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NASA NTRS2010

Sensitivity Analysis of Launch Vehicle Debris Risk Model

As part of an analysis of the loss of crew risk associated with an ascent abort system for a manned launch vehicle, a model was developed to predict the impact risk of the debris resulting from an explosion of the launch vehicle on the crew module. The model consisted of a debris catalog describing the number, size and imparted velocity of each piece of debris, a method to compute the trajectories of the debris and a method to calculate the impact risk given the abort trajectory of the crew module. The model provided a point estimate of the strike probability as a function of the debris catalog, the time of abort and the delay time between the abort and destruction of the launch vehicle. A study was conducted to determine the sensitivity of the strike probability to the various model input parameters and to develop a response surface model for use in the sensitivity analysis of the overall ascent abort risk model. The results of the sensitivity analysis and the response surface model are presented in this paper.

Gee, Ken↗

NASA NTRS2005

AC/DC Power Systems with Applications for future Lunar/Mars base and Crew Exploration Vehicle

ABSTRACT The Power Systems branch at JSC faces a number of complex issues as it readies itself for the President's initiative on future space exploration beyond low earth orbit. Some of these preliminary issues - those dealing with electric power generation and distribution on board Mars-bound vehicle and that on Lunar and Martian surface may be summarized as follows: Type of prime mover - Because solar power may not be readily available on parts of the Lunar/Mars surface and also during the long duration flight to Mars, the primary source of power will most likely be nuclear power (Uranium fuel rods) with a secondary source of fuel cell (Hydrogen supply). The electric power generation source - With nuclear power being the main prime mover, the electric power generation source will most likely be an ac generator at a yet to be determined frequency. Thus, a critical issue is whether the generator should generate at constant or variable frequency. This will decide what type of generator to use - whether it is a synchronous machine, an asynchronous induction machine or a switched reluctance machine. The type of power distribution system - the distribution frequency, number of wires (3- wire, 4-wire or higher), and ac/dc hybridization. Building redundancy and fault tolerance in the generation and distribution sub-systems so that the system is safe; provides 100% availability to critical loads; continues to operate even with faulted sub-systems; and requires minimal maintenance. This report descril_es results of a summer faculty fellowship spent in the Power Systems Branch with the specific aim of investigating some of the lessons learned in electric power generation and usage from the terrestrial power systems industry, the aerospace industry as well as NASA's on-going missions so as to recommend novel surface and vehicle-based power systems architectures in support of future space exploration initiatives. A hybrid ac/dc architecture with source side and load side redundancies and including emergency generators on both ac and dc sides is proposed. The generation frequency is 400 Hz mostly because of the technology maturity at this frequency in the aerospace industry. Power will be distributed to several ac load distribution buses through solid state variable speed, constant frequency converters on the ac side. A segmented dc ring bus supplied from ac/dc converters and with the capability of connecting/disconnecting the segments will supply power to multiple de load distribution buses. The system will have the capability of reverse flow from dc to ac side in the case of an extreme emergency on the main ac generation side.

Chowdhury, Badrul H.↗

NASA NTRS2001

Space radiation dosimetry in low-Earth orbit and beyond

Space radiation dosimetry presents one of the greatest challenges in the discipline of radiation protection. This is a result of both the highly complex nature of the radiation fields encountered in low-Earth orbit (LEO) and interplanetary space and of the constraints imposed by spaceflight on instrument design. This paper reviews the sources and composition of the space radiation environment in LEO as well as beyond the Earth's magnetosphere. A review of much of the dosimetric data that have been gathered over the last four decades of human space flight is presented. The different factors affecting the radiation exposures of astronauts and cosmonauts aboard the International Space Station (ISS) are emphasized. Measurements made aboard the Mir Orbital Station have highlighted the importance of both secondary particle production within the structure of spacecraft and the effect of shielding on both crew dose and dose equivalent. Roughly half the dose on ISS is expected to come from trapped protons and half from galactic cosmic rays (GCRs). The dearth of neutron measurements aboard LEO spacecraft and the difficulty inherent in making such measurements have led to large uncertainties in estimates of the neutron contribution to total dose equivalent. Except for a limited number of measurements made aboard the Apollo lunar missions, no crew dosimetry has been conducted beyond the Earth's magnetosphere. At the present time we are forced to rely on model-based estimates of crew dose and dose equivalent when planning for interplanetary missions, such as a mission to Mars. While space crews in LEO are unlikely to exceed the exposure limits recommended by such groups as the NCRP, dose equivalents of the same order as the recommended limits are likely over the course of a human mission to Mars. c2001 Elsevier Science B.V. All rights reserved.

short duration↗

NASA NTRSDate not supplied

A Crew and Logistics Lander for the Common Habitat Architecture

The Common Habitat Architecture is a conceptual study that explores the use of a large habitat derived from the Space Launch System (SLS) liquid oxygen tank as a core habitation element that can be used for crew missions or training in 0g, 1/6g, 3/8g, and 1g. This is not part of current NASA Artemis mission planning, but instead represents an architecture that could potentially follow after the Artemis missions and initial human Mars landings. This architecture leverages Starship-derived vehicles for crew landing on and ascent from the Moon and Mars in support of long-duration surface missions with pressurized crew transfer baselined as a nominal capability. This is not the Human Landing System variant of Starship but represents a number of modifications to enable long-duration surface missions with an eight-person crew size. A rapid brainstorming study was conducted in February of 2021, using only public data, to identify options to deliver the 90-ton Common Habitat to the surface and emplace it at the intended habitation site. This study compared three lunar lander concepts and three Mars lander concepts before ultimately selecting the SpaceX Starship as the most viable lander. The Common Habitat Architecture assumes that this Starship variant can further be modified for crew and cargo delivery, assuming that the use of a common system will lead to cost benefits. It is assumed that the Starship will expend too much propellant in landing crew and logistics to be able to launch, given the assumed absence of surface propellant production. Consequently, a separable ascent stage is used for crew ascent. The pressurized elements of this modified Starship are discussed: Starship Ascent Module, Airlock, Transfer Tunnel, Pressurized Crew Transfer Module, and Logistics Modules. For each element, a description, dimensions, rough mass estimates, core capabilities, and design features are presented. Key mechanisms and internal structures of the starship are also discussed. This will include flame diverters for the ascend module, the orbital docking hatch, Pressurized Crew Transfer Module Garage door, Starship Ascent Module fairing, flame diverter blow-out panels, Pressurized Crew Transfer Module lift system, logistics module lift system, contingency crew ascent via the logistics module lift system, internal catwalks, and structural interfaces. Concept of Operations will be discussed for both Moon and Mars. This will include in-space crew rendezvous and transfer, crewed landing, shirtsleeve crew transfer, crew departure, contingency surface operations, and final element disposition. Key differences for Mars will be discussed, such as the Martian atmosphere, dust storms, the absence of crew handover, and Deep Space Exploration Vehicle rendezvous. Contingency microgravity maintenance access will also be discussed. This work will demonstrate viable pressurized crew transfer with a Starship-based lander architecture. Forward work includes Garage lighting and camera systems, Starship Ascent Module propulsion system and docking port trades, contingency habitation trades, and mass/power equipment estimation. Finally, forward work includes developing a heavy cargo return system derived from the Crew and Logistics Starship. The goal of this system is the return of at least 10,000 kg payloads from the surfaces of the Moon and Mars.

Lunar Lander↗

NASA NTRS2013

Flight-Deck Strategies and Outcomes When Flying Schedule-Matching Descents

Recent studies at NASA Ames Research Center have investigated the development and use of ground-based (air traffic controller) tools to manage and schedule air traffic in future terminal airspace. An exploratory study was undertaken to investigate the impacts that such tools (and concepts) could have on the flight-deck. Ten Boeing 747-400 crews flew eight optimized profile descents in the Los Angeles terminal airspace, while receiving scripted current day and futuristic speed clearances, to ascertain their ability to fly schedulematching descents without prior training. Although the study was exploratory in nature, four variables were manipulated: route constraints, winds, speed changes, and clearance phraseology. Despite flying the same scenarios with the same events and timing, there were significant differences in the time it took crews to fly the approaches. This variation is the product of a number of factors but highlights potential difficulties for scheduling tools that would have to accommodate this amount of natural variation in descent times. The focus of this paper is the examination of the crews' aircraft management strategies and outcomes. This includes potentially problematic human-automation interaction issues that may negatively impact arrival times, speed and altitude constraint compliance, and energy management efficiency.

Flight Management System↗

NASA NTRS2003

A Dynamic Risk Model for Evaluation of Space Shuttle Abort Scenarios

The Space Shuttle is an advanced manned launch system with a respectable history of service and a demonstrated level of safety. Recent studies have shown that the Space Shuttle has a relatively low probability of having a failure that is instantaneously catastrophic during nominal flight as compared with many US and international launch systems. However, since the Space Shuttle is a manned. system, a number of mission abort contingencies exist to primarily ensure the safety of the crew during off-nominal situations and to attempt to maintain the integrity of the Orbiter. As the Space Shuttle ascends to orbit it transverses various intact abort regions evaluated and planned before the flight to ensure that the Space Shuttle Orbiter, along with its crew, may be returned intact either to the original launch site, a transoceanic landing site, or returned from a substandard orbit. An intact abort may be initiated due to a number of system failures but the highest likelihood and most challenging abort scenarios are initiated by a premature shutdown of a Space Shuttle Main Engine (SSME). The potential consequences of such a shutdown vary as a function of a number of mission parameters but all of them may be related to mission time for a specific mission profile. This paper focuses on the Dynamic Abort Risk Evaluation (DARE) model process, applications, and its capability to evaluate the risk of Loss Of Vehicle (LOV) due to the complex systems interactions that occur during Space Shuttle intact abort scenarios. In addition, the paper will examine which of the Space Shuttle subsystems are critical to ensuring a successful return of the Space Shuttle Orbiter and crew from such a situation.

Henderson, Edward M.↗

NASA NTRS2004

Solid Fuel Delivery System Developed for Combustion Testing on the International Space Station

NASA initiated Bioastronautics and Human Research Initiatives in 2001 and 2003, respectively, to enhance the safety and performance of humans in space. The Flow Enclosure Accommodating Novel Investigations in Combustion of Solids (FEANICS) is a multiuser facility being built at the NASA Glenn Research Center to advance these initiatives by studying fire safety and the combustion of solid fuels in the microgravity environment of the International Space Station (ISS). One of the challenges for the FEANICS team was to build a system that allowed for several consecutive combustion tests to be performed with minimal astronaut crew interaction. FEANICS developed a fuel carousel that contains a various number of fuel samples, depending on the fuel width, and introduces them one at a time into a flow tunnel in which the combustion testing takes place. This approach will allow the science team to run the experiments from the ground, while only requiring the crew to change out carousels after several tests have been completed.

Frate, David T.↗

NASA NTRS2014

Practicing for Mars: The International Space Station (ISS) as a Testbed

Allows demonstration and development of exploration capabilities to help accomplish future missions sooner with less risk to crew and mission Characteristics of ISS as a testbed High fidelity human operations platform in LEO: Continuously operating habitat and active laboratory. High fidelity systems. Astronauts as test subjects. Highly experienced ground operations teams. Offers a controlled test environment.: Consequences to systems performance and decision making not offered in ground analogs International participation. Continuously improving system looking for new technology and ideas to improve operations. Technology Demos & Critical Systems Maturation. Human Health and Performance. Operations Simulations and Techniques. Exploration prep testing on ISS has been ongoing since 2012. Number of tests increasing with each ISS expedition. One Year Crew Expedition starting in Spring 2015. ROSCOSMOS and NASA are partnering on the Participating Crew are Mikhail Kornienko and Scott Kelly Majority of testing is an extension of current Human Biomedical Research investigations Plan for extending & expanding upon current operations techniques and tech demo studies ESA 10 Day Mission in Fall 2015 ESA astronaut focus on testing exploration technologies Many more opportunities throughout the life of ISS! 4/24/2014 david.h.korth@nasa.gov 4 Exploration testing

Korth, David H.↗

NASA NTRS1981

Manned orbit transfer vehicles and their missions

From a study that identified over 100 possible geosynchronous orbit-related applications for manned orbit transfer vehicles (MOTV), a group of 20 are chosen for consideration. These generic missions can be grouped into five categories: (1) inspection service and repair, (2) operation of large systems, (3) debris removal, (4) construction, and (5) unmanned cargo. Among the findings of this study is that space basing permits more efficient use of Space Shuttle flights, since the core propulsion system, crew cabin and general purpose mission hardware need not be launched into space each time. A conservative traffic model shows that $600 million may be saved over five years by space basing, due to the decreased number of Shuttle flights needed to support the space-based MOTV. Crew information, payloads, characteristics of the vehicle, and mission requirements are covered in detail.

Boyland, R. E.↗

NASA NTRS1986

Cytogenetic analyses of peripheral lymphocytes subjected to simulated solar flare radiation

Solar flare protons share many radiological health characteristics of the inner Van Allen Belt protons, and both types of radiation pose serious dangers to a number of missions planned. It is appropriate to evaluate crew dose determination procedures in terms of the type of radiation responsible for the major part of the projected exposure, i.e., protons in the neighborhood of 100 MeV. Monitoring chromosome abnormalities in peripheral lymphocytes is one method to determine an individual's accumulated radiation dosage. Cell culture and harvest is a relatively simple procedure and is well within the capabilities of a station health facility, but the evaluation of prepared microscopic slides is a time consuming and subjective procedure. This project is part of an effort to demonstrate the utility of automated image processing and evaluation procedures in expediting dose evaluation. The initial goal of this project is to produce a set of reference chromosome spreads produced from control lymphocytes and from lymphocytes exposed in whole blood to protons or gamma rays. The results of manual and automated aberration scoring will ultimately be compared to test for systematic differences between the two evaluation procedures and between the two radiation qualities. Proton irradiations are performed at the University of Texas Health Science Center at Houston Cyclotron Facility. Proton dosimetry is supplemented by TLD packets from and by assay of short-lived proton activation products in the irradiation blood samples.

Prichard, H. M.↗

NASA NTRS1987

Aircrew cooperation in the Royal Air Force

The progressive introduction of modern, high performance aircraft, coupled with a significant increase in the complexity of the operational environment, has highlighted crew co-operation as a critical factor in aircraft safety. Investigation into recent MAC aircraft accidents supports the conclusion reached by NASA and other U.S. research institutions that a positive training program is required to improve resource management in the cockpit and prevent a breakdown under stress of the crew process. Past training and regulation has concentrated on the attainment of individual flying skills, but group skills have been neglected through lack of knowledge and understanding of the group process. This long-standing deficiency is now being addressed in the U.S. by the progressive and widespread introduction of theoretical and practical training programs to improve crew co-operation. The RAF should provide similar training for its aircrews through the adaptation and development of existing training resources. Better crew co-operation would not only reduce the number of RAF aircraft accidents but also improve the morale of the Service.

Adcock, C. B.↗

NASA NTRS1989

Space immunology - Past, present and future

Research results on the causes and mechanisms of change in immune systems during spaceflight are briefly reviewed. The most reliable conclusion from the sparse existing data is that postflight crew members exhibit a transient neutrophilia, eosinopenia, monocytopenia, reduced numbers of circulating T cells, and an often pronounced decrease in the ability of their T cells to respond to mitogen stimulation. Clinically, no direct predictive relationship between any of these measurements and increased health risk or disease has been established. Future areas of research are suggested in light of NASA's emerging requirements to support long-duration missions.

Coulter, Gary R.↗

NASA NTRS1992

Microbiological concerns and methodological approaches related to bacterial water quality in spaceflight

A number of microbiological issues are of critical importance to crew health and system performance in spacecraft water systems. This presentation reviews an army of these concerns which include factors that influence water treatment and disinfection in spaceflight such as biofilm formation and the physiological responses of bacteria in clean water systems. Factors associated with spaceflight like aerosol formation under conditions of microgravity are also discussed within the context of airborne infections such as Legionellosis. Finally, a spectrum of analytical approaches is reviewed to provide an evaluation of methodological alternatives that have been suggested or used to detect microorganisms of interest in water systems. These range from classical approaches employing colony formation on specific microbiological growth media to direct (i.e. microscopic) and indirect (e.g. electrochemical) methods as well as the use of molecular approaches and gene probes. These techniques are critically evaluated for their potential utility in determining microbiological water quality through the detection of microorganisms under the influence of ambient environmental stress inherent in spaceflight water systems.

Pyle, Barry H.↗

NASA NTRS2004

Nutritional status changes in humans during a 14-day saturation dive: the NASA Extreme Environment Mission Operations V project

Ground-based analogs of spaceflight are an important means of studying physiologic and nutritional changes associated with space travel, and the NASA Extreme Environment Mission Operations V (NEEMO) is such an analog. To determine whether saturation diving has nutrition-related effects similar to those of spaceflight, we conducted a clinical nutritional assessment of the NEEMO crew (4 men, 2 women) before, during, and after their 14-d saturation dive. Blood and urine samples were collected before, during, and after the dive. The foods consumed by the crew were typical of the spaceflight food system. A number of physiologic changes were observed, during and after the dive, that are also commonly observed during spaceflight. Hemoglobin and hematocrit were lower (P < 0.05) after the dive. Transferrin receptors were significantly lower immediately after the dive. Serum ferritin increased significantly during the dive. There was also evidence indicating that oxidative damage and stress increased during the dive. Glutathione peroxidase and superoxide dismutase decreased during and after the dive (P < 0.05). Decreased leptin during the dive (P < 0.05) may have been related to the increased stress. Subjects had decreased energy intake and weight loss during the dive, similar to what is observed during spaceflight. Together, these similarities to spaceflight provide a model to use in further defining the physiologic effects of spaceflight and investigating potential countermeasures.

Diving/physiology↗

NASA NTRS2011

Recommendations for Enabling Manual Component Level Electronic Repair for Future Space Missions

Long duration missions to the Moon and Mars pose a number of challenges to mission designers, controllers, and the crews. Among these challenges are planning for corrective maintenance actions which often require a repair. Current repair strategies on the International Space Station (ISS) rely primarily on the use of Orbital Replacement Units (ORUs), where a faulty unit is replaced with a spare, and the faulty unit typically returns to Earth for analysis and possible repair. The strategy of replace to repair has posed challenges even for the ISS program. Repairing faulty hardware at lower levels such as the component level can help maintain system availability in situations where no spares exist and potentially reduce logistic resupply mass.This report provides recommendations to help enable manual replacement of electronics at the component-level for future manned space missions. The recommendations include hardware, tools, containment options, and crew training. The recommendations are based on the work of the Component Level Electronics Assembly Repair (CLEAR) task of the Exploration Technology Development Program from 2006 to 2009. The recommendations are derived based on the experience of two experiments conducted by the CLEAR team aboard the International Space Station as well as a group of experienced Miniature/Microminiature (2M) electronics repair technicians and instructors from the U.S. Navy 2M Project Office. The emphasis of the recommendations is the physical repair. Fault diagnostics and post-repair functional test are discussed in other CLEAR reports.

Struk, Peter M.↗

NASA NTRSDate not supplied

Evaluation of Correction Methods for NASA GeneLab Transcriptomic Datasets

Conducting space biology experiments aboard the International Space Station, particularly those utilizing complex model organisms like mice, is expensive and difficult due to limited crew availability, hardware, and space. As a result, sample numbers from these studies are low, reducing the statistical power of any one experiment. Aggregating spaceflight datasets serves as a method to increase sample numbers, allowing for novel insights through bioinformatic analysis of ‘omics data from merged datasets. However, aggregating datasets can introduce unwanted variation including 1) differences in sample handling, processing, and sequencing platforms between datasets (technical variation) as well as 2) differences in experimental design between datasets such as sex or age of the model organism used. In the present study, NASA GeneLab-hosted RNAseq datasets from rodent liver tissues were used to evaluate several statistical methods to correct for this unwanted variation through two approaches, reference-based and standard. The following correction algorithms were applied with (reference-based) and/or without (standard) considering Universal Mouse RNA Reference samples: ComBat and ComBat_seq from the SVA package, median polish, empirical Bayes, and ANOVA-based algorithms from the MBatch package, and negative binomial regression normalization in the DESeq2 package. For each approach, after the correction algorithm was applied, differential gene expression (DGE) analysis of flight and ground control samples was performed with the combined data. The robustness of each tool was evaluated using BatchQC, to determine statistical differences between datasets before and after correction, Principal Component Analysis, to evaluate global gene expression in samples before and after correction, and by comparing DGE analysis of individual datasets and combined datasets before and after correction. The results showed that the reference-based approach introduced several additional (and likely artificial) DEGs when compared with the standard approach. Thus, the most robust standard correction will be implemented in the GeneLab Visualization 2.0 platform when datasets are combined.

GeneLab, RNA-seq, Batch Correction↗

NASA NTRSDate not supplied

Evaluation of Correction Methods for NASA GeneLab Transcriptomic Datasets

Conducting space biology experiments aboard the International Space Station, particularly those utilizing complex model organisms like mice, is expensive and difficult due to limited crew availability, hardware, and space. As a result, sample numbers from these studies are low, reducing the statistical power of any one experiment. Aggregating spaceflight datasets serves as a method to increase sample numbers, allowing for novel insights through bioinformatic analysis of ‘omics data from merged datasets. However, aggregating datasets can introduce unwanted variation including 1) differences in sample handling, processing, and sequencing platforms between datasets (technical variation) as well as 2) differences in experimental design between datasets. In the present study, NASA GeneLab-hosted RNAseq datasets from mouse liver tissues were used to evaluate several statistical methods to correct for this unwanted variation through two approaches, reference-based and standard. The following correction algorithms were applied with (reference-based) and/or without (standard) considering Universal Mouse RNA Reference samples: ComBat and ComBat_seq from the SVA package, median polish, empirical Bayes, and ANOVA-based algorithms from the MBatch package, and negative binomial regression normalization in the DESeq2 package. For each approach, after the correction algorithm was applied, differential gene expression (DGE) analysis of flight and ground control samples was performed with the combined data. The robustness of each tool was evaluated using BatchQC to determine statistical differences between datasets before and after correction, Principal Component Analysis to evaluate global gene expression in samples before and after correction, and by comparing DGE analysis of individual datasets and combined datasets before and after correction. The results showed that the reference-based approach introduced several additional (and likely artificial) DEGs when compared with the respective standard approach. Of the methods tested, standard ComBat and DESeq2 were identified as the most robust correction methods for combining spaceflight mouse liver RNAseq datasets hosted on GeneLab.

GeneLab↗

NASA NTRSDate not supplied

Combining RNA-SEQ Datasets from NASA GENELAB: An Evaluation of Correction Methods

Background: Conducting space biology experiments aboard the International Space Station, particularly those utilizing complex model organisms like mice, is expensive and difficult due to limited crew availability, hardware, and space. As a result, sample numbers from these studies are low, reducing the statistical power of any one experiment. Aggregating spaceflight datasets serves as a method to increase sample numbers, allowing for novel insights through bioinformatic analysis of ‘omics data from merged datasets. However, aggregating datasets can introduce unwanted variation including 1) differences in sample handling, processing, and sequencing platforms between datasets (technical variation) as well as 2) differences in experimental design between datasets. Methods: In the present study, NASA GeneLab-hosted RNAseq datasets from mouse liver tissues were used to evaluate several statistical methods to correct for this unwanted variation through two approaches, reference-based and standard. The following correction algorithms were applied with (reference-based) and/or without (standard) considering Universal Mouse RNA Reference samples: ComBat and ComBat_seq from the SVA package, the median polish, empirical Bayes, and ANOVA-based algorithms from the MBatch package, and negative binomial regression normalization in the DESeq2 package. For each approach, after the correction algorithm was applied, differential gene expression (DGE) analysis of flight and ground control samples was performed with the combined data. The robustness of each tool was evaluated using BatchQC to determine statistical differences between datasets before and after correction, Principal Component Analysis to evaluate global gene expression in samples before and after correction, and by comparing DGE analysis of individual datasets and combined datasets before and after correction. Results: The results showed that the reference-based approach introduced several additional (and likely artificial) differentially expressed genes when compared with the respective standard approach. Conclusions: Of the methods tested, standard ComBat_seq and DESeq2 were identified as the most robust correction methods for combining spaceflight mouse liver RNAseq datasets hosted on GeneLab.

Finsam Samson↗