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At least 163 records · Page 9

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NASA NTRS2021

Why Atmospheric Backscatter Is Important in the Formation of Electron Precipitation in the Diffuse Aurora

In addition to wave particle scattering in the magnetosphere, atmospheric backscatter of magnetospheric electrons is an important process that contributes to the formation of the precipitated electrons in the region of diffuse aurora. Two magnetically conjugate regions are involved in a complex magnetosphere-ionosphere (MI) particle and energy interplay. Based on synthesizing previous theoretical/modeling studies and experimental evidence, we demonstrate the need for improving the quantification of magnetospheric electrons backscatter processes that can affect inner magnetospheric electrodynamics, transport and loss in a way that is not easily predicted. We discuss how these complex and energy-dependent MI coupled processes can be treated in magnetospheric modeling.

diffuse aurora↗

DOE OSTI2026

swss-aurora

Python code for analyzing aurora data in the LANL Space Weather Summer School (O4985)

Holmes, Rebecca↗

DOE OSTI2026

Benchmarking DAOS Filesystem on Aurora

We benchmark the DAOS filesystem on Argonne's Aurora supercomputer (127 nodes, 4,064 targets) using fio, IOR, mdtest, and IO500 to characterize I/O and metadata performance across the DFS API and DFuse+POSIX. Single-client fio shows POSIX bandwidth saturating at 1–2 MiB I/O sizes, with write-heavy workloads outperforming reads. Multi-node IOR shows DFS bandwidth scaling well up to ~32 tasks/node, with write latency growing faster than read latency. An 8-node IO500 evaluation shows DFS achieving ~5x higher bandwidth and ~190x higher IOPS than POSIX. Results indicate DAOS is well-suited to read-heavy workloads like AI training data loading, given appropriately sized transfers and concurrency.

George, Rebecca [College of William and Mary, Will↗

DOE OSTI2024

Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing

Many proteins regulating mitosis have emerged as targets for cancer therapy, including the kinesin spindle protein (KSP) and Aurora kinase B (AurB). KSP is crucial for proper spindle pole separation during mitosis, while AurB plays roles in chromosome segregation and cytokinesis. Agents targeting KSP and AurB selectively affect dividing cells and have shown significant activity in vitro. However, these drugs, despite advancing to clinical trials, often yield unsatisfactory outcomes as monotherapy, likely due to variable responses driven by cyclin B degradation and apoptosis signal accumulation networks. Accumulated data suggest that combining emerging antimitotics with various cytostatic drugs can enhance tumor-killing effects compared to monotherapy. Here, we investigated the impact of inhibiting anti-apoptotic signals with the BH3-mimetic Navitoclax in oral cancer cells treated with the selective KSP inhibitor, Ispinesib, or AurB inhibitor, Barasertib, aiming to potentiate cell death. The combination of BH3-mimetics with both KSP and AurB inhibitors synergistically induced substantial cell death, primarily through apoptosis. A mechanistic analysis underlying this synergistic activity, undertaken by live-cell imaging, is presented. Our data underscore the importance of combining BH3-mimetics with antimitotics in clinical trials to maximize their effectiveness.

Silva, João P. N. (ORCID:0000000344554286)↗

NASA NTRS1964