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At least 163 records · Page 9

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NASA NTRS1976

Operational plans for life science payloads - From experiment selection through postflight reporting

Key features of operational plans developed in a study of the Space Shuttle era life science payloads program are presented. The data describes the overall acquisition, staging, and integration of payload elements, as well as program implementation methods and mission support requirements. Five configurations were selected as representative payloads: (a) carry-on laboratories - medical emphasis experiments, (b) mini-laboratories - medical/biology experiments, (c) seven-day dedicated laboratories - medical/biology experiments, (d) 30-day dedicated laboratories - Regenerative Life Support Evaluation (RLSE) with selected life science experiments, and (e) Biomedical Experiments Scientific Satellite (BESS) - extended duration primate (Type I) and small vertebrate (Type II) missions. The recommended operational methods described in the paper are compared to the fundamental data which has been developed in the life science Spacelab Mission Simulation (SMS) test series. Areas assessed include crew training, experiment development and integration, testing, data-dissemination, organization interfaces, and principal investigator working relationships.

Mccollum, G. W.↗

NASA NTRS1977

A review of animal flight experiments

Extensive experience with biologic systems was obtained with a variety of vertebrate species over the past 18 years. Subhuman primates were precursors to man in the American space flight program; dogs and mice were animals of choice for the Soviet program. Recent attempts to use heavily instrumented animals for observations of long-term physiological effects indicate problems which must be corrected in future experiments for monitoring the effects of environmental stresses over the longer periods required for accomplishing meaningful habitation in near-Earth orbit or for travel to nearby planets.

Sandler, H.↗

NASA NTRS1978

Animal life support transporters for Shuttle/Spacelab

Two transporter devices have been developed by the NASA Ames Research Center, primarily for the purpose of stowing small vertebrates and primates in the mid-deck avionics bay of the Shuttle during launch and re-entry. These animals will be used in Life Science Spacelab experiments. Stowage in the mid-deck area will reduce animal exposure to the high noise levels existing in Spacelab during launch; further, the possible exposure of the animals to high temperatures in Spacelab during re-entry and post-landing will be eliminated. The transporters will provide experimenters more timely access to their animals during experiment-critical, pre-launch, and post-landing periods. Rechargeable batteries in the transporters will provide life support system functions for the animals during periods of transfer and during mission phases in which power is temporarily unavailable. The transporters have been successfully designed, fabricated, and tested. Integrated testing of the transporters was performed in the Space Mission Development III (SMD III) Simulation at the NASA Johnson Space Center.

Berry, W. E.↗

NASA NTRS1979

Effect of space flight on sodium, copper, manganese and magnesium content in the skeletal bones

Sodium content decreased in the human skeletal bones and rose in the rat bones following space flight. In man copper content rose in the femoral bone and decreased in the vertebral body and the sternum, but was unchanged in the rest of the bones. Magnesium content was decreased in the femoral bone and the sternum, and in the vertebrae, but remained unchanged in the rest of the bones. Possible mechanisms of the changes detected are discussed.

Prokhonchukov, A. A.↗

NASA NTRS1981

A 14-day ground-based hypokinesia study in nonhuman primates: A compilation of results

A 14 day ground based hypokinesia study with rhesus monkeys was conducted to determine if a spaceflight of similar duration might affect bone remodeling and calcium homeostatis. The monkeys were placed in total body casts and sacrificed either immediately upon decasting or 14 days after decasting. Changes in vertebral strength were noted and further deterioration of bone strength continued during the recovery phase. Resorption in the vertebrae increased dramatically while formation decreased. Cortical bone formation was impaired in the long bones. The immobilized animals showed a progressive decrease in total serum calcium which rebounded upon remobilization. Most mandibular parameters remained unchanged during casting except for retardation of osteon birth or maturation rate and density distribution of matrix and mineral moieties.

Kazarian, L.↗

NASA NTRS1980

A bandpass filter for the enhancement of an X-ray reconstruction of the tissue in the spinal canal

In this communication, a new bandpass reconstruction filter is developed to partially remove the low spatial frequencies of the bone and the soft tissue in an X-ray reconstruction of a lumbar spine. This partial removal of the low frequencies suppresses the bony vertebral body and the soft tissue components within the projections of actual clinical data. It also has the effect of enhancing the sharp edges of the fatty tissue surrounding the spinal cord region. The intent of this effort is to directly visualize the spinal cord without the need for water-soluble contrast (e.g., metrizamide) to be installed through lumbar punctures.

Reed, I. S.↗

NASA NTRS1983

Space Station and the life sciences

Previous fundamental research in space life sciences is examined, and consideration is devoted to studies relevant to Space Station activities. Microgravity causes weight loss, hemoconcentration, and orthostatic intolerance when astronauts returns to earth. Losses in bone density, bone calcium, and muscle nitrogen have also been observed, together with cardiovascular deconditioning, fluid-electrolyte metabolism alteration, and space sickness. Experiments have been performed with plants, bacteria, fungi, protozoa, tissue cultures, invertebrate species, and with nonhuman vertebrates, showing little effect on simple cell functions. The Spacelab first flight will feature seven life science experiments and the second flight, two. Further studies will be performed on later flights. Continued life science studies to optimize human performance in space are necessary for the efficient operation of a Space Station and the assembly of large space structures, particularly in interaction with automated machinery.

White, R. J.↗

NASA NTRS1984

Computer simulation of protein systems

Ligand binding to dihydrofolate reductase (DHFR) is discussed. This is an extremely important enzyme, as it is the target of several drugs (inhibitors) which are used clinically as antibacterials, antiprotozoals and in cancer chemotherapy. DHFR catalyzes the NADPH (reduced nicotinamide adenine dinucleotide phosphate) dependent reduction of dihydrofolate to tetrahydrofolate, which is used in several pathways of purine and pyrimidine iosynthesis, including that of thymidylate. Since DNA synthesis is dependent on a continuing supply of thymidylate, a blockade of DHFR resulting in a depletion of thymidylate can lead to the cessation of growth of a rapidly proliferating cell line. DHFR exhibits a significant species to species variability in its sensitivity to various inhibitors. For example, trimethoprim, an inhibitor of DHFR, binds to bacterial DHFR's 5 orders of magnitude greater than to vertebrate DHFR's. The structural mechanics, dynamics and energetics of a family of dihydrofolate reductases are studied to rationalize the basis for the inhibitor of these enyzmes and to understand the molecular basis of the difference in the binding constants between the species. This involves investigating the conformational changes induced in the protein on binding the ligand, the internal strain imposed by the enzyme on the ligand, the restriction of fluctuations in atom positions due to binding and the consequent change in entropy.

Osguthorpe, D. J.↗

NASA NTRS1983

Gravitational biology on the space station

The current status of gravitational biology is summarized, future areas of required basic research in earth-based and spaceflight projects are presented, and potential applications of gravitational biology on a space station are demonstrated. Topics covered include vertebrate reproduction, prenatal/postnatal development, a review of plant space experiments, the facilities needed for growing plants, gravimorphogenesis, thigmomorphogenesis, centrifuges, maintaining a vivarium, tissue culture, and artificial human organ generation. It is proposed that space stations carrying out these types of long-term research be called the National Space Research Facility.

Keefe, J. R.↗

NASA NTRS1985

Mammalian Gravity Receptors: Structure and Metabolism

Calcium metabolism in mammalian gravity receptors is examined. To accomplish this objective it is necessary to study both the mineral deposits of the receptors, the otoconia, and the sensory areas themselves, the saccular and utricular maculas. The main focus was to elucidate the natures of the organic and inorganic phases of the crystalline masses, first in rat otoconia but more recently in otoliths and otoconia of a comparative series of vertebrates. Some of the ultrastructural findings in rat maculas, however, have prompted a more thorough study of the organization of the hair cells and innervation patterns in graviceptors.

Ross, M. D.↗

NASA NTRS1984

The influence of gravity on structure and function of animals

Gravity is the only environmental parameter that has remained constant during the period of evolution of living matter on earth. Thus, it must have been a major force in shaping living things. The influence of gravitational loading on evolution of the vertebrate skeleton is well recognized, and scale effects have been studied. This paper, however, considers in addition four pivotal events in early evolution that would seem to have been significant for the later success and diversifcation of animal life. These are evolution of the cytoskeleton, cell motility (flagellae and cilia), gravity detecting devices (accelerometers), and biomineralization. All are functionally calcium dependent in eukaryotes and all occurred or were foreshadowed in prokaryotes. A major question is why calcium was selected as an ion of great importance to the structure and function of living matter; another is whether gravity played a role in its selection.

Ross, M. D.↗

NASA NTRS1985

Report of the Workshop on Geologic Applications of Remote Sensing to the Study of Sedimentary Basins

The Workshop on Geologic Applications of Remote Sensing to the Study of Sedimentary Basins, held January 10 to 11, 1985 in Lakewood, Colorado, involved 43 geologists from industry, government, and academia. Disciplines represented ranged from vertebrate paleontology to geophysical modeling of continents. Deliberations focused on geologic problems related to the formation, stratigraphy, structure, and evolution of foreland basins in general, and to the Wind River/Bighorn Basin area of Wyoming in particular. Geological problems in the Wind River/Bighorn basin area that should be studied using state-of-the-art remote sensing methods were identified. These include: (1) establishing the stratigraphic sequence and mapping, correlating, and analyzing lithofacies of basin-filling strata in order to refine the chronology of basin sedimentation, and (2) mapping volcanic units, fracture patterns in basement rocks, and Tertiary-Holocene landforms in searches for surface manifestations of concealed structures in order to refine models of basin tectonics. Conventional geologic, topographic, geophysical, and borehole data should be utilized in these studies. Remote sensing methods developed in the Wind River/Bighorn Basin area should be applied in other basins.

Lang, H. R.↗

NASA NTRS1986

Investigations with methanobacteria and with evolution of the genetic code

Mycoplasma capricolum was found by Osawa et al. to use UGA as the code of tryptophan and to contain 75% A + T in its DNA. This change could have been from evolutionary pressure to replace C + G by A + T. Numerous studies have been reported of evolution of proteins as measured by amino acid replacements that are observed when homologus proteins, such as hemoglobins from various vertebrates, are compared. These replacements result from nucleotide substitutions in amino acid codons in the corresponding genes. Simultaneously, silent nucleotide substitutions take place that can be studied when sequences of the genes are compared. These silent evolutionary changes take place mostly in third positions of codons. Two types of nucleotide substitutions are recognized: pyrimidine-pyrimidine and purine-purine interchanges (transitions) and pyriidine-purine interchanges (transversions). Silent transitions are favored when a corresponding transversion would produce an amino acid replacement. Conversely, silent transversions are favored by probability when transitions and transversions will both be silent. Extensive examples of these situations have been found in protein genes, and it is evident that transversions in silent positions predominate in family boxes in most of the examples studied. In associated research a streptomycete from cow manure was found to produce an extracellular enzyme capable of lysing the pseudomurein-contining methanogen Methanobacterium formicicum.

Jukes, T. H.↗

NASA NTRS1987

Animal research on the Space Station

The need for in-depth, long- and short-term animal experimentation in space to qualify man for long-duration space missions, and to study the effects of the absence and presence of Earth's gravity and of heavy particle radiation on the development and functioning of vertebrates is described. The major facilities required for these investigations and to be installed on the Space Station are: modular habitats for holding rodents and small primates in full bioisolation; a habitat holding facility; 1.8 and 4.0 m dia centrifuges; a multipurpose workbench; and a cage cleaner/disposal system. The design concepts, functions, and characteristics of these facilities are described.

Bonting, S. L.↗

NASA NTRS1988

Dinosaur bone beds and mass mortality: Implications for the K-T extinction

Mass accumulations of fossilized large terrestrial vertebrate skeletons (bone beds: BB) provide a test for K-T catastrophic extinction hypotheses. The two major factors contributing to BB formation are mode of death and sedimentation rate. Catastrophic mass mortality (CMM) is the sudden death of numerous individuals where species, age, health, gender, or social ranking offer no survivorship advantage. Noncatastrophic mass mortality (NCMM) occurs over time and is strongly influenced by species, age, or gender. In addition to cause of death, sedimentation rate is also important in BB formation. Models of BBs can be made. The CMM drops all individuals in their tracks, therefore, the BB should reflect the living population with respect to species, age, or gender. The NCMM results in monospecific BBs skewed in the direction of the less fit, usually the very young or very old, or towards a specific gender. The NCMM and AM BBs may become more similar the more spread out over time NCMM deaths occur because carcasses are widely scattered requiring hydraulic accumulation, and the greater time allows for more disarticulation and weathering. The CMM and NCMM BB appear to be dominated by social animals. Applying this and the characteristics of mortality patterns to the uppermost Cretaceous Hell Creek Formation indicates that only NCMM and AM BB occur. Furthermore, NCMM BB are rare in the upper third of the Hell Creek. Near the K-T boundary, only AM BB are known. The absence of CMM and NCMM BB appears to be real reflecting a decrease in population levels of some dinosaurs prior to the K-T event. The absence of CMM suggests that the K-T event did not lead to an instantaneous extinction of dinosaurs. Nor was there a protracted die-off due to an asteroid impact winter, because no NCMM BB are known at or near the K-T boundary.

Carpenter, Kenneth↗

NASA NTRS1988

Patterns of megafloral change across the Cretaceous-Tertiary boundary in the Northern Great Plains and Rocky Mountains

The spatial and temporal distribution of vegetation in the terminal Cretaceous of Western Interior North America was a complex mosaic resulting from the interaction of factors including a shifting coastline, tectonic activity, a mild, possibly deteriorating climate, dinosaur herbivory, local facies effects, and a hypothesized bolide impact. In order to achieve sufficient resolution to analyze this vegetational pattern, over 100 megafloral collecting sites were established, yielding approximately 15,000 specimens, in Upper Cretaceous and lower Paleocene strata in the Williston, Powder River, and Bighorn basins in North Dakota, Montana, and Wyoming. These localities were integrated into a lithostratigraphic framework that is based on detailed local reference sections and constrained by vertebrate and palynomorph biostratigraphy, magnetostratigraphy, and sedimentary facies analysis. A regional biostratigraphy based on well located and identified plant megafossils that can be used to address patterns of floral evolution, ecology, and extinction is the goal of this research. Results of the analyses are discussed.

Johnson, Kirk R.↗

NASA NTRS1988

The Triassic-Jurassic boundary in eastern North America

Rift basins of the Atlantic passive margin in eastern North America are filled with thousands of meters of continental rocks termed the Newark Supergroup which provide an unprecedented opportunity to examine the fine scale structure of the Triassic-Jurassic mass extinction in continental environments. Time control, vital to the understanding of the mechanisms behind mass extinctions, is provided by lake-level cycles apparently controlled by orbitally induced climate change allowing resolution at the less than 21,000 year level. Correlation with other provinces is provided by a developing high resolution magnetostratigraphy and palynologically-based biostratigraphy. A large number of at least local vertebrate and palynomorph extinctions are concentrated around the boundary with survivors constituting the earliest Jurassic assemblages, apparently without the introduction of new taxa. The palynofloral transition is marked by the dramatic elimination of a relatively high diversity Triassic pollen assemblage with the survivors making up a Jurassic assemblage of very low diversity overwhelmingly dominated by Corollina. Based principally on palynological correlations, the hypothesis that these continental taxonomic transitions were synchronous with the massive Triassic-Jurassic marine extinctions is strongly corroborated. An extremely rapid, perhaps catastrophic, taxonomic turnover at the Triassic-Jurassic boundary, synchronous in continental and marine realms is hypothesized and discussed.

Olsen, P. E.↗

NASA NTRS1989

Review of wildlife resources of Vandenberg Air Force Base, California

Wildlife resources are reviewed for purposes of developing a Base Biological Monitoring Program (BMP) for Vandenberg Air Force Base (VAFB) in Santa Barbara County, California. The review and recommendations were prepared by review of applicable scientific literature and environmental documents for VAFB, discussing information needs with natural resource management professionals at VAFB, and observations of base field conditions. This process found that there are 29 federally listed vertebrates (endangered, threatened, or Category 2) that occur or may occur in the vicinity of VAFB. There are also 63 other state listed or regionally declining species that may occur in the vicinity of VAFB. Habitats of VAFB represent a very valuable environmental resource for rare and declining wildlife in California. However, little information is available on VAFB wildlife resources other than lists of species that occur or are expected to occur. Recommendations are presented to initiate a long-term wildlife monitoring program at VAFB to provide information for environmental impact assessment and wise land use planning.

Breininger, David R.↗