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At least 163 records · Page 9

Dietary antioxidant and anti-inflammatory intake modifies the effect of cadmium exposure on markers of systemic inflammation and oxidative stress

Chronic cadmium exposure may cause disease through induction of systemic oxidative stress and inflammation. Factors that mitigate cadmium toxicity and could serve as interventions in exposed populations have not been well characterized. We used data from the 2003–2010 National Health and Nutrition Examination Survey to quantify diet's role in modifying associations between cadmium exposure and oxidative stress and inflammation. We created a composite antioxidant and anti-inflammatory diet score (ADS) by ranking participants by quintile of intake across a panel of 19 nutrients. We identified associations and effect modification between ADS, urinary cadmium, and markers of oxidative stress and inflammation by multiple linear regression. An interquartile range increase in urinary cadmium was associated with a 47.5%, 8.8%, and 3.7% increase in C-reactive protein (CRP), gamma glutamyl transferase (GGT), and alkaline phosphatase (ALP), respectively. An interquartile range increase in ADS was associated with an 7.4%, 3.3%, 5.2%, and 2.5% decrease in CRP, GGT, ALP, and total white blood cell count respectively, and a 3.0% increase in serum bilirubin. ADS significantly attenuated the association between cadmium exposure, CRP and ALP. Dietary interventions may provide a route to reduce the impact of cadmium toxicity on the population level. - Highlights: • Cadmium may cause chronic disease through oxidative stress or inflammation. • We developed a score to quantify dietary antioxidant and anti-inflammatory intake. • Cadmium was associated with markers of oxidative stress and inflammation. • Antioxidant and anti-inflammatory intake mitigated the effects of cadmium exposure. • Dietary interventions may be effective against chronic cadmium toxicity.

54 ENVIRONMENTAL SCIENCES↗

Multi-Source Machine Learning and Thermoplastics Enhanced Aerostructure Manufacturing (mTEAM)

RTX Technology Research Center (RTRC), together with Collins Aerospace (Collins) and Oak Ridge National Laboratory (ORNL) has developed an Artificial Intelligence (AI) / Machine Learning (ML) guided solution to advance the manufacturing and assembly of high performance and lightweight thermoplastic composite (TPC) aerospace products. The solution aims to lower risk, cost and lead time for induction heating based welding and consolidation processes for TPC structure. The cost and lead time of part and material specific process development for induction welding (IW) and induction consolidation will be reduced by replacing traditional empirical methods with optimization methods that merge AI/ML and physics-based process simulations and process experiments with sensing and controls. TPC-IW process development is empirical in nature, and uncertainties in material & process behavior exist near & far from the induction coil. Physics-based simulations can be leveraged directly for process optimization but can be too computationally expensive to run in high fidelity and real time to do robust process optimization. The key impact of successful TPC induction consolidation and welding is cost & lead time reduction for part & material specific consolidation and welding recipes. This is an enabler for more rapid deployment of TPC structures via joining assembly, which can reduce energy & cost intensive usage of autoclaves & ovens. The solution aimed to advance the U.S. Department of Energy’s interests in using thermoplastics and automation in composite manufacturing for improvement of products for existing markets via increased production speeds, reduced costs, and lowered use of energy. Welded TPC structures can offer significant weight & energy savings for high-value commercial aerospace & industrial applications compared to metal & thermoset composite structures assembled by mechanical fastening and/or adhesive bonding. The project was organized into two Budget Periods. Budget Period 1 (BP1) was 15 months and its goal was to perform ML process optimization framework development & deployment on lab-coupon aerostructure components. A Go/No-Go Review was performed at the end of BP1 to verify fulfilment of key tasks & milestones to justify a Go Decision to move into the next Budget Period. Budget Period 2 (BP2) was 12 months and its goal was the deployment of the ML framework for ML process optimization of pilot industrial scale aerostructure components. The overall project aim was to develop & demonstrate ML-enhanced modeling framework that learns process-property mapping from multiple data sources at different fidelities. During BP1, the team accomplished key tasks & milestones to demonstrate the concept of multi-source ML for TPC aerostructure consolidation and assembly. First, the team completed documentation of induction based TPC heating requirements including baseline metrics to compare measured results against. Next the team completed demonstration of data generation from physics-based simulations for ML surrogate model generation and demonstrated the integration of physics-based simulation data into multi-source AI/ML algorithms. In parallel, the team established the lab-coupon scale induction welding system and completed a process to label and reduce generated data from physics-based simulation and experiments for ML surrogate models to enable multi-source ML model training & testing. To complete BP1, the team integrated physics-based simulation data and experimental data into multi-source ML algorithms. This was based on the team completing ML deployment of the induction welding on a lab system at RTRC and AI/ML deployment on existing induction welding line at Collins. ORNL visited both Collins and RTRC sites to witness the TPC induction welding process. Then, ORNL designed and constructed a new version of their vision-based sensing system better adapted to acquire process signals of the TPC induction welding process for process anomaly and defect detection. In BP2, the team accomplished key tasks & milestones to scale up multi-source ML for TPC aerostructure consolidation and assembly from the lab-coupon scale to the pilot-industrial scale. In BP2, the team demonstrated real time anomaly & defect detection via experiments performed by ORNL & RTRC. The team completed ML-optimization heating trials for TPC induction consolidation at Collins, and the team confirmed pilot industrial scale experimental data from Collins was compatible with the developed ML pipeline from RTRC. The team completed sub-element scale ML process optimization demonstration at RTRC, where the team leveraged RTRC’s robotic TPC welding setup to de-risk the ML process optimization by performing ML analysis of recorded temperatures to account for complex part features. Then, the team applied its ML-derived control strategies and ML process optimization framework at Collins to the pilot-industrial scale on a demo skin-stiffener part representative of a nacelle aerostructure fan cowl section. The key innovation is the AI/ML framework enabling effective process development of high performance, lightweight, energy efficient TPCs for composite aircraft structures.

36 MATERIALS SCIENCE↗

General Purpose Data-Driven Online System Health Monitoring with Applications to Space Operations

Modern space transportation and ground support system designs are becoming increasingly sophisticated and complex. Determining the health state of these systems using traditional parameter limit checking, or model-based or rule-based methods is becoming more difficult as the number of sensors and component interactions grows. Data-driven monitoring techniques have been developed to address these issues by analyzing system operations data to automatically characterize normal system behavior. System health can be monitored by comparing real-time operating data with these nominal characterizations, providing detection of anomalous data signatures indicative of system faults, failures, or precursors of significant failures. The Inductive Monitoring System (IMS) is a general purpose, data-driven system health monitoring software tool that has been successfully applied to several aerospace applications and is under evaluation for anomaly detection in vehicle and ground equipment for next generation launch systems. After an introduction to IMS application development, we discuss these NASA online monitoring applications, including the integration of IMS with complementary model-based and rule-based methods. Although the examples presented in this paper are from space operations applications, IMS is a general-purpose health-monitoring tool that is also applicable to power generation and transmission system monitoring.

Iverson, David L.↗

Fault Management Technology Maturation for NASA's Constellation Program

This slide presentation reviews the maturation of fault management technology in preparation for the Constellation Program. There is a review of the Space Shuttle Main Engine (SSME) and a discussion of a couple of incidents with the shuttle main engine and tanking that indicated the necessity for predictive maintenance. Included is a review of the planned Ares I-X Ground Diagnostic Prototype (GDP) and further information about detection and isolation of faults using Testability Engineering and Maintenance System (TEAMS). Another system that being readied for use that detects anomalies, the Inductive Monitoring System (IMS). The IMS automatically learns how the system behaves and alerts operations it the current behavior is anomalous. The comparison of STS-83 and STS-107 (i.e., the Columbia accident) is shown as an example of the anomaly detection capabilities.

Waterman, Robert D.↗

Real-Time Early Warning Techniques

Contemporary approaches to aerospace vehicle system monitoring rely heavily on thresholds that represent a compromise between providing warning early enough to avert a mishap while simultaneously minimizing false alarms. While this reliance on thresholds has been in place for decades and has permeated both cockpits and control rooms, we often find it insufficient when retrospectively analyzing data from an accident. To modernize and enhance flight test safety, we introduce new methods of monitoring for anomalous patterns of interaction rather than for thresholds exceedance. For systems with a well characterized baseline we show how the Inductive Monitoring System (IMS), utilized by NASA in the aftermath of the Columbia accident, might be implemented in real-time to provide earlier warning than currently employed techniques. For systems without such a baseline, we introduce new developments in statistical methods relating to critical slowing down, first applied in medicine and physics, which show promise for adaptation to flight test. Finally, the familiar resource constrained environment leads to a reliance on increased instrumentation that is challenging the limits of the current one-sensor, one-indicator threshold paradigm. Existing methods thus fail to accurately reflect the true complexity of a vehicle rich with interdependent interacting systems. We highlight these concepts in a brief summary of the 2001 Air Transat Flight 236 deadstick landing in the Azores. We then suggest control room and cockpit modifications to better display the information gleaned using these novel monitoring methods.

Javorsek, Dan↗

Enhancing Flight Test Safety with Real-Time Early Warning Techniques

Contemporary approaches to aerospace vehicle system monitoring rely heavily on thresholds that represent a compromise between providing warning early enough to avert a mishap while simultaneously minimizing false alarms. While this reliance on thresholds has been in place for decades and has permeated both cockpits and control rooms, we often find it insufficient when retrospectively analyzing data from an accident. To modernize and enhance flight test safety, we introduce new methods of monitoring for anomalous patterns of interaction rather than for thresholds exceedance. For systems with a well characterized baseline we show how the Inductive Monitoring System (IMS), utilized by NASA in the aftermath of the Columbia accident, might be implemented in real-time to provide earlier warning than currently employed techniques. For systems without such a baseline, we introduce new developments in statistical methods relating to critical slowing down, first applied in medicine and physics, which show promise for adaptation to flight test. Finally, the familiar resource constrained environment leads to a reliance on increased instrumentation that is challenging the limits of the current "one-sensor, one-indicator" threshold paradigm. Existing methods thus fail to accurately reflect the true complexity of a vehicle rich with interdependent interacting systems. We highlight these concepts in a brief summary of the 2001 Air Transat Flight 236 deadstick landing in the Azores. We then suggest control room and cockpit modifications to better display the information gleaned using these novel monitoring methods.

Javorsek, Daniel, II↗

The coat protein of Alternanthera mosaic virus is the elicitor of a temperature-sensitive systemic necrosis in Nicotiana benthamiana, and interacts with a host boron transporter protein

Different isolates of Alternanthera mosaic virus (AltMV; Potexvirus), including four infectious clones derived from AltMV-SP, induce distinct systemic symptoms in Nicotiana benthamiana. Virus accumulation was enhanced at 15 °C compared to 25 °C; severe clone AltMV 3-7 induced systemic necrosis (SN) and plant death at 15 °C. No interaction with potexvirus resistance gene Rx was detected, although SN was ablated by silencing of SGT1, as for other cases of potexvirus-induced necrosis. Substitution of AltMV 3-7 coat protein (CP{sub SP}) with that from AltMV-Po (CP{sub Po}) eliminated SN at 15 °C, and ameliorated symptoms in Alternanthera dentata and soybean. Substitution of only two residues from CP{sub Po} [either MN(13,14)ID or LA(76,77)IS] efficiently ablated SN in N. benthamiana. CP{sub SP} but not CP{sub Po} interacted with Arabidopsis boron transporter protein AtBOR1 by yeast two-hybrid assay; N. benthamiana homolog NbBOR1 interacted more strongly with CP{sub SP} than CP{sub Po} in bimolecular fluorescence complementation, and may affect recognition of CP as an elicitor of SN. - Highlights: • Alternanthera mosaic virus CP is an elicitor of systemic necrosis in N. benthamiana. • Virus-induced systemic necrosis is enhanced at 15 °C compared to 25 °C. • Induction of systemic necrosis is dependent on as few as two CP amino acid residues. • These residues are at subunit interfaces within the same turn of the virion helix. • Inducer/non-inducer CPs interact differentially with a boron transporter protein.

60 APPLIED LIFE SCIENCES↗

A Prospective Clinical Trial Combining Radiation Therapy With Systemic Immunotherapy in Metastatic Melanoma

Purpose: Local radiation therapy (RT) combined with systemic anti-cytotoxic T-lymphocyte–associated protein-4 immunotherapy may enhance induction of systemic antimelanoma immune responses. The primary objective of the present trial was to assess the safety and efficacy of combining ipilimumab with RT in patients with stage IV melanoma. The secondary objectives included laboratory assessment of induction of antimelanoma immune responses. Methods and Materials: In our prospective clinical trial, 22 patients with stage IV melanoma were treated with palliative RT and ipilimumab for 4 cycles. RT to 1 to 2 disease sites was initiated within 5 days after starting ipilimumab. Patients had ≥1 nonirradiated metastasis measuring ≥1.5 cm available for response assessment. Tumor imaging studies were obtained at baseline, 2 to 4 weeks after cycle 4 of ipilimumab, and every 3 months until progression. Laboratory immune response parameters were measured before and during treatment. Results: Combination therapy was well-tolerated without unexpected toxicities. Eleven patients (50.0%) experienced clinical benefit from therapy, including complete and partial responses and stable disease at median follow-up of 55 weeks. Three patients (27.3%) achieved an ongoing systemic complete response at a median follow-up of 55 weeks (range 32-65), and 3 (27.3%) had an initial partial response for a median of 40 weeks. Analysis of immune response data suggested a relationship between elevated CD8-activated T-cells and response. Conclusion: This is the second prospective clinical trial of treatment of metastatic melanoma using the combination of RT and systemic immunotherapy and the first using this sequence of therapy. The results from the present trial demonstrate that a subset of patients may benefit from combination therapy, arguing for continued clinical investigation of the use of RT combined with immunotherapy, including programmed cell death 1 inhibitors, which might have the potential to be even more effective in combination with RT.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

In Situ EXAFS-Based Nanothermometry of Heterodimer Nanocrystals under Induction Heating

The ability to heat nanocrystalline materials through magnetic induction has been used in the fields of catalysis, biomedical sciences, and polymer degradation. However, the working temperature to which the inductively coupled material rises is still poorly understood. Herein, we use extended X-ray absorption fine structure spectroscopy in conjunction with thermal imaging to improve the understanding of heating in inductively coupled systems. After extraction of the Debye–Waller factor from the spectroscopy, we obtain the temperature of inductively heated nanocrystals from the correlated Debye model. We combine carbon-supported iron oxide nanocrystals as induction heating agents with platinum nanocrystals as thermal probes. By testing these nanocrystal species as both unattached nanocrystals and heterodimers, we report that nanostructured systems show a significant temperature difference of up to 73.60 °C when compared to their local support environment. Furthermore, this result has implications for inductively heated catalysis, magnetic hyperthermia for targeted cell death, and polymer synthesis.

09 BIOMASS FUELS↗

Ice Protection of Turbojet Engines by Inertia Separation of Water I : Alternate-duct System

Aerodynamic and icing investigations of internal water-inertia separation inlets designed to prevent automatically entrance of large quantities of water into a turbojet engine in icing conditions was conducted on a one-half scale model. A simplified analytical approach to the design of internal water-inertia separation inlets is included. Results show that in order to be effective in preventing screen and guide-vane icing for an inlet of this type, a ram-pressure recovery of 75 percent was attained at design inlet-velocity ratio in an icing condition. For nonicing operation, ram-pressure recovery is comparable to direct-ram inlet.

INLETS, NOSE - CENTRAL↗

Ice Protection of Turbojet Engines by Inertia Separation of Water II : Single-offset-duct System

Investigation of a single-offset-duct system designed to prevent entrance of water into a turbojet engine was conducted on a half-scale nacelle model. An investigation was made to determine ram-pressure recovery and radial velocity profiles at the compressor section and icing characteristics of such a duct system. At a design inlet velocity of 0.77, the maximum ram-pressure recovery attained with effective water-separating inlet was 77 percent, which is considerably less than attainable with a direct-ram inlet. Continuous heating of the accessory-housing surface would be required for inlets that have a small ice storage space.

NOSE SHAPE - DUCTED BODIES↗

Flash radiotherapy accelerator

Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One flash radiotherapy system includes an induction accelerator, and a controllable switch coupled to the induction accelerator. The switch is operable to produce a plurality of voltage pulses to drive the induction accelerator. The radiotherapy system also includes a radiation measurement device to measure output radiation produced by the radiotherapy system and provide feedback to the controllable switch. The controllable switch is operable to, based on the received feedback, modify an amplitude, shape, spacing, number or width of the voltage pulses that are supplied to the particle accelerator to deliver the desired output radiation.

Sampayan, Stephen E.↗

Field oriented control of an induction machine in a high frequency link power system

A field-oriented controlled induction machine drive operating with a high-frequency single-phase sinusoidal voltage link is presented. System performance is investigated by computer simulation and is verified by a test on a prototype system. A novel control loop to minimize the link voltage fluctuation is proposed. The capability of rapid demagnetization of the induction machine by current regulation is investigated. A current-modulation technique termed mode control is proposed, and its performance is compared with that of the conventional delta-modulation technique.

Sul, Seung K.↗

System Modeling and Diagnostics for Liquefying-Fuel Hybrid Rockets

A Hybrid Combustion Facility (HCF) was recently built at NASA Ames Research Center to study the combustion properties of a new fuel formulation that burns approximately three times faster than conventional hybrid fuels. Researchers at Ames working in the area of Integrated Vehicle Health Management recognized a good opportunity to apply IVHM techniques to a candidate technology for next generation launch systems. Five tools were selected to examine various IVHM techniques for the HCF. Three of the tools, TEAMS (Testability Engineering and Maintenance System), L2 (Livingstone2), and RODON, are model-based reasoning (or diagnostic) systems. Two other tools in this study, ICS (Interval Constraint Simulator) and IMS (Inductive Monitoring System) do not attempt to isolate the cause of the failure but may be used for fault detection. Models of varying scope and completeness were created, both qualitative and quantitative. In each of the models, the structure and behavior of the physical system are captured. In the qualitative models, the temporal aspects of the system behavior and the abstraction of sensor data are handled outside of the model and require the development of additional code. In the quantitative model, less extensive processing code is also necessary. Examples of fault diagnoses are given.

Poll, Scott↗

Fabrication and Evaluation of a High Performance SiC Inverter for Wireless Power Transfer Applications

In this study, a high power density SiC high efficiency wireless power transfer converter system via inductive coupling has been designed and developed. The detailed power module design, cooling system design and power stage development are presented. The successful operation of rated power converter system demonstrates the feasible wireless charging plan. One of the most important part of this study is the wind bandgap devices packaged at the Oak Ridge National Laboratory (ORNL) using the in-house packaging technologies by employing the bare SiC dies acquired from CREE, which are rated at 50 A / 1200 V each. These packaged devices are also inhouse tested and characterized using ORNL s Device Characterization Facility. The successful operation of the proposed inverter is experimentally verified and the efficiency and operational characteristics of the inverter are also revealed.

Onar, Omer C↗

A 50-kW Three-Phase Wireless Power Transfer System Using Bipolar Windings and Series Resonant Networks for Rotating Magnetic Fields

The mass and volume of wireless power transfer (WPT) systems for charging electric vehicles are directly related to the rated power of the system. The difficulties of high-power wireless charging are exacerbated by the need to meet the same practical constraints associated with vehicle integration as lower power systems. Therefore, more advanced techniques are necessary to improve power density and specific power of wireless charging systems for high-power applications. This article presents theory and analysis of three-phase inductive WPT systems with bipolar phase windings. Magnetic coupler topologies and the theoretical and practical aspects of series three-phase resonant compensation networks are discussed. The systems under consideration are designed to utilize rotating magnetic fields to achieve a power transfer characteristic that is temporally smoother than single-phase systems. Other benefits associated with rotating magnetic field based WPT, including reduced ferrite mass, filter component requirements, and electromagnetic field emissions, are discussed. Experimental results of a prototype system are presented in both aligned and misaligned configurations. The system is demonstrated transferring 50 kW with 95% dc-to-dc efficiency over a 150-mm airgap in the aligned case. On a per-pad basis, the magnetic couplers achieve a power density of 195 kW/m 2 and a specific power of 3.65 kW/kg. Finally this article is accompanied by a video of the rotating magnetic field produced by a simulated three-phase WPT system.

42 ENGINEERING↗

Electrically-Assisted Tubing Processes for Enhancing Manufacturability of Oxide Dispersion Strengthened Structural Materials for Nuclear Reactor Applications

The overall goal of this project is to enhance the formability of Nanostructured Ferritic Alloys (NFAs) such that high-strength thin-walled claddings can be successfully and economically manufactured for use in future nuclear reactors. Specifically, four objectives were identified: Objective #1 – to achieve a good understanding of the mechanical behavior and resulting microstructure of 14YWT made from the powder form subjected to various Electrically- Assisted (EA) loading conditions. Objective #2 – to conduct EA-flat rolling of 14YWT completed and the prioritization/selection of two alternative designs of EA tube rolling processes. Objective #3 – to design and assemble a new EA tube rolling machine. Objective #4 – to conduct rolling using the new EA rolling machine. The above objectives were achieved and the findings can be further applied to establish other innovative fabrication processes. Specifically, the major accomplishments are summarized as: The use of an EA forming process was investigated to reduce the forming force of ODS ferritic steels. The effect of a continuous electric current on 14YWT during plastic deformation was evaluated. EA uniaxial tension tests show that the electric current is able to reduce the flow stress of 14YWT. 14YWT exhibits a ductility minimum at a current density of 34.5 A/mm2 which is consistent with fractography results. Hardness measurements and TEM results indicate that oxide particles are stable during the EA process. By following the tests, microstructure analysis was performed on the sample in its as-received state and after current treatment. The microstructures are stable when subjected to high current density. The related thermal model was developed to predict the Joule heating temperatures. The temperatures were compared with the experimental results. At last, a temperature-dependent hardening model was used to explore the mechanisms acting during EA deformation. Since the model can accurately predict the yield strength of 14YWT under EA conditions without the incorporation of non-thermal effects, it can be concluded that the reduction in yield strength is due to the Joule heating generated under continuous current loading conditions. An oven-heated pure thermal tension test was conducted to confirm this conclusion. The new EA tube rolling machine has been completely developed. The related work includes: (1) forming process design; (2) analysis of the effect of roll-tube contact geometry on rolling force; (3) analysis of machine performance under mechanical loading; (4) design of machine electrical setting path and insulation; (5) multi-pass process analysis; (6) design of power transmission system (axial/radial/torque feeding mechanisms), roll bearing system, cooling system, workpiece feeding mechanism, and other related mechanical connection support components; (7) design and optimization of roll profiles/dimensions; (8) analysis and simulation of the rolling process; (9) development of engineering drawings and fabrication; (10) assembly and calibration of the EA tube rolling machine; (11) design and integration of the electrical control system; (12) hardware integration for high power supply electrically-assisted rolling process; (13) induction heating system integration; (14) experimental tests for the new rolling process. Through the process from conceptual design to final machine calibration and experimental tests, there are many technical and physical works that have been implemented and improved for the best performance of the innovative prototype.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Effects of Inlet Icing on Performance of Axial-flow Turbojet Engine in Natural Icing Conditions

A flight investigation in natural icing conditions was conducted to determine the effect of inlet ice formations on the performance of axial-flow turbojet engines. The results are presented for icing conditions ranging from a liquid-water content of 0.1 to 0.9 gram per cubic meter and water-droplet size from 10 to 27 microns at ambient-air temperature from 13 to 26 degrees F. The data show time histories of jet thrust, air flow, tail-pipe temperature, compressor efficiency, and icing parameters for each icing encounter. The effect of inlet-guide-vane icing was isolated and shown to account for approximately one-half the total reduction in performance caused by inlet icing.

COMPRESSORS - AXIAL FLOW↗