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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 163 records · Page 9

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NASA NTRS2012

A Statistical Approach to Recognizing Source Classes for Unassociated Sources in the First FERMI-LAT Catalog

The Fermi Large Area Telescope (LAT) First Source Catalog (1FGL) provided spatial, spectral, and temporal properties for a large number of gamma -ray sources using a uniform analysis method. After correlating with the mostcomplete catalogs of source types known to emit gamma rays, 630 of these sources are "unassociated" (i.e., have no obvious counterparts at other wavelengths). Here, we employ two statistical analyses of the primary gamma-ray characteristics for these unassociated sources in an effort to correlate their gamma-ray properties with the active galactic nucleus (AGN) and pulsar populations in 1FGL. Based on the correlation results, we classify 221 AGN-like and 134 pulsar-like sources in the 1FGL unassociated sources. The results of these source "classifications" appear to match the expected source distributions, especially at high Galactic latitudes. While useful for planning future multiwavelength follow-up observations, these analyses use limited inputs, and their predictions should not be considered equivalent to "probable source classes" for these sources. We discuss multiwavelength results and catalog cross-correlations to date, and provide new source associations for 229 Fermi-LAT sources that had no association listed in the 1FGL catalog. By validating the source classifications against these new associations, we find that the new association matches the predicted source class in approximately 80% of the sources.

SOURCES↗

NASA NTRS2014

The Cosmology Large Angular Scale Surveyor (CLASS): 38 GHz Detector Array of Bolometric Polarimeters

The Cosmology Large Angular Scale Surveyor (CLASS) experiment aims to map the polarization of the Cosmic Microwave Background (CMB) at angular scales larger than a few degrees. Operating from Cerro Toco in the Atacama Desert of Chile, it will observe over 65% of the sky at 38, 93, 148, and 217 GHz. In this paper we discuss the design, construction, and characterization of the CLASS 38 GHz detector focal plane, the first ever Q-band bolometric polarimeter array.

CMB↗

NASA NTRSDate not supplied

Define Minimum Safe Operational Volume for Aerial Vehicles in Upper Class E Airspace

The variety of vehicle performance in upper Class E airspace requires a method that can efficiently compute the minimum safe operational boundary between aircraft. This work presents a mathematical method to define the minimum safe operational boundary needed for aerial vehicles operating in upper Class E airspace. This method focuses on the extra separation required by vehicle maneuverability, communication delay, and control/operator response time. A sensitivity study is then performed to provide a general understanding of the impact of these factors on the extra separation needed. Experiments with pairwise encounters are conducted to verify the results generated by the proposed methods.

Separation standard↗

NASA NTRSDate not supplied

Microbes Share Rides Too: Updating Encapsulated Bioburden Estimate Values in Electronic Parts Common to Class D Mission Platforms.

As NASA develops more planetary protection missions that are Category III and in the Class D/rideshare mission platform, there is an increasing reliance on estimation of prelaunch bioburden to understand needs for burn up and breakup analyses or other methods to meet pre-launch bioburden levels. Current levels estimated for the encapsulated bioburden of semiconductor parts cited by NASA have been based on estimates of semiconductor manufacturing approaches from the 1970s that do not incorporate over fifty years of evolving cleanliness of semiconductor manufacturing processes and facilities. This investigation will focus on direct sampling of semiconductor parts for encapsulated bioburden values, drawing upon Goddard’s strength in EEE parts, supply chain management, destructive parts analysis and existing local planetary protection lab facilities to prepare and measure encapsulated bioburden at a statistically significant level for standard electronics parts common to known Class D/rideshare platforms.

planetary protection↗

NASA NTRSDate not supplied

Microbes Share Rides Too: Updating Encapsulated Bioburden Estimate Values in Electronic Parts Common to Class D Missions

As NASA develops more planetary protection missions that are Category III and in the Class D/rideshare mission platform, there is an increasing reliance on estimation of prelaunch bioburden to understand needs for burn up and breakup analyses or other methods to meet pre-launch bioburden levels. Current levels estimated for the encapsulated bioburden of semiconductor parts cited by NASA have been based on estimates of semiconductor manufacturing approaches from the 1970s that do not incorporate the evolving cleanliness of semiconductor manufacturing since that time. This investigation will focus on direct sampling of semiconductor parts for encapsulated bioburden values, drawing upon Goddard’s strength in EEE parts, supply chain management, destructive parts analysis and existing local planetary protection lab facilities to prepare and measure encapsulated bioburden at a statistically significant level for standard electronics parts common to known Class D/rideshare platforms.

planetary protection↗

NASA NTRSDate not supplied

Roadmap to Cooperative Operating Practices for Strategic Conflict Detection and Resolution in the Upper Class-E Traffic Management Concept

As the governing body of flight operations in the highly anticipated emergent area of Upper Class E airspace (60,000 ft and above), the Federal Aviation Administration (FAA) has recognized the potential for a possible extensible traffic management system for new entrants into this domain. Following the successes with Unmanned Aircraft Systems (UAS) Traffic Management (UTM) and Advanced / Urban Air Mobility (AAM / UAM) Traffic Management programs, FAA put forth an initial concept of operations for supporting the start of the Upper Class E Traffic Management (ETM) concept. Like UTM and AAM / UAM, ETM is envisioned to also be a community-based, industry driven cooperative management concept. However, tailoring it to be adaptable to the atmospheric communication, navigation, and surveillance deficits, as well as the diverse vehicle and mission profiles operating in the ETM environment will be the challenge. As such, the National Aeronautics and Space Administration (NASA) Ames Research Center has been investigating several technologies that will help enable industry in the development of this new type of cooperative operating environment. These technologies are being prototyped and will be tested in a collaborative evaluation of an initial ETM system in late 2023. The evaluation will concentrate on building out ETM system technologies that will inform the participants regarding operational intent sharing, strategic conflict detection, and the resultant deconfliction process. In addition to the technical aspects, key roles and responsibilities will need to be defined. This will be done through exploring community-agreed upon Cooperative Operating Practices (COPs) that include procedures and capabilities to aid in timely, strategic conflict identification and resolution to be developed during the evaluation. As an initial step to the evaluation, the ETM research team at NASA Ames solicited industry feedback on various aspects of ETM operations from subject matter experts. A virtual tabletop walkthrough session was held over a two-day period to follow a roadmap through the functional steps needed to build COPs, focusing on strategic conflict detection and resolution. Overall, the ETM tabletop provided insights into how the community wanted to instantiate the generation and sharing of operational intent, detect strategic conflicts and resolve those conflicts using a preliminary set of procedural community-agreed upon COPs.

Upper Class-E Traffic Management (ETM)↗

NASA NTRSDate not supplied

Roadmap to Cooperative Operating Practices for Strategic Conflict Detection and Resolution in the Upper Class E Traffic Management Concept

Upper Class E Traffic Management (ETM)↗

NASA NTRSDate not supplied

A Web-Based Negotiation Tool for Conflict Resolution in Upper Class E Traffic Management

In Upper Class E airspace 60,000 feet (or Flight level / FL600), vehicles such as High Altitude Long Endurance (HALE) balloons and slow fixed-wing gliders have diverse vehicle characteristics and limited maneuverability. Due to these unique characteristics of high-altitude operations, a new type of strategic negotiation-based conflict resolution method has been proposed to avoid potential conflict between vehicles in Upper Class E airspace, well in advance of the conflict point and with ample time for bilateral negotiation. This paper introduces the first real-time web-based negotiation tool for high-altitude operations. To facilitate negotiation, this tool incorporates a bilateral negotiation model with an algorithm to assess conflict risks and generate new flight trajectories with a given flight path deviation. This tool allows users to make decisions during negotiation manually and automatically while enforcing the needed constraints for negotiation to be successful. Operators can make decisions at every step while they interact with each other on separate devices. To conduct sensitivity analysis, a mechanism that automates human inputs to the user interface is also developed for this web-based negotiation tool, such that fast-time simulations can be constructed and used to explore various scenarios to gain insights into this web-based negotiation model. Using this tool, a study was conducted to evaluate the impact of different negotiation strategies, vehicle types, vehicle crossing angles, and operator response times during the negotiations on metrics such as total negotiation completion time, number of negotiation rounds, and extra flight distance to avoid the conflict due to negotiation, compared to ones without negotiation. The results suggest that operators benefit from using negotiated flight paths with quick response times, across various crossing angles and vehicle types. Various Negotiation Strategies are investigated to simulate the behaviors associated with different types of negotiations. The findings demonstrate that, in comparison to the conventional method where a single operator assumes full responsibility, negotiation-based strategic deconfliction reduces the total extra flight distance by an average of 24% - 27%. On an individual basis, each operator may be able to save an average of 65% of their extra flight distance.

Upper Class E Traffic Management (ETM)↗

NASA NTRSDate not supplied

Initial Development of an Upper Class E Traffic Management (ETM) System for Stratospheric Flight Operations

Advances in technologies across multiple areas have spurred the motivation and development of new entrants and use cases for the national airspace system to accommodate. The stratosphere, encompassing Upper Class E airspace, is of particular interest due to the types of aircraft that can operate there and the unique missions that can be carried out. The diversity of aircraft that plan to operate and the long durations envisioned presents a challenge for the management of that airspace in a manner that does not burden the current paradigm of air traffic service provision. Upper Class E Traffic Management (ETM) is an approach pioneered by NASA and FAA to enable the cooperative management of high-altitude airspace through operations in cooperative areas facilitated by information exchanges and coordination based on common operating practices. NASA has developed, implemented, and commenced initial tests of the underlying systems and architecture to enable ETM operations. The implementation is the first of its kind and meant to serve as a reference for broader adoption. This paper will present the architecture and details of the system components as well as how it has been implemented for the test. Summary results of initial connectivity tests are included to highlight the functionality of the ETM system, which provides the path forward for more complex operations and interactions at a greater scale.

Upper Class E Traffic Management↗

DOE OSTI2025

Class B Materials Code Case

Class B Materials Code Case to include: FY25 - High temperature design methodology, overview of ASME Section III (Division 5), Design for elevated temperature service, Goal to address current gaps, evaluation of proposed rules, allowable stress development, Class A materials (existing ASME approach), variable confidence index, data extrapolation, bounding value for SEE, and next steps.

11 - NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

DOE OSTI2025

A distinct class of ferredoxin:NADP + oxidoreductase enzymes driving thermophilic ethanol production

Biofuel production from lignocellulosic biomass offers a transformative solution to reduce global fossil fuel dependency. Certain thermophilic anaerobes, including Clostridium thermocellum, show promise for renewable ethanol production due to their ability to break down plant material at high temperatures. However, achieving commercially viable ethanol yields has proven challenging despite extensive engineering efforts. Here, we characterized 27 ferredoxin:NADP + oxidoreductase (Fnor) enzymes for their enzyme activity, nicotinamide cofactor specificity, thermotolerance, and functional expression in C. thermocellum . We identified a subset of 10 of these enzymes as a novel class of Fnor enzymes suited for metabolic pathways aimed at high-titer ethanol production. When expressed in engineered C. thermocellum , these enzymes increased ethanol production up to 2.2-fold. These findings establish a novel ethanol pathway and provide insights into physiological roles and biotechnological applications of this new class of Fnor enzymes.

09 BIOMASS FUELS↗

DOE OSTI2025

Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter -derived cephalosporinase-33 (ADC-33), a class C β-lactamase present in carbapenem-resistant Acinetobacter baumannii (CR Ab )

ABSTRACT Antimicrobial resistance inAcinetobacter baumanniiis partly mediated by chromosomal class C β-lactamases, theAcinetobacter-derived cephalosporinases (ADCs). Recently, a growing number of emerging variants were described, expanding this threat. Consistent with other β-lactamases, one of the main areas of variance exists in the Ω-loop region near the site of cephalosporin binding. Interestingly, a common alanine duplication (Adup) is found in this region. Herein, we studied specific Adup variants expressed in a uniformEscherichia coligenetic background that demonstrated high-level resistance to multiple oxyimino-cephalosporins. For ceftolozane and ceftazidime, the Adup ADCs significantly increased levels of resistance (minimum inhibitory concentration [MIC] ≥ 512 µg/mL and MIC ≥ 1,024 µg/mL, respectively). These observations were consistent with the increasedk cat /K M for ceftazidime. For cefiderocol, three Adup variants exhibited increased MICs and increasedk cat /K M for this compound. Timed electrospray ionization mass spectrometry demonstrated stable cephalosporin:ADC adducts with ADC-30 (non-Adup), but not with ADC-33 (Adup), consistent with turnover. The X-ray crystal structure of Adup variant ADC-33 in complex with ceftazidime was determined (1.57 Å resolution) and suggests that increased turnover is facilitated by conformational changes (shift in Tyr221 and orientation of the oxyimino portion of the R1 side chain) and repositioning of water in the active site. These changes appear to favor substrate-assisted catalysis as an alternative mechanism to base-assisted catalysis. These studies also provide unprecedented insight into the mechanism underlying oxyimino-cephalosporin hydrolysis by expanded-spectrum ADC β-lactamases and possibly other class C β-lactamases, which is of critical importance to future drug design. IMPORTANCE The characterization of emergingAcinetobacter-derived cephalosporinase (ADC) variants is necessary to understand the increasing resistance to β-lactam antibiotics inAcinetobacterspp. In this study, cefiderocol retains effectiveness against ADC variants with and without an Ω-loop alanine duplication (Adup). However, the presence of the Adup appears to introduce loop flexibility and structural alterations resulting in increased resistance and steady-state turnover of larger cephalosporins. Further characterization provides unprecedented insight into the mechanism of cephalosporin hydrolysis by ADC β-lactamases and supports a concomitant increase in ADC structural flexibility and cephalosporin affinity that leads to more efficient hydrolysis. In addition, the crystal structure of ADC-33 in complex with ceftazidime is consistent with a substrate-assisted catalysis mechanism. The structural differences in the ADC-33 active site leading to ceftazidime catalysis provide a better understanding of β-lactamase Adup variants and open important opportunities for future drug design and development.

Microbiology↗

DOE OSTI2025

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

ABSTRACT Influenza infection and vaccination impart strain-specific immunity that protects against neither seasonal antigenic variants nor the next pandemic. However, antibodies directed to conserved sites can confer broad protection. Here, we identify and characterize a class of human antibodies that engage a previously undescribed, conserved epitope on the influenza hemagglutinin (HA) protein. Prototype antibody S8V1-157 binds at the normally occluded interface between the HA head and stem. Antibodies to this HA head–stem interface epitope are non-neutralizingin vitrobut protect against lethal influenza infection in mice. These antibodies bind to most influenza A subtypes and seasonal human variants, and are present at low frequencies in the memory B cell populations of multiple human donors. Vaccines designed to elicit these antibodies might contribute to “universal” influenza immunity. IMPORTANCE Antibodies to the influenza virus hemagglutinin (HA) protein confer the strongest protection against infection. Human antibodies elicited by infection and/or vaccination fail to protect against antigenically novel animal, pandemic, or human seasonal viruses. Improved vaccines are needed. We identify a novel class of antibodies that bind most divergent HA subtypes and all seasonal human HA antigenic variants tested. These antibodies confer protection from lethal influenza challenge in animal models. The corresponding epitope on the HA head is occluded by its interaction with the stem and is inaccessible in the well-resolved prefusion state. The immunogenicity of this head–stem interface indicates that poorly understood conformations of HA presenting widely conserved surfaces are explored in biochemical, cell-based, andin vivoassays. Head–stem interface antibodies warrant further investigation as an avenue to improve influenza vaccines and therapeutics.

Microbiology↗

DOE OSTI2024

Multivariate Testing of Sampling Techniques to Address Class Imbalance in Building Use Type Classification

This study addresses the challenges inherent in building use type classification, particularly focusing on the issue of class imbalance in the training datasets for machine learning classifiers. We comprehensively analyze the efficacy of various class-balancing sampling techniques. Employing Monte Carlo simulations and Bayesian optimization, we evaluated the performance of multiple sampling methods, including Random Oversampling, Random Undersampling, SMOTE, Borderline-SMOTE, and ADASYN, across a dataset encompassing nine southeastern coastal states of the United States. Our findings reveal that simple random over- and undersampling techniques outperform more sophisticated methods. Additionally, we show inherent value in creating an imbalance in training data to effectively train a machine learning classifier for distinguishing between residential and nonresidential buildings. This study provides valuable guidance for future research on building use type classification research and lays essential groundwork for developing attribute-rich building stock datasets.

Adams, Daniel↗

DOE OSTI2026

Scalable Federated Learning for Scientific Foundation Models on Leadership-Class Systems

Federated learning (FL) at leadership-class HPC systems remains largely unexplored, despite growing interest in deploying federated workflows on modern HPC systems. This paper provides the first system-level empirical characterization of federated fine-tuning of pretrained foundation models on an exascale supercomputer under a multi-node deployment. Using up to 96 concurrent FL clients deployed across Frontier nodes, we study the impact of client scale, model size, data heterogeneity, partial participation, and differential privacy on runtime, communication overhead, and convergence stability. Our results show that pretrained transformer models remain robust to heterogeneity, client dropout, and privacy noise, while system efficiency degrades rapidly with scale as synchronizat and orchestration dominate runtime. We further demonstrate that system-aware execution strategies, including intra-node aggregation and early aggregation, significantly reduce wall-clock time without degrading model quality. These findings establish a practical performance baseline and inform the design of communication-efficient FL systems on leadership-class HPC platforms.

Kotevska, Olivera [ORNL] (ORCID:0000000316772243)↗

DOE OSTI2024

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C

Abstract Approved inhibitors of KRASG12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This approach provides no direct target coverage of the active protein. Expectedly, adaptive resistance to KRASG12C (OFF)-only inhibitors is observed in association with increased expression and activity of KRASG12C(ON). To provide optimal KRASG12C target coverage, we have developed BBO-8520, a first-in-class, direct dual inhibitor of KRASG12C(ON) and (OFF) forms. BBO-8520 binds in the Switch-II/Helix3 pocket, covalently modifies the target cysteine, and disables effector binding to KRASG12C(ON). BBO-8520 exhibits potent signaling inhibition in growth factor–activated states, in which current (OFF)-only inhibitors demonstrate little measurable activity. In vivo, BBO-8520 demonstrates rapid target engagement and inhibition of signaling, resulting in durable tumor regression in multiple models, including those resistant to KRASG12C(OFF)-only inhibitors. BBO-8520 is in phase 1 clinical trials in patients with KRASG12C non–small cell lung cancer. Significance: BBO-8520 is a first-in-class direct, small molecule covalent dual inhibitor that engages KRASG12C in the active (ON) and inactive (OFF) conformations. BBO-8520 represents a novel mechanism of action that allows for optimal target coverage and delays the emergence of adaptive resistance seen with (OFF)-only inhibitors in the clinic. See related commentary by Zhou and Westover, p. 455

Oncology↗

DOE OSTI2025

Does class matter? Understanding differential pandemic recovery via a building typology

This study investigates the recovery of building-level footfall from the COVID-19 pandemic using privacy-preserving mobile devices-based footfall data within 60 downtown areas in the USA and Canada. Using clustering, we identify five distinct building typologies based on their characteristics, including rent, quality and recovery rates. The results reveal significant variation of recovery rates by building features. We find negative relationships with footfall recovery for both the percentage of office and remote work tenants and building quality. In contrast, buildings with traditional work tenants and retail functions achieve higher recovery rates. We also test the ‘flight to quality’ hypothesis via on our typology results. High-quality office buildings (Class A+) continue to have high rents but experience low physical footfall recovery, which suggests that this class is not as resilient as portrayed. The findings thus suggest the importance of considering both economic and footfall resilience in evaluating the performance of office buildings.

Covid-19↗

DOE OSTI2024

On a class of selection rules without group actions in field theory and string theory

We discuss a class of selection rules which i) do not come from group actions on fields, ii) are exact at tree level in perturbation theory, iii) are increasingly violated as the loop order is raised, and iv) eventually reduce to selection rules associated with an ordinary group symmetry. We start from basic field-theoretical examples in which fields are labeled by conjugacy classes rather than representations of a group, and discuss generalizations using fusion algebras or hypergroups. We also discuss how such selection rules arise naturally in string theory, such as for non-Abelian orbifolds or other cases with non-invertible worldsheet symmetries.

Kaidi, Justin (ORCID:0000000161440729)↗