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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 163 records · Page 9

Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2

Metazoan cell polarity is controlled by a set of highly conserved proteins. Lethal giant larvae (Lgl) functions in apical-basal polarity through phosphorylation-dependent interactions with several other proteins as well as the plasma membrane. Phosphorylation of Lgl by atypical protein kinase C (aPKC), a component of the partitioning-defective (Par) complex in epithelial cells, excludes Lgl from the apical membrane, a crucial step in the establishment of epithelial cell polarity. We present the crystal structures of human Lgl2 in both its unphosphorylated and aPKC-phosphorylated states. Lgl2 adopts a double β-propeller structure that is unchanged by aPKC phosphorylation of an unstructured loop in its second β-propeller, ruling out models of phosphorylation-dependent conformational change. Here, we demonstrate that phosphorylation controls the direct binding of purified Lgl2 to negative phospholipids in vitro. We also show that a coil–helix transition of this region that is promoted by phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is also phosphorylation-dependent, implying a highly effective phosphorylative switch for membrane association.

59 BASIC BIOLOGICAL SCIENCES↗

NSTX-U advances in real-time deterministic PCIe-based internode communication

Distributing control mechanisms across modern commercial off the shelf (COTS) GNU/Linux systems often introduces difficult to mitigate non-deterministic behavior. Existing methods to address this problem involve non-real-time technologies such as Remote Direct Memory Access (RDMA) over Infiniband or custom Ethernet solutions, such as RDMA over Converged Ethernet (RoCE) or userspace Ethernet drivers, that trade determinism for ease of use or lower cost. The National Spherical Torus Experiment Upgrade (NSTX-U) is pursuing a new design that allows direct communication between heterogeneous systems with scalable, microsecond latency with 1 μs of jitter on that latency, outside of the constant transmission delay at the physical layer. The future design of the NSTX-U Real-time Communication System will utilize direct PCIe-to-PCIe communication with kernel support tuned for low overhead, allowing two (or more, through a switch) real-time (RT) systems to communicate and share resources as one larger entity. As a result, this greatly increases the processing capability of the primary Plasma Control System (PCS), turning previously insurmountable computational challenges into a more manageable divide and conquer parallel task.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Multiple striated heat fluxes patterns on the EAST first wall generated by lower hybrid wave absorption in the scrape-off layer

Multiple striated heat fluxes on the EAST first wall are observed with lower hybrid wave (LHW) heating on the EAST device. Our analysis indicates that the heat source for the striated heat flux is from LHW absorption in the scrape-off layer (SOL). Magnetic field line tracing from the front of the LHW antenna grills is in good agreement with the striated heat flux profile. In addition the relative intensity of the LHW absorption in the SOL is consistent with the measured striated heat flux. However, the heat flux at inner strike points and outer strike points significantly decreased when the ion cyclotron resonance frequency (ICRF) wave was switched off, while there was no change for the striated heat flux, suggests that the striated heat flux is independent on the injected power to the core plasma.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Implementation of an impurity diagnostic suite on the Pegasus-III experiment

A suite of diagnostics used to assess impurity content and dynamics has been updated, upgraded, and installed on the Pegasus-III Experiment. Typical plasma parameters during local helicity injection start-up are τ shot ~10 ms, n e ~ 1 × 10 19 m –3 , and T e ~ 50 eV. The deployed diagnostics are compatible with this modest temperature and density regime and provide species identification, source localization, and estimation of radiation losses. Impurity species are determined by recording time-evolving, single line-of-sight spectra at 1.25 kfps using a SPRED (Survey, Poor Resolution, Extended Domain) vacuum ultraviolet spectrometer. SPRED is equipped with 450 g/mm grating, giving a spectral resolution of 0.33 nm and a spectral range from ~10 to 110 nm, useful to identify light impurity species in this temperature and density range. An absolutely calibrated spectrometer that collects light from the plasma at R tan = 15.9 cm and Δt ≥ 2 ms is used as a visible survey spectrometer and for continuum measurements. The radiated power from the plasma is estimated with a photodiode-based diagnostic. Two 16-channel absolute extreme ultraviolet diode arrays are placed behind pinhole apertures, resulting in 32 lines of sight at Z = 0, with a spatial resolution of 2–3 cm and a time response of 60 kHz. A photometrically calibrated collinear D α /near infrared filtered photodiode-based system measures the D α emission and around 1040 nm. All these instruments have been designed to suppress electromagnetic interference from megawatt-class switching power supplies.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Vertical oscillations of dust particles in a strongly magnetized plasma sheath induced by horizontal laser manipulation

Experimental studies are presented where dust particles are suspended in the lower sheath region of an argon rf discharge at a strong vertical magnetic field from B = 1.5 T up to 2.27 T. There the particles arranged in an ordered pattern imposed by the upper mesh electrode. It is observed that the particles jump to a new equilibrium position, where they exhibit self-excited vertical oscillations when illuminated by a horizontal laser beam. Furthermore, the dust motion is weakly damped during an upward jump and strongly damped during the return to the equilibrium after the laser is switched off. A model based on delayed charging is presented that can describe the observed behavior.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Charge-exchange losses of beam ions in MAST Upgrade: experiments and modelling

Dedicated experiments were performed on MAST Upgrade to study beam-ion losses caused by charge exchange (CX) with edge neutrals. The fuelling was switched from the high-field side to the low-field side mid-discharge. Direct measurements suggest a strong increase in the neutral density around the plasma and a decrease in the beam-ion density, which is qualitatively explained by CX losses. Measurements by a resistive bolometer have suggested particle bombardment during neutral beam injection, providing a unique opportunity to separate CX from other loss mechanisms. To verify and quantify CX losses, the orbit-following code ASCOT, which accounts both for CX neutralization and reionization, was used to simulate beam-particle power loads on the bolometer. Simulations reproduce measured bolometer power loads during high-field-side fuelling, verifying CX losses of approximately 10% of the off-axis beam power. Toroidally symmetric simulations overestimate power loads on the bolometer during low-field-side fuelling, which is explained by toroidal asymmetry in the neutral density distribution, as is demonstrated by toroidally asymmetric simulations. Results suggest significantly higher CX losses during low-field-side fuelling, up to about 50% of off-axis beam power.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Evolution and hot electron generation of laser–plasma instabilities in direct-drive inertial confinement fusion

A series of 2D in-plane plane wave particle-in-cell simulations find distinctive paths of laser-plasma instability evolution in OMEGA-scale implosions, depending on the initial electron temperature. At low temperatures, two-plasmon decay (TPD) dominates in both initial growth and the steady state. At high temperatures, the initial dominant modes switch to stimulated Raman scattering, but TPD still dominates a steady state characterized by cavitation and Langmuir turbulence. A hot electron scaling is also obtained from the simulations that, when combined with laser/plasma conditions from hydro simulations, can predict hot electron generation in implosions that do not employ smoothing-by-spectral-dispersion (SSD). It also shows that under the same laser/plasma conditions, SSD can reduce hot electron generation.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Wide-Bandgap Semiconductor Amplifiers for Fusion Plasma Heating and Control

This paper discusses power electronics developed under the ARPA-E GAMOW program to support nuclear fusion power production. The goal of this project was to develop and assess the potential for wide-bandgap (WBG) semiconductor devices in power electronics to enable high-efficiency and high-voltage solid-state systems for fusion plasma generation, heating, and control. The power electronics use an architecture in which multiple high-power boards can be combined to produce megawatt-level power, where using multiple boards provides high reliability. Two main areas of power electronics boards are developed in this project for fusion plasma heating and control applications: (1) pulse generation and control and (2) radiofrequency generation. The first area is for boards capable of driving high-voltage millisecond pulses at high duty cycles. The envisioned application of these pulses is in plasma control of magnetohydrodynamic instabilities, plasma position, and edge-localized modes. Pulse-width modulation allows for the implementation of a wide variety of linear and nonlinear control systems. The boards developed for this project could actuate control coils based on digital input signals and can be parallelized to provide megawatts of output power. The design of the pulse generator is a low-side load switch. A load switch was designed and constructed that utilized 2-kV-rated field-effect transistor (FET)-based cascodes developed by Qorvo under this project to perform initial testing of these cascodes. The second area is being implemented using class E amplifiers with WBG devices and a reactance steering network to handle inductive or capacitive plasma loads. Applications include ion cyclotron resonance heating (ICRH) and high-harmonic fast-wave (HHFW) heating. A class E reactance steering network is demonstrated in modeling and experiment with a resistive-inductive load that models an inductively-coupled plasma. Power combining of boards with class E reactance steering networks is also simulated and demonstrated experimentally, to enable scaling up to high power. Modeling of high-power-density cooling and remaining useful life is conducted to enable reliable, effectively cooled high-power electronics for fusion applications.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

NSTX-U In-Vessel Control Coils’ Design Concept

In this paper, a successful conceptual design was completed to develop in-vessel control coils [non-axisymmetric control coils (NCCs)]. The NCCs are a series of saddle coils that are intended to satisfy a number of physics criteria including magnetic breaking, error field control, fast resistive wall mode (RWM) control, and edge-localized-mode stabilization. Customized mineral-insulated cable (MIC) was selected for the conductor material. The MIC was made from oxygen-free copper conductor, high purity magnesium oxide powder insulation, and 304 stainless steel sleeve cover. Sample MIC was purchased from an outside supplier, and various tests were conducted for design and performance verification including high-voltage testing, which necessitated the development of special test terminations. A concept design was also developed for terminating the MIC ends using the nonconductive and vacuum-sealed technique. Two alternative designs were proposed for joints inside the vacuum vessel (VV). The NCCs are designed to be mounted in front of the primary passive plates and underneath the plasma-facing component (PFC) tiles. The passive plates will be modified to accommodate the coils. A new PFC tile design concept was developed using high-Z materials. New designs for the penetrations through the VV wall were developed. One port per coil was planned. Finally, a new power patch panel will be required to provide the ability for various combinations of connections between the NCC, the existing RWM coils, and the existing switching power amplifier power suppliers.

42 ENGINEERING↗

Safety factor and turbulence dynamics dependence of the L-H power threshold on DIII-D

The L-H transition power threshold (PLH) is discovered to have a vital dependence on q 95 , at n e ~ 3.2 × 10 19 m -3 on DIII-D. Comprehensive 2D turbulence and flow measurements in the plasma edge reveal the co-existence of two frequency bands of broadband modes across the L-H transition with higher flow shear at higher q 95 , which can help explain the linear decrease in PLH as q 95 is increased from 3.5 to 4.9. Density fluctuation measurements by beam emission spectroscopy at higher q 95 show that the lower frequency band (<20 kHz) of the broadband modes propagates in the ion diamagnetic direction in the lab frame (identified as an ion mode), whereas the higher frequency band (>20 kHz) propagates in the electron diamagnetic direction (identified as an electron mode). The turbulence amplitude at the plasma edge is higher at higher q 95 , implying a higher drive for a Reynolds stress driven zonal flow. At lower density, n e ~ 1.5 × 10 19 m -3 , there is little dependence of PLH on q95. Linear CGYRO kinetic simulation has shown a switch from one mode to two modes at higher q 95 at n e ~ 3.2 × 10 19 m -3 compared to lower q 95 . The ion temperature profile has been shown to strongly impact the dual mode characteristics with the increasing growth rate of the ion mode at a higher edge Ti gradient. The observations imply that it may be possible to reduce the required input power to trigger the L-H transition for ITER if both the ion and electron modes are similarly driven in the plasma edge.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Commissioning of the Power Supplies and Coils of the SMART Tokamak

The small aspect ratio tokamak (SMART) is a spherical tokamak (ST) that offers unique capabilities for studying the potential of negative triangularity. It has been designed, constructed, and is currently being operated by the Plasma Science Fusion Technology (PSFT) Laboratory at the University of Seville. SMART has a total of 21 coils, organized into seven independent circuits and driven by five modular power supplies (PS). The PS operation relies on switching converter technology based on IGBT and supercapacitors (SCs). The PS delivers predefined current waveforms to the copper coil system consisting of the central solenoid (CS), 12 toroidal field (TF) coils, three series pairs of poloidal field (PF) coils, and two independent PF coils. This study details the commissioning and validation of the PS toroidal and solenoid coils, as well as the assembly of coils in SMART. The maximum rated current and slope were measured, along with the series impedance of the coils, the output current ripple, and the noise levels. The internal parameters of the SCs were measured, and optimized current profiles were proposed to enhance overall performance. A comparison has been made between the theoretical values and the experimental results, providing insight into the performance of the PS and areas for improvement.

Power electronics↗

Laser wavelength dependence of particle acceleration mechanisms in high intensity laser–solid density plasma interactions

We investigate the generation of relativistic electrons and the subsequent ion acceleration due to target-normal sheath acceleration when ultra-intense (⁠ I > 10 18 W/cm 2 ⁠) short pulse (⁠ τ L < 10ps⁠) lasers are incident onto solid density targets as laser wavelength is varied. Scaling laws for the hot electron temperature, T hot ⁠, and the maximum ion energy, E max ⁠, are recast as a function of laser wavelength. These predictions are compared to results from particle-in-cell computer simulations in a variety of geometries, including cases where realistic plasma density profiles as determined by a radiation hydrodynamics code are used. It is found that the wavelength dependence observed in simulation is less pronounced than what is predicted from the well-established scaling laws. An assessment of how switching to longer laser wavelengths, specifically 2 μm Tm:YLF technology, would impact current high energy density science applications and diagnostics is made.

Electromagnetism↗

Plasma-assisted atomic layer epitaxial growth of aluminum nitride studied with real time grazing angle small angle x-ray scattering

Wide bandgap semiconducting nitrides have found wide-spread application as light emitting and laser diodes and are under investigation for further application in optoelectronics, photovoltaics, and efficient power switching technologies. Alloys of the binary semiconductors allow adjustments of the band gap, an important semiconductor material characteristic, which is 6.2 eV for aluminum nitride (AlN), 3.4 eV for gallium nitride, and 0.7 eV for (InN). Currently, the highest quality III-nitride films are deposited by metalorganic chemical vapor deposition and molecular beam epitaxy. Temperatures of 900 °C and higher are required to deposit high quality AlN. Research into depositing III-nitrides with atomic layer epitaxy (ALEp) is ongoing because it is a fabrication friendly technique allowing lower growth temperatures. Because it is a relatively new technique, there is insufficient understanding of the ALEp growth mechanism which will be essential to development of the process. Here, grazing incidence small angle x-ray scattering is employed to observe the evolving behavior of the surface morphology during growth of AlN by ALEp at temperatures from 360 to 480 °C. Increased temperatures of AlN resulted in lower impurities and relatively fewer features with short range correlations.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study

In order to shorten the course of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, we examined the antiviral efficacy and safety of 3 weeks of response-guided therapy with an NS3 protease inhibitor and dual NS5A inhibitor–NS5B nucleotide analogue. In this open-label, phase 2a, single centre study, Chinese patients with chronic HCV genotype 1b infection without cirrhosis were randomly allocated by a computer program to one of three treatment groups (sofosbuvir, ledipasvir, and asunaprevir; sofosbuvir, daclatasvir, and simeprevir; or sofosbuvir, daclatasvir, and asunaprevir) until six patients in each group (1:1:1) achieved an ultrarapid virological response (plasma HCV RNA <500 IU/mL by day 2, measured by COBAS TaqMan HCV test, version 2.0). Patients with an ultrarapid virological response received 3 weeks of therapy. Patients who did not achieve an ultrarapid response were switched to sofosbuvir and ledipasvir for either 8 weeks or 12 weeks. Furthermore, the primary endpoint was the proportion of patients with a sustained virological response at 12 weeks (SVR12) after treatment completion, analysed in the intention-to-treat population. All patients who achieved an ultrarapid virological response were included in the safety analysis. This trial is registered with ClinicalTrials.gov, number NCT02470858. Between April 5, 2015, and April 15, 2015, 26 eligible patients were recruited. 12 patients were assigned to sofosbuvir, ledipasvir, and asunaprevir; six to sofosbuvir, daclatasvir, and simeprevir; and eight to sofosbuvir, daclatasvir, and asunaprevir. Six patients in each group achieved an ultrarapid virological response (18 [69%]). All patients with an ultrarapid virological response who were given 3 weeks of triple therapy achieved SVR12. The most common adverse events were fatigue (one [17%] of six patients receiving sofosbuvir, ledipasvir, and asunaprevir; one [17%] of six patients receiving sofosbuvir, daclatasvir, and simeprevir; and two [33%] of six patients receiving sofosbuvir, daclatasvir, and asunaprevir) and headache (one [17%] patient in each group). There were no patients who experienced any serious adverse events. In this proof-of-concept study, all patients with chronic HCV without cirrhosis who achieved an ultrarapid virological response on triple direct-acting antiviral regimens by day 2 and received 3 weeks of treatment were cured, with excellent tolerability. By shortening the duration of therapy from the currently recommended 12 weeks to 3 weeks, we could drastically reduce the cost of therapy and the rate of adverse events. Further large-scale studies should be done to confirm our findings.

59 BASIC BIOLOGICAL SCIENCES↗

Wave induced density modification in RF sheaths and close to wave launchers

With the return to full metal walls - a necessary step towards viable fusion machines - and due to the high power densities of current-day ICRH (Ion Cyclotron Resonance Heating) or RF (radio frequency) antennas, there is ample renewed interest in exploring the reasons for wave-induced sputtering and formation of hot spots. Moreover, there is experimental evidence on various machines that RF waves influence the density profile close to the wave launchers so that waves indirectly influence their own coupling efficiency. The present study presents a return to first principles and describes the wave-particle interaction using a 2-time scale model involving the equation of motion, the continuity equation and the wave equation on each of the time scales. Through the changing density pattern, the fast time scale dynamics is affected by the slow time scale events. In turn, the slow time scale density and flows are modified by the presence of the RF waves through quasilinear terms. Although finite zero order flows are identified, the usual cold plasma dielectric tensor - ignoring such flows - is adopted as a first approximation to describe the wave response to the RF driver. The resulting set of equations is composed of linear and nonlinear equations and is tackled in 1D in the present paper. Whereas the former can be solved using standard numerical techniques, the latter require special handling. At the price of multiple iterations, a simple ’derivative switch-on’ procedure allows to reformulate the nonlinear problem as a sequence of linear problems. Analytical expressions allow a first crude assessment - revealing that the ponderomotive potential plays a role similar to that of the electrostatic potential arising from charge separation - but numerical implementation is required to get a feeling of the full dynamics. A few tentative examples are provided to illustrate the phenomena involved.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Nanoscale control of LaAlO 3 /SrTiO 3 conductance beyond the polar catastrophe

Conductive atomic force microscope (c-AFM) lithography can be utilized to create a wide range of LaAlO 3 /SrTiO 3 (LAO/STO)-based nanoelectronic devices in a reconfigurable manner. Experiments were generally performed with intrinsically insulating LAO/STO heterostructures, with LAO thickness less than the critical value at which a polar catastrophe takes place [<4 unit cell (u.c.)]. Here, we use inductively coupled plasma reactive ion etching (ICPRIE) to fabricate c-AFM “canvases” on intrinsically conducting LAO/STO samples with ≥4 u.c. LAO. We observe that its interfacial two-dimensional electron gas (2DEG) can be pinched off and then switched back on by c-AFM lithography. Nanowires created with initially conductive LAO/STO interfaces have an order-of-magnitude longer lifetime in ambient conditions, when compared to an identically created 3.4 u.c. LAO/STO nanowire. We also demonstrate key nanoscale properties such as ballistic transport in a quasi-one-dimensional electron waveguide at a 5 u.c. LAO/STO interface. This approach frees c-AFM-written nanodevice designs from time constraints in air associated with <4 u.c. LAO/STO heterostructures.

36 MATERIALS SCIENCE↗

Ion acceleration with a narrow energy spectrum by nanosecond laser-irradiation of solid target

In laser-driven plasma, ion acceleration of aluminum with the production of a quasi-monoenergetic beam has occurred. A useful device to analyze the ions is the Thomson parabolas spectrometer, a well-known diagnostic that is able to obtain information on charge-to-mass ratio and energy distribution of the charged particles. At the LENS (Laser Energy for Nuclear Science) laboratory of INFN-LNS in Catania, experimental measures were carried out; the features of LENS are: Q-switched Nd:YAG laser with 2 J laser energy, 1064 nm fundamental wavelengths, and 6 ns pulse duration.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗