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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 163 records · Page 9
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Phenotypically anchored transcriptomics across diverse agrichemicals reveals conserved pathways and unique gene expression signatures in zebrafish

Agrichemicals such as herbicides, fungicides, insecticides, and biocides are widely used in agriculture, yet some are associated with adverse effects in humans and the environment. While many of these chemicals have been extensively studied in vitro and are included in the EPA’s ToxCast program, comprehensive in vivo comparisons using RNA sequencing across structurally diverse agrichemicals, in a single screening platform, are lacking. In this study, we examined structurally diverse agrichemicals found in the U.S. Environmental Protection Agency’s (EPA) Toxcast Phase I and II library by statically exposing early life stage zebrafish at 6 h post fertilization (hpf) until 120 hpf at concentrations ranging from 0.25 to 100 µM. Morphological outcomes were assessed at 120 hpf across 10 endpoints, including yolk sac edema, craniofacial malformations, and axis abnormalities. Chemicals that produced robust concentration-response relationships were selected for transcriptomic profiling. For transcriptomic analysis, zebrafish were statically exposed to each chemical and sampled at 48 hpf, prior to the onset of morphological effects observed at 120 hpf. Differential expression analysis identified between 0 and 4,538 differentially expressed genes (DEGs) per chemical, with no clear correlation to morphological severity. Both DEG and co-expression network analyses revealed chemical-specific expression patterns that converged on shared biological pathways, including neurodevelopment and cytoskeletal organization. Key regulatory genes such as mylpfa and krt4 were identified within co-expression modules, suggesting their potential role in conserved toxicity mechanisms. Semantic similarity analysis of enriched gene ontology (GO) terms, when compared to existing datasets, highlighted gaps in the annotation of neurodevelopmental processes, indicating that some in vivo effects may not be fully captured by current curated resources. The results provide new insights into the modes of action of diverse agrichemicals and establish a framework for understanding how agrichemical structure relates to biological function in a vertebrate model.

agrichemical↗
NASA NTRS1966

Expandable insert serves as screw anchor

Expandable self-locking adapter secures components to panels having one accessible side. Mounting holes in the panels may not be threaded to accommodate screws, therefore, the adapter contains a female thread that will mate a mounting screw.

Source record↗
NASA NTRS1969

Technique for anchoring fasteners to honeycomb panels

Two-piece fastener bushing provides mounting surface for components on a three-inch thick honeycomb structure. Specially constructed starter drill and sheet metal drill permit drilling without misalignment. Tapered knife-edge cutting tool removes honeycomb core material without tearing the adjacent material.

Brown, W. J.↗
NASA NTRS1971

Anchoring spacecraft to planets

For planet tracking, the immense mass relative to applied nongravitational forces (for even the smaller asteroids) removes limitations on the ability to model orbital motion mathematically. A lander on a natural satellite (other than the moon) would not suffer from nongravitational effects, and would further have a large mean motion, which is important for observing gravitational effects. The tracking of a Mars lander over a long period would yield conclusions in the areas of relativity (determination of the parameter beta), the inertial framework, Mars' internal structure (based on the polar moment), and Mars' physical ephemeris.

Cain, D. L.↗
NASA NTRS2002

The Arabidopsis SKU5 gene encodes an extracellular glycosyl phosphatidylinositol-anchored glycoprotein involved in directional root growth

To investigate how roots respond to directional cues, we characterized a T-DNA-tagged Arabidopsis mutant named sku5 in which the roots skewed and looped away from the normal downward direction of growth on inclined agar surfaces. sku5 roots and etiolated hypocotyls were slightly shorter than normal and exhibited a counterclockwise (left-handed) axial rotation bias. The surface-dependent skewing phenotype disappeared when the roots penetrated the agar surface, but the axial rotation defect persisted, revealing that these two directional growth processes are separable. The SKU5 gene belongs to a 19-member gene family designated SKS (SKU5 Similar) that is related structurally to the multiple-copper oxidases ascorbate oxidase and laccase. However, the SKS proteins lack several of the conserved copper binding motifs characteristic of copper oxidases, and no enzymatic function could be assigned to the SKU5 protein. Analysis of plants expressing SKU5 reporter constructs and protein gel blot analysis showed that SKU5 was expressed most strongly in expanding tissues. SKU5 was glycosylated and modified by glycosyl phosphatidylinositol and localized to both the plasma membrane and the cell wall. Our observations suggest that SKU5 affects two directional growth processes, possibly by participating in cell wall expansion.

NASA Discipline Plant Biology↗
NASA NTRS2004

Anchoring the Population II Distance Scale: Accurate Ages for Globular Clusters

The metal-poor stars in the halo of the Milky Way galaxy were among the first objects formed in our Galaxy. These Population II stars are the oldest objects in the universe whose ages can be accurately determined. Age determinations for these stars allow us to set a firm lower limit, to the age of the universe and to probe the early formation history of the Milky Way. The age of the universe determined from studies of Population II stars may be compared to the expansion age of the universe and used to constrain cosmological models. The largest uncertainty in estimates for the ages of stars in our halo is due to the uncertainty in the distance scale to Population II objects. We propose to obtain accurate parallaxes to a number of Population II objects (globular clusters and field stars in the halo) resulting in a significant improvement in the Population II distance scale and greatly reducing the uncertainty in the estimated ages of the oldest stars in our galaxy. At the present time, the oldest stars are estimated to be 12.8 Gyr old, with an uncertainty of approx. 15%. The SIM observations obtained by this key project, combined with the supporting theoretical research and ground based observations outlined in this proposal will reduce the estimated uncertainty in the age estimates to 5%).

Chaboyer, Brian C.↗
NASA NTRS2006

Till the Ductile Anchor Hold: Towards Space Settlements in the 21st Century.

Humans are restless explorers. For 99% of humanity s time on Earth, we have been nomadic wanderers, not farmers, warriors, factory workers, developers, or NASA employees. Only recently--for only a few thousand years--have most humans been tied to the land as many are now. But as more and more of us live in information societies and some indeed in dream societies where our identity derives from the knowledge we share and the image we project, and not from the property we own or the manual work we do, the time may be coming when we should break free from the land, and roam once again. But beware: the reality of Man and Woman the Explorer has a very dark side as well. Many people where I live view the recent experience of Man on the Move as a history of theft, murder, racism, exploitation, and genocide. So we need to be very careful if we say that space exploration is only natural for humans, since the experience has not been very uplifting and noble for most recipients of the exploring of others. But such warnings are not new. Humans have been alerting each other to the dangers of change and novelty from the very beginning: Who and what is this?

Dator, Jim↗
NASA NTRS2009

The International Lunar Network (ILN) Anchor Nodes Mission Update

NASA s Science Mission Directorate (SMD) established the Lunar Quest Program (LQP) to accomplish lunar science objectives embodied in the National Academies report The Scientific Context for Exploration of the Moon (2007) and the NASA Advisory Council-sponsored Workshop on Science Associated with the Lunar Exploration Architecture (2007). A major element of LQP's lunar flight projects is the International Lunar Network (ILN), a network of small geophysical nodes on the lunar surface. NASA plans to provide the first two stations around 2014 and a second pair in the 2016-2017 timeframe. International involvement to provide additional stations will build up the network so that 8-10 nodes could be simultaneously operating. This flight project complements SMD's initiatives to build a robust lunar science community through R&A lines and increases international participation in NASA's robotic exploration of the moon.

Cohen, B. A.↗
NASA NTRS2010

Predicting Ares I Reaction Control System Performance by Utilizing Analysis Anchored with Development Test Data

The Ares I launch vehicle is an integral part of NASA s Constellation Program, providing a foundation for a new era of space access. The Ares I is designed to lift the Orion Crew Module and will enable humans to return to the Moon as well as explore Mars.1 The Ares I is comprised of two inline stages: a Space Shuttle-derived five-segment Solid Rocket Booster (SRB) First Stage (FS) and an Upper Stage (US) powered by a Saturn V-derived J-2X engine. A dedicated Roll Control System (RoCS) located on the connecting interstage provides roll control prior to FS separation. Induced yaw and pitch moments are handled by the SRB nozzle vectoring. The FS SRB operates for approximately two minutes after which the US separates from the vehicle and the US Reaction Control System (ReCS) continues to provide reaction control for the remainder of the mission. A representation of the Ares I launch vehicle in the stacked configuration and including the Orion Crew Exploration Vehicle (CEV) is shown in Figure 1. Each Reaction Control System (RCS) design incorporates a Gaseous Helium (GHe) pressurization system combined with a monopropellant Hydrazine (N2H4) propulsion system. Both systems have two diametrically opposed thruster modules. This architecture provides one failure tolerance for function and prevention of catastrophic hazards such as inadvertent thruster firing, bulk propellant leakage, and over-pressurization. The pressurization system on the RoCS includes two ambient pressure-referenced regulators on parallel strings in order to attain the required system level single Fault Tolerant (FT) design for function while the ReCS utilizes a blow-down approach. A single burst disk and relief valve assembly is also included on the RoCS to ensure single failure tolerance for must-not-occur catastrophic hazards. The Reaction Control Systems are designed to support simultaneously firing multiple thrusters as required

Stein, William B.↗
NASA NTRS2010

NASA's International Lunar Network Anchor Nodes and Robotic Lunar Lander Project Update

NASA Marshall Space Flight Center and The Johns Hopkins University Applied Physics Laboratory have been conducting mission studies and performing risk reduction activities for NASA's robotic lunar lander flight projects. Additional mission studies have been conducted to support other objectives of the lunar science and exploration community and extensive risk reduction design and testing has been performed to advance the design of the lander system and reduce development risk for flight projects.

Cohen, Barbara A.↗
NASA NTRS2013

Rock Gripper for Sampling, Mobility, Anchoring, and Manipulation

A new gripper mechanism can be used as an end effector for a long arm that reaches out from a nearby spacecraft for a touch-and-go type of mission. The gripper would stabilize the arm and allow samples to be collected and in situ science to be done from a fixed platform. In the long term, this style of gripper could even be used as handholds for astronauts trying to move about on/near small asteroids. The prototype developed has demonstrated a 120 N gripping force, and improvements continue to be made.

Parness, Aaron↗