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At least 163 records · Page 9

Immunohistochemical evidence of rapid extracellular matrix remodeling after iron-particle irradiation of mouse mammary gland

High-LET radiation has unique physical and biological properties compared to sparsely ionizing radiation. Recent studies demonstrate that sparsely ionizing radiation rapidly alters the pattern of extracellular matrix expression in several tissues, but little is known about the effect of heavy-ion radiation. This study investigates densely ionizing radiation-induced changes in extracellular matrix localization in the mammary glands of adult female BALB/c mice after whole-body irradiation with 0.8 Gy 600 MeV iron particles. The basement membrane and interstitial extracellular matrix proteins of the mammary gland stroma were mapped with respect to time postirradiation using immunofluorescence. Collagen III was induced in the adipose stroma within 1 day, continued to increase through day 9 and was resolved by day 14. Immunoreactive tenascin was induced in the epithelium by day 1, was evident at the epithelial-stromal interface by day 5-9 and persisted as a condensed layer beneath the basement membrane through day 14. These findings parallel similar changes induced by gamma irradiation but demonstrate different onset and chronicity. In contrast, the integrity of epithelial basement membrane, which was unaffected by sparsely ionizing radiation, was disrupted by iron-particle irradiation. Laminin immunoreactivity was mildly irregular at 1 h postirradiation and showed discontinuities and thickening from days 1 to 9. Continuity was restored by day 14. Thus high-LET radiation, like sparsely ionizing radiation, induces rapid-remodeling of the stromal extracellular matrix but also appears to alter the integrity of the epithelial basement membrane, which is an important regulator of epithelial cell proliferation and differentiation.

NASA Discipline Radiation Health↗

Characterization of Modern Spacecraft Materials under Space-simulated Environment

External spacecraft materials play an important role in satellite protection from the harsh space environment. Research has shown that the physical, chemical, and optical properties of matter change continuously as a result of exposure to solar radiation and aggressive chemical species produced in Earth’s upper atmosphere. Thorough knowledge of the material properties evolution throughout a planned mission lifetime helps to improve the reliability of spacecraft. Moreover, the establishment of correlation factors between true space exposure and accelerated space weather experiments at ground facilities enables accurate prediction of on-orbit material performance based on laboratory-based testing. The presented work aims to evaluate the radiation effects of low Earth orbit (LEO) environment, namely, exposure to the high-energy electrons, atomic oxygen (AO), and vacuum ultraviolet (VUV), of several modern spacecraft materials. The studied materials represent the “flight duplicates” of samples that will be launched as a part of the Materials International Space Station Experiment Flight Facility (MISSE-FF) mission in 2022. MISSE-FF flight sample collection comprises different classes of polymers, including polyimides from the Kapton family, manufactured by E.I du Pont de Nemours and Co., Polyethylene terephthalate (PET) materials, liquid crystal polymers, PI/Polyhedral Oligomeric Silsesquioxanes (POSS), and carbon and glass fiber reinforced polymers. A sequential exposure approach was undertaken to allow monitoring of degradation induced by each environmental component (electrons, AO, and VUV) separately. Surface morphology, optical, and charge transport properties of selected materials were characterized using different techniques, namely, atomic force and scanning electron microscopy, ultraviolet visible (UV/Vis) transmission, reflectance, Bidirectional Reflectance Distribution Function (BRDF), and surface potential decay measurements.

Elena Plis↗

Spacecraft Materials Degradation Under Space-Simulated Low Earth Orbit (LEO) Environment

External spacecraft materials play an important role in satellite protection from the harsh space environment. Research has shown that the physical, chemical, and optical properties of matter change continuously as a result of exposure to solar radiation and aggressive chemical species produced in Earth’s upper atmosphere. Thorough knowledge of the material properties evolution throughout a planned mission lifetime helps to improve the reliability of spacecraft. Moreover, the establishment of correlation factors between true space exposure and accelerated space weather experiments at ground facilities enables accurate prediction of on-orbit material performance based on laboratory-based testing. The presented work aims to evaluate the radiation effects of low Earth orbit (LEO) environment, namely, exposure to the high-energy electrons, atomic oxygen (AO), and vacuum ultraviolet (VUV), of several modern spacecraft materials. The studied materials represent the “flight duplicates” of samples that are launched as a part of the 16th Materials International Space Station Experiment Flight Facility (MISSE-FF) mission in 2022.

Elena A Plis↗

Ground Testing of the MISSE-16 Materials

External spacecraft materials play an important role in satellite protection from the harsh space environment. Research has shown that the physical, chemical, and optical properties of matter change continuously as a result of exposure to solar radiation and aggressive chemical species produced in Earth’s upper atmosphere. Thorough knowledge of the material properties evolution throughout a planned mission lifetime helps to improve the reliability of spacecraft. Moreover, the establishment of correlation factors between true space exposure and accelerated space weather experiments at ground facilities enables accurate prediction of on-orbit material performance based on laboratory-based testing. The presented work aims to evaluate the radiation effects of low Earth orbit (LEO) environment, namely, exposure to the high-energy electrons and atomic oxygen (AO), of heritage and novel spacecraft materials selection. The studied materials represent the “flight duplicates” of samples that are launched as a part of the 16th Materials International Space Station Experiment Flight Facility (MISSE-FF) mission in 2022.

Elena A. Plis↗

Spacecraft Materials Degradation Under Space-Simulated Low Earth Orbit (LEO) Environment

External spacecraft materials play an important role in satellite protection from the harsh space environment. Research has shown that the physical, chemical, and optical properties of matter change continuously as a result of exposure to solar radiation and aggressive chemical species produced in Earth’s upper atmosphere. Thorough knowledge of the material properties evolution throughout a planned mission lifetime helps to improve the reliability of spacecraft. Moreover, the establishment of correlation factors between true space exposure and accelerated space weather experiments at ground facilities enables accurate prediction of on-orbit material performance based on laboratory-based testing. The presented work aims to evaluate the radiation effects of low Earth orbit (LEO) environment, namely, exposure to the high-energy electrons, atomic oxygen (AO), and vacuum ultraviolet (VUV), of several modern spacecraft materials. The studied materials represent the “flight duplicates” of samples that are launched as a part of the 16th Materials International Space Station Experiment Flight Facility (MISSE-FF) mission in 2022.

Elena Plis↗

HST observations of 3C 66B - A double-stranded optical jet

The central region of the synchrotron jet in 3C 66B imaged with ultrahigh spatial resolution by the Faint Object Camera on the HST is discussed. A close correspondence between the general characteristics of the smoothed optical image and the radio map is observed, implying that the young and old relativistic particles occupy similar regions to within about 130 pc. Focus is placed on the double-stranded filamentary nature of the jet, and it is speculated that this could reflect edge-brightening effects due to enhanced radiation from a skinlike structure surrounding the jet. It is noted that the similarity of optical and radio morphologies points to the fact that localized particle acceleration occurs along the jet; however, the filamentary structure and a low filling factor of radiation agree with a model in which the electrons are accelerated within the nucleus and are transported along the jet in a channel having low magnetic field.

Macchetto, F.↗

Magnetohydrodynamic Effects in Propagating Relativistic Ejecta: Reverse Shock and Magnetic Acceleration

We solve the Riemann problem for the deceleration of arbitrarily magnetized relativistic ejecta injected into a static unmagnetized medium. We find that for the same initial Lorentz factor, the reverse shock becomes progressively weaker with increasing magnetization s (the Poynting-to-kinetic energy flux ratio), and the shock becomes a rarefaction wave when s exceeds a critical value, sc, defined by the balance between the magnetic pressure in the ejecta and the thermal pressure in the forward shock. In the rarefaction wave regime, we find that the rarefied region is accelerated to a Lorentz factor that is significantly larger than the initial value. This acceleration mechanism is due to the strong magnetic pressure in the ejecta.

Mizuno, Y.↗

A review of turbulent-boundary-layer heat transfer research at Stanford, 1958-1983

For the past 25 years, there has existed in the Thermosciences Laboratory of the Mechanical Engineering Department of Stanford University a research program, primarily experimental, concerned with heat transfer through turbulent boundary layers. In the early phases of the program, the topics considered were the simple zero-pressure-gradient turbulent boundary layer with constant and with varying surface temperature, and the accelerated boundary layer. Later equilibrium boundary layers were considered along with factors affecting the boundary layer, taking into account transpired flows, flows with axial pressure gradients, transpiration, acceleration, deceleration, roughness, full-coverage film cooling, surface curvature, free convection, and mixed convection. A description is provided of the apparatus and techniques used, giving attention to the smooth plate rig, the rough plate rig, the full-coverage film cooling rig, the curvature rig, the concave wall rig, the mixed convection tunnel, and aspects of data reduction and uncertainty analysis.

Moffat, R. J.↗

Spatiotemporal relationships between growth and microtubule orientation as revealed in living root cells of Arabidopsis thaliana transformed with green-fluorescent-protein gene construct GFP-MBD

Arabidopsis thaliana plants were transformed with GFP-MBD (J. Marc et al., Plant Cell 10: 1927-1939, 1998) under the control of a constitutive (35S) or copper-inducible promoter. GFP-specific fluorescence distributions, levels, and persistence were determined and found to vary with age, tissue type, transgenic line, and individual plant. With the exception of an increased frequency of abnormal roots of 35S GFP-MBD plants grown on kanamycin-containing media, expression of GFP-MBD does not appear to affect plant phenotype. The number of leaves, branches, bolts, and siliques as well as overall height, leaf size, and seed set are similar between wild-type and transgenic plants as is the rate of root growth. Thus, we conclude that the transgenic plants can serve as a living model system in which the dynamic behavior of microtubules can be visualized. Confocal microscopy was used to simultaneously monitor growth and microtubule behavior within individual cells as they passed through the elongation zone of the Arabidopsis root. Generally, microtubules reoriented from transverse to oblique or longitudinal orientations as growth declined. Microtubule reorientation initiated at the ends of the cell did not necessarily occur simultaneously in adjacent neighboring cells and did not involve complete disintegration and repolymerization of microtubule arrays. Although growth rates correlated with microtubule reorientation, the two processes were not tightly coupled in terms of their temporal relationships, suggesting that other factor(s) may be involved in regulating both events. Additionally, microtubule orientation was more defined in cells whose growth was accelerating and less stringent in cells whose growth was decelerating, indicating that microtubule-orienting factor(s) may be sensitive to growth acceleration, rather than growth per se.

NASA Discipline Plant Biology↗

Orion MPCV Touchdown Detection Threshold Development and Testing

A robust method of detecting Orion Multi-Purpose Crew Vehicle (MPCV) splashdown is necessary to ensure crew and hardware safety during descent and after touchdown. The proposed method uses a triple redundant system to inhibit Reaction Control System (RCS) thruster firings, detach parachute risers from the vehicle, and transition to the post-landing segment of the Flight Software (FSW). An in-depth trade study was completed to determine optimal characteristics of the touchdown detection method resulting in an algorithm monitoring filtered, lever-arm corrected, 200 Hz Inertial Measurement Unit (IMU) vehicle acceleration magnitude data against a tunable threshold using persistence counter logic. Following the design of the algorithm, high fidelity environment and vehicle simulations, coupled with the actual vehicle FSW, were used to tune the acceleration threshold and persistence counter value to result in adequate performance in detecting touchdown and sufficient safety margin against early detection while descending under parachutes. An analytical approach including Kriging and adaptive sampling allowed for a sufficient number of finite element analysis (FEA) impact simulations to be completed using minimal computation time. The combination of a persistence counter of 10 and an acceleration threshold of approximately 57.3 ft/s2 resulted in an impact performance factor of safety (FOS) of 1.0 and a safety FOS of approximately 2.6 for touchdown declaration. An RCS termination acceleration threshold of approximately 53.1 ft/s(exp)2 with a persistence counter of 10 resulted in an increased impact performance FOS of 1.2 at the expense of a lowered under-parachutes safety factor of 2.2. The resulting tuned algorithm was then tested on data from eight Capsule Parachute Assembly System (CPAS) flight tests, showing an experimental minimum safety FOS of 6.1. The formulated touchdown detection algorithm will be flown on the Orion MPCV FSW during the Exploration Flight Test 1 (EFT-1) mission in the second half of 2014.

Daum, Jared↗

Focused interplanetary transport of approximately 1 MeV solar energetic protons through self-generated Alfven waves

We present a model of the focused transport of approximately 1 MeV solar energetic protons through interplanetary Alfven waves that the protons themselves amplify or damp. It is based on the quasi-linear theory but with a phenomenological pitch angle diffusion coefficient in the 'resonance gap.' For initial Alfven wave distributions that give mean free paths greater than approximately 0.5 AU for approximately 1 MeV protons in the inner heliosphere, the model predicts greater than roughly an order of magnitude amplification (damping) in the outward (inward) propagating resonant Alfven waves at less than or approximately equal to o.3 AU heliocentric distance. As the strength of proton source is increased, the peak differential proton intensity at approximately 1 MeV at 1 AU increases to a maximum of approximately 250 particles (/(sq cm)(s)(sr)(MeV)) and then decreases slowly. It may be attenuated by a factor of 5 or more relative to the case without wave evolution, provided that the proton source is sufficiently intense that the resulting peak differential intensity of approximately 1 MeV protons at 1 AU exceeds approximately 200 particles (/(sq cm)(s)(sr)(MeV)). Therefore, in large solar proton events, (1) one may have to take into account self-amplified waves in studying solar particle propagation, (2) the number of accelerated protons escaping from a flare or interplanetary shock may have been underestimated in past studies by a significant factor, and (3) accelerated protons escaping from a traveling interplanetary shock at r less than or approximately equal to 0.3 AU should amplify the ambient hydromagnetic waves siginificantly to make the shock an efficient accelerator, even if initially the mean free path is greater than or approximately equal to 1 AU.

Ng, C. K.↗

Low-gravity Orbiting Research Laboratory Environment Potential Impact on Space Biology Research

One of the major objectives of any orbital space research platform is to provide a quiescent low gravity, preferably a zero gravity environment, to perform fundamental as well as applied research. However, small disturbances exist onboard any low earth orbital research platform. The impact of these disturbances must be taken into account by space research scientists during their research planning, design and data analysis in order to avoid confounding factors in their science results. The reduced gravity environment of an orbiting research platform in low earth orbit is a complex phenomenon. Many factors, among others, such as experiment operations, equipment operation, life support systems and crew activity (if it is a crewed platform), aerodynamic drag, gravity gradient, rotational effects as well as the vehicle structural resonance frequencies (structural modes) contribute to form the overall reduced gravity environment in which space research is performed. The contribution of these small disturbances or accelerations is precisely why the environment is NOT a zero gravity environment, but a reduced acceleration environment. This paper does not discuss other factors such as radiation, electromagnetic interference, thermal and pressure gradient changes, acoustic and CO2 build-up to name a few that affect the space research environment as well, but it focuses solely on the magnitude of the acceleration level found on orbiting research laboratory used by research scientists to conduct space research. For ease of analysis this paper divides the frequency spectrum relevant to most of the space research disciplines into three regimes: a) quasi-steady, b) vibratory and c) transient. The International Space Station is used as an example to illustrate the point. The paper discusses the impact of these three regimes on space biology research and results from space flown experiments are used to illustrate the potential negative impact of these disturbances (accelerations) on space biology research.

Jules, Kenol↗

Neural Network Based Representation of UH-60A Pilot and Hub Accelerations

Neural network relationships between the full-scale, experimental hub accelerations and the corresponding pilot floor vertical vibration are studied. The present physics-based, quantitative effort represents an initial systematic study on the UH-60A Black Hawk hub accelerations. The NASA/Army UH-60A Airloads Program flight test database was used. A 'maneuver-effect-factor (MEF)', derived using the roll-angle and the pitch-rate, was used. Three neural network based representation-cases were considered. The pilot floor vertical vibration was considered in the first case and the hub accelerations were separately considered in the second case. The third case considered both the hub accelerations and the pilot floor vertical vibration. Neither the advance ratio nor the gross weight alone could be used to predict the pilot floor vertical vibration. However, the advance ratio and the gross weight together could be used to predict the pilot floor vertical vibration over the entire flight envelope. The hub accelerations data were modeled and found to be of very acceptable quality. The hub accelerations alone could not be used to predict the pilot floor vertical vibration. Thus, the hub accelerations alone do not drive the pilot floor vertical vibration. However, the hub accelerations, along with either the advance ratio or the gross weight or both, could be used to satisfactorily predict the pilot floor vertical vibration. The hub accelerations are clearly a factor in determining the pilot floor vertical vibration.

Kottapalli, Sesi↗

Properties of Ground Level Enhancement Events and the Associated Solar Eruptions During Solar Cycle 23

Solar cycle 23 witnessed the most complete set of observations of coronal mass ejections (CMEs) associated with the Ground Level Enhancement (GLE) events. We present an overview of the observed properties of the GLEs and those of the two associated phenomena, viz., flares and CMEs, both being potential sources of particle acceleration. Although we do not find a striking correlation between the GLE intensity and the parameters of flares and CMEs, the solar eruptions are very intense involving X-class flares and extreme CME speeds (average approx. 2000 km/s). An M7.1 flare and a 1200 km/s CME are the weakest events in the list of 16 GLE events. Most (80 %) of the CMEs are full halos with the three non-halos having widths in the range 167 to 212 degrees. The active regions in which the GLE events originate are generally large: 1290 msh (median 1010 msh) compared to 934 msh (median: 790 msh) for SEP-producing active regions. For accurate estimation of the CME height at the time of metric type II onset and GLE particle release, we estimated the initial acceleration of the CMEs using flare and CME observations. The initial acceleration of GLE-associated CMEs is much larger (by a factor of 2) than that of ordinary CMEs (2.3 km/sq s vs. 1 km/sq s). We confirmed the initial acceleration for two events for which CME measurements are available in the inner corona. The GLE particle release is delayed with respect to the onset of all electromagnetic signatures of the eruptions: type II bursts, low frequency type III bursts, soft X-ray flares and CMEs. The presence of metric type II radio bursts some 17 min (median: 16 min; range: 3 to 48 min) before the GLE onset indicates shock formation well before the particle release. The release of GLE particles occurs when the CMEs reach an average height of approx 3.09 R(sub s) (median: 3.18 R (sub s) ; range: 1.71 to 4.01 R (sub s) ) for well-connected events (source longitude in the range W20–W90). For poorly connected events, the average CME height at GLE particle release is ∼66 % larger (mean: 5.18 R (sub s) ; median: 4.61 R (sub s) ; range: 2.75–8.49 R (sub s) ). The longitudinal dependence is consistent with shock accelerations because the shocks from poorly connected events need to expand more to cross the field lines connecting to an Earth observer. On the other hand, the CME height at metric type II burst onset has no longitudinal dependence because electromagnetic signals do not require magnetic connectivity to the observer. For several events, the GLE particle release is very close to the time of first appearance of the CME in the coronagraphic field of view, so we independently confirmed the CME height at particle release. The CME height at metric type II burst onset is in the narrow range 1.29 to 1.8 R(sub s), with mean and median values of 1.53 and 1.47 R(sub s). The CME heights at metric type II burst onset and GLE particle release correspond to the minimum and maximum in the Alfven speed profile. The increase in CME speed between these two heights suggests an increase in Alfvenic Mach number from 2 to 3. The CME heights at GLE particle release are in good agreement with those obtained from the velocity dispersion analysis, including the source longitude dependence. We also discuss the implications of the delay of GLE particle release with respect to complex type III bursts by approx 18 min (median: 16 in; range: 2 to 44 min) for the flare acceleration mechanism. A similar analysis is also performed on the delay of particle release relative to the hard X-ray emission.

Geomagnetic Storms↗

Crack propagation and arrest in pressurized containers

The problem of crack propagation and arrest in a finite volume cylindrical container filled with pressurized gas is considered. It is assumed that the cylinder contains a symmetrically located longitudinal part-through crack with a relatively small net ligament. The net ligament suddenly ruptures initiating the process of fracture propagation and depressurization in the cylinder. Thus the problem is a coupled gas dynamics and solid mechanics problem the exact formulation of which does not seem to be possible. The problem is reduced to a proper initial value problem by introducing a dynamic fracture criterion which relates the crack acceleration to the difference between a load factor and the corresponding strength parameter. The results indicate that generally in gas filled cylinders fracture arrest is not possible unless the material behaves in a ductile manner and the container is relatively long.

Erdogan, F.↗

Crack propagation and arrest in pressurized containers

The problem of crack propagation and arrest in a finite volume cylindrical container filled with pressurized gas is considered. It is assumed that the cylinder contains a symmetrically located longitudinal part-through crack with a relatively small net ligament. The net ligament suddenly ruptures initiating the process of fracture propagation and depressurization in the cylinder. The problem is formulated by making two major assumptions, namely, that the shell problem is quasi-static and the gas dynamics problem is one-dimensional. The problem is reduced to a proper initial value problem by introducing a dynamic fracture criterion which relates the crack acceleration to the difference between a load factor and the corresponding strength parameter. The main results are demonstrated by considering two examples, an aluminum cylinder which may behave in a quasi-brittle manner, and a steel cylinder which undergoes ductile fracture. The results indicate that generally in gas-filled cylinders fracture arrest is not possible unless the material behaves in a ductile manner and the container is relatively long.

Erdogan, F.↗

Analysis and design of steady transonic flow over airfoils by the method of parametric differentiation

The results reported here are based on applying the method of parametric differentiation (MPD) to transform the nonlinear differential equation governing small-disturbance transonic flow to a linear equation. Implicit approximate factorization and monotone methods were used to accelerate convergence of the linear problem by an order of magnitude over successive line over-relaxation. The relative merits of using MPD are discussed in comparison to conventional small-disturbance applications. Several MPD analyses are performed on an array of airfoils. A design procedure utilizing MPD is discussed and demonstrated for two nonlifting cases.

Halt, D. W.↗