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At least 163 records · Page 9

Hematopoietic Stem Cell Therapy to Countermeasure Cancer in Astronauts during Exploration of Deep Space

Exposure to cosmic radiation can cause chromosomal mutations, which may lead to cancer in astronauts engaged in space exploration. Therefore, our goals are to develop countermeasures to prevent space-induced cancer using hematopoietic stem cell therapy (HSCT) and gene therapy. This presentation focuses on HSCT for cancer. Our previous experiments on a simulated, space-induced immuno-deficiency model (mouse hind limb unloading ) indicated that transplanted hematopoietic stem cells (HSCs) could enhance the host's immunity by effectively eliminating bacterial infection (Ohi S, et. al. J Grav Physiol 10, P63-64, 2003; Ohi S, et. al. Proceedings of the Space Technology and Applications International Forum (STAIF) . American Institute of Physics, New York, pp. 938-950, 2004). Hence, we hypothesized that the HSCs might be effective in combating cancer as well. Studies of cocultured mouse HSCs with beta-galactosidase marked rat gliosarcoma spheroids (9L/lacZ), a cancer model, indicated antagonistic interactions , resulting in destruction of the spheroids by HSCs. Trypan Blue dye-exclusion assays were consistent with the conclusion. These results show potential usehlness of HSCT for cancer. Currently, the NASA Hydrodynamic Focusing Bioreactor (HFB), a space analog tissue/cell culture system, is being used to study invasion of the gliosarcoma (GS) spheroids into mouse brain with or without co-cultured HSCs. This may simulate the metastasis of gliosarcoma to brain. There is a tendency for the HSCs to inhibit invasion of GS spheroids into brain, as evidenced by the X-gal staining.

Ohi, S.↗

Dark Matter Constraints from Observations of 25 Milky Way Satellite Galaxies with the Fermi Large Area Telescope

The dwarf spheroidal satellite galaxies of the Milky Way are some of the most dark-matter-dominated objects known. Due to their proximity, high dark matter content, and lack of astrophysical backgrounds, dwarf spheroidal galaxies are widely considered to be among the most promising targets for the indirect detection of dark matter via gamma rays. Here we report on gamma ray observations of 25 Milky Way dwarf spheroidal satellite galaxies based on 4 years of Fermi Large Area Telescope (LAT) data. None of the dwarf galaxies are significantly detected in gamma rays, and we present gamma ray flux upper limits between 500MeV and 500 GeV. We determine the dark matter content of 18 dwarf spheroidal galaxies from stellar kinematic data and combine LAT observations of 15 dwarf galaxies to constrain the dark matter annihilation cross section. We set some of the tightest constraints to date on the annihilation of dark matter particles with masses between 2 GeV and 10TeV into prototypical standard model channels. We find these results to be robust against systematic uncertainties in the LAT instrument performance, diffuse gamma ray background modeling, and assumed dark matter density profile.

satellite↗

Retrieval of Microphysical Characteristics of Particles in Atmospheres of Distant Comets from Ground-Based Polarimetry

We summarize unique aperture data on the degree of linear polarization observed for distant comets C/2010 S1, C/2010 R1, C/2011 KP36, C/2012 J1, C/2013 V4, and C/2014 A4 with heliocentric distances exceeding 3 AU. Observations have been carried out at the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences (Nizhnij Arkhyz, Russia) during the period from 2011 to 2016. The measured negative polarization proves to be significantly larger in absolute value than what is typically observed for comets close to the Sun. We compare the new observational data with the results of numerical modeling performed with the T-matrix and superposition T-matrix methods. In our computer simulations, we assume the cometary coma to be an optically thin cloud containing particles in the form of spheroids, fractal aggregates composed of spherical monomers, and mixtures of spheroids and aggregate particles. We obtain a good semi-quantitative agreement between all polarimetric data for the observed distant comets and the results of numerical modeling for the following models of the cometary dust: (i) a mixture of submicrometer water-ice oblate spheroids with aggregates composed of submicrometer silicate monomers; and (ii) a mixture of submicrometer water-ice oblate spheroids and aggregates consisting of both silicate and organic monomers. The microphysical parameters of these models are presented and discussed.

Numerical modeling↗

Microstructure and mechanical properties of bulk and plasma-sprayed y2O3-partially stabilized zirconia

Bulk 8.0 weight percent yttria partially stabilied zirconia (PSZ) was studied by light microscopy, transmission electron microscopy, X-ray analysis, microhardness testing, and fracture toughness testing. The as received PSZ contained spheroidal and grain boundary precipitates up to 4 micrometers in size. Spheroids up to 1.26 micrometers were metastable tetragonal; large spheroids were monoclinic. Grinding the PSZ into powder did not cause a significant amount of tetragonal to transform to monoclinic. This indicates that transformation toughness is not a significant mechanism in PSZ. Aging the PSZ at 1500 C caused the fine tetragonal precipitates to grow from 0.06 to 0.12 micrometers, in 250 minutes. A peak hardness of 1400 kg/sq mm was attained after 50 minutes. Solution annealing and quenching the as received PSZ eliminated the large precipitates, but fine tetragonal precipitates reformed on quenching. Aging at 1500 C caused the fine 0.02 micrometers tetragonal precipitates to grow into plates about 0.10 by 0.50 micrometers. A peak hardness of 1517 kg/sq mm was obtained after 250 minutes. On further aging, monoclinic percipitates formed along grain boundaries. The fracture toughness of the aged and unaged solution annealed and quenched PSZ was found to be between 2 and 3 MN /square root of m cubed. This range of fracture toughness is consistent with PSZ's that do not undergo transformation toughening.

Valentine, P. G.↗

Hollow-Sphere Production Line

After initial formation, spheroids processed without contaminating touch of solid objects. Spheroid in process supported by acoustic levitation at each work station and transported between stations by combination of acoustic levritation and acoustic propulsion. Automatic sequence of target-pellet fabication allows no contact of solid ojbect with spheroids in process. Potential for manufacture of precise microcapsules for catalysts and medications.

Lee, M. C.↗

A model of the planetary nebula NGC 2392 determined from velocity observations

High-resolution slit spectra are combined with published photometric and velocity data to develop a model of the double-ring planetary nebula NGC 2392. The inner ring is due to an incomplete, prolate spheroid shell with most of the material concentrated near the minor axis circumference. The spheroid is seen almost pole-on, open at the sharp ends, and the formal velocity of expansion (93 km/s) at the ends is a record high for planetary nebulae. The outer ring is a nearly round spheroid of approximately 16 km/s expansion velocity and a different tilt angle than the inner shell. It is surrounded by rapidly expanding material with velocities of at least 75 km/s. A high-velocity stream of material is formed at the open ends of the inner shell and is accelerated by the central star's stellar wind to velocities of at least + or - 190 km/s, providing the first direct evidence for the kinematic role of a strong stellar wind. The inner shell age is approximately 800 yr, arguing that the shell material was preferentially ejected from the equator of the parent star, in contradiction with the usual predictions of theory.

Odell, C. R.↗

Recent investigations on disk galaxies in massive halos

The dynamic evolution of a disk embedded in an oblate spheroidal galaxy is investigated by means of numerical simulations performed at NASA Ames, involving self-consistent fully three-dimensional integration of 100,000-body systems. A flat disk containing 1000 particles (of equal mass and with no random motion), with its center coincident with the center of the oblate spheroid and at an angle of 30, 60, or 90 deg to the spheroid equatorial plane is started in differential rotation. The results are presented graphically and discussed in detail. The galaxy center is found to shift so that the disk center orbits about it, in a complex motion with nutation, rotation, and precession; warping of the disk is also observed. The possible connections between these findings and observations of complex motions at the Galactic center are considered.

Miller, R. H.↗

Factor of 2 error in balloon-borne atmospheric conduction current measurements

An exact expression is derived for the atmospheric current to a prolate spheroidal antenna. The effective collection area is considered, obtaining a solution for a spherical antenna and the vertical wire antenna. A factor of two error in the studies of the effective area of an antenna of arbitrary geometry by Kasemir and Ruhnke (1958) and Ogawa (1973) is discussed. The effects of the instrument-atmospheric interaction as they apply to the atmospheric conduction current measurement are considered. Electric field enhancement factors for spheroids and approximate solutions for spheroids and other elongated objects are given.

Few, A. A.↗

A gamma-ray constraint on the nature of dark matter

If even a small component of the Galactic spheroid consists of the weakly interacting majorana fermions that are cold-dark-matter candidate particles for the Galactic halo, there should be a substantial flux of annihilation gamma rays from a source of about 1-deg extent at the Galactic center. COS B observations already constrain the halo cold-dark-matter (CDM) content entrained in the inner spheroid to be less than about 10 percent. A somewhat weaker constraint applies to the CDM believed to be present in the Galactic disk, but still only about 15 percent can be in such particles. Monochromatic line photons of energy 3-10 GeV are also predicted, and future experiments may be capable of improving these limits. Since both theoretical models of galaxy formation in a CDM-dominated universe and mass models for the rotation curve in the inner Galaxy suggest that a substantial fraction of the spheroid component should be nonluminous and incorporate entrained halo CDM, the hypothesis that the halo CDM consists predominantly of weakly interacting fermions such as photinos or heavy majorana mass neutrinos or higgsinos may already be subject to observational test.

Silk, Joseph↗

The role of three-dimensional shapes in the break-up of charged drops

The nonlinear dynamics of nonaxisymmetric inviscid charged conducting drops near the Rayleigh charge limit (R = 4) is investigated analytically. It is shown that only axisymmetric spheroid drops bifurcate from the sphere family when the charge is increased, that oblate spheroids at R greater than 4 are unstable to nonaxisymmetric disturbances governing drop breakup, and that prolate spheroids at R less than 4 are unstable only to axisymmetric disturbances tending to increase the length of the drop along its symmetry axis. The effects of external electric fields and rigid-body rotation are also analyzed, and the solutions for the amplitude equations at R just less than 4 (equivalent to the dynamical equations of the Henon-Heiles Hamiltonian) are explored.

Natarajan, R.↗

Protogalaxies

It is argued that the observed sample of flat-spectrum galaxies seen in recent deep surveys must contain both early disk systems and early spheroid systems in order to match observed number counts if q sub 0 = 0.5. The low average density of neutral hydrogen in damped L-alpha systems at z = 2 - 3 separates the disk formation at z less than about 2 from spheroid formation at z greater than about 3. Based on color arguments, the period of spheroid formation is assigned to z = 4.

Cowie, Lennox L.↗

Foam formation in low gravity

An apparatus that produced the first polyurethane foam in low gravity has been described. The chemicals were mixed together in an apparatus designed for operation in low gravity. Mixing was by means of stirring the chemicals with an electric motor and propeller in a mixing chamber. The apparatus was flown on Consort 1, the first low-gravity materials payload launched by a commercial rocket launch team. The sounding rocket flight produced over 7 min of low gravity during which a polyurethane spheroidal foam of approximately 2300 cu cm was formed. Photographs of the formation of the foam during the flight show the development of the spheroidal form. This begins as a small sphere and grows to approximately a 17-cm-diam spheroid. The apparatus will be flown again on subsequent low-gravity flights.

Wessling, Francis C.↗

The effects of small ice crystals on the infrared radiative properties of cirrus clouds

The effects of nonspherical small ice crystals on the IR radiative properties of cirrus clouds are investigated utilizing light scattering properties of spheroidal particles. Employing the anomalous diffraction theory for spheres and results from the exact spheroid scattering program, efficient parameterization equations are developed for calculations of the absorption and scattering properties for small ice crystals. Parameterization formulas are developed for large ice crystals employing results computed from the geometric ray-tracing method and the Fraunhofer diffraction theory for hexagonal crystals and spheroids.

Takano, Y.↗

The effects of small ice crystals on the infrared radiative properties of cirrus clouds

To be successful in the development of satellite retrieval methodologies for the determination of cirrus cloud properties, we must have fundamental scattering and absorption data on nonspherical ice crystals that are found in cirrus clouds. Recent aircraft observations (Platt et al. 1989) reveal that there is a large amount of small ice particles, on the order of 10 micron, in cirrus clouds. Thus it is important to explore the potential differences in the scattering and absorption properties of ice crystals with respect to their sizes and shapes. In this study the effects of nonspherical small ice crystals on the infrared radiative properties of cirrus clouds are investigated using light scattering properties of spheroidal particles. In Section 2, using the anomalous diffraction theory for spheres and results from the exact spheroid scattering program, efficient parameterization equations are developed for calculations of the scattering and absorption properties for small ice crystals. Parameterization formulas are also developed for large ice crystals using results computed from the geometric ray-tracing technique and the Fraunhofer diffraction theory for spheroids and hexagonal crystals. This is presented in Section 3. Finally, applications to the satellite remote sensing are described in Section 4.

Takano, Y.↗

M dwarfs, microlensing, and the mass budget of the Galaxy

We show that faint red stars do not contribute significantly to the mass budget of the Galaxy or to microlensing statistics. Our results are obtained by analyzing two long exposures of a high-latitude field taken with the Wide Field Camera (WFC) on the newly repaired Hubble Space Telescope (HST). Stars are easily distinguished from galaxies essentially to the limiting magnitudes of the images. We find five stars with 2.0 less than V - I less than 3.0 and I less than 25.3 and no stars with V - I greater than 3.0. Therefore, main-sequence stars with M(sub I) greater than 10 that are above the hydrogen-burning limit in the dark halo or the spheroid contribute less than 6% of the unseen matter. Faint red disk stars, M-dwarfs, contribute at most 15% to the mass of the disk. We parameterize the faint end of the cumulative distribution of stars, Phi, as a function of luminosity L(sub V), d Phi/d ln L(sub V) proportional to L(sub V exp -gamma). For spheroid stars, gamma less than 0.32 over the range 6 less than M(sub V) less than 17, with 98% confidence. The disk luminosity function falls, gamma less than 0, for 15 approximately less than M(sub V) approximately less than 19. Faint red stars in the disk or thick disk, and stars with M(sub V) less than 16 in the spheroid contribute tau less than 10(exp -8) to the optical depth to microlensing toward the Large Magellanic Cloud.

Bahcall, John N.↗

Method for confining the magnetic field of the cross-tail current inside the magnetopause

A method is presented for analytically representing the magnetic field due to the cross-tail current and its closure on the magnetopause. It is an extension of a method used by Tsyganenko (1989b) to confine the dipole field inside an ellipsoidal magnetopause using a scalar potential. Given a model of the cross-tail current, the implied net magnetic field is obtained by adding to the cross-tail current field a potential field B = - del gamma, which makes all field lines divide into two disjoint groups, separated by the magnetopause (i.e., the combined field is made to have zero normal component with the magnetopause). The magnetopause is assumed to be an ellipsoid of revolution (a prolate spheroid) as an approximation to observations (Sibeck et al., 1991). This assumption permits the potential gamma to be expressed in spheroidal coordinates, expanded in spheroidal harmonics and its terms evaluated by performing inversion integrals. Finally, the field outside the magnetopause is replaced by zero, resulting in a consistent current closure along the magnetopause. This procedure can also be used to confine the modeled field of any other interior magnetic source, though the model current must always flow in closed circuits. The method is demonstrated on the T87 cross-tail current, examples illustrate the effect of changing the size and shape of the prescribed magnetopause and a comparison is made to an independent numerical scheme based on the Biot-Savart equation.

Sotirelis, T.↗

Constraints on PSC Particle Microphysics Derived From Lidar Observations

Based on extensive T-matrix computations of light scattering by polydispersions of randomly oriented, rotationally symmetric nonspherical particles, we analyze existing lidar observations of polar stratospheric clouds (PSCs) and derive several constraints on PSC particle microphysical properties. We show that sharp-edged nonspherical particles (finite circular cylinders) exhibit less variability of lidar backscattering characteristics with particle size and aspect ratio than particles with smooth surfaces (spheroids). For PSC particles significantly smaller than the wavelength, the backscatter color index Alpha and the depolarization color index Beta are essentially shape-independent. Observations for type Ia PSCs can be reproduced by spheroids with aspect ratios larger than 1.2, oblate cylinders with diameter-to-length ratios greater than 1.6, and prolate cylinders with length-to-diameter ratios greater than 1.4. The effective equal-volume-sphere radius for type la PSCs is about 0.8 microns or larger. Type Ib PSCs are likely to be composed of spheres or nearly spherical particles with effective radii smaller than 0.8 microns. Observations for type II PSCs are consistent with large ice crystals (effective radius greater than 1 micron modeled as cylinders or prolate spheroids.

Liu, Li↗

NanoSIMS Reveals New Structural and Elemental Signatures of Early Life

The young technology of NanoSIMS is unlocking new information from organic matter in ancient sediments. We have used this technique to characterize sub-micron scale element composition of Proterozoic organics that are clearly biogenic as a guide for interpreting problematic structures in terrestrial or extraterrestrial samples. We used the NanoSIMS 50 of the National Museum of Natural History in Paris to map carbon, nitrogen (as CN), and sulfur in organic structures from the approximately 0.8 Ga Bitter Springs Formation. We analyzed spheroidal and filamentous microfossils as well as organic laminae that appeared amorphous by optical and scanning electron microscopy. In clear-cut microfossils, a coincidence between optical images and NanoSIMS element maps suggests a biological origin for the mapped carbon, sulfur, and nitrogen; this conclusion is supported by high resolution NanoSIMS maps showing identical spatial distributions of C, CN and S. High resolution images also demonstrate distinctive nano structure of the filaments and spheroids. In the amorphous laminae, NanoSIMS reveals morphologies reminiscent of compressed microfossils. Distinct CN/C ratios of the spheroids, filaments, and laminae may reflect their biological precursors (cell walls, cyanobacterial sheaths, and microbial communities/biofilms, respectively). Similar amorphous laminae comprise a preponderance of the organic matter in many Precambrian deposits. Thus it is possible that NanoSIMS will provide fresh insight into a large body of previously uninterpretable material. Additionally, NanoSIMS analysis may establish new biosignatures that will be helpful for assessing the origin and biogenicity of controversial Archean structures and any organic materials that may occur in Martian or other extraterrestrial samples.

Oehler, Dorothy Z.↗