively monitoring the skies. Issues such as poor communication between operators, difficulty in performing operations, and the constant need for vigilance frequently burden ATC operators. Additionally, the projected increase in air traffic in the coming years will only exacerbate the stress associated with this role. To address these issues, we propose a system that assists ATC operators in situations such as handovers, emergencies, and routing aircraft to avoid weather hazards. Our solution includes an Artificial Intelligence (AI) and Machine Learning (ML)-based Flight Pathways Planning System (FPPS) designed to find the fastest and most optimal routes for aircraft, taking into account weather conditions, restricted terrain, and Extended-Range Twin-Engine Operational Performance Standards (ETOPS) ratings. The proposed Predictive Weather Planning Model, included in FPPS, adjusts routes based on real-time and forecasted weather conditions. Additionally, our NVIDIA Omniverse 3D Visualization System offers a highly interactive environment for better visualization and a clear view of the airspace. By incorporating these systems, the roles of ATC, ATCT, and TRACON operators will become more manageable and less stressful, equipping them to efficiently handle the growing density of airspace.

Regina Ayoubi↗

Evaluating the Efficacy of Conditional Variational Autoencoders in Generating Synthetic Single Nuclei RNA-Seq Data for Space Biology Research

Astronauts are subject to unique stressors during spaceflight, leading to changes in their cellular function. However, neither astronauts nor model organisms respond the same to spaceflight, and research implicates a contribution of omics components in differential responses. Understanding how gene expression affects astronaut health is critical for the success of long-term space missions, prompting interest in developing personalized predictive models leveraging artificial intelligence (AI) and machine learning (ML) techniques. Developing such models requires extensive data, which is challenging to obtain and share. This study explores the use of conditional variational autoencoders (CVAEs) to synthetically generate single-nuclei RNA-seq (snRNA-seq) data. CVAEs build on standard variational autoencoders (VAEs) by conditioning data generation on covariates like sample identity and mission parameters, enhancing the relevance of generated data for specific contexts. For our work, we built two CVAEs with varying degrees of sparsity to optimize both interpretability and generative power. We train and validate models on existing snRNA-seq data collected from the brain tissue of mice subjected to spaceflight conditions and their ground control counterparts. We evaluate model performance using statistical tests and visualizations to compare synthetic data to real data. We aim to demonstrate that these prototype CVAE architectures could be used in future space biology work and that this is a method worth further exploring.

Sarah Golts↗

Using Artificial Intelligence and Machine Learning to Enhance Mission Design and Operations of the Habitable Worlds Observatory (HWO)

One key aspect in the development of HWO is the early deployment of artificial intelligence (AI) and machine learning (ML) to enhance mission science and operations. Our subtask group is part of the HWO AI/ML working group and focuses on AI and ML for mission operations. Our task group seeks to educate other HWO working groups about AI and ML capabilities for mission operations, investigate how to bridge technology gaps, and enable new capabilities particularly in the areas of observational scheduling, instrument health monitoring, and downlink operations. We focus on mission tasking / scheduling both for mission analysis in development and operations. AI and ML for mission scheduling includes: tools to support proposal calls and review, ensuring fairness in calls for proposals, community peer reviews and ease workloads, as well as in-flight and ground software development (e.g., using natural language processing (NLP) to support process automation from requirements). AI and ML for the mission’s development and operations include 1) anomaly detection and prediction (from onboard and ground based tools) to monitor the spacecraft’s health, 2) ground-based automated scheduling for mission operations including long-term and short-term planning and maintenance, and 3) flight system flexible execution (as flight proven for Spitzer and JWST) to enable robust execution despite execution variations, and 4) data analysis for prioritization (e.g., real-time data evaluation leading to autonomous actions and adjustments, high-priority identification, onboard data compression, etc.). Incorporation of ML and AI will enable HWO to address the major science questions related to exoplanet characterization, general astrophysics, and solar system exploration and also extend the boundaries of space mission technologies.

Mark Moussa↗

Domain Aware Techniques in AI: A Survey

An open literature survey of domain aware methods for next generation artificial intelligence as part of a workshop for DNN, R&D

97 MATHEMATICS AND COMPUTING↗

Optimization of Mitigating System Performance Index to Improve Nuclear Power Plant Safety and Efficiency

MSPI (Mitigation System Performance Index) is one of the risk-informed, plant-specific performance indicators of NRC’s Reactor Oversight Process. MSPI is used by the regulator and nuclear industry to monitor and assess the performance of plant mitigating systems. In this project, a calculation tool has been developed by incorporating the plant operation data, Probabilistic Risk Assessment (PRA) data, and industry baseline values to automate the calculation process of MSPI and the generation of the report. This is the first stage in an effort to optimize the MSPI through advanced artificial intelligence (AI) and machine learning (ML) techniques to improve nuclear power plant safety and efficiency.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Applications of Deep Learning to physics workflows

Modern large-scale physics experiments create datasets with sizes and streaming rates that can exceed those from industry leaders such as Google Cloud and Netflix. Fully processing these datasets requires both sufficient compute power and efficient workflows. Recent advances in Machine Learning (ML) and Artificial Intelligence (AI) can either improve or replace existing domain-specific algorithms to increase workflow efficiency. Not only can these algorithms improve the physics performance of current algorithms, but they can often be executed more quickly, especially when run on coprocessors such as GPUs or FPGAs. In the winter of 2023, MIT hosted the Accelerating Physics with ML at MIT workshop, which brought together researchers from gravitational-wave physics, multi-messenger astrophysics, and particle physics to discuss and share current efforts to integrate ML tools into their workflows. The following white paper highlights examples of algorithms and computing frameworks discussed during this workshop and summarizes the expected computing needs for the immediate future of the involved fields.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Nuclear-Integrated Energy Units: Advancing Cybersecurity for Resilient Energy Systems

Rapidly increasing usage of nuclear-integrated energy units has created new challenges in terms of cybersecurity. This paper discusses the potential cyberthreat challenges and cyber risks associated with the widespread adoption of these units, and the role of artificial intelligence (AI) and machine learning (ML) techniques in enhancing the security and resilience of these systems.

20 FOSSIL-FUELED POWER PLANTS↗

Neural networks for modeling and control of particle accelerators

Charged particle accelerators support a wide variety of scientific, industrial, and medical applications. They range in scale and complexity from systems with just a few components for beam acceleration and manipulation, to large scientific user facilities that span many kilometers and have hundreds-to-thousands of individually-controllable components. Specific operational requirements must be met by adjusting the many controllable variables of the accelerator. Meeting these requirements can be challenging, both in terms of the ability to achieve specific beam quality metrics in a reliable fashion and in terms of the time needed to set up and maintain the optimal operating conditions. One avenue toward addressing this challenge is to incorporate techniques from the fields of machine learning (ML) and artificial intelligence (AI) into the way particle accelerators are modeled and controlled. While many promising approaches within AI/ML could be used for particle accelerators, this dissertation focuses on approaches based on neural networks. Neural networks are particularly well-suited to modeling, control, and diagnostic analysis of nonlinear systems, as well as systems with large parameter spaces. They are also very appealing for their ability to process high-dimensional data types, such as images and time series (both of which are ubiquitous in particle accelerators). In this work, key studies that demonstrated the potential utility of modern neural network-based approaches to modeling and control of particle accelerators are presented. The context for this work is important: at the start of this work in 2012, there was little interest in AI/ML in the particle accelerator community, and many of the advances in neural networks and deep learning that enabled its present success had not yet been made at that time. As such, this work was both an exploration of possible application areas and a generator of proof-of-concept demonstrations in these areas.

43 PARTICLE ACCELERATORS↗

Accelerating Hanford Site Cleanup through Operations Research Modeling - 20238

The Hanford Site cleanup effort will require the integration of dozens of unique facilities and processes, many of which will be first-of-a-kind in implementation and design. Each facility will be governed by its own set of operating logic, configured with a unique array of unit operations, and subject to a set of constraints that will affect its behavior. The collection of facilities have multiple points of interface, making the operations of any one facility potentially significant to the operations of other up- or downstream processes. It is therefore highly desirable to accurately predict these operations, as it allows for Site officials to identify and preempt bottlenecks and vulnerabilities before they unexpectedly inhibit the cleanup mission. With the quantity and complexity of the processes that will be on Site, building a pen-and-paper or even a spreadsheet-assisted model of the cleanup mission quickly becomes overwhelming in scope and inaccurate in execution. The Engineering organization for the Site's Tank Operations Contract (TOC) has therefore implemented the use of operations research (OR) modeling to simulate and predict future operations of Site facilities. These models are created using a discrete event simulation tool that allows for the development of detailed, versatile, and robust models. Not only can these models account for complex logical behaviors, but they can also simulate process details down to the level of vessel sizing, labor utilization, equipment reliability, and resource availability. To date, the TOC has developed OR models for several facilities on Site, including for single-shell tank (SST) farms, double-shell tank (DST) farms, the Effluent Treatment Facility (ETF), and the waste transfer system. These models have focused on identifying bottlenecks and operational constraints, and have been used to quantify the effects of implementing process changes. This latter point is particularly valuable, as it allows for several alternatives to be studied in a virtual setting before committing resources to making a change in the field. The decision to develop OR models has gained tremendous support from the Site's stakeholders and the U.S. Department of Energy (DOE) management, and has prompted the use of the tool to support additional internal and external initiatives. Recently, an initiative was proposed to use the models to help identify and provide quantitative backing for risks and opportunities for the TOC. This application of OR could not only help inform how the TOC manages its risks (e.g. quantities and types of spare parts), but could also help drive process improvements whose benefits might otherwise be hard to quantify. The models have also been used to drive the TOC's cloud computing, artificial intelligence (AI), and machine learning (ML) initiatives. These initiatives will not only improve the ability of the TOC to more rapidly respond to the needs of its customers, but it will also aid in the ability of the TOC to analyze and improve the processes it studies. Partnership with two external software development and consulting companies (Lanner and Ynformed) has furthered not only the application of AI and ML within the TOC, but has also spurred the development of new/improved software tools and platforms used by the companies. These partnerships have proven to be mutually beneficial and productive, and have set a precedent for the types of gains that can be made by exploring such options. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Composable optimization and control toolkit for scientific applications

Applications of Artificial Intelligence (AI) and Machine Learning (ML) can improve the computational efficiency and scientific research output. In order to improve interoperability and reuse of AI/ML software, a composable approach is required. This talk presents a composable approach for scientific workflow development that allows seamless integration of various modules developed by independent researchers. These practices will reduce redundant software development by allowing re-use of workflow modules across projects, teams, departments and facilities. We will present three use cases that follow the composable approach namely, Scientific Optimization and Control Toolkit (SOCT), SciDAC QuantOm workflow, and JLab Nuclear Physics experimental workflows. This talk will dive deeper into SOCT and present the details of the composable code development for optimization and control algorithms using reinforcement learning.

Rajput, Kishansingh↗

7 Innovations in high-rate composite manufacturing: integrating additive manufacturing with compression molding process

Advanced composites play a pivotal role in modern engineering, offering exceptional strength-to-weight ratios and tailored properties, essential for various industries. High-rate composite manufacturing techniques have rapid production capabilities, which are essential for meeting the demands of industries requiring cost-saving, efficiency, and quick turnaround times. This chapter explores the Additive Manufacturing- Compression Molding (AM-CM) system developed by Oak Ridge National Laboratory (ORNL) for advanced composites manufacturing. The AM-CM system integrates additive manufacturing with compression molding, facilitating the production of polymer composite parts with superior mechanical properties and meticulously controlled microstructures. This innovative system not only ensures precise material deposition but also operates as a fast composite manufacturing process, enhancing productivity and performance, which are needed attributes across industrial applications. Through comprehensive mechanical testing and microstructural analysis, AM-CM promotes remarkable fiber alignment and reduced porosity in composite parts compared to alternative thermoplastic high-rate composite manufacturing methods. Furthermore, AM-CM enables overmolding reinforcement using continuous carbon fiber and supports selective reinforcement through customizable toolpaths. It also facilitates the production of hybrid materials to achieve tailored mechanical properties. Future advancements in AM-CM technology aim to enhance process efficiency, broaden material versatility, and improve part performance. This involves exploring novel materials, advancing process monitoring, implementing automation technologies, and integrating artificial intelligence (AI) and machine learning (ML) for predictive modeling and real-time optimization in composite manufacturing. These developments will establish the AM-CM system as a transformative technology in composite manufacturing, driving innovation across industries.

Hassen, Ahmed [ORNL] (ORCID:0000000328521222)↗

Understanding the High Energy Higgs Sector with the CMS Experiment and Artificial Intelligence

This dissertation describes efforts towards understanding the Higgs boson at the highest energies humanly accessible, using the CMS experiment at the Large Hadron Collider and advances in artificial intelligence (AI) and machine learning (ML). We present searches for resonant and nonresonant Higgs-boson (H) pair production in the all-hadronic two beauty-quark and two vector boson (V) final state, using a novel strategy to measure the quartic HHVV coupling and search for new Higgs-like bosons. By targeting highly Lorentz-boosted Higgs pairs, we probe effects of potential new physics in the high energy Higgs sector, which could hold answers to fundamental mysteries of nature such as baryon asymmetry. To enable these and future searches, we introduce as well significant developments in AI/ML, including in the identification of boosted H$\rightarrow$VV decays with deep transformer networks and advances in AI-accelerated fast simulations of the CMS detector. The latter notably includes the development of the first, highly performant generative models for point-cloud data in high energy physics, which have the potential to improve CMS' computational efficiency by up to three orders of magnitude. We also highlight novel solutions to the important and challenging problems of calibrating and validating these ML techniques. Finally, we present new approaches to search for new physics in a model-agnostic manner, using physics-informed ML methods equivariant to Lorentz transformations. The quartic HHVV coupling is observed (expected) to be constrained to $[-0.04, 2.05]$ ($[0.05, 1.98]$) at the 95% confidence level relative to the standard model prediction, representing the second-most sensitive measurement of this coupling by CMS to date. Exclusion limits on the production cross section of new heavy resonances decaying to two Higgs-like bosons are expected to be as low as 0.3 fb for high resonance masses.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

High Performance Computing Management: A Sustainable System Software Approach

The demand for high performance computing (HPC) resources continues to grow, driven by the increasing complexity of modeling and simulation, artificial intelligence (AI), and machine learning (ML) workloads [Porter]. The growing energy consumption demand of these HPC systems is a significant concern, both in terms of operational costs and environmental impact. AI hardware accelerators are expected to reach 1.5% of the world’s power consumption by 2029 [Shah].

97 - MATHEMATICS AND COMPUTING↗

Machine Learning for Well Log Analysis in Uranium Mining

This project explores the use of Artificial Intelligence (AI) and Machine Learning (ML) techniques to automate well log analysis for uranium mining. Geophysical log data—spontaneous potential, resistivity, and gamma ray—were used to classify lithology, correlate well logs and identify roll front zonation patterns, which are critical for locating uranium ore bodies. Supervised ML algorithms such as eXtreme Gradient Boosting (XGBoost), Categorical Boosting (CatBoost), and Random Forest were trained to classify lithology with high accuracy. Gradient Boosting Machines (GBM), XGBoost, Random Forest, and Neural Networks were also used for role front zone identification. Moreover, a Fast Dynamic Time Warping (FastDTW) algorithm was employed for well log correlation. Additionally, sample lag was addressed using dynamic programming. Results demonstrate the potential of AI and ML to streamline well log analysis and enhance uranium exploration workflows.

11 - NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗